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Intracellular in Medical News

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

... development of a drug that targets and eradicates intracellular pathogens, which to date, have proven to be very ... patients. Zysolin(TM) improves the intracellular activity of Tobramycin - in layman's term, ... thus improving its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and ...

Life Sciences Discovery awards health research program grants

... rural communities, and developing highly-targeted intracellular drug delivery mechanisms. (See Backgrounder ... $7,163,794 Program title: Center for intracellular Delivery of Biologics Program focus: To better ... conditions. This program will identify new intracellular drug vehicles for clinical use that could result ...

Parasites that live inside cells use loophole to thwart immune system

... scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key ... within macrophages themselves. To do so, these intracellular pathogens deploy an arsenal of weapons to avoid ... no one had really explored the possibility that intracellular pathogens could directly exploit ...

Persistent bacterial infection exploits killing machinery of immune cells

... However, some harmful bacteria, known as intracellular pathogens, live inside cells and can even survive ... says Dr. Murray. "We wanted to determine just how intracellular bacteria were turning on the genes that make ... The research team discovered that intracellular pathogens increase levels of arginase, thereby ...

Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals

... associated with a rapid increase in the level of intracellular calcium. The effect was inhibited by two P2 ... mediated by P2 receptors and increased level of intracellular calcium. The data further support the development ... mediated by P2 receptors and increased level of intracellular calcium and that the data further support the ...

Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent

... two distinct activities. It inhibits the RAS/MAPK intracellular signaling pathway, which is mutated in many ... may avoid some of the redundancies inherent in intracellular signaling, Falardeau said. The agent also ... which is over-expressed in multiple cancers. This intracellular PBR binding may allow the drug to accumulate ...

Pathway to cell death redefined in landmark study

... lysosome. The authors report that the family of intracellular serpins may help cells survive in the face of ... they hoped, by studying the relatively limited intracellular serpin repertoire of C. elegans, they could gain ... skin cancer, those whose tumors express a lot of intracellular serpins dont do as well. Now we know that SRP-6 ...

Pathway to cell death redefined in landmark study

... lysosome. The authors report that the family of intracellular serpins may help cells survive in the face of ... they hoped, by studying the relatively limited intracellular serpin repertoire of C. elegans, they could gain ... skin cancer, those whose tumors express a lot of intracellular serpins dont do as well. Now we know that SRP-6 ...

Zysolin(TM) Pre-clinical Data Supports Once-a-day Dosing in Humans

... intubated and mechanically-ventilated patients. Zysolin(TM) improves the intracellular activity of Tobramycin - in layman's term, increasing the drug ... human macrophages, thus improving its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and Staphylococcus bacterial strains ...

Stanford researchers harness nanoparticles to track cancer-cell changes

... , the Stanford team was able to simultaneously monitor changes in two intracellular proteins that play crucial roles in the development of cancer. Successful ... that slightly changes a protein's shape, in effect turning it on. Two intracellular proteins, Stat1 and Stat6, play crucial roles in the development of ....

Gut instinct: Salmonella bacteria's molecular tactics to cause illness

... required while switching on a new set of protein factors necessary for intracellular survival. In a domino effect, part of this transition activates magnesium ... regulatory systems are activated can the proper activation of genes for intracellular survival be switched on and delicately maintained. The sequence of ...

Light shines for potential early cancer diagnosis technique

... cell's fundamental "building blocks," such as proteins, nucleosomes and intracellular membranes, and detect changes to this cell nanoarchitecture. Conventional ... varying degrees; the most aggressively malignant cell line showed the most intracellular disorder. When viewed using microscopy, all three cell lines looked ...

Celator(R) Pharmaceuticals Presents Phase 1 Results With CPX-351 in Patients With Advanced Leukemia at the American Society of Hematology Meeting

... and evidence of direct uptake of CPX-351 by leukemia cells with subsequent intracellular release of the drugs. Exposure of leukemic cells to synergistic drug ... is associated with liposome-mediated bone marrow drug accumulation, intracellular delivery of encapsulated agents to leukemia cells, and increase efficacy. ...

New research offers insight into oral cancer, chronic pediatric ear infections, and hearing health

... study, conducted by Australian researchers, indicate that the presence of intracellular bacteria in the middle ear plays an important role in the development of ... according to researchers, using antibiotics that specifically target intracellular bacteria may prove to be a more effective course of treatment. ...

A potential route for human tumor gene therapy

... H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value. Inhibition of the upregulation of NHE-1 gene expression in human gastric carcinoma cells can induce intracellular acidification, resulting in apoptosis of tumor cells, which is helpful for ...

How does CO2 insufflation pressure affect proliferation and improve apoptosis?

... very sharply with the insufflated pressure. The extracellular and intracellular pH was an important regulator of cell functions, such as ATP production, cell cycle, intracellular signaling and apoptosis. It is likely that all these changes influence the ...

EGFR protects cancer cells from starvation via a kinase-independent mechanism

... found that the EGFR enables human cancer cells to maintain adequate intracellular glucose levels by stabilizing the sodium/glucose transporter 1 (SGLT1) via ... suggest that EGFR, independent of its kinase activity, maintains the basal intracellular glucose level and thereby prevents cancer cells from succumbing to ...

Unexpected role: EGFR protects cancer cells from starving

... interfere with EGFR stabilizing SGLT1, allowing cancer cells to maintain intracellular glucose levels," Fidler said. "To destroy tumor cells by depriving them of ... target EGFR and therefore interfere with SGLT and therefore interfere with intracellular glucose remains to be seen, but it's a terrific target to shoot for." ...

