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Genotype in Medical News

Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

... more than 50 percent of their hepatitis C virus genotype 1-infected patients and will prescribe ... boceprevir for the treatment of hepatitis C virus genotype 1-infected treatment-naive patients, over 60 ... improvements in sustained virologic response in genotype 1-infected patients is the most important ...

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

... High Mutation Rates Keep HCV Elusive II-4 genotype I - Least Responsive and Most Common Variant of ... RNA Test II-35 HCV Core Antigen EIA II-36 genotype Tests II-36 Liver Biopsy II-36 Treatment ... React Poorly to Treatment II-43 genotype 1 - The Most Prevalent HCV Strain II-44 Table ...

New Treatment Combo Better Against Hepatitis C

... show. Current treatment for hepatitis C (HCV) genotype 1, the most common subtype, is a combination of ... 40 to 50 percent of patients infected with HCV genotype 1 can be cured by standard of care, but nothing ... these drugs are approved, say to any patient with genotype 1 hepatitis C, we've got a two-out-of-three ...

Valeant Pharmaceuticals Highlights Taribavirin Phase IIb 60-Week Data Presentation at European Association for the Study of Liver (EASL) Annual Meeting

... After Treatment (SVR12) In Naive Patients With genotype 1 Chronic-Hepatitis C", with an oral presentation ... population of subjects infected Hepatitis C genotype 1. At the end of week 60, the statistically ... open-label study in 278 treatment-naive, genotype 1 patients evaluating taribavirin at weight-based ...

2-day results predict ultimate response to therapy in chronic hepatitis C

... (SVR). About one-half of patients infected with genotype 1 do not achieve SVR. Studies have shown that ... Americans. A recent study of those with chronic genotype 1 HCV infection found that only 28 percent of ... States, monitored 341 patients with chronic HCV, genotype 1, who underwent therapy with peginterferon and ...

In Hepatitis C Virus Treatment, Interviewed Experts Indicate That Telaprevir- and Boceprevir-Based Regimens Have Advantages Over Pegasys/Ribavirin in Sustained Virologic Response

... effect on sustained virologic response in genotype 1 patients as the attribute that most influences ... higher sustained virologic response in genotype 1 patients with only 24 weeks of treatment ... advantage in efficacy in patients infected with genotype 1 over the current peginterferon/ribavirin ...

Study Showing Improved Virologic Response with Nitazoxanide in Chronic Hepatitis C Published in Gastroenterology

... chronic hepatitis C virus (HCV) infection with genotype 4 was published in the March issue of ... treatment in patients with chronic hepatitis C genotype 1 in clinical trials in the U.S., and we look ... in 97 patients with previously untreated genotype 4 chronic hepatitis C at 2 centers in Egypt. ...

Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients

... patients with chronic hepatitis C virus (HCV) genotype 1. In that study, a 48-week boceprevir regimen ... treatment-naive adult patients with chronic HCV genotype 1. The study enrolled a total of 1,099 patients, ... for 48 weeks in adult patients with chronic HCV genotype 1 who failed prior treatment (relapsers and ...

PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine

... how previously untreated Latino patients with HCV genotype 1, the most difficult-to-treat genotype, ... of SVR among Latino patients infected with HCV genotype 1.(1) "As leaders in hepatology, we are ... and 300 non-Latino whites infected with HCV genotype 1 who had not been previously treated.(1) The ...

Schering-Plough Announces FDA Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy for Treating Pediatric Hepatitis C

... In the study, patients infected with HCV genotype 1 or 4 and those with HCV genotype 3 with HCV RNA greater than 600,000 IU/mL (high ... weeks of therapy, while those infected with HCV genotype 2 or 3 with HCV RNA less than 600,000 IU/mL (low ...

For children with sickle cell disease, lung disease is part of the package

... found that of children with SCD, hemoglobin-beta genotype SS was associated with an increased risk of loss ... lung function across childhood. The hemoglobin SS genotype is more common than hemoglobin SC genotype (one in 600 versus one in 800 life births) and is ...

Children's Hospital Contributes Genotype Data to Enhance Autism Research Worldwide

... of Philadelphia has contributed a large genotype dataset to the Autism Genetic Resource Exchange ... committee, predicts that "the high-density genotype data on the AGRE families will provide novel ... by complementing and extending the genotype data made available by other research teams," ...

