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Glycoprotein in Medical News

Novel vaccine concept developed by scientists at the Wistar Institute

... secret is using a herpes simplex protein called glycoprotein D to block a specific receptor molecule on ... One of thee inhibitory signals is blocked by glycoprotein D from herpes virus. In a study that will be ... are vaccine delivery systems, made by fusing the glycoprotein D with genes from target antigens increase the ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... pi (GSTP1); glycinamide ribonucleotide formyltransferase (GARFT); glycoprotein NMB; B-lymphocyte stimulator (BLyS); gonadotropin-releasing hormone ... TRAIL-r2; tumor suppressor candidate 2 (TUSC2), FUS1; tumor- associated glycoprotein 72 (TAG-72); vitamin D receptor (VDr); Von Willebrand factor; X-linked ...

Ashwell receptor reduces mortality during sepsis

... host factors involved in blood coagulation, including platelets and a glycoprotein called von Willebrand Factor (vWF). When this occurs, the Ashwell receptor recognizes the change in the glycoprotein structure and removes those pro-coagulation factors from circulation ...

HORIZONS AMI trial data will help set guidelines

... we sought to determine whether using bivalirudin instead of heparin and glycoprotein IIb/IIIa inhibitors in patients with a heart attack after angioplasty ... either the standard anticoagulant regimen of unfractionated heparin plus a glycoprotein IIb/IIIa inhibitor or bivalirudin alone. The patients are to be followed ...

Horizons AMI trial data to be presented at TCT 2007

... in patients with stable coronary artery disease instead of heparin and glycoprotein IIb/IIIa inhibitors reduces bleeding, which has been associated with ... to receive either the standard anticoagulant unfractionated heparin plus a glycoprotein IIb/IIIa inhibitor or bivalirudin alone. The patients are to be followed ...

For ST-Elevation Myocardial Infarction (STEMI), Interviewed Experts Indicate That The Medicines Company's Angiomax/Angiox Has Efficacy Advantages Over Sales-Leading ReoPro

... because it is associated with significantly lower mortality rates than the standard PCI adjunctive therapy of unfractionated heparin and a glycoprotein IIb/IIIa inhibitor," said Decision Resources Analyst Jeremy Goldman, M.D. "This mortality reduction is associated with lower rates of bleeding with ...

Novavax Reports Fourth Quarter and 2008 Year-End Financial Results

... , evaluating the immunogenicity and efficacy of a Respiratory Syncitial Virus ("RSV") vaccine candidate in mice directed against the surface glycoprotein (or "G" protein). The vaccine induced strong antibody responses against RSV and protected mice against RSV replication in the lungs on challenge. ...

No Increase in Clots With Drug-Eluting Stents

... no difference in the rate of patients developing stent thrombosis whether they were taking the blood thinner Angiomax (bivalirudin) or heparin plus glycoprotein IIb/IIIa inhibitors, which also help prevent clots from forming. Although patients treated with Angiomax had a higher rate of acute stent ...

The Only 100% Biologically Pure Lycopene Cream in the World

... CO2 Fluid Extraction. Paphos' cerosome delivery system speeds up the transcutaneous absorption of the lycopene. As lycopene is released, the glycoprotein envelope acts as filler, binding water molecules deep in the dermis. This action plumps the skin, reducing fine lines and wrinkles. A clinical ...

The future of interventional cardiology presented at TCT 2008

... with Acute ST-Segment Elevation Myocardial Infarction HORIZONS-AMI: A Prospective Randomized Trial of Bivalirudin vs. Unfractionated Heparin Plus glycoprotein IIb/IIIa Inhibitors in Patients with Acute ST-Segment Elevation Myocardial Infarction: Long-Term Follow-Up and Interaction with Stent Type ...

TCT update: press conference schedule announced for TCT

... with Acute ST-Segment Elevation Myocardial Infarction HORIZONS-AMI: A Prospective Randomized Trial of Bivalirudin vs. Unfractionated Heparin Plus glycoprotein IIb/IIIa Inhibitors in Patients with Acute ST-Segment Elevation Myocardial Infarction: Long-Term Follow-Up and Interaction with Stent Type ...

Key found to breakthrough drug for clot victims

... acting anticoagulant. The molecule enhances this ability, the research team discovered, by attaching itself to a receptor, or sticking point, called glycoprotein Ib (GPIb), located on the surface of platelets. In doing so, WE-thrombin shoulders aside and thus inhibits the protein (the von Willebrand factor) ...

