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Dendritic in Medical News

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

... BP-GMAX-CD1, a novel pharmacologically regulated dendritic cell vaccine for the treatment of prostate ... genetically modifying autologous antigen-loaded dendritic cells to express an inducible costimulatory CD40 ... administration, these genetically modified dendritic cells are activated in draining lymph nodes by ...

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

... suppressor of the immune response, straight to dendritic cells, which typically show the immune system ... are given right after a transplant, just as dendritic cells are giving the immune system a heads up to ... would be needed for just a few weeks, until the dendritic cells have learned instead to ignore it, Dr. ...

Study identifies biomarker that safely monitors tumor response to new brain cancer treatment

... a potential ally, but the brain has few dendritic cells -- key sentries of the immune system that ... immune attack. Without the surveillance of dendritic cells, brain tumors go undetected and proliferate ... (the immune stimulatory cytokine Flt3L) attracts dendritic cells from bone marrow into the tumor while ...

Computer simulation captures immune response to flu

... before or vaccinated. T cells partner with dendritic cells to make careful decisions about which key ... will trigger a full-scale immune counterattack. dendritic cells roam the body, checking each particle they ... invader "label." Upon encountering an invader, a dendritic cell will "swallow it," cut it up, and carry the ...

Study reveals current multi-component vaccines may need reworking

... T cell, a white blood cell that partners with dendritic cells to make careful decisions about which ... attention. Upon encountering an invader, a dendritic cell will "swallow it," cut it up, and carry the ... complex (MHC} class II proteins inside the dendritic cells present peptides on the cell's surface for ...

Not just a long-distance relationship: Immune cells in skin fight off infection better than the rest

... immune response to viral infection - known as dendritic cells. "Dendritic cells are like police ... for the first time that a particular type of dendritic cells was responsible for triggering the immune ... diseases of the skin such as psoriasis, where dendritic cells trigger the immune system to attack the ...

Dendritic cells ensure immune tolerance

... Vhringer has now investigated exactly what role dendritic cells play in this process. There has long been ... trigger an autoimmune response. It follows that dendritic cells play a major part in protecting against ... which can present antigens to them. It is the dendritic cells that are primarily responsible for this ....

Vitamin A signals offer clues to treating autoimmunity

... Distributed around the body, dendritic cells act as the security alarms of the immune system. After sensing the presence of intruders, dendritic cells can transmit the alarm to white blood cells ... Primate Research Center have discovered that dendritic cells can respond to the same compound, through ...

Helicobacter pylori can multiply in autophagic vesicles

... is not only found in macrophages, but also in dendritic cells and gastric epithelial cells". This new ... antibodies. In view of the critical role of dendritic cells in presenting H. pylori antigen to ... it is possible that H. pylori -infected dendritic cells induce an inadequate immune response to H. ...

Gene therapy eliminates brain tumors through selective recruitment of immune cells

... major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not ... HMGB1 released from dying tumor cells activates dendritic cells and stimulates a strong and effective ... receptor 2, or TLR2, found on the surface of dendritic cells. "Toll receptors play a major role in ...

Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies

... administer a monoclonal antibody, which targets dendritic cells, followed by a DNA plasmid that works as a ... Investigative Dermatology, to define pathogenic dendritic cell subsets and maturation states present in human atherosclerosis, to compare the function of dendritic cells from atherosclerotic plaques compared ...

Mathematical models of adaptive immunity

... in defence against disease, T cells, B cells, and dendritic cells. T cells are a type of white blood cell ... also playing a key role in adaptive memory. dendritic cells aid the other immune cells by processing ... cells and APCs (Antigen presenting cells) such as dendritic cells in the lymph node is one of the great ...

NIH scientists discover crucial control in long-lasting immunity

... B cells and another type of white blood cell, the dendritic cell, interact dynamically within mouse lymph ... was that that SAP-negative T cells can bind to dendritic cells without any problems, although dendritic cells have antigenic arms similar to those of B ...

New nano device detects immune system cell signaling

... signals the researchers detected originated in dendritic cells the sentinels of the immune system that do ... immune cells." The reason for this is that the dendritic cells, T-cells and B-cells in the immune system, ... function as individual, unattached cells. If dendritic cells detect invaders in the body, they rapidly ...

