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Discovery may result in new test to determine predisposition to cancer

... cells and then transformed them with a DNA fragment that detects the efficiency and the accuracy of ... The key in this experiment was that the DNA fragment was not irradiated. In this way, the researchers ... of double strand break repair in the DNA fragment that did not receive any radiation. The effect ...

Enzyme with a sugar antenna

... ligation". In this technique, one peptide fragment is attached to the terminal cysteine group (sulfur-containing amino acid) of a second peptide fragment by means of a thioester groupa selective reaction ... synthesis to make the critical peptide fragment that has the sugar antenna. ...

JCI online early table of contents: Jan. 12, 2009

... T cells that recognize HLA-B27 bound to a defined fragment of the viral protein RdRp. New understanding ... why HCV finds it hard to mutate the RdRp fragment enough to escape the CD8+ T cell immune response. ... response by mutating several parts of the RdRp fragment of interest. Each of the mutations affected the ...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

... The discovery of the cytoplasmic small RNA fragment of the non-coding MALAT1 molecule, which the CSHL ... to alert the cell that the long non-coding RNA fragment that it originally split off from-- MALAT1--is ... within the nucleus while expelling the mascRNA fragment into the cytoplasm is still elusive. "The answer ...

Researchers discover new way to reverse poor circulation and heal wounds

... Hocking had already built this heparin-binding fragment separately from its larger parent protein. ... team injected the heparin-binding fibronectin fragment into anesthetized animals. As expected, the fragment alone triggered a rapid and reversible dilation ...

Structures from the human immune system's oldest branch shed light on a range of diseases

... Netherlands, have determined the structure of C3 convertase and of the C3b fragment in complex with factor H. The work appears this month in two companion ... of immune-related diseases. "It was a surprise to see that the factor H fragment is spread across the entire C3b complex," notes Lambris. Factor H ...

Why do people with Down syndrome have less cancer?

... of the DSCR1 protein blocks calcineurin and is testing to see whether that fragment can be delivered specifically to endothelial cells, to prevent them from ... compound made by the body. Discovered in the Folkman lab, endostatin is a fragment of collagen 18 -- whose gene is also on chromosome 21. People with Down ...

Nose-spray vaccine against botulism effective in first tests

... safer to work with. A specific end-piece protein called heavy chain 50-kDa fragment (Hc50) has been identified as part of the mechanism that enables BoNT/C to ... Research Institute of Infectious Diseases (USAMRIID), found that Hc50 fragment of BoNTs, unlike the whole toxin used in the current vaccine, are not ...

Double duty: Loss of protective heart failure protein causes high blood pressure

... researchers will test a recently developed approach employing only a small fragment of the protein with a similar therapeutic potency. This fragment, Dr. Most ... like a real drug. The researchers hope that either the small protein fragment itself or a synthetic analogue will enable a novel therapeutic approach to ...

Virginia Judge Rules Medical Device Pioneer Committed Malpractice

... injury to the nerve with pain and difficulty using the right leg. A fragment of bone and disc the size of an olive was retrieved from Dr. Garver's ... surgeon, Dr. Patrick Mastroianni, testified at the trial that he found the fragment pressing against the nerve root. Removal caused some relief of Dr. ...

FDA Approval of Cimzia(R) for Crohn's Disease Represents Latest Milestone for Nektar's PEGylation Technology Platform

... Cimzia(R) marks the first FDA approval of a PEGylated Fab' fragment of a humanized anti-TNF-alpha antibody SAN FRANCISCO, ... to conventional therapy. Cimzia(R) is the first and only PEGylated Fab' fragment of a humanized anti-TNF-alpha antibody approved by the FDA. Cimzia(R) is ...

Gamma Secretase Modulators Show Promise in Alzheimer's Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics

... APP molecule into two major pieces comprised of a soluble extracellular fragment and a membrane-associated fragment. The second enzyme, gamma secretase (g-secretase), then cleaves the membrane- associated fragment into one of several different Ab peptides that vary in length from 34 to ...

VCU Massey Cancer Center to partner with Israeli biotech firm

... cancer developed by BioCancell. Its new therapeutic agent links a DNA fragment that is responsible for tumor-specific expression of a gene, with a suicidal toxin gene. When the agent is injected directly into the tumor, the DNA fragment will induce the expression of the suicidal toxin in the cancer cells but ...

