Scientists learn why even treated genital herpes sores boost the risk of HIV infection

... New research helps explain why infection with herpes simplex virus-2 (HSV-2), which causes genital ... that successful treatment of such genital herpes lesions with the drug acyclovir does not reduce ... time points: when the patients had genital herpes sores and breaks in the skin, when these lesions ...

Condoms May Reduce Herpes Risk

... can reduce their risk of getting genital herpes by 30 percent, a new study finds. The herpes simplex virus 2 (HSV-2) causes genital herpes, ... unclear whether using a condom to prevent getting herpes was going to be effective, but this shows that it ...

Test Before Corneal Transplant May Improve Outcome

... Even inactive herpes virus can cause inflammation, transplant ... July 1 (HealthDay News) -- Among patients with herpes simplex virus who need a corneal transplant, ... helps focus light for vision, can be damaged when herpes simplex virus infects the eye. In some cases, the ...

Herpes medication does not reduce risk of HIV transmission

... as a safe and effective treatment to suppress herpes simplex virus-2 (HSV-2), which is the most common ... Multiple studies have shown that frequent genital herpes recurrences increase the amount of HIV in the ... tract. The HIV virus is also shed from genital herpes ulcers and individuals with such ulcers transmit ...

Treatment Target for Herpes Pinpointed

... for a treatment, and possibly a cure, for the herpes virus. A viral protein known as VP16 is apparently responsible for pushing herpes out of its latent state and back into an active ... to 90 percent of people worldwide carry the herpes virus, although not all show symptoms. "It's a ...

Circumcision Guards Against STDs

... the rates of infection with the virus that causes herpes went down by 28 percent, and the transmission of ... viruses. They screened the blood samples for HPV, herpes (specifically HSV-2) and syphilis. Two years ... who'd been circumcised had been infected with the herpes virus, while 10.3 percent of the men in the ...

Epiphany Biosciences Initiates Program to Assess Valomaciclovir (EPB-348) as Adjunctive Therapy in Multiple Sclerosis (MS)

... a number of herpes-related viruses, including herpes simplex (HSV), Epstein-Barr virus (EBV), herpes zoster (HZV), and human herpes virus 6 (HHV-6). The drug is currently being ...

Herpes: Scientists find cellular process that fights virus

... elusive virus responsible for cold sores: Type 1 herpes simplex (HSV-1). As reported in the advance ... "Once human cells are infected with Type 1 herpes simplex, the virus comes back because it hides ... membrane of an infected cell can unmask Type 1 herpes simplex and stimulate the immune system to ...

NanoBio to Announce Key Clinical and Preclinical Data on Its Topical Anti-infective Lotions at AAD 2009

... development of its novel topical treatments for herpes labialis, onychomycosis and tinea capitis. The ... on the company's development programs for acne, herpes and antifungal products will be available. ... Antiviral Nanoemulsion (NB-001) for Recurrent herpes Labialis Poster # P2517, 4:00 p.m. -- ...

Rheumatoid Arthritis Drugs Raise Shingles Risk

... There have, however, been reports of severe herpes zoster in people taking TNF blockers. TNF ... no statistically significant association between herpes zoster and the other drugs studied or with TNF ... with TNF blockers for early signs and symptoms of herpes zoster." A vaccine against shingles is ...

ViroPharma Reports Results of Phase 3 Clinical Trial for Maribavir in Bone Marrow Transplant Patients

... Cytomegalovirus CMV is a member of the herpes virus group, which includes the viruses that cause chicken pox, mononucleosis, herpes labialis (cold sores), and herpes genitalis (genital herpes). Like ...

In Time, Cream Might Prevent Herpes Transmission

... that play a key role in the transmission of the herpes virus has been developed by U.S. researchers. ... week before to a few hours after exposure to the herpes virus. "As far as we could tell, the treatment ... 536 million people worldwide are infected with herpes simplex virus type 2 (HSV-2), the most common ...

Engineered virus targets and kills apparent cancer stem cells in neuroblastoma

... researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by ... his colleagues tested the effect of an oncolytic herpes simplex virus called rQNestin34.5 on cells. ... infected tumorigenic cells with another oncolytic herpes virus called rQLuc, which does not target cells ...

New Hope Against the Cold Sore Virus

... Driving herpes simplex out of hiding could bring about a cure, ... breakouts of unsightly cold sores, caused by the herpes simplex 1 virus, but new research is finally ... say they've unlocked the mystery of how herpes simplex 1 slips into dormancy and stays dormant ...

