Dermatologists Debunk Myths, Offer Advice for Conditions that Hit Below the Belt
... by a
herniation or rupture of fat through the fibrous
tissue and the subsequent
pulling back of this ... explored to treat cellulite work by softening
bands and contracting them at the same time, which effectively
tightens up the fibrous
bands. One procedure Dr. Weiss is ...
Urine Test for Heart Disease Shows Promise
... Heart Association meeting in Washington, D.C.
"Collagen forms a fibrous
cap on the epithelium, the lining of the arteries," Muehlen explained. "These fibrous
caps produce collagen fragments."
High concentrations of those ...
Link between chronic kidney disease and oxygen-deprived tissue
... oxygenation even further. As CKD progresses, kidneys become full of fibrous
tissue and cannot filter wastes out of blood or regulate body salt. ... by HIF-1, a protein that turns on many genes that promote the synthesis of fibrous
connective tissue, thus interfering with the kidneys normal filtering ...
Paving the way for future pan-European clinical trials
... launch of two trials into rare bone conditions, osteosarcoma and fibrous
dysplasia. The two trials now underway are being coordinated through the ... in the reduction of bone pain and osteolytic lesions in patients with fibrous
dysplasia of the bone, a rare congenital bone disease characterized by ...
New Collagen Meniscus Implant Opens New Vista for Knee Repair
... up a whole new field of meniscus reconstruction. The implant permits segmental rebuilding of portions damaged or missing meniscus cartilage, the fibrous
shock absorber of the knee.
To date doctors have only been able to remove, suture repair or replace the whole meniscus with cadaver tissue. ...
Prescient Medical Receives Frost & Sullivan Product Innovation of the Year Award
... guidewire-deliverable device supports the body's natural healing process and promotes growth of endothelial cells over the lesion's thin fibrous
cap to prevent it from rupturing," explained Bhavatharini Rajesh, Research Analyst, Frost & Sullivan.
The vProtect(TM) Luminal Shield ...
Brookhaven Lab and Hybridyne Imaging Technologies Inc., win R&D 100 award
However, the current imaging methods have limitations. Benign and cancerous tumors cannot easily be distinguished by ultrasound, and fibrous
tissues can be mistakenly identified as tumors if patients have had radiation treatment of the prostate previously. Traditional nuclear imaging ...
Carotid Artery Sections React Differently to Plaque
... right and left carotid arteries expands by 11 percent, on average, to keep blood flowing when complex plaque -- made up of cholesterol, calcium and fibrous
tissue -- forms. Meanwhile, the internal carotid artery, which leads to the brain, decreases by as much as 16 percent when people have ...
Canonsburg Woman Undergoes Robot-Assisted Weight Loss Procedure at AGH
... revision, I found the patient’s abdomen was frozen with adhesions [scar tissue that had formed after her previous surgery and that nothing but fibrous
tissue was covering the area of interest. Yet, with the unrestricted range of motion of the robot’s ‘fingers’ I was able to ...
New Heart Valve Repair System Tested for Safety
... risks such as lung problems, irregular heartbeat and infection, the news release noted.
The PTMA system changes the shape of the mitral annulus (a fibrous
ring encircling the mitral valve) and prevents blood leakage by allowing the valve's two leaflets to close more tightly.
"Heart failure prevalence ...
Overweight male teens with normal blood pressures showing signs of heart damage
... Raja says. Structural changes in the young hearts can be linked to a lesser-known aldosterone fact: it also promotes inflammation and formation of fibrous
tissue in the heart muscle.
Overweight females in the group did not have elevated aldosterone levels or the associated heart damage, Dr. Raja ...
NYP/Weill Cornell physician-scientists present at 2009 American Transplant Congress in Boston
... The authors will present their findings about the development and validation of a new gene-based urine test for the diagnosis of renal interstitial fibrous
and tubular atrophy (scarring of the kidney transplant) -- the most common cause of kidney transplant failure. Before now, an invasive biopsy test ...
A Winning Strategy to Beat Spring Sporting Injuries
... require more stringent immobilization, such as a cast, and could take up to 10 weeks to heal.
Plantar fasciitis: This type of heel pain in a fibrous
plantar fascia band of tissue may require orthotics (custom-made shoe inserts) to ease discomfort. The injury is common in baseball and softball ...
