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FDA Approves New 3000 IU Vial Size for Kogenate(R) FS, antihemophilic factor (recombinant)

... vial size of Kogenate(R) FS , antihemophilic factor (recombinant). The new vial size offers greater ... for safe reconstitution and fast recombinant factor VIII treatment in a small, tamper-evident box ... Kogenate(R) FS, antihemophilic factor (recombinant) , is a ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. BIBW 2992 is the ... inhibits vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR) and fibroblast ...

Advanced targeted therapies effective as first-line treatment for lung cancer

... OUTCOMES OF PATIENTS WITH EPIDERMAL GROWTH factor RECEPTOR (EGFR) MUTATIONS IN IPASS (IRESSATM PAN ... STUDY) (ABSTRACT # B9.5) An epidermal growth factor receptor (EGFR) is a protein found on the surface of cells to which an epidermal growth factor (EGF) binds. When an EGF attaches to an EGFR, it ...

Bcl6 gene sculpts helper T cell to boost antibody production

... is short for B-cell lymphoma 6, a transcription factor previously shown to be selectively expressed in ... of Bcl6 in the absence of transforming growth factor beta (TGF) to drive T cell differentiation into Tfh. "Not only is Bcl6 a transcription factor expressed by Tfh cells, it also has a major ...

Stayhealthy and Innovative Wellness Solutions Announce Partnership to Bring Innovation to the Workplace Wellness Market

... as overweight - excess body fat is the number one factor driving the incidence and severity of the most ... weight as a measure of health. The health risk factor lies in excess body fat, or the ratio of lean ... to losing weight, it is also a significant factor in everything from chronic headaches, fatigue, ...

Why African-Americans are at greater risk of hypertension and kidney disease

... believe that a heightened level a certain growth factor in the blood may explain why blacks have a ... level of a protein, called transforming growth factor B1 (TGF-B1), raises the risk of hypertension and ... in black patients, higher levels of the growth factor are correlated with lower renin activity -- an ...

Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII

... showed that sucrose-formulated recombinant factor VIII (rFVIII-FS) reduced bleeding and provided ... experience with sucrose-formulated recombinant factor VIII in patients with hemophilia A. Pooled ... formation with sucrose-formulated recombinant factor VIII in patients with hemophilia A: Results from ...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... in Phase II clinical development, and its oral factor Xa inhibitor anticoagulant antidote in ... Co., Inc. for betrixaban, an investigational oral factor Xa inhibitor anticoagulant currently in Phase II ... as Drug Targets Reconstructed Recombinant factor Xa as an Antidote to Reverse Anticoagulation ...

Bayer HealthCare Launches Hemophilia Self-Infusion Training Program

... designed to make infusion of recombinant factor VIII easier for both patients with hemophilia A ... than family members or a nurse to receive their factor therapy, and thus feel more in control of their ... or reduced levels of the blood clotting protein factor VIII leading to prolonged or uncontrolled ...

Portola Pharmaceuticals to Host Conference Call at 11:00 a.m. Eastern Time Tomorrow to Discuss Betrixaban Partnership and Provide Corporate Update

... betrixaban, the company's investigational oral factor Xa inhibitor anticoagulant currently in Phase II ... About Betrixaban Betrixaban is an oral factor Xa inhibitor that has been specifically designed ... two lead Phase 2 compounds, betrixaban, an oral factor Xa inhibitor, and elinogrel, a P2Y12 ADP receptor ...

Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products

... discovery, development and commercialization of factor VIIa products to treat hemophilia and other ... and preclinical development by Catalyst of factor VIIa products, including CB 813, Catalyst's ... serves as an excellent fit with our recombinant factor VIII ...

Sad Dads May Lead to Crying Infants

... the mother, which is already known to be a risk factor for excessive infant crying," van den Berg said. ... measurable depression during pregnancy is a risk factor for excessive infant crying at 2 months of age," ... as the authors suggest, there may be a genetic factor involved," he said. More information The ...

Elsevier Announces 2008 Journal Impact Factor Highlights

... announced the highlights of its journal impact factor performance in 2008. Elsevier overall saw 75% of ... editors and our societies. This year's impact factor growth is one indication of the hard work and ... of the best in their fields." The impact factor is a measure of the frequency with which the ...

Smoking more than 5 cigarettes a day provokes migraine attacks

... Tobacco acts as a precipitating factor for headaches, specifically migraines. This is ... of tobacco as a precipitating, non-causal factor of migraine attacks has produced contradictory ... According to Pascual, "smoking is a precipitating factor of this type of headache, as the prevalence of ...