Vaccine shows promise in preventing mono

... study was conducted by Etienne M. Sokal, MD, PhD, and colleagues at several Belgian institutions and pharmaceutical companies. The vaccine targets glycoprotein 350, a protein that facilitates the entry of EBV into immune system cells. In this preliminary, Phase II clinical trial, 181 young adults who had ...

Different anticoagulant regimens yield equal results

... patients with ACS (unstable angina or less severe heart attacks known as non-ST-elevation myocardial infarctions) who were given either heparin plus glycoprotein (GP) IIb/IIIa inhibitors (4,603 patients), the thrombin (blood-clotting enzyme) inhibitor bivalirudin by itself (4,612 patients), or bivalirudin ...

New genetic lineage of Ebola virus discovered in great apes

... and more particularly that of ZEBOV. Investigations were restricted by the scarcity of available data. Only 12 gene sequences coding for the glycoprotein (GP), a molecular structure that enables the virus to penetrate a cell before infecting it, have currently been identified. Furthermore, these ...

JCI table of contents: Nov. 8, 2007

... or one of its receptors (TNFR1 and TNFR2) were found to mount strong antiviral CD8+ T cell responses targeting the lymphocytic choriomeningitis virus glycoprotein (GP). By contrast, CD8+ T cell responses targeting tumors engineered to express the same GP protein were abrogated in TNF-alphadeficient mice. ...

Scientists Identify Antibodies That Block Human and Animal SARS Viruses

... virus," added the alumna of Madras University. The researchers identified two human antibodies that bind to a region on the SARS virus' spike glycoprotein that is called the receptor binding domain (RBD). One of the antibodies, called S230.15, was found in the blood of a patient who had been infected ...

Good News for Sufferers of Heart Attack, Chest Pain

... of heart-protecting drugs in these patients increased markedly, including use of aspirin, cholesterol-lowering statins, clot-reducing drugs called glycoprotein IIb/IIIa inhibitors, blood thinners such as clopidogrel and heparin, and blood pressure-reducing drugs including ACE inhibitors. At the same ...

Good News for Sufferers of Heart Attack, Chest Pain

... of heart-protecting drugs in these patients increased markedly, including use of aspirin, cholesterol-lowering statins, clot-reducing drugs called glycoprotein IIb/IIIa inhibitors, blood thinners such as clopidogrel and heparin, and blood pressure-reducing drugs including ACE inhibitors. At the same ...

Doctors Treat Early Heart Attacks Before Labs Could Confirmation It

... within 12 hours. The research was an analysis of a larger trial, the Superior Yield of the New strategy of Enoxaparin, Revascularization, and glycoprotein IIb/IIIa inhibitors (SYNERGY) trial. The study included patients who met two of the following criteria: at least 60 years old, elevated heart markers ...

U.S., Australian Scientists Develop Vaccine Against Deadly Viruses

... with the ease in which they jump from animals to humans. The new vaccine is composed of a component of the virus particle known as the G glycoprotein and its use has demonstrated complete protection from infection by Nipah virus in a feline model. Because these viruses are so similar, immunization ...

Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks

... in expression and communication between many proteins," Bogatkevich noted. Using the proteomic approach they found that the amount of antifibrotic glycoprotein hypatocyte growth factor (HGF) was reduced in the blood and epithelial lining fluid of African-American scleroderma patients than in Caucasians. And ...

Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

... and that subtle changes occur in two other proteins associated with dystrophin in the membrane of muscle cells. These proteins form the dystrophin glycoprotein complex. Dystrophin and DGC are also lost in Duchenne muscular dystrophy. The loss of dystrophin and damage to the DGC appear to be key players ...

Osteopontin: a useful biomarker in asbestos-related cancer

... subjects with asbestos-related biomarker disease with preoperative levels in patients with surgically treated pleural mesothelioma. Osteopontin is a glycoprotein that is over expressed in lung, breast, colorectal, gastric, and ovarian cancer and in melanoma. High levels of osteopontin have previously been ...

Angioplasty plus stenting better than thrombolysis for elderly patients with AMI

... in elderly populations have yielded conflicting results, researchers explain. These studies were performed before intracoronary stents and use of glycoprotein IIb/IIIa antagonists were routinely employed. Therefore, Dr. Hanoch Hod, of Chaim Sheba Medical //Center in Tel Hashomer, Israel, and associates ...

Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery

... of a clinical scoring system, risk classification, and patient presentation; The marker that can identify at-risk women is fetal fibronectin (fFN).A glycoprotein that is secreted by the fetal membrane and found in the choriodecidual junction, fFN is responsible for cellular adhesions. The level of fFN in the ...
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