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Downstream in Medical News

Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions

... manufacturing solutions for upstream and downstream processing and moves the 'disposable factory' ... and manufacturing of cell culture media and downstream purification products. The alliance is expected ... and development services for upstream and downstream processes in the biopharmaceutical industry. ...

Does HBV infection induce acute cellular DNA damage?

... evidence so far that the ATM/ATR kinases or their downstream pathways are triggered by HBV infection. A ... protein and increased phosphorylation of multiple downstream targets including Chk1, p53 and H2AX. In contrast ... phosphorylated form of ATM at Ser-1981 and its downstream substrate Chk2 phosphorylation at Thr-68 did not ...

New findings may improve treatment of inherited breast cancer

... Scientists have identified some of the elusive downstream molecules that play a critical role in the ... linked with BRCA1, very little is known about the downstream mediators of BRCA1 function in tumor ... These findings identify SIRT1 and Survivin as downstream mediators of BRCA1-regulated tumor suppression ...

Emory researchers identify signaling protein for multiple myeloma

... that mediates signaling in cells as critical in downstream signaling of FGFR3 in myeloma cells. Dr. ... mechanism to turn-on RSK2 by FGFR3. FGFR3 impacts downstream proteins through phosphorylation at special ... connection between the oncogenic FGFR3 and its downstream protein kinase RSK2, which plays a critical role ...

Group Health Cooperative Shows Investing in More Primary Care Pays for Itself

... Broke even on its primary care staffing investment through reduced downstream utilization costs. Emergency room/urgent care visits were 29 percent ... contact with patients through secure e-mail and phone. Decreased downstream utilization led to return on investment. "These results ...

Group Health Cooperative shows investing in more primary care pays for itself

... Broke even on its primary care staffing investment through reduced downstream utilization costs. Emergency room/urgent care visits were 29 percent less ... contact with patients through secure e-mail and phone. Decreased downstream utilization led to return on investment. "These results lay the ...

IntegriChain Announces Measurement of Retail Inventory(TM) (MRI) Analytic

... information service which provides a highly accurate (>99%) view into downstream sales of pharmaceutical products into over 300,000 dispensing locations in ... an unparalleled level of transparency into inventory movement in the downstream market. "We see this as a watershed tool for financial reporting, ...

Also in the Nov. 11 JNCI

... Paul van Diest, P.J.vandiest@umcutrecht.nl , + 31887556565 downstream RAS Signaling Protein May Be Lung Cancer Target Blocking expression of ... efficacy in treating human disease. To determine whether blocking a downstream component of the RAS signaling pathway could reduce tumor cell growth, Amy ...

A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found

... complex with FGFR1 and that EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. However, alterations of EphA4 are not well understood ... with FGFR1 and that the EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. FGFR1 expression was correlated with EphA4 ....

New nano device detects immune system cell signaling

... also noticed something unexpected: some T-cells that were trapped in wells downstream of those with dendritic cells, which had never been in direct contact with ... chamber and filled it with T-cells. Then she hooked the second chamber downstream of the first." When she did so, the T-cells in the second chamber ...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

... Relatively little is known about the important molecular events that are downstream of the MLL fusion gene. Previous research indicates that Rac1 a protein ... in mice with AML expressing MLL-AF9. To test the importance of Rac1's downstream regulatory pathway in human AML expressing MLL-AF9, the research team ...

EPA scientists recognized with prestigious honor

... of the Contributions of Headwater Streams to the Integrity of downstream Waters: Hydrological Connectivity between Headwater Streams and downstream Waters: How Science Can Inform Policy. Journal of the American Water ...

New regulatory circuit identified for aggressive, malignant brain tumor

... knowledge of the complex interactions between multiple disrupted genes and downstream targets. Dr. Lynda Chin from Dana-Farber Cancer Institute, Dr. Cameron ... are more likely to be bystanders of the cancer process, offers Dr.Brennan. downstream functional validation of high probability candidates should yield novel ...