A new take on growth factor signaling in tamoxifen resistance

... Differences in growth factor (GF) signaling may cause the poor prognosis in ... to determine that there is increased growth factor activation from the gene expression profiles of ... finding by showing that treatment with the growth factor heregulin, which induced ...

'Life force' linked to body's ability to withstand stress

... These dimensions, known as the "Five factor Model" of personality, served to organize ... Inventory, an instrument based on the Five factor Model. The study found that the difference ... personality by examining the degree to which each factor was associated with differences between people in ...

Structures from the human immune system's oldest branch shed light on a range of diseases

... to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of C3, to ... and of the C3b fragment in complex with factor H. The work appears this month in two companion ... describing the structure formed between C3b and factor H, a key regulator of the complement system, is ...

New Anticoagulant Pill Works Well in Trial

... trial shows. Rivaroxaban is a pill that blocks factor Xa, which is involved in blood clotting. In ... the drug at various doses. "The use of an oral factor Xa inhibitor in patients stabilized after an ... rivaroxaban, as a fixed-dose, direct and oral factor Xa inhibitor, provide a sound rationale to pursue ...

Strides Made in Hemophilia Research

... into animals' cells to make the clotting protein, factor VIII, which is missing in people with hemophilia. ... endothelial cells, which are the main source of factor VIII. Researchers hope the new approach will ... mice injected with these nanoparticles had factor VIII levels that were the same as those of normal ...

UNC study suggests new approach to common cause of blindness

... at a protein called vascular endothelial growth factor or "VEGF." The discovery -- made in mouse ... drugs that block the effects of VEGF, a growth factor that promotes the growth of abnormal blood vessels. However, because this factor is also involved in the growth and health of ...

Over half of people with rheumatoid arthritis have periodontitis

... Moderate to Severe Periodontitis may be a Risk factor for Developing RA in Non-Smokers A second ... that, although smoking is an established risk factor for both RA and periodontitis, non-smoking ... sera were assessed for ACPA and rheumatoid factor (RF) positivity using ELISA (enzyme-linked ...

Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009

... (Abst# 859-P): "Vascular Endothelial Growth factor Zinc Finger Protein Activator (SB-509) in Mild to ... Conduction Using Vascular Endothelial Growth factor Zinc Finger Protein Activator (SB-509): Interim ... Finger DNA-binding Protein (ZFP) Transcription factor (ZFP TF(TM)) designed to upregulate the ...

Experts reach consensus on diagnosis and treatment of bleeding disorders in women

... in, or a dysfunction of, von Willebrand factor (VWF), a protein necessary for normal platelet adhesion and protection of factor VIII (FVIII) from proteolysis in the circulation. ... platelet number and function and her coagulation factor profile should be assessed in collaboration with ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

... of certain mutations of the epidermal growth factor receptor (EGFR) pathway, are believed to be ... including mCRC, receptors of the epidermal growth factor protein that reside on each cell are abnormally ... interfere with the cell's epidermal growth factor receptor to impede cellular proliferation and ...

Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting

... Placement of a gene encoding a therapeutic growth factor into the wound environment allows for sustained ... production of micro quantities of the growth factor by the body's own cells within the wound site, an ... (TRC) is focused on the development of growth factor therapeutics for the treatment of severe chronic ...

Arizona Shows More Than a 20% Drop in Smoking Rates

... -- New information from the Behavioral Risk factor Surveillance System 2008, shows that the rate of ... May 1st, 2007. About Behavioral Risk factor Surveillance System The Behavioral Risk factor Surveillance System (BRFSS) is a state-based ...

BELLUS Health reports results for first quarter of fiscal 2009

... is 212,349,035, representing a potential dilution factor of 424%, based on the number of common shares ... be 137,595,789, representing a potential dilution factor of 275%, based on the number of common shares ... be 56,437,714, representing a potential dilution factor of 113%, based on the number of common shares ...

Urine Test Predicts Vein Clot Risk

... study found. "Microalbuminuria is a known risk factor for arterial conditions such as myocardial ... Association . "Now it is also found to be a risk factor for venous thromboembolism. This is the first time it has shown to be a risk factor for VTE." Tests to detect albumin and other ...

Patient Convenience Focus of New Upgrades to HeliTrax System by CSL Behring

... and dosing of Helixate® FS , Antihemophilic factor (Recombinant). The details recorded can then be ... or defective blood coagulation proteins known as factor VIII or factor IX. The most common form of the disease is ...

Instrumentation Laboratory Wins Patent Infringement and Unfair Competition Trial Against Diagnostica Stago Relating to Reagents for Hemostasis Diagnostics

... for determining the presence of gene mutations of factor V, which is one of the causes of thrombophilia. ... assays for the detection of APC resistance and factor V Leiden mutations. We are committed to ... C, protein S, activated protein C resistance, factor V Leiden, homocysteine, ThromboPath, and Xpert ...