Engineering chimeric polypeptides to illuminate cellular redox states

... Parallel with this advance is the emerging recognition that the intracellular redox environment exerts a profound influence on the normal cellular ... student and co-author of the publication. Given the importance of the intracellular redox state in determining a cells fate, and the increasing evidence that ...

Major Advance in the Observation of DNA Molecules

... a new method for observing DNA using atomic force microscopy (AFM) under intracellular physico-chemical conditions. These findings, published in the Journal ... compaction of DNA molecules. The presence of very large molecules in the intracellular environment impacts directly the degree of DNA compaction, and thus its ...

An AIDS-related virus reveals more ways to cause cancer, Penn researchers find

... first report of LANA interfering with the crucial cellular protein called intracellular Notch, says lead author Erle Robertson, PhD, Professor of Microbiology and ... of cells in many organs, such as the brain, heart, blood, and muscle. intracellular notch, or ICN, promotes cell growth and proliferation, therefore it must ...

Penn study finds pro-death proteins required to regulate healthy immune function

... The molecular basis of both findings is based on how Bax and Bak work on intracellular membranes. Specifically, the team found that when the T-cell receptor ... investigation showed that the amount and rate of calcium release from intracellular stores was altered in the mutant cells. The inadequate calcium signals ...

Rigel Announces Second Quarter 2009 Financial Results

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

Human cells secrete cancer-killing protein, UK study finds

... a tumor cell, it triggers a biological process called apoptosis or "cell suicide." Consistent with previous research by Rangnekar's laboratory with intracellular Par-4, the newly discovered secreted Par-4 acts selectively against cancer cells, leaving healthy cells unharmed. Few other molecules are known to ...

Rigel to Host Conference Call to Discuss Results of Its Phase 2b TASKi3 Clinical Trial of R788 in Rheumatoid Arthritis

... develops novel, small molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

Study aims to induce recovery from ankylosing spondylitis

... worldwide Cochrane Collaboration in evidence-based medicine. The treatment protocol is based on a molecular understanding of the interaction of intracellular and biofilm bacteria with the operation and control of the body's nuclear receptors. Dysregulation of these receptors has been shown to promote the ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... School of Medicine have found a way to do just that, by lighting up cells as they die. Apoptosis is a carefully orchestrated sequence of intracellular events that leads to the cell's death. "The cell takes itself apart in a finite series of steps," said Matthew Bogyo, PhD, associate professor of ...

Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations

... . As siRNA needs to be delivered intracellularly to be effective as a therapeutic, the Cobalamin technology may be particularly beneficial as an intracellular delivery technology, as the demand for vitamin B12 increases in many disease states." The ability of the Cobalamin technology to increase the ...

Breakthrough Testing For Early Heart Disease - In the Doctor's Office

... and complementary therapies including cardiovascular health programs, bioidentical hormone replacement therapy , immune system strengthening and intracellular nutrient and antioxidant analysis. His goal is to help individuals attain optimal health, often while undergoing conventional care. Dr. ...

Rigel to Present at Jefferies Healthcare Conference

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

Rigel's R788 Evaluated in Phase 2 Trial in Multiple Cancers

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer

... on the surface of HER2-positive breast cancer cells. Trastuzumab blocks the extracellular portion of the receptor, while neratinib blocks the intracellular portion. Researchers think that the combination may provide the one-two punch necessary to knock out the tumor cells. Forty-five women with ...

Trius Presents New Data on Torezolid Antibiotic for Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections

... of the oxazolidinone class currently marketed. Poster presentations on TR-701 also highlighted data characterizing torezolid's pharmacodynamics, high intracellular concentrations and resulting bactericidal activity. Human Phase 1 clinical studies showed that oral torezolid, administered at doses from 200 to 400 ...

Rigel to Present at JMP Securities Research Conference

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

Recent developments at Burnham Institute for Medical Research, May 2009

... that a combination therapy might be safe. Dr. Xu's laboratory also described how the amyloid precursor protein in diseased neurons influences the intracellular trafficking of other proteins involved in cell signaling and processing of the amyloid precursor protein itself in the Journal of Cell Biology . ...

Process controlling T cell growth and production identified

... T-cell is always circulating in the body and maintained at a constant level. Memory T cells are created when nave CD8 T cells are activated to fight intracellular pathogens such as viruses or bacteria. The fight against infections prompts creation of memory T cells that then "remember" antigens or proteins ...

New Technology Allows Better Monitoring of Cancer Cells

... In a study that appears April 15 in the online journal PLoS One , the researchers used the technology to simultaneously monitor changes in two intracellular proteins that play important roles in cancer development. If further development of the technique is successful, the researchers said, it could ...

New insights into how brain responds to viral infection

... (called Poly I:C) from the outside and the inside, the scientists were able to show for the first time the differences between extracellular and intracellular immune response in these supportive brain cells. Depending on whether the virus-like challenge was introduced extracellularly or intracellularly, ...

Hollow gold nanospheres show promise for biomedical and other applications

... than traditional nanoparticle structures used for SERS, providing a sensor element that can be more easily incorporated into cells for localized intracellular measurements," Schwartzberg, now at UC Berkeley, reported in a 2006 paper published in Analytical Chemistry. The collaboration with Li began when ...

Rigel to Present at Barclays Capital Healthcare Conference

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...
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