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Glucagon in Medical News

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to ... JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent ... levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of ...

UT Southwestern scientists discover leptin can also aid type 1 diabetics

... pancreas that raises glucose levels. Normally, glucagon is released when the glucose, or sugar, level in the blood is low. In insulin deficiency, however, glucagon levels are inappropriately high and cause the ... was mediated by complete suppression of the high glucagon levels, said Dr. Xinxin Yu, assistant instructor ...

Discovery of new signal pathway important to diabetes research

... narrow interval, and we need both insulin and glucagon to remain in good health. "A person with low ... Much more is known about insulin secretion than glucagon secretion, and so Professor Berggren's team ... cells also secreted glutamate, which facilitates glucagon release and makes it more efficient. The ...

New Diabetes Drug Shows Promise in Trial

... stimulates insulin production," Madsbad explained. "Then it also promotes glucagon release from the pancreas. It also changes appetite, and therefore you eat less." glucagon is a hormone that helps manage blood sugar levels. "We want more ...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Takeda Receives New Information on Alogliptin (SYR-322) NDA

... insulin secretion--and it has the potential to improve pancreatic beta-cell function. Furthermore, it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed. About Takeda Pharmaceutical Company Limited Located ...

Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Isis Reports Financial Results and Highlights for Fiscal year 2007

... weight gain or nausea. * Isis initiated Phase 1 studies of ISIS 325568, an antisense drug partnered with OMI, that targets the glucagon receptor, GCGR. * Isis identified a development candidate, ISIS 377131, an antisense drug also partnered with OMI that targets the ...

Takeda submits new drug application for alogliptin (syr-322) in the US

... to food, and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness. ...

Benefit of exenatide has not yet been proven

... body, GLP-1. Incretins are hormones that are produced in the gastrointestinal tract. In the pancreas, they stimulate insulin secretion and inhibit glucagon secretion, depending on the blood glucose level. In addition, they affect gastric as well as brain functions: they delay the emptying of the stomach ...

Isis Announces HSR Approval and Closure of Its Collaboration With Ortho-McNeil, Inc.

... development and commercialization rights to two of its diabetes drugs, ISIS 325568 and ISIS 377131, which selectively inhibit the production of glucagon receptor (GCGR) and glucocorticoid receptor (GCCR), respectively. Additionally, Ortho-McNeil will provide funding to Isis to support the joint ...

Isis Acquires Symphony GenIsis

... drugs. The collaboration includes licensing of two of the drugs previously held by Symphony GenIsis, ISIS 325568 and ISIS 377131, which target glucagon receptor and glucocorticoid receptor. In addition, Isis has reaquired full ownership of ISIS 301012, its cholesterol-lowering drug targeting ...

Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions

... 30-day supply of medications for diabetes and all other medical conditions. This should include insulin, oral anti-diabetic agents and glucagon emergency kit (if prescribed by your physician). * Blood glucose testing supplies including lancets, test strips and preferably at least ...

New Drug for Diabetes

... 2 -- who take insulin injections. Insulin does not totally suppress the glucagon that the body secretes. Often, diabetics notice that their blood sugar ... in the blood, but Doctors say, "What's happening is you're making excess glucagon following a meal." The hormone amylin works to control the output of that ...

Alternative Option for Type2 Diabetes Treatment

... greater reductions in postprandial [after a meal] glycemia and favorable (GLP-1 analogues) or neutral (DPP4 inhibitors) effects on weight. glucagon [a hormone secreted by the pancreas]-like peptide 1 analogues were associated with gastrointestinal adverse effects, while DPP4 inhibitors had a ...

Gene Responsible for Ageing Process Discovered and Calorie Restriction Could Help

... family of genes. Both PHA-4 and Foxa are involved in the complex process of glucose metabolism. In mammals, the gene is linked with a hormone called glucagon which increases levels of glucose in the bloodstream to maintain the body's energy balance especially during fasting. Scientists from Louisiana ...

Gene Responsible for Ageing Process Discovered – and Calorie Restriction Could Hel

... family of genes. Both PHA-4 and Foxa are involved in the complex process of glucose metabolism. In mammals, the gene is linked with a hormone called glucagon which increases levels of glucose in the bloodstream to maintain the body's energy balance especially during fasting. Scientists from Louisiana ...

‘Baby Food’ to Battle Obesiy

... and yogurt had a positive effect on genetically obese lab rats. Reportedly, oligo fructose increased the amounts of a hormone named GLP-1; glucagon like peptide that was responsible for a feeling of satiety. The fiber also had a stimulating effect on the gene that was responsible for this ....

New compounds Help Sustain relief For Patients With Symptoms of Bowel Disorders

... patients with Crohn's disease who have not responded to other therapies." Teduglutide is an analog of the naturally occurring human peptide glucagon Like Peptide-2 (GLP-2). GLP-2 is a peptide growth factor secreted in the distal intestine and is involved in regeneration, maintenance and repair of ...

Sitagliptin, Under Investigation For Type 2 Diabetes

... to lower blood glucose levels by increasing the level of active incretin hormones which increase insulin from pancreatic beta-cells and decrease glucagon from pancreatic alpha cells in a glucose-dependent manner (when blood glucose is elevated and not when blood glucose is low). If approved, ...

Good carb, bad carb? Experts debate.

... is stored so fast that within two or three hours, levels may be lower than they were before the meal. Suddenly, the body needs more fuel. But because glucagon is still in short supply, the body does not tap into its fat supply for energy. The inevitable result? Hunger. That, at least, is the theory. ...
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