RNA snippet suppresses spread of aggressive breast cancer

... CAMBRIDGE, Mass. (June 11, 2009) A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical ...

PercSys Introduces Accordion CoAx(TM) Stone Control Device for Facilitating Percutaneous Kidney Stone Treatments

... tool during PCNL procedures, as it both facilitates retrograde contrast injections for diagnosis and renal targeting as well as prevents antegrade fragment migration into the ureter," said Demetrius H. Bagley MD, Nathan Lewis Hatfield Professor of Urology, Thomas Jefferson University Hospital, ...

New P.E. Drug Approved In Europe While Premature Ejaculation Cure Remains Out of Reach to American Men

... cure remains inaccessible in the U.S., it's the inherent risks tied to this solution for how to last longer in bed," adds Baclini. Only a fragment of men who experience lack of climax control seek help for this distressing problem that can disrupt personal relationships and intimacy. ...

Gold Nanospheres Show Promise in 'Boiling' Out Cancer

... as a new treatment for the deadly skin cancer. The treatment uses gold nanospheres guided directly to the melanoma cells by a special protein fragment called a peptide placed inside the nanosphere. Using a technique known as photoablation therapy (PAT), doctors expose the tumors to near infrared ...

Musicians' Brains Tuned to Emotions in Sound

... music studies, the better the ability of the nervous system to process emotion in sound. During the study, participants heard a 250-millisecond fragment of a distressed baby's cry. Electrodes placed on the volunteers' scalps measured their sensitivity to the sound. The results showed that musicians' ...

Brain damage found in cognitively normal people with Alzheimer's marker

... to preventing irreversible brain injury." The results were published in the February issue of Annals of Neurology . A-beta 42 is a protein fragment that clumps together in the brain to form the plaques that have long been the diagnostic hallmark of the disease. In an earlier study, the same ...

New test may help to ensure that dengue vaccines do no harm

... its ability to reproduce). Complicating matters is a second feature of antibodies, one which is the same across all antibodies: the crystalizable fragment (Fc). The Fc is designed to bind to proteins called the Fc receptors on the surfaces of macrophages, immune cells that roam the bloodstream seeking ...

Autism Consortium members publish in PNAS: Mechanism, treatment for Rett syndrome -- top cause autism girls

... IGF1 Reverses Rett Symptoms in Mice; Clinical Trial Planned This groundbreaking study demonstrated that by treating mice with a peptide fragment of IGF1, a molecule that is utilized by the brain for neuronal and synaptic development, the symptoms of Rett Syndrome in the mice were largely ...

The physics of explosives and blast helmets

... and abdominal trauma (e.g., organ perforation or hemorrhage) caused by high values of blast overpressure; penetrating trauma caused by high velocity fragment impact; or severe blunt trauma (e.g., fractures and traumatic amputations) caused by lower velocity blunt impacts. For people who survive explosions, ...

New Blood Test Better Identifies Heart Failure Patients in ER

... time, making it superior to both the B-Natriuretic peptide (BNP) test (60.6 percent) and the NTproBNP test (63 percent), which measures a biological fragment associated with BNP. Shortness of breath is a common symptom of patients arriving at the emergency room, but it can have many causes including ...

VIASPACE Subsidiary Wins $786,000 U.S. Navy Contract

... sensor system consists of a new and powerful detector called a Differential Mobility Spectrometer, a novel "soft-ionization" method that does not fragment or multiply ionize-sampled specimens, and a micro-gas chromatograph for confirmation and enhanced detection capability all integrated into a compact ...

Presidential candidates' health plans offer divergent approaches to health system reform

... standards. Senator McCain would allow states to use Medicaid funds in a way that allows eligible families to buy private insurance, but this could fragment the program's risk pools into healthy and less healthy groups. Required coverage. Senator McCain would not require anyone to have health insurance. ...

Type, Severity of Iraq War Injuries Change Over Time

... with the initial phase of the war, there were more major injuries per Marine during the insurgency (2.4 compared to 1.6). There were also more fragment wounds during the insurgency, (61 percent versus 48 percent). But, there were fewer gunshot wounds during the insurgency (33 percent compared to 43 ...

Gene therapy improves survival and quality of life of dogs with cancer

... another growth substance, insulin-like growth factor-1 (IFG-1), which have anabolic effects. The therapeutic process involves injecting the DNA fragment into a muscle and applying electroporationshort, mild, controlled electric fieldsin the area of the injection. It opens the cell membrane pores and ...

