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Differentiation in Medical News

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

... that selected Wnt activators induce the differentiation of mesenchymal stem cells to mature, bone-forming ... small molecules that can direct lineage-specific differentiation to an osteoblast phenotype," said Paul Grayson, ... activator of the canonical Wnt pathway stimulates differentiation of mesenchymal stem cells to an osteoblast ...

Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration

... small molecules that may be used to induce the differentiation of adult stem cells in the body for ... pathways and small molecules that can induce differentiation to mature, bone-forming osteoblasts offers a new ... strategies and mechanisms for lineage-specific differentiation to an osteoblast phenotype. The ability to ...

How cells change gears: New insights published in Nature Genetics

... the role of the transcriptional network during differentiation in leukemia cells could offer a glimpse into the ... factor network during the processes of differentiation and maturation into immune cells known as ... that appears to play an important role in cell differentiation in white blood cells. "It's a long shot, but if ...

Scientists Identify Key Gene That Protects Against Leukemia

... a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell ... a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell ... signals that regulate the proliferation and differentiation of hematopoietic stem cells, the multipotent, ...

Frost & Sullivan Honours Outstanding Achievements in Healthcare

... - 2008 European Point-of-Care Immunoassay Product differentiation Innovation Award Aesku.Diagnostics - 2008 ... Tissue Sealants & Topical Hemostats Product differentiation Innovation Award Xenometrix AG - 2009 ... 2008 European Insurance Claims Management Product differentiation Innovation Award IBM - 2008 European ...

New stem cell therapy may lead to treatment for deafness

... conditions that allowed for the progressive differentiation into neurons and hair cells with the same ... that future studies will aim to improve the differentiation system. They are currently working on using the knowledge gleaned from this study to optimize the differentiation of human embryonic stem cells into ear cell ....

Stem cells could halt osteoporosis, promote bone growth

... Faculty of medicine. "We realised that this differentiation process involved IFN gamma-related genes, but ... is an integral factor for mesenchymal stem cells' differentiation into osteoblasts also in-vivo," says Dr. Kremer. ... results proved that IFN gamma is key to the differentiation of mesenchymal cells into bone cells, and to ...

UC San Diego engineers develop novel method for accelerated bone growth

... diameter can be controlled to induce selective differentiation of stem cells into osteoblast (bone-forming) ... "The use of nano topography to induce preferred differentiation was reported in recent years by other groups, but ... here is a way to introduce desirable guided differentiation using only nanostructures instead of resorting to ...

USC researchers identify key mechanism that regulates the development of stem cells into neurons

... a novel mechanism in the regulation and differentiation of neural stem cells. Researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow into neurons. The ...

Decoding Muscle Stem Cell Development

... "found that glucose restriction (GR) impaired differentiation of skeletal myoblasts and activated AMP-activated ... in numerous physiological processes, including differentiation of skeletal muscle cells, and has been implicated ... show that a specific pathway controls muscle cell differentiation in response to low nutrient levels. "We ...

Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells

... cells reprogrammed to have the same unlimited differentiation characteristics of embryonic stem cells, say ... further research must be done to confirm the differentiation potential of iPS cells. This finding that iPS ... scientists from UCLA were able to induce the differentiation of mouse iPS cells into functional heart cells," ...

Same process discovered to both form skeleton and protect it for life

... believe represents the stages involved in the differentiation of mesenchymal cells into mature osteoblasts. The ... studies, researchers manipulated the osteoblast differentiation process at different stages in study mice. The ... genetic tools to shut down Notch early in the differentiation process, at the point where the signals would ...

Forever young: Differentiation blocked in tumor stem cells

... of tissue-specific stem cell maturation and differentiation tumor stem cells arise, and which, if any, of the ... To better understand the development and differentiation pathways that play a significant role in cancer ... BMPs are known to mediate proliferation, differentiation and apoptosis in NSCs, depending on the stage of ...

The new source of islet cells

... diabetic patients. The article describes the differentiation of rat pancreatic ductal epithelial cells into ... stem cells into islet cells, the process of cell differentiation and growth is long. Moreover, the amount of islet ... the clinical needs. To shorten the process of differentiation and enhance the output of insulin-producing cells ...