Gene Variants Can Predict Threat of Heart Disease

... histories. The participants were given a genotype score, ranged from 0 to 18, based on how many ... the unfavorable SNPs they had. Those with higher genotype scores had higher LDL (bad) cholesterol and lower HDL (good) cholesterol levels. Those with genotype scores of 11 or higher had a 63 percent greater ...

GSK Data Suggests Efficacy of Advair(R) and Serevent(R) is Not Impacted by Genetic Profile

... in patients with asthma with the Arg/Arg genotype of the beta-2 adrenergic receptor gene. In the ... with the Arg/Arg genotype, those with the Arg/Gly genotype and those with the Gly/Gly genotype. Patients ... significant difference between any of the three genotype groups for the primary endpoint, morning ...

Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC

... at the interaction between the CYP2E1, ALDH2 genotype and heavy alcohol drinking, with case-control ... significant interaction between the CYP2E1, ALDH2 genotype and alcohol drinking. We found there was synergetic interaction with polymorphisms of CYP2E1, ALDH2 genotype and heavy alcohol drinking. Individuals with ...

Genome-wide association study on Parkinson's disease finds public home at NIH

... dbGaP database contains individual-level data on genotype (an individuals genetic makeup), and phenotype ... participants, such as protocols and summaries of genotype and phenotype data. The controlled-access portion ... approved researchers to download individual-level genotype and phenotype data from which the study ...

What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?

... time, the team also observed the link between TS genotype and IRS of TS. Three genotypes of TS were found: ... IRS in cancer tissues was observed between 2R/3R genotype and 2R/2R genotype. These results suggested TS genotype may be a genetic factor which can be used to ...

GenOdyssee Receives Notice of Allowance from U.S. Patent Office for Improved Interferon-Alpha Aimed at Hepatitis C

... a Natural Protein With Improved Anti-HCV genotype 1 Activity PARIS, France, February 14 ... therapeutic drugs such as erythropoietin". genotype 1 HCV has in recent years become the predominant ... 100 million people are infected with HCV genotype 1 worldwide and that ...

The onchocerciasis parasite showing signs of resistance

... Each occasion involved measurement of the genotype frequency of heterozygotes and homozygotes for ... As a control, they monitored the changes in genotype frequency of two other genes, known for their ... and 1998, the percentage of parasites showing a genotype homozygous for this gene fell from 79 to 31% in ...

Shorter HCV treatment shows notable success

... ). HCV genotype is the single most important predictor of a ... ribavirin. Only about half of all patients with genotype 1 will achieve a sustained viral response, compared to 70 to 90 percent of patients with genotype 2 or 3. Regardless of HCV genotype, patients who ...

In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment

... the most difficult-to-treat form of the disease, genotype 1 HCV. Efficacy was consistent across all weight groups. For patients infected with genotype 2 or 3, a 24 week course of treatment with flat ... patient groups, such as patients with genotype 1 and African-American patients. Patients being ...

PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy

... treatment is 24 weeks for nave patients with HCV genotype 1 with low viral load and rapid virologic response (RVR) or HCV genotype 2 or 3. The recommended duration of treatment is 48 weeks for nave patients with HCV genotype 1 and high viral load or low viral load without ...

Genes Might Help Drive Overeating

... being very motivated to get food and having the genotype made people eat the most," Temple said. "We had ... The bottom line: "A combination of [having] this genotype with being very motivated to consume food or with ... doom you to obesity, however. "People who had the genotype were heavier, but there were certainly people who ...

Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C

... up to a maxiumum dose of 1400 mg. Those with HCV genotype 2 or 3, which is more responsive to ... alfa-2b in African American patients with HCV genotype 1. genotype 1 is the hardest to treat, and it afflicts ...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... single doses (Phase 1a) and in patients chronically infected with HCV genotype 1 following repeat dosing for 3 days (Phase 1b). The Phase 1b study will ... ascending dose trial has now been initiated in patients with chronic HCV genotype 1 infection. Subjects will be enrolled at multiple centers and randomized ...

NEJM study points to new era in hepatitis C treatment

... double-blinded trial followed 250 patients with untreated hepatitis C genotype 1. Researchers measured rates of sustained viral response or viral cure -- ... flu-like symptoms, depression, fatigue, insomnia and anemia. "Treating genotype 1 hepatitis C, the most common form of the infection in the United States, ...