Arteries from distinct regions of the body have unique immune functions

... cells embedded in the arterial walls called dendritic cells act like smoke-sensing fire alarms for the ... body, do not. A possible explanation is that dendritic cells from iliac arteries are better able to ... Weyand says. Weyand hypothesizes that the dendritic cells in arteries are mainly performing a ...

Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes

... Researchers conducting a clinical trial of a dendritic cell vaccine designed to fight malignant brain ... a finding previously reported by the researchers: dendritic cell vaccination and chemotherapy work ... in 1997, Black led the development of the dendritic cell vaccine because gliomas and other cancer ...

Cancer drug shows promise against graft vs. host disease

... inhibitors, on key immune system cells called dendritic cells. In mice, both drugs were able to ... studied the responses of immune system dendritic cells in mice given SAHA and ITF 2357, another new HDAC inhibitor. dendritic cells are important immune system cells whose ...

Immune Design Announces $18 Million Series A Financing

... and novel technologies targeting and controlling dendritic cells, which have recently been shown to ... technologies to Immune Design. "By targeting dendritic cells, we hope to both improve the response ... at Rockefeller University and the discoverer of dendritic cells; Dr. Inder Verma, professor in the ...

Neuroscientists show insulin receptor signaling regulates structure of brain circuits

... Dr. Cline said. Time-Lapse Images of dendritic Branching The team went on to perform other ... The team also secured time-lapse images of dendritic formations, the ethereal, branch-like structures ... engaged and sending signals inside the neuron, dendritic growth is enhanced, specifically in response to ...

New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh

... were then captured by white blood cells known as dendritic cells which released the nucleic acid molecules within the dendritic cells. The released molecules reprogrammed these ... PhD found that the microspheres reprogram dendritic cells to block the signaling mechanism that sends ...

New Hope for Liver Diseases

... to treatment may be done by monitoring the dendritic cells, the cells that are the most potent ... Researchers have found that therapy affects the dendritic cells differently. Mengshol's team studied blood ... at the population of two different types of dendritic cells, among other factors. Levels of one type ...

JCI table of contents: May 22, 2008

... A new target for tumor immunotherapy on dendritic cells? Many researchers are interested in ... proteins to a subset of immune cells known as dendritic cells (DCs) that express the protein CD8-alpha. ... indicated that the molecule, which was named dendritic cell NK lectin group receptor-1 (DNGR-1), was an ...

NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO

... is an effective antigen loading platform for dendritic cell-mediated induction of anti-tumor immunity ... vaccine that employs powerful immune cells called dendritic cells. The bacterial approach to activate the dendritic cells may provide a new avenue for developing a ...

Suspected cause of type 1 diabetes caught 'red-handed' for the first time

... They caught the immune cells, known as dendritic cells, "red-handed": carrying insulin and ... this condition. "Now that we've isolated dendritic cells from the pancreas, we can look at why they ... "That may allow us to find ways to inhibit dendritic cell function in order to block the disorder." ...

Immune system pathway identified to fight allergens, asthma

... of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related ... May edition of the journal Nature Medicine. dendritic cells are vital to immune response in that they ... a pathway that allergens use to act directly on dendritic cells to propel differentiation into the T ...

Stopping a receptor called 'nogo' boosts the synapses

... molecule also affected tiny structures known as dendritic spines, crucial connections that are extensions ... lots of the nogo receptor had a different mix of dendritic spines than normal mice. In the hippocampus, the mutant mice had fewer mushroom-shaped dendritic spines and more stubby and thin spines than the ...

USC researchers discover novel way to develop tumor vaccines

... restricts inflammatory signal transduction in dendritic cells. When it is inhibited, the dendritic cells overproduce an array of cytokines and ... immune responses triggered by A20-deficient dendritic cells are capable of destroying various types of ...

Scripps research scientists devise approach that stops HIV at earliest stage of infection

... sexual contact, it hitches a ride with the dendritic cells of the immune system that stand guard for ... receptor protein, known as DC-SIGN, on the dendritic cells. By sticking to these immune system ... HIV manages to evades immune detection while the dendritic cells travel to the ultimate goal of the virus: ...