Cancer-obesity link discovery by MSU researchers could aid prevention efforts

... colon cells to produce more of a growth factor that can increase blood supply to early cancer ... or fat, is recognized as a significant risk factor for diabetes and heart disease, but the role of ... strategy for reducing obesity as a risk factor for colon cancer, 95 percent of all people who ...

American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide

... to inappropriately turn on a transcription factor critical to the growth of prostate cancer cells. ... at activities of a receptor for Epidermal Growth factor (EGF), which helps control cellular growth. These ... found that in prostate cancer, apoptosis inducing factor (AIF) promotes cell survival, unlike its ...

New study finds continued abstinence is key to increased survival from alcohol-related liver disease

... found that abstinence from alcohol is the key factor in long-term prognosis, even with relatively ... found that drinking status was the most important factor determining long-term survival in alcohol-related ... diagnosis of cirrhosis was the more important factor determining survival with a seven year survival ...

CSL Behring Marks World Hemophilia Day with $2M Coagulation Factor Donation to World Federation of Hemophilia

... to donating to WFH two (2) million units of factor VIII concentrate (FVIII) each year for the next ... $2 million, will be made using coagulation factor concentrate with a minimum shelf-life of one ... on product donations to help introduce clotting factor concentrates in developing countries and these ...

Bayer HealthCare Marks 20th Anniversary of World Hemophilia Day With Euro 250,000 Contribution to the World Federation of Hemophilia

... Developing a long-acting recombinant factor VIII product to assess the safety and efficacy of ... Developing a next-generation recombinant factor VIIa protein that may provide additional ... developed antibodies - or inhibitors - to either factor VIII ...

CSL Behring to Launch Next GameFaces Program Challenge

... or defective blood coagulation proteins known as factor VIII or factor IX. The most common form of the disease is ... A, or classic hemophilia, in which the clotting factor VIII is either deficient or defective. Hemophilia ...

Also in the March 24 JNCI

... and overall mortality in individuals taking factor D. In the current analysis, Philip R. Taylor, ... 10-year follow-up data. Individuals who took factor D continued to show benefits, with a 5% reduction ... mortality of 33.62% of participants not taking factor D to 32.19% of participants ...

JCI table of contents: March 23, 2009

... such as osteoporosis. TITLE: Wnt inhibitory factor 1 is epigenetically silenced in human ... to conclude that hypoxia seems to be a key factor driving tumor progression. In an accompanying ... as psoriasis. TITLE: Loss of serum response factor in keratinocytes results in hyperproliferative ...

Study IDs Gene Variants Tied to Sudden Cardiac Death

... arrhythmias by limiting meds in those with risk factor MONDAY, March 23 (HealthDay News) -- ... common genetic variants associated with a risk factor for sudden cardiac death have been identified by ... general population is a potent and heritable risk factor for sudden death. In addition, QT prolongation ...

Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs

... sex organs; anti-inflammatory transforming growth factor beta-1 which supports connective tissues such as joints and tendons; von Willebrand's factor which supports skin tissue; para-thyroid hormone ... general body metabolism; and nerve growth factor which supports the central and peripheral nervous ...
Other Contents
(Date:4/18/2014)... PROVIDENCE, R.I. [Brown University] Asteroid and comet impacts ... animals on regional or even global scales. But new ... preserve the signatures of ancient life at the time ... Brown geologist Pete Schultz has found fragments of leaves ... a several ancient impacts in Argentina. The material could ...
(Date:4/17/2014)... trials to treat tuberculosis could be the basis for ... bacteria, fungal infections and parasites, yet evade resistance, according ... collaborators. , Led by U. of I. chemistry professor ... drug SQ109 attacks the tuberculosis bacterium, how the drug ... to malaria and how targeting multiple pathways reduces ...
(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
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(Date:4/18/2014)... one of your worst memories? How did it make ... during a negative personal experience, such as how sad ... to emotional distress, especially when you can,t stop thinking ... up, thinking about the context of the memories, rather ... effective way to alleviate the negative effects of these ...
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/18/2014)... . A ... A team led by Ludwik Leibler from the Laboratoire ... Letourneur from the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Universits Paris ... principle of adhesion by aqueous solutions of nanoparticles can ... tissues. This easy-to-use gluing method has been tested on ...
(Date:4/17/2014)... in benign prostate tissue was associated with high-grade, ... found even in those with low prostate-specific antigen ... Cancer Epidemiology, Biomarkers & Prevention , a ... , An analysis of prostate tissue biopsies collected ... the Prostate Cancer Prevention Trial (PCPT) found that ...
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
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