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Hypertrophy in Medical News

Study finds increased 'sibling risk' of obstructive sleep apnea in children

... 11,648 girls had a first hospital diagnosis of hypertrophy of the tonsils, or hypertrophy of the adenoids and tonsils. The overall standardized incidence ratios for adenotonsillar hypertrophy among those who had at least one affected sibling ...

Enzyme weakens the heart

... Enzyme activates stress response and hypertrophy of the heart A key molecule for cardiac hypertrophy brought on by stress is the naturally occurring ... that is normally activated by stress, leading to hypertrophy of the heart. "There was still some slight ...

Drug therapy for PKU reverses heart damage

... in both phenylketonuria (PKU) and cardiac hypertrophy is the chemical tetrahydrobiopterin (BH4). In ... principle that damage to the left ventricle from hypertrophy can be stopped and reversed, providing a ... estimated to have above- normal blood pressure. hypertrophy increases by two to three times an adults risk of ...

Gene Mutations for Rare Heart Disease Also Found in Kids

... same 10 gene mutations responsible for cardiac hypertrophy (thickening of the heart muscle) in adults are ... little is known about the causes of cardiac hypertrophy in children, so no diagnostic tests for children ... Most of the genes implicated in cardiac hypertrophy encode sarcomere proteins, which help the heart ...

JCI table of contents: Oct. 25, 2007

... because our understanding of the molecular mechanisms by which cardiac hypertrophy can be reversed is limited. But now, new research in mice by Cam Patterson ... amino acid, lysine 63. TITLE: Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins ...

Study in this Week's Issue of Cell Finds Injected Growth Factor Spurs Heart Regeneration

... on echocardiograms) improved as compared with untreated controls. The NRG1-injected mice also lacked the left-ventricular dilation and cardiac hypertrophy that typify heart failure; both were seen in the controls. When the researchers also stimulated production of a cellular receptor for NRG1, known ...

Center receives grant renewal for hypertension and vascular disease studies

... money to continue studying the mechanisms by which the renin angiotensin system, which regulates blood pressure, contributes to hypertension, cardiac hypertrophy (a thickening of the heart muscle that results in a decrease in size of the chamber of the heart), and other conditions. In addition, new studies ...

New blood test greatly reduces false-positives in prostate cancer screening

... Dana-Farber. The two-year study involved 484 participants. The group comprised 204 men with known prostate cancer, 110 men with benign prostatic hypertrophy (BPH), and 170 healthy men in a control group. (BPH can elevate PSA levels in the blood, which often leads to a biopsy to rule out prostate cancer.) ...

Black Youths With High BP May Face Elevated Heart Risks

... patients under age 21, researchers from Johns Hopkins Children's Center found that about 60 percent of those who were black had left ventricular hypertrophy (LVH), a condition that can cause heart failure, problems with heart rhythm and death. The researchers found LVH in just 37 percent of the other ...

Heart failure risk model validated

... coronary heart disease before. The nine measures are: age, history of coronary heart disease, smoking, blood pressure, heart rate, left ventricular hypertrophy measured by electrocardiography, and blood levels of glucose, creatinine and albumin. Several individual risk factors for heart failure have been ...

New Initiative Urges Women to Address Men's Health this New Year

... cancer. Your doctor will likely monitor for prostate cancer before and during treatment with androgens. -- Patients with benign prostatic hypertrophy (BPH) who are treated with androgens are at an increased risk of worsening of BPH symptoms. About Solvay Pharmaceuticals, Inc. Solvay ...

Slow exercise (not fast) is better for menopausal women

... Annual Meeting in Marseille [Poster Session A5]. Dr Snger's research group has investigated two particular methods of physical training. hypertrophy resistance training is a traditional approach designed to induce muscle growth whereas 'SuperSlow' is a more recently devised system which involves ...

Gender differences and heart disease

... derive a lesser benefit than men from two common high-blood-pressure-lowering drugs -- losartan and atenolol -- for the reduction of left-ventricular hypertrophy (LVH). The condition is a thickening and enlargement of muscle of the left ventricle of the heart and a marker for future heart disease. The ...

