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Hepatic in Medical News

Are imaging features of hepatic angiomyolipoma related to its clinical setting?

... of 10 patients (three male and seven female) with hepatic angiomyolipoma, with a mean age of 55.1 years ... Of these patients, dynamic contrast CT showed hepatic angiomyolipoma as a hypervascular mass with ... in six sporadic cases, and multiple, small hepatic angiomyolipomas, with or without a fat component ...

Is RTA a new potential option for the treatment of hydatid cysts?

... detachment. RTA was performed on 17 cysts (9 hepatic and 8 pulmonary), and was followed by pathology ... with a 100% success rate was seen in both hepatic (9/9) and lung cysts (8/8). A layer of host ... remained attached to the pericystium both in hepatic and lung cysts, with small and focal de novo ...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

... liver function abnormalities, including severe hepatic adverse events. Post-marketing ... Use in Specific Populations hepatic impairment: PREZISTA/r is not recommended for use in patients with severe hepatic impairment. There are no pharmacokinetic or ...

Study examines dietary influences of liver disease

... that dietary factors influence the development of hepatic steatosis and its progression to more severe ... are the most important known risk factors for hepatic steatosis. Also, dietary lipids may directly ... relevant dietary factors are more likely to have hepatic effects through obesity-related fatty liver ...

Hyperion Therapeutics Raises $60 Million Series C

... for UCD as well as a Phase II study in low grade hepatic encephalopathy. Concurrent with the Series C ... in the treatment of both urea cycle disorders and hepatic encephalopathy," said Daniel Perez of Bay City ... in brain damage, coma, and/or death. About hepatic Encephalopathy ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

... - Company preparing to initiate phase II trial in hepatic encephalopathy - SOUTH SAN FRANCISCO, ... of HPN-100 administered orally to subjects with hepatic impairment and cirrhosis and to subjects with normal hepatic function. A total of thirty-two subjects were ...

AZOR(R) Receives FDA Approval as First-Line Treatment for High Blood Pressure

... of the olmesartan medoxomil component. hepatic Impairment Since amlodipine is extensively ... is 56 hours in patients with severely impaired hepatic function, caution should be exercised when administering AZOR to patients with severe hepatic impairment. Laboratory Tests There was a ...

Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill

... be used with caution in patients with severe hepatic impairment and should be used with care in patients with mild-to-moderate hepatic impairment, including patients with biliary ... Avoid use of EXFORGE HCT in patients with severe hepatic impairment. In patients with ...

JCI online early table of contents: April 13, 2009

... a spectrum of disease states, beginning with hepatic steatosis, which leads to steatohepatitis, ... new insight into the mechanisms underlying hepatic steatosis in obese insulin-resistant rodents. ... protein SREBP-1c, which is intimately involved in hepatic lipogenesis (and ...

FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia

... perforation Isolated cases of significant hepatic dysfunction and hepatic failure have been reported in patients being ... should be monitored for evidence of worsening hepatic function. Adverse events may occur after the ...

Long-term L-carnitine supplementation prevents development of liver cancer

... factor and should be viewed as a mechanism in hepatic carcinogenesis, and that long-term L-carnitine ... and/or carnitine deficiency during induction of hepatic carcinogenesis. The research team by ... mechanisms whereby carnitine deficiency provokes hepatic carcinogenesis. (2) to understand the ...

Cathepsin B increases apoptosis in fulminant hepatic failure

... necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a ... is involved in the pathogenesis of fulminant hepatic failure. To ascertain its pathogenic role in hepatic failure, the research examined the protective ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... taking dose. Use with caution in patientswith hepatic impairment. ECGs should be obtained to monitor ... CYP3A4 inhibitors. Use caution in patients with hepatic impairment. Obtain ECGs at baseline, seven days ... Liver function abnormality Serum bilirubin and hepatic transaminases The use of Tasigna may result in ...

Liver Cirrhosis May Also Harm Brain, Heart

... have heart-rate issues and a condition known as hepatic (liver) encephalopathy, which occurs when an ... amount of unfiltered toxins reaches the brain. hepatic encephalopathy can affect both physical and ... found strong ties between heart rate issues and hepatic encephalopathy. A person's level of inflammatory ...