New strategies with greater antitumorous efficacy

... cells is that they lose their normal level of differentiation and, instead of exercising a determined function, ... cells to retinoids depends on the degree of differentiation of these cells. In general, highly differentiated ... of modulation -GSH modulation and that of the differentiation inductors. They have found a link between the two ...

Bcl6 gene sculpts helper T cell to boost antibody production

... reported in the journal Immunity that cytokines IL-6 and IL-21 drive the differentiation of Tfh cells. However, how these cytokines work had been unclear. In the ... in the absence of transforming growth factor beta (TGF) to drive T cell differentiation into Tfh. "Not only is Bcl6 a transcription factor expressed by Tfh cells, ...

Intravenous Immune Biologics Will Suffer from the Pending Shift in Coverage from the Medical to the Pharmacy Benefit

... in Immune Biologics: Tightening Payer Control Offers Opportunities for differentiation , the majority of surveyed pharmacy directors say they currently cover ... in Immune Biologics: Tightening Payer Control Offers Opportunities for differentiation The new Formulary Forum report is based on a survey of 50 pharmacy ...

Stem Cells' "Suspended" State Preserved by Key Step, Scientists Report

... an efficient reprogramming. Chd1 is important for allowing the normal differentiation process, and it is essential for playing the 'differentiation tape' ... used to simulate normal cell specialization, the scientists detected no differentiation of cardiac muscle, and also no formation of a tissue known as primitive ...

Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors

... of the Nara Medical University. "The known multipotency of BMSCs during differentiation and their known ability to produce neurotrophic factors, such as nerve ... tumors and speculate that one of the mechanisms by which BMSCs promote the differentiation of ES cells is related to secreted soluble factors, including neurotrophic ...

New book summarizes current knowledge on the biology of the vertebrate skeleton

... of bone, molecular control of cartilage and bone cell fates, and terminal differentiation and remodeling. The first is currently a major question in developmental ... are also discussed. The second theme considers the molecular basis of differentiation in cartilage and bone, and the regulation of these processes by ...

For Erectile Dysfunction, Physicians Indicate That Opportunity Exists for Emerging Therapies with Improved Efficacy in Difficult-to-Treat Patient Subpopulations

... Seek Improvements in Efficacy for Underserved Patients and Product differentiation on Onset and Duration of Action finds that a therapy that provides ... Seek Improvements in Efficacy for Underserved Patients and Product differentiation on Onset and Duration of Action is a DecisionBase 2009 report. ...

Biomarker associated with poor outcome in aggressive childhood cancer

... target genes to activating them. Because many targets of RA induce differentiation or cell death, RA is used as a therapeutic agent in many cancers, ... expression of ZNF423 was led to a growth advantage and resistance to RA differentiation in neuroblastoma cells while increased expression of ZNF423 led to growth ...

Frost & Sullivan Commends Nycomed for Excellence in Product Differentiation Innovation

... -- The "2008 European Tissue Sealants & Topical Hemostats Product differentiation Innovation Award" is conferred on Nycomed in recognition of its ... States, after approval. The Frost & Sullivan Award for Product differentiation Innovation is presented to the company that has best demonstrated the ...

Frost & Sullivan Lauds Pioneer Surgical Technology for Development of Tissue Scaffold E-Matrix

... rests with the fact that it provides a suitable matrix for cell growth and differentiation in addition to being tissue-specific. (Logo: ... is used with and its ability to provide a superior scaffold for growth and differentiation of cells. It has also been used in combination with nanocrystalline ...

Cell microenvironments hold key to future stem cell therapies

... rational modulation of the microenvironmental milieu can impose specific differentiation phenotypes on normal stem or progenitor cells, and perhaps even impose ... this study was the suggestion that modulation of stem and progenitor cell differentiation pathways might be used to "normalize" malignant breast cells. "Normal ...

New advancements in the use of adult, embryonic stem cells for tissue regeneration

... and muscular dystrophy. A procedure has been developed to direct the differentiation of human ESCs to pancreatic islet cells, including insulin producing ... their own biological and bioethical issues. Biological issues include the differentiation and survival time of reprogrammed somatic cells, and the need to develop ...