BioDiscovery Joins Illumina Connect Bioinformatics Program

... Illumina Connect, a bioinformatics program offered by Illumina, Inc., for downstream analysis of microarray data. After collaborating with Illumina, ... value for scientists and the medical community looking to advance their downstream analysis functionality," said Dr. Shams. "The user-friendly Nexus ...

The genetics of MLL leukemogenesis

... the histone methyltranferase enzyme called MLL, inducing it to turn-on downstream gene targets that transform blood progenitor cells into leukemia stem cells (LSCs). While some of the downstream targets of MLL are known (Hox genes, for example), the genetic changes ...

Verizon Introduces Broadband Video Call Center Link for Deaf or Hard-of-Hearing Customers in Mid-Atlantic Region

... Internet service in more than 1,700 communities in 16 states, offering downstream connection speeds ranging from up to 5 Mbps (megabits per second) to up to ... communication at good frame rates, customers need a high-speed line with a downstream speed of at least 256 kilobits per second or higher. Verizon's High Speed ...

JCI table of contents: Sept. 4, 2007

... at Duke University Medical Center, have identified a new signaling pathway downstream of the beta1-adrenergic receptor in the heart that protects the muscle ... kinases 5 and 6 and resulted in transactivation of EGFR. Signaling downstream of EGFR activation protected the heart muscle cells from the toxic effects ...

NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions

... technologies to the production of stabilized rice bran ("SRB"), rice bran oil ("RBO"), cereal products for infants and adults and high value downstream derivatives of SRB and RBO. Recent Transactions Consistent with Plans to Exit Non-core Investments "In order to provide greater ...

Recondo Technology Introduces New Software Service for Hospitals

... ) Without accurate and timely eligibility determination, hospitals experience countless downstream problems, such as delayed payment, rework, low patient satisfaction, billing errors, denials, and bad debt. These operational problems, created by ...

GenVault's GenSolve(TM) Reagents Enable State-of-the-Art Genomic Analysis of Dried Blood Spots

... in limited supply and archived for long periods in a dry state. Of major significance is the fact that DNA recovered by GenSolve(TM) is suitable for downstream analysis on state-of-the-art technology, allowing us to capitalize on the resources we have to facilitate population scale studies", said Professor ...

Abnormal Brain Circuits May Prevent Movement Disorder

... cerebellar pathway problem in all DYT1 carriers. When we went back and looked at those without symptoms, we saw that they had an additional lesion downstream in the portion of the pathway connecting directly to the motor cortex." This second area of pathway disruption abrogated the effects of the ...

NutraCea Announces Additions to Management Team; Chief Operating Officer Extends Employment Contract

... we believe will develop a sustainably profitable business. Leo's deep knowledge and understanding of the industry, of our business model and of the downstream technological applications that add value to our stabilized rice bran products will be instrumental in the future success of NutraCea." ...

MO BIO Laboratories, Inc. Launches PowerFood(TM) Microbial DNA Isolation Kit

... compounds associated with food cultures, such as lipids and polysaccharides. The kit provides high quality, inhibitor-free DNA for use in downstream applications including PCR, qPCR and genotyping assays The PowerFood Microbial DNA Isolation Kit is available now. For more information ...

Blood Test Shows Statistically Significant Association With Alzheimer's Disease (AD), May Predict Conversion of Mild Cognitive Impairment to AD

... results of this study support the cell cycle hypothesis of Alzheimer's disease - specifically, that G1/S cell cycle regulatory failure leads to the downstream development of the characteristic pathologies of the disease, the amyloid plaques and tau tangles. Most importantly, the findings validate the use of ...

Temple University Health System to Improve Supply Chain with Broadlane

... correctly by suppliers. Under this unique program, Broadlane will manage the price discrepancy resolution process and subsequently provide benefits downstream to TUHS' accounts payable processes.   Informatics for access to reports and to improve insight related to contracts, capital ...

Making Obese Mice Slim, Without Diet or Exercise

... to target neurons or other pathways in which leptin plays a key role. "The hope is there will be new drugs that would target the neurons or the downstream pathways of the neurons to help control blood glucose in people who suffer from type 2 diabetes and who are obese," Bjorbaek said. Weiss said ...