Gene therapy 'trains' immune system to destroy brain cancer cells and reverses behavioral deficits

... sustain a systemic anti-tumor immune response dendritic cells, or antigen-presenting cells do not ... FMS like tyrosine kinase 3 ligand (Flt3L), drew dendritic cells into the brain. Another protein, herpes ... gancyclovir (GCV), killed tumor cells. dendritic cells clean up debris from dying cells and in the ...

A new view of drugs used to treat rheumatoid arthritis

... and organization of cells known as follicular dendritic cells, which help form the germinal centers. Follicular dendritic cells have long tentacles that lock onto B cells ... were smaller and less organized. Follicular dendritic cells are like the fabric that keeps together the ...

Vaccines for Ovarian and Breast Cancer in Early Trials

... cells, which are then put into the patients' own dendritic cells. dendritic cells are responsible for initiating the body's ... drugs is most effective. The "re-educated" dendritic cells are then injected back into the patient at ...

UCR researcher awarded $2.1M stem cell grant to study Alzheimer's disease

... to become a certain kind of immune cell, called a dendritic cell. By engineering the stem cells to express certain proteins, his lab will attempt to coax the dendritic cells into activating Alzheimers specific immune ... kinds of stem cells from a patient to make dendritic cells that can then be given back to the same ...

Clinical trial evaluating brain cancer vaccine is underway at NYU

... component of the vaccine. Separately, patients dendritic cells, a powerful type of immune cell, will be obtained and sent to a laboratory for purification. dendritic cells may be able to teach the immune system to ... patients tumor cell material is combined with the dendritic cells to form the vaccine. ...

New understanding of basic units of memory

... nubs, or protrusions in the synapses known as dendritic spines. The recycling plants are located within the body of these dendritic spines. We believe that the existence of this recycling ability explains in part how individual dendritic spines retain their unique identity amidst this ...

M.D. Anderson-led team reports possible key to autoimmune disease

... immune defense cells in psoriasis. Plasmacytoid dendritic cells (pDCs) are highly specialized to recognize ... drives the development of human psoriasis These dendritic cells normally do not respond to self-DNA, ... ingredient in psoriatic tissue that activates the dendritic cells. The peptide is a member of a family of ...

Scientists learn why even treated genital herpes sores boost the risk of HIV infection

... found a significantly higher concentration of immune cells called dendritic cells with the surface protein called DC-SIGN at the sites of healed ... in control tissue, whether or not the patient was treated with acyclovir. dendritic cells with DC-SIGN ferry HIV particles to CD4+ T cells, which the virus ...

Scientists show how a neuron gets its shape

... They specifically looked at a group of 12 sensory neurons whose dendritic tips converge at the worm's nose in a sensory organ called the amphid. These dendritic tips collect information from the outside environment and give the worm ...

New discovery gives tuberculosis vaccine a shot in the arm

... a new role for type I interferon, in which it improves the ability of dendritic cells to stimulate an immune response against the bacterium known to cause ... work. Coccia and her colleagues made this discovery by obtaining human dendritic cells from the blood of healthy volunteers. The cells were divided in two ...

Brain Cancer Vaccine's Immune Response Key to Outcomes

... study finds TUESDAY, July 15 (HealthDay News) -- An in-trial dendritic cell vaccine that fights malignant brain tumors called glioblastoma ... medical center. The study also supports past findings that the dendritic cell vaccination can work well with chemotherapy to improve treatment. The ...

OHSU Cancer Institute finds that drug stimulated immune system in prostate cancer

... CTLA-4. The T cells are initially activated by other immune cells, called dendritic cells, that display the foreign, or cancerous, antigens to the T cells and ... appears on the surface of the T cells, and when CTLA-4 interacts with the dendritic cells, the next set of signals are to turn the response down, or even off. ...
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(Date:10/29/2014)... City on September 19, 2014, leading geneticist and humanitarian ... Genome Sciences and Medicine at the University of Washington ... Tel Aviv University, was awarded the 2014 Lasker-Koshland Special ... her honorary degree from TAU, Prof. King was the ... and for the past 18 years she has been ...
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