Herpes Suppression May Not Prevent HIV Infection

... THURSDAY, June 19 (HealthDay News) -- The herpes drug aciclovir (Zovirax) doesn't reduce the risk ... study finds. Previous research has shown that herpes simplex virus type-2 (HSV-2) infection -- the most common cause of genital herpes -- increases the risk for HIV-1 infection by two- ...

Abbott Receives FDA Approval for HUMIRA(R) (Adalimumab) for Polyarticular Juvenile Idiopathic Arthritis

... pharyngitis, increased aminotransferases, herpes zoster, myositis, metrorrhagia and appendicitis. ... of treatment with HUMIRA and included cases of herpes simplex, pneumonia, urinary tract infection, pharyngitis, and herpes zoster. Safety of HUMIRA in pediatric patients ...

Novel vaccine concept developed by scientists at the Wistar Institute

... Center could be the answer. The secret is using a herpes simplex protein called glycoprotein D to block a ... signals is blocked by glycoprotein D from herpes virus. In a study that will be published ... she says. Glycoprotein D is part of the herpes viral envelope and is expressed on the surface of ...

Study finds genetic link to human herpes susceptibility

... a high probability that people who are prone to herpes simplex virus (HSV) outbreaks can inherit that ... called fever blisters). Cold sores occur when the herpes virus reactivates from its quiescent state within ... of new drugs that reduce the frequency of herpes outbreaks, according to John D. Kriesel, M.D., ...

Transport's Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode

... System (SoloVir(TM) ETS) for recurrent herpes labialis (cold sores). SoloVir(TM) ETS uses ... Spotswood Spruance, MD, a noted expert on herpes labialis and a member of Transport's Scientific ... clinical community a new paradigm for treating herpes more efficaciously by administering treatment to ...

Targets on the horizon: Emerging therapies and novel targets

... said. Nerve-sparing therapy with oncolytic herpes virus for cancers with neural invasion: Abstract PR 8. A cancer-targeting herpes virus could effectively stop the spread of cancer ... colleagues worked with a genetically engineered herpes simplex virus called NV1023, which had been ...

An AIDS-related virus reveals more ways to cause cancer, Penn researchers find

... shed new light on how Kaposis Sarcoma-associated herpes Virus (KSHV) subverts normal cell machinery to ... such as p53 and VHL, for degradation. Other herpes viruses, such as the one that causes cold sores ... hide out in cells as well. Whether these latent herpes viruses use some of the same strategies that we ...

Consumer Reports' Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best

... is a form of intense nerve pain caused by the herpes zoster virus -- affecting over a million people ... the nerve pain associated with diabetes or herpes zoster infection (shingles) -- Pregabalin ... the nerve pain associated with diabetes or herpes zoster infection (shingles) The anticonvulsant ...

VivaGel(R) Demonstrates Anti-HIV and Herpes Activity Following Human Administration

... retains antiviral activity against human immunodeficiency virus (HIV) and herpes simplex virus (HSV, the virus that causes genital herpes), following ... These samples were tested for their ability to prevent HIV and genital herpes (HSV-2) infection of susceptible cells in the laboratory. The study ...

Boost Natural Killer Cells to Prevent Swine Flu

... Babesia, or HIV are more likely to have lower Natural Killer Cell levels. herpes Simplex, Human herpes 6, Epstein Barr and Cytomegalus viruses also suppress immunity. Dr. ...

Poor people suffer disproportionately from chronic infections

... families are much more likely to suffer from serious infections such as herpes or hepatitis A than their counterparts in wealthier households. Two ... ulcer disease; hepatitis A and B, which can cause liver disease; and herpes simplex 1 and cytomegalovirus (CMV), both implicated in cardiovascular ...

Targeting Cancer's Own Stem Cells to Fight Recurrence

... cells or "tumor-initiating cells" which, when targeted with a reprogrammed herpes virus, are prevented from turning malignant. The finding bolsters the ... in neuroblastoma cells. When the stem cells were infected with a herpes simplex virus which specifically targets nestin, they did not form tumors ...

Topical treatment for cold sores achieves efficacy of oral drugs; represents paradigm shift

... activity in the dermis and epidermis, where it surrounds and fuses with herpes simplex virus and disrupts the outer envelope of the pathogen," Flack ... integrity, so it is not absorbed into the bloodstream." Because the herpes simplex virus causes both cold sores and genital herpes, there is a strong ...

