JCI table of contents: Oct. 25, 2007
receptor makes T cells attack
Mice lacking the histamine
H1 receptor (H1R) are less susceptible than ... diseases such as multiple sclerosis.
receptor H1 is required for TCR-mediated p38 MAPK ...
EpiCept Announces Presentation of New Ceplene(TM) Data at the 49th Annual Meeting of the American Society of Hematology
... The new data compares the effects of post-consolidation
immunotherapy with histamine
dihydrochloride (HDC) in conjunction with low
dose interleukin- 2 (IL-2) ... Center.
Poster # 36 Title: "Post-consolidation Immunotherapy with histamine
Dihydrochloride and Interleukin-2 in AML: Long Term Follow-Up of ...
Drug Limits Stomach Trouble in Patients Taking Low-Dose Aspirin
... the FAMOUS trial were published online July 6 in The Lancet , and will appear in an upcoming print issue.
Famotidine lowers acidity by binding to histamine
particles in the stomach. The drug is broken down by enzymes in the liver. The drug may offer an alternative to proton pump inhibitors (PPIs), which ...
Dermatologic and Ophthalmic Drugs Advisory Committee Unanimously Recommends Bepreve(TM) for the Treatment of Ocular Itching Associated with Allergic Conjunctivitis
... 12, 2009.
About Bepreve (bepotastine besilate ophthalmic solution) 1.5%
Bepreve is a non-sedating, highly selective antagonist of the histamine
(H1) receptor. It has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed tissues. The compound's ...
High Activity, Plant Based Diamine Oxidase Enzyme Introduced by Bio-Research Products
... and diaminohexane. With better availability and with higher activity, Bio-Research's diamine oxidase can also play a role in diagnostic assays for histamine
Bio-Research Products is a producer of high purity enzymes used in medical diagnostic tests and in other demanding applications. It ...
ISTA Pharmaceuticals Announces FDA Advisory Committee to Review Bepreve(TM) for the Treatment of Ocular Itching Associated with Allergic Conjunctivitis
... of September 12, 2009.
About Bepreve(TM) (bepotastine ophthalmic solution)
Bepreve is a non-sedating, highly selective antagonist of the histamine
(H1) receptor. It has a stabilizing effect on mast cells and it suppresses the migration of eosinophils into inflamed tissues. The compound's ...
'Qu-Chi' Acupressure Band Gives Hayfever Misery the Elbow
... as a Class 1 medical device and carries the CE mark.
The 'Qu-Chi' point has previously been shown to reduce the affective
effects of histamine
type reactions in the Body ('Preventive effect of
acupuncture on histamine-induced itch: A blinded, randomized,
placebo-controlled, crossover trial' ...
Sublingual immunotherapy for inhalant allergies deserves deeper consideration
... These reactions often involve tissue destruction, blood vessel dilation, and production of many inflammatory substances, including histamine. histamine
produces common allergy symptoms such as itchy, watery eyes, nasal and sinus congestion, headaches, sneezing, scratchy throat, hives, and shortness ...
The Makers of BENADRYL(R) and the National Park Foundation Encourage People to Pledge to Spend More Time Enjoying Outdoor Moments
... throughout the year that can lead to allergy symptoms.
About BENADRYL (R)
BENADRYL(R) is an antihistamine that helps block the action of histamine
in the body. BENADRYL(R) helps provide relief of upper respiratory allergy symptoms including sneezing, runny nose, itchy, watery eyes and itching of ...
Children's Sugar-Free, Dye-Free ZYRTEC(R) Allergy Syrup Now Available
... like sneezing, runny nose and itchy-watery eyes.
About ZYRTEC (R)
ZYRTEC(R) is an antihistamine that helps block the action of histamine
in the body. ZYRTEC(R) helps provide 24 hour relief of indoor and outdoor upper respiratory allergy symptoms including symptoms of sneezing, runny ...
AGA releases evidence-based GERD guidelines
... esophagitis, symptomatic relief and maintaining healing of esophagitis). In these uses, proton pump inhibitors (PPIs) are more effective than histamine
receptor antagonists (H 2 RAs), which are more effective than placebo.
II. Long-term use of PPIs for the treatment of patients with esophagitis ...
GlaxoSmithKline Presents Innovative Neuroscience Pipeline
... D2 and serotonin
5HT2 receptors, whilst having minimal activity on receptors believed to be
responsible for side-effects, such as dopamine D1, histamine
M1, alpha and beta adrenergic receptors. This profile has the potential to
deliver efficacy similar to the present antipsychotics ...
ISTA Pharmaceuticals Expands Its Pipeline in Allergy Treatments
... development in late 2008 or early 2009.
Bepotastine has three primary mechanisms of action. It is a non-sedating,
selective antagonist of the histamine
1 (H1) receptor, it has a stabilizing
effect on mast cells, and it suppresses the migration of eosinophils into
inflamed tissues. The compound's ...
Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
... mistakenly identifies
it as an intruder.(7) An allergic reaction results, involving the body's
release of various inflammatory mediators, including histamine
leukotrienes, as a defense against the allergens, causing symptoms such as
sneezing, nasal congestion, runny nose, and itching of the palate, ...
WBC in Lung Produces Histamine: Study
... watery eyes, and wheezing.