PREZISTA(R) Now Available for Pediatric Patients Six Years of Age and Older as part of HIV Combination Therapy

... liver function abnormalities, including severe hepatic adverse events. Post-marketing cases ... not recommended for use in patients with severe hepatic impairment. There are no pharmacokinetic or safety data available in patients with severe hepatic impairment. PREZISTA should be used ...

PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine

... any of its components, autoimmune hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; ... treatment. PEGASYS is also contraindicated in hepatic decompensation with Child-Pugh score greater than ... C (CHC) patients with cirrhosis may be at risk of hepatic decompensation and death when treated with alpha ...

May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?

... While older large series of patients with hepatic granulomas have found sarcoidosis and tuberculosis to be the most common causes of hepatic granulomas, recent works have noted some patients with chronic hepatic C ...

A potential drug for ischemia/reperfusion related liver injury

... hepatic injury caused by ischemia/reperfusion (I/R) has ... effect of resveratrol against I/R-induced hepatic injury, using biochemical and histological ... group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... is needed for patients with mild to moderate hepatic insufficiency or in patients with mild renal ... syndrome [see Warnings and Precautions (5.3); hepatic enzyme elevations. DRUG INTERACTIONS ... from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging ...

Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease

... highly accurate in detecting moderate-to-severe hepatic fibrosis even with the variety in age, types of ... with a needle, can underestimate the degree of hepatic fibrosis about 20 to 30 percent of the time ... changes can help stop the progression of hepatic fibrosis to liver cirrhosis and liver failure, ...

New study indicates that exercise prevents fatty liver disease

... activates specific precursors known to promote hepatic steatosis," said Jamal Ibdah, professor of ... signs of factors responsible for promoting hepatic steatosis. In the animals tested immediately at ... of voluntary running, there were no signs of hepatic steatosis. "Physical activity prevented fatty ...

Low-carb diets alter glucose formation by the liver

... study shows that a low-carbohydrate diet changes hepatic energy metabolism. When carbohydrates are ... has been difficult. To better understand hepatic energy production and glucose formation among ... Medical Center measured the sources of hepatic glucose and TCA cycle flux in weight-stable ...

An effective strategy for inhibition of cirrhosis

... Medicin Qianggan-Rongxian decoction can inhibit hepatic fibrosis resulted from chronic liver injure, ... and type IV collagen are good serum markers of hepatic fibrosis. In this study, the serum contents of ... decrease serum levels of ALT and AST in rats with hepatic injury caused by DMN. It indicates that ...

Stem cells from umbilical cord used in the treatment of hepatic diseases

... be an appropriate therapy for the treatment of hepatic diseases such as hepatitis, and therefore mean an ... cord blood cells (HUCBCs) can be useful for hepatic regenerative medicine, as they can nest in the ... to rat in which HUCBCs were injected through the hepatic portal vein of rats with hepatitis caused by ...

How to diagnose peliosis hepatis

... upper right abdominal pain for four months. After hepatic lobectomy of the right lobe, histopathological ... hypodensity lesion in segment VIII was peliosis hepatic and gumma, respectively. This study, performed ... the differential diagnosis of an atypical focal hepatic lesion. Besides looking into the patient's ...

New findings: The anti-fibrotic mechanism of plant extract Cpd 861

... In human hepatic stellate cells, the key cells involved in both ... in the World Journal of Gastroenterology. hepatic fibrosis, which can lead to portal hypertension ... collagens) is the major pathogenic feature in the hepatic fibrosis process. Although remarkable progress ...

Antipodean Pharmaceuticals Announces Results of Phase 2 Study of Lead Compound MitoQ(R)

... interventions such as MitoQ, which block either hepatic necroinflammation or fibrogenesis." "In the ... Targeted antioxidants can reduce the hepatic oxidative damage that is induced by viral ... (mitoquinone mesylate), for the treatment of hepatic inflammatory disorders caused by oxidative stress ...