Study further expands understanding of leptin's role in brain neurocircuitry

... our finding that the mice had greatly increased activity levels despite still being highly overweight provides hope that POMC neurons and downstream neuronal systems might eventually be tapped to develop drugs that increase the will to voluntarily exercise in individuals who are overweight or ...

2-drug combination appears safe and active in metastatic kidney cancer

... proliferation. Therefore, Plimack and colleagues suspect that blocking TORC2 signaling activity could improve patient outcomes. Bryostatin blocks a downstream effector of TORC2, called protein kinase C. Plimack and colleagues designed the phase I trial to test the safety of the bryostatin-temsirolimus ...

Why do people with Down syndrome have less cancer?

... drugs work by simply binding to VEGF (like Avastin) or blocking its ability to bind to its cellular receptors. "We're now moving further downstream by going inside the cell," Ryeom says. "When we targeted calcineurin, we suppressed the ability of endothelial cells to grow and form vessels. While ...

A surprise 'spark' for pre-cancerous colon polyps

... If you're trying to match therapies with a specific genetic mutation, it helps to understand the earliest steps in tumor formation, as well as the downstream consequences." APC stands for adenomatous polyposis coli. It is classified as a tumor suppressor gene. Before the new study, scientists believed ...

Now we know what blocks the effects of a newly developed anticancer therapy

... of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, ...

JCI online early table of contents: May 1, 2009

... of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, ...

Shell Finance Executive Streng Elected to Codexis Board

... to the Codexis Board of Directors, bringing the Board to eight members. Mr. Streng is based in Houston, Texas, where he is employed by Shell downstream Inc., and is responsible for finance for refinery and petrochemical plants in the Shell Group worldwide. He joined the Shell Group in 1990, and has ...

PUR Water Filtration Systems Can Reduce Trace Levels of Pharmaceuticals Found in Some U.S. Tap Water

... American households. In March 2009 researchers from Baylor University and the EPA found trace levels of pharmaceuticals in fish caught downstream from wastewater treatment plants in Chicago, Dallas, Orlando, suburban Philadelphia and Phoenix. PUR faucet filtration systems ...

Instead of fighting breast cancer, immune cell promotes its spread

... blocking both RANKL and IKK alpha in those breast tumor cells inhibited lung metastases. "More importantly," he said, "blocking the signaling pathway downstream of RANKL blocks primary metastasis and can potentially be developed as a treatment strategy." Results such as these are helping to change the ...

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

... kinase 2 (PAK2), a key target for cancer growth and fibrotic tissue development, is activated in one type of tissue but not another. PAK2 is a downstream component of transforming growth factor beta (TGF-β) signaling in mesenchymal cells those that make up connective tissues in the body, as well ...

New tests provide new insight into why patients are in heart failure

... which ones. Because even if patients have enough corin and consequently enough active ANP or BNP there can still be problems with activation of downstream signals that ultimately tell the kidneys to increase elimination of salt and fluids. At the other end of the spectrum, some patients Dr. Ibebuogu ...

Therapure Biopharma Inc. and LFB Biotechnologies Announce Development Services Contract for New Therapeutic Protein

... a blood protein. As a contract development and manufacturing organization (CDMO) Therapure Biopharma applies scientific, manufacturing, and downstream purification expertise with an intimate understanding of advanced biology, complex proteins, and regulatory processes to develop effective and ...

New study shows how spikes in nitrite can have

... informs ongoing basic and translational studies by highlighting the importance of the dose-effect relationship for nitrite and the broad array of downstream targets possibly involved in its cardioprotective efficacy, the researchers concluded. ...

What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?

... of colon cancer cells, and induces apoptosis, and expression of the growth response-1 gene in early phase. These processes are activated downstream of the suppression one by one via a PPAR- gamma -independent pathway. Moreover, an inductive chemical compound associated with CDDO causes PPAR- ...
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