Pancreatic Islets in Forefront of Diabetes Research
... involves the transplantation of pancreatic islets
from a donated pancreas to a person with ... such as limited engraftment [acceptance of the islets
within the recipient], chronic immunosuppression ...
To meet the increasing demand for human islets
for transplantation and research, islet-sharing ...
Cell transplantation and diabetes: New sites, new devices
... perhaps most supportive, microenvironment for islets
- is the pancreas itself," said Van der Windt and ... for selecting a donor at an age when the islets
have favorable properties, when islet-like cell ... islet cells can provide an unlimited source of islets
and in quantities that may satisfy the metabolic ...
Pancreatic Cells Turned Into Insulin-Producing Beta Cells
... them into beta cells, then coalescing them into islets
or groups of beta cells to transplant into patients.
Currently, some diabetics are treated with islets
taken from human cadavers, but it takes two ... treatment for some diabetics is to transplant islets
into the liver, so we know that liver cells are a ...
UIC in NIH-funded islet transplantation study for type 1 diabetes
... and generate an unlimited supply of islets
so that many more people would benefit from this ...
Islet transplantation involves isolating islets
from a donor pancreas and infusing the cells into ... liver. If the transplant is successful, the islets
lodge in the small blood vessels of the liver and ...
Suspected cause of type 1 diabetes caught 'red-handed' for the first time
... structures in the pancreas known as the islets
of Langerhans. They caught the immune cells, ... because the immune system has destroyed the islets
of Langerhans, which contain the body's only beta ...
Scientists detected dendritic cells in the islets
years ago. Dendritic and other antigen-presenting ...
Studies test new approaches to islet transplantation
... to transplanting clusters of insulin-producing islets
in adults with difficult-to-control type 1 ...
In islet transplantation, clusters of islets
are extracted from a donor pancreas and infused ... liver. In a successful transplant, the islets
become embedded in the liver and begin producing ...
Curing Diabetes, Pigs Turn to Lions
... conditions such as blindness, stroke and heart attack. Replacing islets
is the basis for the potential diabetes cure. Spring Point Project ... high-health, 'medical-grade' pig donors are produced as a source for the islets
suitable for human transplantation.
The Lions Clubs, ....
Popular diabetes treatment could trigger pancreatitis, pancreatic cancer
... the pancreas particularly how they affected beta cells in the pancreas's islets
of Langerhans. Beta cells are responsible for releasing insulin in people ... in sufficient amounts in diabetes patients. HIP rats approximate both the islets
and metabolism of people with Type 2 diabetes. The drugs were tested in 40 ...
University of Minnesota receives $40 million for type 1 diabetes research
... Project, a nonprofit organization that raises medical-grade pigs to supply islets
for transplantation. The researchers are currently developing a cell ... help us find the best cure faster. Stem cells provide another source of islets
for transplantation and offer us tremendous potential to conquer this ...
Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro
... three additional types of cells that along with β-cells make up the islets
of Langerhans. Together, these islet cells produce insulin and other ... for dedifferentiation of all the different cells that make up the islets
of Langerhans is a totally new finding," Dr. Rosenberg said.
"At this ...
New nanotube sensor can continuously monitor minute amounts of insulin
... the minute amounts of insulin released by special pancreatic cells called islets
The new electrode is built from multiwalled carbon ... transplant rejection. It will also allow them to verify the health of the islets
cells before they are transplanted into patients.
Stem Cells Finally Found in Pancreas
... are one of several types of cells making up clusters of cells called the islets
Insulin is a hormone that moves blood sugar from the ... of beta cells is more gradual.
Islet-cell transplantation, in which islets
are transferred from one person to another, is performed today but is ...
Circulating fats kill transplanted pancreas cells, study shows
... received transplants of complexes of pancreatic cells, called islets. The islets
are implanted in the liver, where they at first make insulin, but over ... beta cells into the animals livers. Fat accumulations were found around islets
four weeks after transplantation. Insulin levels declined, and the animals ...
Stem Cells Buy Freedom From Insulin for Type 1 Diabetics
... Richard Burt, of Northwestern University Feinberg School of Medicine in Chicago. "Why new onset? Because we wanted to make sure there were still some islets
there. We don't believe stem cells form islet cells, but if the islet cells are still there, there might be regeneration if we stop the attack soon ...
LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
... Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets
and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to ...
FDA OKs 1st Embryonic Stem Cell Trial
... that was funded by Geron Corp.
Geron is also working on using embryonic stem cells to treat failing hearts and to create insulin-producing islets
for type 1 diabetics, Okarma said.
"Embryonic stem cells are really nature's own way of making more of ourselves," Okarma said. "We are simply ...
Common cooking spice shows promise in combating diabetes and obesity
... macrophages in fat tissues throughout the body. These cells produce "cytokine" molecules that can cause inflammation in organs such as the heart, and islets
of the pancreas, while also increasing insulin resistance in muscle and liver. Researchers hypothesized that by suppressing the number and activity ...
Science, hope for adults with type 1 diabetes focus of JDRF's Annual Global Diabetes Research Forum
... intact islets. This finding gives hope for islet cell regeneration or restoration," Atkinson noted. He pointed out another key finding: that some islets
have beta cells that don't produce insulin. "If we know beta cells are there, then we can focus on finding ways to get them to produce insulin," Dr. ...