Ibuprofen No Better at Reducing Alzheimer's Risk

... no effect in treating the disease. Meanwhile, some basic science studies have indicated that certain NSAIDs might reduce production of a peptide fragment called A beta 42, which is a key component of the plaques that develop in the brains of people with Alzheimer's. The researchers behind the new ...

High circulating D-dimers are associated with presence of ascites

... with liver cirrhosis may develop serious coagulopathy and a hyperfibrinolytic state, which contributes to the bleeding tendency. Plasma levels of fragment D-dimer (D-dimer) represent an accurate marker of fibrinolytic activity. The finding of a high plasma D-dimer concentration in patients with liver ...

First atomic-level look at a protein that causes brain disease

... studies, and improve our understanding of CAA, he said. His team partnered with biochemists from Case Western Reserve University, who took a fragment of the human prion protein for CAA and tagged it with chemical markers. Jaroniec explained that, while the prion protein used in the study is ...

Immunotherapy: enlisting the immune system to fight cancer

... nearby healthy tissue. In this trial, the researchers gave patients an intravenous dose of MFECP1, a recombinant fusion protein consisting of a fragment of an antibody raised against the substance carcinoembryonic antigen (CEA), which is produced by the cancer, and carboxypeptidase G2 (CPG2), an ...

FORSTEO(R) Receives Approval from the European Commission for the Treatment of Glucocorticoid-Induced Osteoporosis

... (7.2 percent) compared to alendronate (3.4 percent) at 18 months of therapy.(3) Information about Teriparatide Teriparatide is the active fragment (1-34) of the human parathyroid hormone and acts to stimulate bone formation by directly affecting bone forming cells (osteoblasts), indirectly ...

What should we do when esophageal perforation occurs?

... to the ENT clinic complaining of severe dysphagia, substernal pain, and fever five days after chewing on a piece of chicken. Imaging revealed a fragment of bone in the upper part of esophagus, air in the retropharyngeal space and the upper part of the posterior mediastinum, and deep subcutaneous ...

Court of Appeals Reverses Lower Court Decision in Favor of TriMed, Inc. Patent Infringement Case

... trial in 2008. About TriMed, Inc.: TriMed, Inc., a leader in the advancement of innovative orthopaedic fixation systems and specializes in small fragment fracture fixation, holds numerous patents within the field. It is headquartered in Valencia, CA with offices in Walpole, MA and Sweden. ...

A strange case of upper obstructive syndrome

... prosthesis was detached from duodenal wall and the intestine failed to close transversely (Figure 3). To protect the intestinal wall, a pediculated fragment of the greater omentum was placed between the duodenum and aortic bypass. Furthermore, a gastrojejunal Roux anastomosis was employed. The prosthesis ...

JCI table of contents: Feb. 21, 2008

... cancer who had received nonmyeloablative HCT. Further analysis identified the tumor peptide recognized by these CD8+ T cells and it was found to be a fragment of a protein not expressed by healthy cells. The gene responsible for making this protein was part of a region of human chromosome 6 derived from a ...

UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy

... of the defective SMN1 gene, the UD research team used a gene in the human body that is nearly an exact copy (SMN2). Then they introduced a small fragment of this healthy gene's DNA--a genetic bandage referred to as an oligonucleotide--into a diseased cell, triggering the cell to heal itself. Tests ...

UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy

... of the defective SMN1 gene, the UD research team used a gene in the human body that is nearly an exact copy (SMN2). Then they introduced a small fragment of this healthy gene's DNA--a genetic bandage referred to as an oligonucleotide--into a diseased cell, triggering the cell to heal itself. Tests ...

Experimental Vaccine Halts Prostate Cancer in Mice

... and immunology at the University of Southern California, Los Angeles. When the mice were 8 weeks old, they got one injection consisting of a fragment of DNA that coded for prostate stem cell antigen (PSCA), a protein that is overproduced as prostate cancers grow. That injection alerted the immune ...

DuPont Selects South Carolina Site for Planned $500 Million Investment to Expand Production of High-Performance Kevlar(R) Fiber

... gas, enabling exploration in deeper water; -- Enhanced honeycomb structures, providing strength for next generation aircraft; -- Superior fragment protection for the next generation of armored vehicles; -- Flame resistance and strength to help bedding manufacturers meet fire resistant ...
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