Trigger for Stem Cell Differentiation Detailed

... (HealthDay News) -- New details about a key trigger of embryonic stem cell differentiation have been uncovered by researchers at the Stanford University School of ... that direct their destiny may help in efforts to more accurately guide the differentiation of embryonic stem cells for use in therapy, the researchers said. ...

Protein 'switch' suppresses skin cancer development

... examined the signaling pathways involved in overproliferation and reduced differentiation in IKKα -deficient cells. In one, they found that IKKα turns ... Hu's group concluded that IKKα is a switch for proliferation and differentiation and is essential to maintaining skin homeostasis, or stability, and ...

The first autism disease genes

... with synaptic abnormalities. Neurexin induces glutamate postsynaptic differentiation in contacting dendrites, while neuroligins induce presynaptic differentiation in glutamate axons. The neurexin-neuroligin link thus appears to be ...

Novel hydrogel systems for dentin regeneration

... matrix have utilized synthetic and non-synthetic scaffolds to direct cell differentiation and matrix mineralization (in the case of bone). The most promising among ... to provide a natural 3D environment that can control and direct the differentiation and function of dental stem cells for the targeted regeneration of the ...

Penn researchers find key developmental pathway activates lung stem cells

... been shown to play important roles in embryonic stem cell replication and differentiation suggests that these two pathways are linked not only in lung stem cells ... identified through ongoing screens, could allow for forced expansion and differentiation of key stem cell populations in the lung and other tissues for adult ...

Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program

... the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. The R-spondin proteins also amplified ... program, which target a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, ...

New Mount Sinai research tracks effects of addictive drugs on brain

... marijuana activates many different transcription factors, triggering the differentiation of neurons, causing permanent changes in a persons brain. Another result ... the discovery of a new role of the breast cancer gene BRCA 1 in neuronal differentiation and the effects of addictive drugs upon them. ...

Test of maturity for stem cells

... body cells. Biologists and medical scientists plan to make use of this differentiation ability to selectively harvest cardiac, skin or nerve cells for the ... IBMT in St. Ingbert. Two prototypes of laboratory devices for stem cell differentiation enable the complex careers of stem cells to be systematically examined for ...

Scientists identify 'gatekeepers' of breast cancer transition to invasive disease

... of the myoepithelial cell layer due to defective myoepithelial cell differentiation regulated by intrinsic and microenvironment signals. Thus, myoepithelial ... carcinoma transition; understanding the pathways that regulate their differentiation may open new venues for cancer therapy and prevention, offers Dr. Polyak. ...

Readily available treatment could help prevent heart disease in kidney patients

... and excess phosphate stays in the bloodstream. There it can induce the differentiation of blood-vessel-wall cells into bone-forming cells. Scientists ... for phosphate, and in the walls of blood vessels it blocks the process of differentiation into bone-forming cells," Hruska says. "It's possible that BMP-7 also ...

A product for the detection and characterization of brucellosis launched at University of Navarra

... health and food safety. Bruce-ladder permits the identification and differentiation of the microorganism via the amplification of sequences of specific genes ... in marine mammals. A more rapid and safe analysis "Up to now, differentiation of Brucella was only performed in central laboratories, by means of ...

Function of molecular switch pinpointed in severe congenital neutropenia

... in bone marrow stem cells and known to help control the growth and differentiation of blood cells, including those that become neutrophils. When it works ... of neutrophils by blocking the development of macrophages, the default differentiation pathway. Specifically, GFI1 acts as a molecular switch to moderate the ...

JCI table of contents: Jan. 24, 2008

... Although it has been proposed that drugs targeting the in vivo differentiation of these cells might provide a new strategy for regenerative medicine, ... capable of specifically targeting MSCs and that can also regulate their differentiation has proven an enormous obstacle. In a new study, David Scadden and ...

Fungus Sheds Light on Development of Human Genders

... called a high mobility group (HMG)-domain protein that leads to sex differentiation through an unknown process. This protein is similar to the one encoded ... fungus. "Fungi are good model systems for the evolution of human sexual differentiation because the genetic sequences responsible for sex are smaller versions of ...
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