Promising advances in islet cell transplants for diabetes
... the study.
All patients in the study achieved insulin independence, but those who received the UIC protocol required fewer than half the number of islets
as those who were treated under the Edmonton protocol.
The four patients who received the Edmonton protocol needed either two or three sequential ...
Aspirin-like compounds increase insulin secretion in otherwise healthy obese people
... to the dose size.
In conjunction with the human studies, the researchers also conducted laboratory studies on insulin-producing cells (known as islets
of Langerhans) from mice and humans. The researchers observed that triflusal significantly increased the insulin secreted by these cells.
Coming soon: Cell therapies for diabetes, cancer?
... beating donors has been studied in animal models. Studies have shown that islet structure was well maintained after thawing, although the number of islets
decreased. Techniques for freezing human islet cells from non-heart beating donors are being developed with an emphasis on evaluating the thawed ...
Living donors may be best source of insulin-producing islets for diabetes treatment
... Transplantation, obtaining islet cells (clusters of pancreatic cells that create insulin) from living donors may be a solution to the shortage of islets
available for transplantation. In samples taken from living donors, 94 percent of the cells were viable for transplant, compared to only 42 percent ...
The new source of islet cells
... cells and release more insulin after induction.
The results of this study suggest a promising future for many diabetic patients who need islets
transplantation. Due to the high percentage of diabetes mellitus and severe complications around the world, this case reported by Dr. Liu et al. is ...
Lilly and MacroGenics Announce Licensing and Collaboration Agreement
... of the
pancreas. Researchers believe teplizumab may control the T lymphocytes that
mediate destruction of the insulin-producing beta cells of the islets
the pancreas. In doing so, they believe teplizumab may have the ability to
preserve and protect the remaining beta cells of the pancreas. ...
Pigs Arrive at Bio-secure Center
... profit organization for the expedition of pig islets
in the treatment of diabetes.
This project ... reversal of diabetes in humans, by transplanting islets
from the ‘medical grade’ pigs, into the pancreas ... diabetes in monkeys, by transplanting healthy islets
from pigs, into their pancreas. Its report was ...
New data from NIH lab confirms protocol to reverse type 1 diabetes in mice
... the activity of the immune cells that destroy islets
in type 1 diabetes. They also introduced donor ... cells to retrain the immune system not to attack islets
and found that the protocol not only halted the ... diabetes, in which regeneration of remaining islets
may be the dominant mechanism. ...
MRI Can Monitor Transplanted Islets
... said that they were able to track transplanted islets
in mice using the guidelines laid down for human ... studies show that there is a significant loss of islets
following transplantation due to many factors, ... type 1 diabetes, in which the insulin-producing islets
are attacked by the body's immune system. In an ...
First-Ever Robotic Pancreatectomy Performed at UIC
... in the patient's liver. Without a pancreas to produce insulin, Near would need insulin for the rest of his life. By transplanting the patient's own islets
cells, there is no risk of rejection as in other organ transplants, and the cells lodge in the liver and make insulin.
Compared to his first ...
LCT Reports Major Step for Islet Transplantation in Diabetes Patient
The scientific paper outlines how LCT has demonstrated the long-term safety, viability and function of its encapsulated porcine islets
in a human patient over an extended period of time, without the use of immunosuppression.
In 1996 a 41 year old diabetic was injected with ...
Transplanted Pig Cells in Human Produce Insulin
... international journal Xenotransplantation outlines how LCT has demonstrated the long-term safety, viability and function of its encapsulated porcine islets
in a human patient over an extended period of time, without the use of immunosuppression.
In 1996, a 41-year-old diabetic was injected with ...
Juvenile Diabetes may Be Caused by Mad Cow Protein
In Fraser Scott's lab, OHRI the rats prone to diabetes displayed a few strange traits, molecules of prion protein aggregated in the beta cells of islets
of pancreas. Destruction of these cells caused Diabetes.
Another thing noticed by them was that after 1-3 days of administering high doses of ...
Diabetes cure can be achieved using pig islets
... islet cells from the donor (pig) pancreas and transplanting them into the portal vein of the liver in people with diabetes. Then the transplanted islets
will sense blood glucose levels and release the appropriate amount of insulin to control blood glucose in the body. After transplantation these ...
Diabetes May Be Cured In 10 Days
... lives of children. //
But the method developed by doctors at Oxford's Churchill Hospital involves the removal of the clusters of cells known as islets
from a donated pancreas in highly sterile conditions, according to BBC News.
The cells are then injected directly into the patient's liver in ...
Transplant helps diabetes
... working on improving the protocol mainly by developing better immunosupressing, antirejection drugs that are less toxic to islet cells. Since islets
are considered foreign to the host, drugs have to be used to prevent the body from rejecting the cells.Sometimes these may cause further kidney ...
... addition Denise Faustman and colleagues at the Massachusetts General Hospital have rid the mice of the immune cells that attack the pancreas and the islets
in the first place.//
Once the mutinous cells were eliminated,the researchers coaxed the mice's remaining immune cells to develop ...