Astrocytes help separate man from mouse
... that brain injury is associated with a loss of astrocytic domain organization and a decrease in cognitive function.
In people, cells known as fibrous
astrocytes, which are mainly for structural support, are on average more than twice as large as their counterparts in mice and rats. Also, people ...
U-M researcher's idea jells into potential new disease-detection method
... and molecular gels, you can use heat to dissolve the material, which then precipitates out into a gel structure. This gel structure is basically a fibrous
network that entraps solvent in little pockets," she said.
The researchers wanted to design a material made up of molecules that would organize ...
Better health and prosperity in Europe via improved clinical research
... that pharmaceutical companies will put money into clinical trials of new treatments. In the sorry economics of suffering and death, osteosarcoma and fibrous
dysplasia are known as orphan diseases, partly because no wealthy pharmaceutical company wants to "adopt" them, and partly because the incidence is ...
'Holy powder' ingredient makes membranes behave for better health
... line of research, Ramamoorthy's team is using the same methods to investigate the effects of curcumin on the formation of amyloids---clumps of fibrous
protein believed to be involved in type 2 diabetes, Alzheimer's disease, Parkinson's disease, and many other maladies. In addition, the researchers ...
Cell microenvironments hold key to future stem cell therapies
... However, when these cells are in an actual human being (in vivo) they are surrounded by a multitude of other cells plus a supporting network of fibrous
and globular proteins called the extracellular matrix (ECM), as well as many other nearby molecules, all of which may be simultaneously sending them ...
Smith & Nephew Endoscopy's OSTEORAPTOR(TM) Anchor Provides Bioabsorbable Solution for Labral Tears in the Hip and Shoulder
... labral repair procedures in the hip joint and an estimated 185,000 procedures for the shoulder. Labral repairs are necessary when the labrum, the fibrous
cartilage ring that rims the joint socket, tears or becomes stretched due to impingement or acute injury. Damage to the labrum in the hip may be a ...
Anti-Cholesterol Drug May Ease Back Pain
... of collagen II (which makes up moveable joints) had increased, and the production of collagen I (which plays a role in the development of excess fibrous
connective tissues) had decreased. Lovastatin caused no harm to the nucleus pulposus cells, the researchers reported.
The findings were to be ...
Radiofrequency treatment better than ethanol injection for small liver tumors
... explained by the fact that more predictable tumor ablation was possible," the authors suggest. While injected ethanol might be stopped by the liver's fibrous
septum or by satellite nodules, the heat from the radiofrequency electrode tip is distributed more homogenously.
A Possible Cure for Unsightly Cellulite?
... appearance of cellulite, but to date there is no proven, permanent "cure" for cellulite.
"Cellulite is caused by bands of fibrous
tissue that connect the muscle to the skin," says Alan Gold, MD, President of the American Society for Aesthetic Plastic Surgery (ASAPS). ...
'Intelligent' materials to revolutionize surgical implants
... technique builds on an existing technique known as electrospinning, and will utilise a vastly superior electrospinning source to create bespoke fibrous
materials. Electrospinning is a process that uses an electrical charge to turn polymers into extremely thin fibres that are 'spun' to form a mat of ...
SpectraCell Laboratories Offers Additional Test for Heart Attack and Stroke Risk
... plaque and cause
a heart attack or stroke.
Lipid measurement and cardiac imaging cannot identify which patients
have rupture-prone plaque with thin fibrous
caps. Therefore, finding
serologic markers with high specificity for advanced plaque is a useful
diagnostic tool in cardiovascular risk ...
Study in Circulation provides detail on how low blood flow promotes vascular disease
... the innermost part of a vessel called the lumen. The inside of that inner tube is lined with a layer of endothelial cells, which is surrounded by the fibrous
cells of the intima, which is surrounded by a layer of smooth muscle cells in the media. Many blood vessels are muscular because the flexing of such ...
New Treatment Offers Hope for Beating Aggressive Cancers
... pancreatic cancer, colon cancer, renal
(kidney) cancer, mesothelioma, and a group of sarcomas, including
osteosarcoma, chondrosarcoma and malignant fibrous
who have other cancers can be considered on a case-by-case basis, since
many of them may benefit also. Having received ...