FDA Approves VELCADE(R) (Bortezomib) for Injection for Patients with Previously Untreated Multiple Myeloma

... (14% vs 9%), abdominal pain (14% vs 7%), paresthesia (13% vs 4%), herpes zoster (13% vs 4%), bronchitis (13% vs 8%), hypokalemia (13% vs 7%), ... pain (each 15%), bone pain (14%), back pain and hypotension (each 13%), herpes zoster, nasopharyngitis, upper respiratory tract infection, myalgia and ...

Specialized white blood cells coordinate first responders to viral infection

... researchers looked for a role for regulatory T cells during the start of a herpes simplex virus infection in mucus membranes. When regulatory T cells are deficient in mice, the herpes simplex virus replicates rapidly in the mucus membranes and spreads to the ...

Potential viral therapy weapon for difficult cancers is safe and effective in study

... CINCINNATI Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a ... safety, specifically toxicity to nerve tissues. Most research of oncolytic herpes simplex viruses (oHSVs) has so far been limited to those engineered by ...

First Responders Acquire Revolutionary MyClyns(TM) Protective Spray

... MyClyns has also demonstrated virucidal activity against HIV-1 and herpes Simplex Virus type 1 in independent laboratory tests. "We have had an ... MyClyns has also demonstrated virucidal activity against HIV-1 and herpes Simplex Virus type 1 in independent laboratory tests. MyClyns protects ...

Transcript of Elizabeth Mazzocchi Press Conference

... and humiliation every day for the rest of my life. When I learned I had herpes in September 2006, I confronted him, and he told me that he had known ... at least one of whom subsequently confirmed that she, too, contracted herpes from Esai Morales. II. Lawsuit Many of the details of Esai Morales' ...

ViroPharma Receives European Orphan Drug Designation for CAMVIA(TM)

... used anti-CMV drugs. About Cytomegalovirus CMV is a member of the herpes virus group, which includes the viruses that cause chicken pox, mononucleosis, herpes labialis (cold sores), and herpes genitalis (genital herpes). Like other ...

MedThink Communications Retained by NanoBio Corporation

... of Michigan, NanoBio's lead product candidates target treatments for herpes labialis (cold sores), onychomycosis (nail fungus) and mucosal vaccines ... The company's pipeline also includes products that target genital herpes, herpes zoster (shingles) and methicillin-resistant Staphylococcus aureus ...

Birth Control May Help Ward Off Bacterial Vaginosis

... before. Bacterial vaginosis is also associated with sexual activity, douching and sexually transmitted diseases, including chlamydia, gonorrhea, herpes simplex virus and HIV. Researchers aren't sure if bacterial vaginosis makes a woman more susceptible to the other infections or if the other ...

Abbott Introduces Molecular Diagnostic System Intended for Broad Identification of Infectious Agents

... influenza and broad viral detection. In an early research study, viral isolates from adenovirus, alphavirus, enterovirus, flavivirus, herpes virus and human parvovirus B19 were injected into human plasma specimens from healthy volunteers. This was followed by a retrospective study of 54 ...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

... (15 percent vs. 14 percent), nasopharyngitis (14 percent vs. 12 percent), headache (12 percent vs. 14 percent), cough (11 percent vs. 9 percent) and herpes simplex (10 percent vs. 10 percent). The incidence of nervous system and psychiatric AEs was comparable between the INTELENCE and placebo arms. ...

STD Test Express Offers Free Doctor Consultations With Every STD Test

... exposure to detect infection, this DNA-based test can detect HIV as early as 28 days after exposure. Other tests available tests include chlamydia, herpes I & II, gonorrhea, hepatitis B and C, and syphilis. After a test order is approved by a physician, consumers choose from over 1,800 ...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... technology constructs have already been shown to induce protection in animal challenge models against a variety of diseases such as malaria and herpes simplex virus and as therapeutic vaccines in two different autoimmune conditions. Data showed that L.E.A.P.S. vaccines were able to induce these ...

BioVex To Announce Updated Survival Data From a Phase II Clinical Study of OncoVEX GM-CSF in Metastatic Melanoma at The 2009 American Society of Clinical Oncology Meeting

... M.D., will present the data in an abstract (number 9035) entitled "Phase II clinical trial with a second generation, GM-CSF encoding, oncolytic herpes virus in unresectable metastatic melanoma," at ASCO on Monday, June 1, 2009 from 8:00am - 12:00pm EDT during the melanoma poster session located in ...