They say that histamine
can be produced in large amounts in the lung by ... first to show that lung neutrophils can produce histamine
in significant quantities, according to principal ...
Caughey says the result could mean that histamine
acts as a link between airway infections and ...
Anti Inflammatory Evaluation Of Plumeria Acuminata Leaves
... methanol extract of leaves of Plumeria Acuminata on carrageenan, dextran, histamine
and serotonin-induced inflammation in rat hind paw oedema models. ... sex weighing 180a€“200 g were used. In acute model carrageenan, dextran, histamine
and serotonin models were used to induce inflammation in rat hind paw and ...
New Treatment For People Allergic To Cats
... gamma Feline domesticus causes the release of histamine
in people allergic to cats. The latest innovation ... the antibody that could stop the release of histamine
on being associated with cats.
The new ... a single dose the treatment blocks the release of histamine
that causes allergic reactions. As a result the ...
Allergic Individuals Should Keep Away from Cats, Say UK Scientists
... that provokes the body into producing histamine, a protein.
produces swelling and irritation of the upper airways and causes typical ... receptors on the surface of immune cells. This triggers the release of histamine
in the body, causing symptoms such as itching, sneezing and runny eyes and ...
Scientists Uncover Cause of Antipsychotic Drug Weight Gain
... activates AMPK to the same extent as clozapine. To confirm that the histamine
receptor connects the drug, AMPK activity and appetite, the team gave clozapine to mice genetically engineered without a histamine
Results? Peace. No heightened AMPK activity. ...
Passive Smoking Worsens Allergies
... levels of IgE (the antibody produced in response to allergen exposure) and histamine
(one of the substances responsible for the symptoms of inflammation). ... than for study participants who were exposed to ragweed/clean air. Nasal histamine
levels were also 3.3 times higher for those exposed to ragweed/secondhand ...
Chilean President's Cousin Successfully Tests Allergy 'Knockout' Technique on Mice
... occur when, as a result of exposure to allergens, mast cells react violently and release an enormous array of pro-inflammatory substances, of which histamine
is a well-known example. They later on attract inflammatory cells that will maintain the response, which often persists as a chronic disease. ...
AAAAI Offers Advice on Stinging Insect Allergies
... person's body produces an allergic substance called Immunoglobulin E (IgE) antibody, which reacts with the venom. This triggers the release of histamine
and other chemicals that cause allergic symptoms and, in the most severe of cases, a rapid fall in blood pressure, loss of consciousness and ...
Doctors in UK Promoting Awareness of Gastro-oesophageal Reflux Disease
If the symptoms are not frequent - less than five times a month - they can be treated with over-the-counter medications such as antacids and histamine
antagonists (drugs to counter histamines).
Histamines are chemicals found in plant and animal tissue and released from certain type of cells as ...
Holiday Season Could Ring in “Heartburn Season
... available. Emphasis has since shifted to prevention.
Those who are planning to indulge in foods likely to cause them heartburn can now take a histamine
receptor blocker (H2 blockers), which slow the production of stomach acid and are generally available over the counter.
“Most people suffering ...
Substance P May Pre-empt VIP in Regulating Temperature
... study that appeared in the November 2004 issue of the Journal of Physiology. In that paper, Wong, Minson and additional colleagues reported that the histamine
1 receptor, which is involved in seasonal allergies, has a role in skin blood flow changes during heat stress.
Minson’s research primarily ...
Potential New Therapeutic Target for Asthma, Allergies and Cancer
... cells could be a source of S1P. Mast cells are found in all body tissues and rapidly produce and secrete a number of inflammatory substances such as histamine
and S1P when activated by an inflammatory stimulus. Spiegel said that S1P in turn amplifies allergic and inflammatory responses. Therefore, S1P ...
Fermented Milk offers protection against allergies in infants
... which inactivates the invading organisms that may cause disease. But, when allergens are involved, Ig E also activates cells releasing histamines. histamine
causes allergic responses like inflammation and constriction of airways.
Ji-Ruei Liu and his team from the National Formosa University ...
Allergy OTC Medicines–Speak With Your Pharmacis
If the symptoms are a runny nose, sneezing, itching of the nose, and watery eyes, chances are it’s the body’s reaction to elevated histamine
levels. For that group of symptoms, an antihistamine could be sufficient by itself.
However, many antihistamines have the ability to make ...
Cancer and psoriasis triggered by mast cells
... The body's mast cells are linked to allergic reaction in a manner with which histamine
and other inflammatory substances are released. However, researchers at Karolinska// Institute have now shown how mast cells can cause diseases like ...
Fruits and vegetables found to interact with drugs in a dangerous way
... include anti-infectives, anti-inflammatory drugs, cardiovascular agents, central nervous system agents, estrogens, gastrointestinal agents, histamine
H1 antagonists, immunosuppressants, and erectile dysfunction drugs. Caution has to be taken in particular with sedatives like triazolam, midazolam ...
Controlling Allergies Before They Start
... allergic symptoms. Anti-histamines only block histamine. Researchers say the new drug works by blocking the pathway within the mast cell, so the histamine
is never released.
However ,currently, the drug does not have a name and is referred to as R112 and specialists say the effects of the drug will ...