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Gliomas in Medical News

Delivering Chemo Directly Into Brain Tumors Shows Promise

... Survival times for those with malignant gliomas increased, study found MONDAY, May 4 ... clinical trials, researchers report. Malignant gliomas are difficult to treat using standard ... are better than any treatment for recurrent gliomas we have now," said study author Dr. Jeffrey ...

Brain Tumor Drug May Help Spur Cancer's Return

... have identified cells in brain tumors called gliomas that have stem cell-like qualities and are able ... chemotherapy drugs. "Current treatment for gliomas works for a while and then usually fails," ... -- which is the standard treatment for gliomas -- actually increased the number of ...

Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers

... Better models for research into human gliomas are urgently needed. Last year alone, about ... About 77 percent of malignant brain tumors are gliomas and their prognosis is usually bleak. While they ... incurable even with current therapies. gliomas originate in brain cells known as "glia" and are ...

Mayo Clinic identifies best treatments for long-term survival in brain tumor patients

... Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive ... ). gliomas are a type of brain tumor that form in the brain ... can spread within the nervous system. Low-grade gliomas are malignant and slow growing; overall, ...

Mayo Clinic Identifies Best Treatments for Long-Term Survival in Brain Tumor Patients

... Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive ... ). gliomas are a type of brain tumor that form in the brain ... can spread within the nervous system. Low-grade gliomas are malignant and slow growing; overall, ...

Radiologists use special MRI to identify brain cancer early

... and University College, London. Low-grade gliomas are primary brain tumors that grow slowly over several years. Eventually, almost all low-grade gliomas progress to high-grade gliomas, which carry a poor prognosis. Patients with low-grade gliomas are often young and may remain clinically well ...

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

... glioblastoma (GBM) and malignant anaplastic gliomas (AA). Ph II Study - Interim Results Twenty-five patients with advanced malignant gliomas were treated with a loading dose of 600 mg (150mg ... activity observed in patients with anaplastic gliomas is of great interest as these patients are in ...

New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas

... Barcelona, Spain: Childhood brainstem gliomas (BSGs) are rare but can be very difficult to ... with high grade gliomas, while in low grade gliomas the response was comparable with the best ... many centres use radiation therapy for high-grade gliomas and diffuse intrinsic pontine tumours, the ...

Drummer Eddie Cleland Resumes Life After Brain Surgery and Tells About it at Conference

... Cleland's tumor was a diffuse astrocytoma, also called a Grade II glioma. gliomas arise from glial cells, which provide support for nerve cells in the brain. Low-grade gliomas (Grade I and II) are considered pre-malignant. Although not yet cancers, ...

UAB joins elite brain cancer research group

... and principal investigator for the Ivy Genomics-Based Medicine Project. gliomas are tumors that arise by transformation of the body's glial cells, which ... The consortium members strive to unravel how genetic differences between gliomas can lead to more effective and even personalized treatments for patients. ...

St. Jude finds young age may give survival advantage to children with certain brain tumors

... of glioma that originates in the cerebrum: Young children with high-grade gliomas originating in the cerebrum seem to have a better prognosis when compared ... properties also seem to play a role in the latter case. Brainstem gliomas account for 10 to 15 percent of all brain tumors in children; and DPGs ...

Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells

... Journal of the National Cancer Institute. In an animal study, mice with gliomas that were treated with a single injection of reovirus survived ... cultures taken from brain tumor surgical specimens. Primary refers to gliomas originating in the brain, not metastasizing from other locations. ...

Drug study for brain cancer shows promising results

... cancer live without their cancer progressing within six months. Although gliomas [fast-growing malignant brain tumors] are nearly always incurable, use of ... Hospital is one of the large study sites. The same process that makes gliomas so deadly may turn out to be exactly the same thing that makes it possible ...

Genome of Leukemia Patient Reveals Common Mutations

... patients. Scientists at the Washington University School of Medicine in St. Louis detected one mutation that's common in brain tumors called gliomas and another that was found in a second patient with AML. Neither of the mutations had been previously linked to leukemia. The fact that these ...

NCCN Updates Guidelines for Central Nervous System (CNS) Cancers

... better the patient is able to carry out daily activities. The new NCCN Guidelines adjusted the age range for patients with specific low grade gliomas who may consider fractionated external beam radiation therapy or chemotherapy as additional options to observation following maximal safe resection ...

Reversing effects of altered enzyme may fight brain tumor growth

... have known that a mutation in the gene encoding the enzyme, isocitrate dehydrogenase (IDH1), contributed to certain brain tumors called low grade gliomas and secondary glioblastomas, but no one understood how. Guan, Yue Xiong, PhD, at the University of North Carolina and their co-investigators have now ...

Avastin effective at delaying brain tumor progression in recurrent disease

... of the targeted therapies for gliomas, this has been the most promising. And this is practice changing." Therapy for treating recurrent high-grade gliomas is palliative. All patients with these high-grade tumors eventually die of their cancer. However, bevacizumab has the potential to be the best ...

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

... commitment to providing effective treatments in a variety of presentations for specific patient needs and patient convenience." About Malignant gliomas The worldwide incidence rate of primary malignant brain and central nervous system tumors, using the world standard population, is 3.7 per 100,000 ...

Chemo Alone Effective in Treating Kids' Brain Tumors

... III study compared two different chemotherapy regimens, and confirmed that chemotherapy can be used to control inoperable or progressive low-grade gliomas in children, said principal investigator Dr. Joann Ater, a professor of pediatrics at the Children's Cancer Hospital at M.D. Anderson. The study ...

Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes

... treatments. Upon founding the Maxine Dunitz Neurosurgical Institute in 1997, Black led the development of the dendritic cell vaccine because gliomas and other cancer cells are not readily detected or attacked by the immune system. Dendritic cells are the immune system's most powerful ...

Ivy Foundation Funds New Brain Cancer Research Consortium : $3M Stage I Project Aims to Improve Personalized Medicine for Patients

... funded foundation dedicated to improving survival and quality of life for people diagnosed with a brain tumor. Our approach is to fund research in gliomas for improved diagnostics and treatments for patients. In its inception year, 2008, The Ivy Foundation will grant $12,000,000 to patient-focused ...

Vaccine May Boost Survival of Brain Cancer Patients

... the way for marketing of the vaccine in two to four years, Sampson said. More information The U.S. National Library of Medicine has more on gliomas . SOURCES: John Sampson, M.D., Ph.D., associate professor, neurosurgery, Duke University, and associate deputy director, ...

Cancer researchers receive NIH grant to advance brain tumor therapies from lab to clinical trials

... Every year about 19,000 children and adults are diagnosed with primary brain tumors, according to the National Cancer Institute. Malignant gliomas are the most common, accounting for more than half and including astrocytomas, oligodendrogliomas and glioblastoma multiforme. Current ...

Too many gene copies stimulate tumor cell growth

... BRAF gene. As pharmacologic and genetic silencing of the BRAF signaling pathway and the BRAF gene, respectively, prevented tumor cells from low-grade gliomas growing in culture, it was suggested that inhibiting the signaling pathway downstream of BRAF might be beneficial for individuals with low-grade ...

JCI online early table of contents: April 8, 2008

... BRAF gene. As pharmacologic and genetic silencing of the BRAF signaling pathway and the BRAF gene, respectively, prevented tumor cells from low-grade gliomas growing in culture, it was suggested that inhibiting the signaling pathway downstream of BRAF might be beneficial for individuals with low-grade ...

Simons Foundation grant boosts brain tumor research

... of improving the diagnosis, treatment, and prevention of autism and related conditions. Indeed, work conducted through the BTC into the biology of gliomas which arise from supporting tissue known as glia has the potential to shed new light on the role of glial cells in autism and a variety of ...

Language centers revealed, brain surgery refined with new mapping

... eight years, Berger and his team tested negative language mapping on a total of 250 consecutive patients (146 men and 104 women), all of whom had gliomas -- a common and often fatal brain tumor -- affecting the dominant hemisphere of their brain. One week following surgery, 194 of the 250 patients ...

Study suggests existing drugs may be useful in treating brain tumors

... cancers." Meanwhile, Gutmann's lab had conducted extensive research showing how the environment immediately surrounding NF1 brain tumors known as gliomas influences their formation and maintenance. Most NF1 brain tumors occur in the optic pathway, the region of the brain that relays information from ...

Cancer Drug can Extend Survival in Patients With Deadly Brain Tumors

... to twice as long as comparative therapies. Though gliomas remain incurable in nearly all cases, the ... 18,000 people are diagnosed with gliomas in the United States each year, making them the ... malignant tumors of the central nervous system. gliomas are difficult to treat because they grow quickly ...

Cancer Stem Cells Could Hold Key to Brain Tumor Therapy

... understand the causes of tumor growth so that gliomas can be targeted with new drugs. “Malignant ... glioma cells enhanced the angiogenesis of gliomas through increased levels of VEGF. Using an antibody to mark the cancer stem cells in gliomas obtained from patient specimens, the Rich ...

Novel Suicide Gene Therapy Used to Treat Malignant Brain Tumors

... undergo radiation therapy and chemotherapy, if needed. “Malignant gliomas are unique in their ability to grow uncontrollably and aggressively invade ... give our brain tumor patients freedom from this disease.” Malignant gliomas account for more than half of the more than 18,000 primary malignant brain ...

New Carrier Developed To Deliver Drugs to Gliomas

... for delivering radioactive iodine dose to cure deadly brain tumors such as gliomas is under investigation.// Synthetic scorpion venom is used as carriers ... Center at Cedars-Sinai. About 17,000 Americans are diagnosed with gliomas each year. The tumors are extremely aggressive and deadly, with only eight ...

PI-103 Effective against Brain Cancer

... solid tumor of childhood, and about half of the people diagnosed with gliomas die within a year of diagnosis. Weiss and his colleagues report in the ... kinase inhibitor in particular – PI-103 -- is unusually effective against gliomas in mice. They believe the inhibitor is a promising drug candidate, and ...

New Oncogene for Brain Cancer

... are highly resistant to treatment. This makes IGFBP2 an important candidate for development of targeted therapy to treat gliomas, Zhang says. gliomas kill about 13,000 people in the United States annually. The possibilities are not limited to brain cancer, Fuller notes, because of the ...

Genes That Allow Brain Cancer-Causing Stem Cells to Resist Treatment Identified

... Another finding suggests that cancer stem cells are responsible not only for regeneration of tumor cells but also encourage their migration. gliomas are extremely difficult to treat because they evade treatment and because they are highly invasive. “The identification and study of brain ...

Discovery Of New Molecule Could Solve Cancer Spread Mystery

... Importantly, dual inhibition of p110á and mTOR with a low dose of PI-103 elicited no drug-related toxicity and was highly effective against human gliomas transplanted into mice. These data suggest that combinatorial inhibition of mTOR and p110á represents a safe and effective therapy in the ...

Chicken pox beholds brain tumour risk

... later in life. In the previous study which was done a couple of years ago , an unexpected finding was that the patients with brain tumour called gliomas were less likely to have had varicella zoster, another condition caused by chiken pox virus.// The recent study undwells the fact that glioma ...
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