Genetic Disorder Drug Helps Reverse Heart Muscle Enlargement

... BH4 in stopping and reversing the weakening and damage done -- even in severe cases -- to the heart muscle as a result of hypertension and subsequent hypertrophy [enlargement]," senior investigator Dr. David Kass, a professor at the Johns Hopkins University School of Medicine and its Heart Institute, said in a ...

New potential treatment for muscular dystrophy appears to be safe

... in the various measures of effects on muscle tissue suggests that MYO-029 reached its intended target, producing a modest degree of muscle fiber hypertrophy and increased muscle mass in some treated subjects, noted Kathryn R. Wagner of The Johns Hopkins University School of Medicine and her coauthors. ...

Stroke Risk Factors Drain Memory

... were linked to memory loss -- high systolic blood pressure (that's the top number in a blood-pressure reading), diabetes, and left ventricular hypertrophy (thickening of part of the heart muscle, often caused by high blood pressure). Researchers interviewed 17,626 people who were enrolled in a ...

JCI table of contents: Feb. 21, 2008

... PDF of this article at: https://www.the-jci.org/article.php?id=33160 RELATED MANUSCRIPT TITLE: Curcumin prevents and reverses murine cardiac hypertrophy AUTHOR CONTACT: Peter. P. Liu University of Toronto, Toronto, Ontario, Canada. Phone: (416) 340-3035; Fax: (416) 340-4753; E-mail: ...

Report Finds 'Widespread Steroid Use in Baseball'

... because of elevated cholesterol, you get cholesterol plaque buildup." Steroid abuse can also cause a dangerous thickening of heart muscle called hypertrophy --- the same kind of heart-muscle enlargement seen in patients with congestive heart failure, experts warn. Linn Goldberg (no relation to Nieca ...

The structural basis of familial hypertrophic cardiomyopathy is revealed

... illustrates how the conformational instability within the sarcomere affects ability of the heart to function properly and may lead to compensatory hypertrophy in cardiac muscle tissue, which is a trademark phenotype of FHC. This study allows for a better understanding of the origination of FHC at the ...

Preventing or reducing enlarged heart may decrease risk for diabetes

... This new study finds an important new benefit -- namely a better chance of avoiding diabetes among patients who exhibit a reduction of their hypertrophy during treatment," says the study's principal investigator, Dr. Peter Okin, director of clinical affairs and professor of medicine in the Greenberg ...

Preventing or reducing enlarged heart decreases risk of heart failure

... NEW YORK (Sept. 10, 2007) -- For high-blood-pressure patients, preventing or reducing enlarged heart (left ventricular hypertrophy or LVH) reduces risk of heart failure. The study is published in the Sept. 4 Annals of Internal Medicine and led by physician-scientists at ...

Breakthrough for Treatment of Fatal Heart Condition

... has found that the progression of cardiac hypertrophy can be halted by increasing one of the bodys ... the symptoms can be managed, the cause of heart hypertrophy cannot yet be treated. This research provides a ... possible treatment. says Dr Ooi. Cardiac hypertrophy is a relatively common condition often caused by ...

Fetal Heart-Cell Enzyme and Onset of Heart Failure

... the way for new targets for treating cardiac hypertrophy and heart failure, appears in an advanced online ... “We found that in various mouse models of cardiac hypertrophy and heart failure, treatment with chemical HDAC ... warrant testing for cardiac disease to stop the hypertrophy that accompanies the re-expression of the ...

Fat Metabolism Of Heart Muscles Affected By High Blood Pressure

... found that hearts with muscle thickening// or hypertrophy due to high blood pressure get less energy ... who had high blood pressure that resulted in hypertrophy of the muscle of the left ventricle, the chamber ... will develop hypertrophy, and not everyone with hypertrophy has long-term problems, according to de las ...

Obesity is Linked to Enlarged Heart

... the hearts pumping chamber. Known to physicians as left ventricular hypertrophy (LVH), the condition potentially can lead to heart failure and rhythm ... says Dr. Movahed. Previous studies have shown that left ventricular hypertrophy is associated with a higher risk of mortality. Analyzing 17,261 heart ...

Hypertension, Prehypertension in Youngsters Linked With Heart Enlargement

... of left ventricular hypertrophy. The prevalence of left ventricular hypertrophy was three times higher among those with hypertension and two times higher ... compared to those with normal blood pressure. Left ventricular hypertrophy is an abnormal thickening of the muscles of the heart's left ventricle ...

