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Homozygous in Medical News

Isis Reports Strong Financial Results and Highlights for First Quarter of 2009

... from a Phase 3 study evaluating mipomersen in homozygous Familial Hypercholesterolemia (FH) patients and ... from our Phase 3 study evaluating mipomersen in homozygous Familial Hypercholesterolemia patients. We ... is planning an initial European submission for homozygous Familial Hypercholesterolemia (FH) with timing ...

Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008

... from a Phase 3 study evaluating mipomersen in homozygous Familial Hypercholesterolemia (FH) patients and ... 3 study evaluating mipomersen in patients with homozygous FH. Also we and our partners expect to report ... enrollment in a Phase 3 mipomersen study in homozygous FH subjects. Initiating four additional ...

What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?

... There are three predominant genotypes of TS: (1) homozygous with two tandem repeats (2R/2R); (2) homozygous with three tandem repeats (3R/3R); (3) ... (n = 22) and 3R/3R (n = 40). Patients who were homozygous for triple-repeated (3R/3R) sequences showed ...

The onchocerciasis parasite showing signs of resistance

... the percentage of parasites showing a genotype homozygous for this gene fell from 79 to 31% in subjects ... inferred that the parasites showing a genotype homozygous for β-tubulin are more susceptible to it. As ... there were more microfilariae in the uterus of homozygous female parasites than in those of heterozygous ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... pain in a patient on therapy with lovastatin. homozygous Familial Hypercholesterolemia MEVACOR is less effective in patients with the rare homozygous familial hypercholesterolemia, possibly because ... (see ADVERSE REACTIONS) in these homozygous patients. Information for Patients Patients ...

IDO2 an active enzyme to target in pancreatic cancer

... to have an active IDO2 enzyme. Nineteen percent of the patients were homozygous wild-type, meaning they had two active alleles, and 42 percent of the ... meaning they had one active allele. Twenty-five percent were homozygous for two inactive IDO2 alleles. The remaining 14 percent were difficult to ...

Scientists identify new congenital neutropenia syndrome and causative gene mutation

... the other is not) in the neutrophil elastase (ELA2) gene. In 2007, Klein's lab identified another causative mutation in a subgroup of SCN patients: homozygous mutations (where the defect is present in both copies of the gene) in the HAX1 gene. To conduct the current study, the researchers focused on five ...

ADHD Gene Doesn't Predict Response to Drugs

... "What we found is that the children who have two copies of the Val isoform had an even harder time orienting their goals than children who are homozygous for Met [that is, have two copies of the Met isoform] or even Val/Met," he said. Each person two copies of the COMT gene, one from each parent. ...

Isis Reports Financial Results and Highlights for First Quarter of 2008

... Phase 3 program in patients with high cholesterol at high risk for cardiovascular disease including an ongoing Phase 3 study in patients with homozygous Familial Hypercholesterolemia (FH). o Isis reported updated safety data on mipomersen from an ongoing open-label extension study in ...

FDA Provides Clarity to Isis Regarding the Development Path for Mipomersen

... has indicated that reduction of LDL-cholesterol is an acceptable surrogate endpoint for accelerated approval of mipomersen for use in patients with homozygous familial hypercholesterolemia (hoFH). The FDA will require data from two ongoing preclinical studies for carcinogenicity to be included in the hoFH ...

Isis Reports Financial Results and Highlights for Fiscal year 2007

... strong progress with our most important asset, mipomersen. Earlier in the year, we announced the initiation of the Phase 3 studies in patients with homozygous Familial Hypercholesterolemia. Today we are announcing that we are initiating the rest of the Phase 3 program for mipomersen including studies in ...

Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year

... cholesterol levels with statins alone or who are intolerant of statins. Mipomersen is currently in phase 3 development for patients with homozygous familial hypercholesterolemia, and a U.S. marketing application for this indication is anticipated in 2009. The product offers an innovative ...

Human embryonic stem cell lines created that avoid immune rejection

... and the subsequent derivation of cell lines having the morphology and markers characteristic of human embryonic stem cells. In a paper entitled, HLA homozygous Stem Cell Lines Derived from Human Parthenogenetic Blastocysts, the authors emphasize two key factors that would make this technology so valuable for ...

Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations

... have substantiated and replicated the links of CFH, CFB and Chromosome 10 to AMD. Additional research published in 2007 found that people with homozygous risk profiles for CFH, CFB and LOC387715/HTRA1 have as great as a 250 times increased risk of developing AMD. About Optherion: Optherion, Inc. is ...

Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months

... the most severely affected patients may need apheresis, an expensive and time-consuming procedure that removes the "bad" cholesterol from the blood. homozygous FH is rare, affecting about one in one million people, but heterozygous FH is much more common with a prevalence of approximately one in every 500 ...

Study Questions Genetic Screening for Treatable Diseases

... Research Institute in La Jolla, Calif., said, "Not until clinicians and researchers better understand the factors that determine whether a patient homozygous for the N370S (GD) mutation will develop severe disease or none at all will screening for Gaucher disease become useful. Until then, screening for ...

New Therapy to Treat Patients With Severely Elevated Cholesterol Levels

... of Medicine (NEJM). In this study, patients with homozygous familial hypercholesterolemia (FH), a high-risk ... designed and carried out the current study in homozygous FH patients with support from the Doris Duke ... as AEGR-733. Patients who suffer from homozygous FH typically respond poorly to standard drug ...

Gene Responsible for Blindness in Infants and Children Identified

... the UK, Dr. Koenekoop and his team, including Dr. Irma Lopez, used a new technique called SNP (single nucleotide polymorphism) technology to identify homozygous regions in the genome, which led to the discovery of the new gene called LCA5. In the past, large families were necessary to find genes, but ...

Genetic Variation Linked to Age-Related Macular Degeneration

... up in the retina of the eye) to vision-disabling late AMD and the risks increased with each successive stage to stage 11 for late AMD. Individuals homozygous (having two identical gene alleles at the corresponding site on a chromosome) for the CFH Y402H gene had a 48 percent cumulative risk of developing ...

Cigarette Smoking and High Body Mass Index Increase the Risk of AMD

... cigarette smoking was associated with a fivefold increased risk and high BMI (30 or higher) was associated with a twofold higher risk of AMD. The homozygous risk genotype (CC) plus smoking conferred a tenfold higher risk of AMD, compared with non-smokers with the non-risk (TT) genotype, while the risk ...

CCR5 Mutation Confers Immunity Against HIV But Not Against West Nile Virus Illness

... who had gene mutation on both the copies. Among the Coloradans who were WNV-positive and who self-reported their race as white, the percentage of homozygous individuals was 8.3. In conclusion the researches said that CCR5 gene is very closely associated with the development of WNV infection. It would ...

Too much coffee is too bad

... and osteoporosis.They found that women with high caffeine intakes had significantly higher rates of bone loss at the spine, and that women who were homozygous for a mutation in the vitamin D receptor (VDR) gene were at greater risk for caffeine-related bone loss.// Women in the high cafeeine category ...
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