Toxins in cigarette smoke prevent stem cells from becoming cartilage
... When this group of stem cells is free to differentiate, the newly formed cartilage cells immediately begin manufacturing collagen 2, the tough, fibrous
protein framework for cartilage. Along with interfering with SOX-9, BaP was also found to reduce levels of type II collagen gene expression.
ESF's EMRC strengthens training course on clinical trials management
ESF is co-ordinating two clinical trials through its EUROCORES scheme. These trials are into two rare bone conditions, osteosarcoma (Euramos) and fibrous
dysplasia (Profidys). International and European collaborations are vital for such rare conditions because no single country has sufficient patients ...
Freeze-dried tendon implants prove effective in early studies
... this technique fared worse than autografts because patients bodies would recognize the donated tendon as foreign, attempt to wall it off with fibrous
proteins and in some cases reject the transplant. The field then looked at whether synthetic scaffolds made of gel or fiber mesh could serve as ...
JCI table of contents: Nov. 15, 2007
... mechanisms underlying lung scarring
Pulmonary fibrosis is an incurable disease where the lung becomes scarred due to pathologic accumulation of fibrous
scar tissue. Telomerase is a protein most notable for its connections to aging and cancer, but it has also been shown to have increased activity in ...
JCI table of contents: Oct. 18, 2007
View the PDF of this article at: https://www.the-jci.org/article.php?id=24311
ONCOLOGY: The origin of one cancer
histiocytoma (MFH) is a soft tissue cancer commonly diagnosed in late adult life. New data generated by a team of researchers from Columbia ...
Hepatic Stellate Cells Found Capable of Tissue Repair
... begin producing collagen and other proteins that lead to the formation of fibrous
tissue and scarring. Akassoglou's team looked at the molecular-cellular interface to discover how tissues respond to deposition of the fibrous
protein, fibrin. In studies of a mouse model with excessive fibrin ...
Researchers Have Found the Role of Protein in Accelerating Breast Cancer Progression
... of PTN produced breast cancers of a more aggressive subtype. In those same mouse models, highly malignant cells of scirrhous carcinoma-a hard, fibrous
tumour-were found to express very high levels of the mouse mammary tumour virus (MMTV)-Ptn transgene along with increases in collagen, elastin, ...
New Therapies may Help to Avoid Transplant in Some Heart Failure Patients
... removal of the LVAD prior to transplantation found evidence of important improvements.
The size of the heart muscle cells, the amount of the fibrous
collagen and levels of the protein TNF-alpha all decreased significantly between pump implant and heart transplant signs of reduced heart damage. ...
Research may Yield Improved Treatment for Diseased Lungs
... stiffness in the mice in a process that mimics scleroderma, a disease in which the body produces too much collagen, the body's ubiquitous fibrous
structural protein that strengthens blood vessels.
Patients with certain kinds of scleroderma also contract a kind of pulmonary hypertension ...
Hormone-based Heart Pill to Control High Blood Pressure
... properties include its ability to dilate blood vessels, promote salt discharge in urine, and prevent both excessive cell growth and growth of fibrous
tissues. The researchers tested the oral BNP by inducing high blood pressure in laboratory animals, and then giving them the experimental drug. ...
Inhibiting Blood to Save the Brain
... A fibrous
protein called fibrinogen, found in circulating blood and important in blood clotting, can promote multiple sclerosis (MS) when it //leaks from the ...
A Better Way to Deliver Cancer Drugs
... problems with past systems like this is they're seen as foreign by the body, and tissue grows around it," Allen explains. In this situation, called fibrous
encapsulation, the surrounding tissue can often prevent proper drug release or keep the drug from reaching the tumor. "We haven't had this problem," ...
Risk Of Soft Tissue Sarcomas In Hereditary Retinoblastoma Survivors
... of smooth muscle cells that was diagnosed in 23 of the patients. Other frequently diagnosed sarcomas were fibrosarcoma (13 patients), malignant fibrous
histiocytoma (12), rhabdomyosarcoma (8), and liposarcoma (3). The authors calculated that there was a 184-fold increase in soft-tissue sarcomas among ...