Researchers Identify Key Step in Cocaine-Induced Heart Enlargement, Sudden Death

... pathway that we’ve identified likely also plays an important role in heart hypertrophy due to hypertension, heart attacks and heart failure,” Dr. Henning said. ... 5 million Americans use cocaine on a regular basis. Cardiac hypertrophy may affect as many as 47 percent of chronic cocaine users with normal ...

Transcendental Meditation Can Help

... factors that contribute to the cause or progression of heart failure, such a high blood pressure, stress, metabolic syndrome, left ventricular hypertrophy (enlargement of the heart) and severity of atherosclerosis (hardening of the arteries). Further validation of the outcomes of this study is planned ...

Transcendental Meditation To The Rescue of Cardiac Patients

... in continuation with an older one which talked about the positive effects of TM on high blood pressure, stress, metabolic syndrome, left ventricular hypertrophy and severity of atherosclerosis. JYT ...

Insect Protein Effective for Treating Heart Enlargement, Arrythmias

... and investigates the cellular and molecular mechanisms leading to arrhythmia. The researchers used a mouse model with pressure-induced cardiac hypertrophy to study soluble epoxide hydrolase inhibitors isolated in the laboratory of Bruce Hammock, a distinguished professor of entomology who directs the UC ...

Children and Chronic Kidney Disease

... had evidence of heart enlargement.' Persistently elevated blood pressure, or hypertension is a well-known risk factor for left-ventricular hypertrophy (LVH), a thickening or enlarging of the lower left chamber of the heart, and the conventional wisdom has been that the degree of hypertension ...

Protein Increase Decreases Risk of Heart Failure

... attack. Certain cell receptors called Gq-coupled receptors, which include alpha-adrenergic and angiotensin receptors, play a role in cardiac hypertrophy and "have been implicated in being elevated in some models of heart disease," he says. "When these agents act on the heart, they stimulate pathways ...

For High BP Patients, Preventing Enlarged Heart Decreases Risk of Atrial Fibrillation

... drug, the beta-blocker atenolol, in reducing LVH. Left Ventricle Hypertrophy Chronic high blood pressure can lead to left ventricular hypertrophy (LVH), a dangerous enlargement of muscle surrounding the heart's main pumping chamber. The condition can be monitored via electrocardiograph -- an ...

Increased Nighttime BP, a Significant Predictor of Congestive Heart Failure

... University, Uppsala, Sweden, and colleagues analyzed BP characteristics of 951 elderly men, free of CHF, valvular disease, and left ventricular hypertrophy at baseline between 1990 and 1995. They followed the participants until the end of 2002. Twenty-four-hour ambulatory blood pressure monitoring was ...

Hypertension Not Given Priority during Treatment

... (52.2%), diabetes (39.5%) and family history of cardiovascular disease (15.7%). In addition, one-fifth of the patients (20.3%) had left ventricular hypertrophy (enlarged hearts) and more than one-in-ten (12.8%) had microalbuminuria, an indicator of subclinical cardiovascular disease. Despite having blood ...

The Size Of The Heart Does Matter

... blacks and 580 whites showed that all had high blood pressure. Compared to whites, blacks were nearly twice as likely to suffer from left ventricular hypertrophy ( LVH ), or an enlarged heart. They were 2.5-times more likely to have a thickening of the heart muscle. LVH leads to heart attack or stroke ...

Ultrasound test may detect heart condition early

... something we haven't really been able to evaluate before--the relaxing ability of the heart. They found that patients with HCM, regardless of whether hypertrophy was present, demonstrated impaired cardiac relaxation. ...

New technique for heart enlargement

... in Houston, an author of this study, offers promise that younger patients will be diagnosed earlier with the disease, instead of after puberty when hypertrophy usually begins to develop. Advances like this one may make a difference with this disease as well as help us understand and prevent sudden death in ...

A ray of light on Cardiology

... angiotensin-converting enzyme (ACE) inhibitor ramipril, used for the treatment of hypertension, can retrieve, and may even prevent, left ventricular hypertrophy (LVH), thereby lowering the risk of stroke and myocardial infarction (MI), a new study has shown.Results from the landmark Heat Outcome Prevention ...
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