Researchers study new drug and indications for heated chemotherapy treatment

... of IPHC in patients with peritoneal cancer and hepatic metastases (HM), or liver cancer that has ... that patients with peritoneal carcinoma and hepatic metastases undergoing cytoreductive surgery and ... In select patients with peritoneal carcinoma and hepatic metastases, cytoreductive surgery and IPHC may ...

How to effectively avoid many common complications and liver damage in bile duct exploration?

... surgery. In operations combining laparoscopic hepatic left lateral lobectomy with fiber ... Fu Zhou General Hospital performed laparoscopic hepatic left lateral lobectomy combined with fiber ... complications. In this research, laparoscopic hepatic left lateral lobectomy combined with fiber ...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy

... medical need in the treatment of hepatic encephalopathy," said Roger Williams M.D., ... of this multi-factorial disease process." About hepatic Encephalopathy hepatic encephalopathy (HE) is a serious, progressive and ...

New IDSA Clinical Practice Guidelines Recommend NOXAFIL(R) (Posaconazole) for Antifungal Prophylaxis in Certain High-Risk Patients

... clinical trials, there were infrequent cases of hepatic reactions (e.g., mild to moderate elevations in ... and/or clinical hepatitis). Rarely, more severe hepatic reactions including cholestasis or hepatic failure including fatalities were reported ...

An emerging candidate for protecting patients from liver injury after abdomen surgery

... Ginsenosaide Rb1 (R1) is able to prevent hepatic microcirculatory disturbance and subsequent liver ... pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol ... This enables a dynamic examination of the hepatic microcirculatory parameters under investigation ...

JCI online early table of contents: Jan. 10 2008

... by a condition known as either fatty liver or hepatic steatosis, which is the accumulation of fat in ... copies of the Ppara gene developed severe hepatic steatosis followed by HCC. However, neither ... functional copies of the Ppara gene developed hepatic steatosis and HCC. Consistent with the idea that ...

MRI techniques evolving towards better assessment of liver fibrosis

... way to determine the existence and extent of hepatic fibrosis. It could eventually help the ... ). Currently, the best way to assess hepatic fibrosis is liver biopsy; however, it is an ... imaging have shown promise for detecting hepatic fibrosis, though they require further refinement. ...

Who is the arch-criminal in the development of hepatopulmonary syndrome?

... dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with ... and severity of HPS and the degree of hepatic dysfunction, and explored how intestinal ... deterioration between the lung function and the hepatic function in the cirrhotic rats. This indicated ...

High-fat diet makes mice susceptible to liver injury

... to obesity, can range in severity from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH) ... Tregs have recently emerged as a key player in hepatic immune regulation, so researchers, led by Xiong ... were fed a normal diet.) They examined the mices hepatic lymphocyte population by flow cytometry. The ...

Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies

... taking dose. Use with caution in patients with hepatic impairment. ECGs should be obtained to monitor ... CYP3A4 inhibitors. Use caution in patients with hepatic impairment. Obtain ECGs at baseline, seven days ... AST/ALT, and alkaline phosphatase. Check hepatic function tests periodically. Electrolyte ...

Attenuation of NASH by stimulation of free fatty acid metabolism

... MCD diet, when fed to rodents, rapidly produces hepatic steatosis and steatohepatitis by blocking fatty ... of NASH remains to be defined. In hepatic steatosis, an excess of non-esterified fatty ... A potential strategy to protect the liver from hepatic steatosis would involve mechanisms to ...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

... INTELENCE. Use in Specific Populations hepatic Impairment: INTELENCE should be used with caution in patients with severe hepatic impairment (Child-Pugh Class C) as pharmacokinetics of INTELENCE have not ...

NUCYNTA(TM) (tapentadol) CII Immediate Release Tablets Now Available for Relief of Moderate to Severe Acute Pain

... NUCYNTA(TM) is not recommended in patients with severe renal or hepatic impairment. NUCYNTA(TM) should be used with caution in patients with moderate hepatic impairment. Like other drugs with mu-opioid agonist activity, NUCYNTA(TM) ...
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