Genetic risk for anxiety does not have to be destiny

... how social context and different forms of early adversity interact with genotype to influence behavior. Animals reared in small social groups were ... particularly among those with a low activity MAOA genotype. However, no genotype effects were evident in monkeys reared in larger social cages. There ...

Human papillomavirus genotype distribution in New Mexico cervical cancers

... in the future. Large population-based studies that examine HPV genotype distribution in the United States have been lacking. Such studies are ... New Mexico. The investigators used DNA-based testing to identify the HPV genotype that was present in tumor samples. In addition, they tested 4,007 cervical ...

Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results and Highlights

... eleven patients who received ANA598 at 200 mg twice-daily (bid). The five genotype 1a patients who received ANA598 demonstrated a median viral load decline of 1.5 log10, while the six genotype 1b patients who received ANA598 demonstrated a median viral load decline ...

Exploring Genetic Link Between Migraines, Cardiovascular Trouble

... twist, women who reported migraine with aura and had the DD or DI genotype had a doubling of their risk for cardiovascular disease. There appeared ... all, you might see an effect." And, the authors stated, the ACE DD/DI genotype could simply be a marker for a heightened risk of cardiovascular disease ...

Researchers Zero In on GI Cancers

... [whether surgery is an option] and overall survival," Li said. One genotype predicted a 94 percent response rate to preoperative chemoradiation, ... the genotype, the study found. Median survival for those with a "good" genotype was 25.5 months, vs. 7.4 months for those with a "bad" genotype, according ...

InterMune Reports Results from Triple Combination Study of ITMN-191

... in hepatitis C virus (HCV) treatment-naive patients infected with HCV genotype 1. ITMN-191 is being developed in collaboration with Roche (SWX: ROG). ... study in treatment-naive patients chronically infected with HCV genotype 1 was designed to inform the dose selection and study design of the ...

Common infant virus may trigger type 1 diabetes

... group included babies who had been identified at birth to carry the HLA genotype conferring the highest known risk for type 1 diabetes. The group not carrying the high-risk genotype included babies born at the same time and in the same area to the high ...

Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment

... (RBV), is effective in 30 to 50 percent of patients infected with chronic genotype 1 HCV infection, the most common type in the United States. The ... days of treatment for the first cohort of fifty (50) treatment nave HCV+, genotype 1, patients (once daily dose of 25 mg or 75 mg TMC435 versus placebo), ...

Too Much Salt Boosts Blood Pressure

... were the ones who had high blood pressure. That was independent of the genotype for this specific gene." But, Conlin added, it would be an ... genes when they salt their food, Conlin said. "You can't worry about your genotype because you can't do anything about it," he said. "This study reaffirms ...

Other highlights in the April 29 JNCI

... Selecting Patients Based on genotype May Increase Efficacy of Tamoxifen Breast cancer patients who carry ... inhibitors in the clinical trial. Therefore, women with wild-type CYP2D6 genotype may derive as much benefit from tamoxifen as from aromatase inhibitors. ...

Newborn Screening Suggests Decline in Cystic Fibrosis

... found that the incidence of a severe form of the disease, caused by the genotype ΔF508/ΔF508, also dropped dramatically. Before 2003, at least ... in the Massachusetts area, according to the study. "The most severe genotype has dropped out dramatically. The new mix has some severe genotype, but ...

MIGENIX Reports Preliminary Celgosivir Viral Kinetics Study

... a satisfactory outcome for approximately 50% of patients infected with HCV genotype 1 (the most prevalent genotype in North America). In addition, these drugs can cause significant side ...

HGS announces results of Phase 2B trial of Albuferon for chronic hepatitis C

... alfa-2b), in combination with ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C. This Phase 2b study demonstrated that, with half as ... active-controlled Phase 2b trial, 458 treatment-naive patients with genotype 1 chronic hepatitis C were randomized to four treatment groups: Albuferon ...

HGS unveils positive QOL results from Phase 2B trial of Albuferon for hepatits C

... alfa-2b), in combination with ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C. The study demonstrated that patients in the ... active-controlled Phase 2b trial, 458 treatment-naive patients with genotype 1 chronic hepatitis C were randomized to four treatment groups: Albuferon ...
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