Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

... with different disease mechanisms. The results also showed that the heritability the variation in disease susceptibility that can be explained by genetic ... RA as the HLA SE alleles. In light of the finding of the similar heritability of ACPA-positive and ACPA-negative RA, the authors conclude: "This means ...

Genetic Factors for Smoking Boost Chronic Bronchitis Risk

... Swedish study says it's first to quantify heritability of the disease FRIDAY, Feb. 29 (HealthDay News) -- While ... that does not differ by sex, is the first to our knowledge to quantify heritability of the disease," Jenny Hallberg, of the department of public health ...

Cardiac Artery Trouble Boosts Family Heart Risk

... journal. "This time, we specifically investigated the possibility of high heritability of the condition. That was the case." In one report, Schunkert and his ... showed that this was a relatively rare condition, and the data on its heritability was not conclusive, he said. It's possible that the Baltimore study may ...

Vulnerability to post-traumatic stress disorder runs in families, study shows

... and depression, PTSD and anxiety, and finally depression and anxiety. Until now, Goenjian said, the only studies that have suggested such a heritability of PTSD have been twin studies. "It's very hard to do family studies on PTSD because typically only single individuals, not whole families, are ...

Discovery of new family of genetic mutations involved in inflammatory intestinal disease

... Both diseases affect men and women equally and run in families, suggesting a genetic cause. "In spite of the large number of studies on the heritability of IBD", said Dr. Festen, "only very few of the genes responsible have been identified to date. 3Interestingly, one of the new genes we found for ...

Scientists uncover further steps leading to celiac disease

... and weight loss. Currently only a restricted diet can diminish symptoms. Professor van Heel said: So far our findings explain nearly half of the heritability of coeliac disease - now studies with many more samples from individuals with coeliac disease are needed to identify the precise causal genetic ...

Genetic factors in smoking also increase risk of chronic bronchitis

... Registry, showing a genetic effect for the development of chronic bronchitis that does not differ by sex is the first to our knowledge to quantify heritability of the disease, she said. Because chronic bronchitis had previously been reported to be more prevalent in women than men, the results pointed to ...

IOM Workshop Calls for Greater Research Focus on Environmental Causes of Autism

... last Friday released a report from the April 18-19 workshop Autism and the Environment, demonstrating a marked shift in the research agenda from heritability factors to toxic environmental exposures in the development of autism. The National Autism Association (NAA) and SafeMinds have long called for a ...

Severe heart defect likely caused by genetic factors

... Center. The study to be published in the Oct. 16 edition of the Journal of the American College of Cardiology is the first to show the high heritability and likely genetic underpinnings of HLHS and recommend a direction for future research into its cause, development and possible therapeutic ...

Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD

... factors (i.e., premature birth and in utero or childhood exposures to toxic substances) in this group, the authors write. In addition, given the high heritability of ADHD and its negative impact on social, academic and career outcomes, it is plausible that families with ADHD may cluster within the lower ...

Some Common Human Injuries Also Common in Dogs

... surgeries to repair damages that may be caused by congenital orthopedic diseases. According to Roush, the nutrition of the dog as a puppy and heritability are risk factors for congenital orthopedic diseases such as osteochondritis dissecans, or OCD, which affects shoulders, elbows and spinal ...

Environmental Toxin Causes Heritable Adult-Onset Diseases

... would be expected if they were the result of genetic mutations alone. Scientists have long known about epigenetic changes, but their high rate of heritability and their importance in the control of gene activity were not appreciated until recently. Skinner said the finding that an environmental toxin ...

AMD influenced by Variation in 3 Genes

... these subtypes of advanced AMD with respect to the variations found in the genes. Dr. Seddon and her colleagues previously reported that the heritability of AMD is high (46% to 71%) in a large US cohort of elderly twins (Arch Ophthalmol 2005), and that another common CFH variant as well as smoking and ...

John Hopkins Develops An Online Tool To Help In Research Of Certain Rare Diseases

... on genes may lead to future genetic tests that can help doctors better diagnose and treat these syndromes,' he says. 'Studying the genetics, heritability and molecular underpinnings of Bardet-Biedl syndrome uncovered the role of cilia in this and other syndromes,' says Katsanis. 'The clinic informing ...

Its All In The Genes

... that if a pair of twins were identical the chances of them both being self-employed was higher than if they were non-identical. ‘This relatively high heritability suggests the importance of considering genetic factors to explain why some people are entrepreneurial, while others are not,’ said Spector. ...

Bone Fractures In Elderly Can Be Genetical

... type of fracture and age, the authors report. Less than 20 percent of the overall age-adjusted fracture variance was explained by genetic variation. heritability was considerably greater for first hip fracture before the age of 69 years and between 69 and 79 years than for hip fractures after 79 years of ...