Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer
... BP-GMAX-CD1, a novel pharmacologically regulated dendritic
cell vaccine for the treatment of prostate ... genetically modifying autologous antigen-loaded dendritic
cells to express an inducible costimulatory CD40 ... administration, these genetically modified dendritic
cells are activated in draining lymph nodes by ...
Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs
... suppressor of the immune response, straight to dendritic
cells, which typically show the immune system ... are given right after a transplant, just as dendritic
cells are giving the immune system a heads up to ... would be needed for just a few weeks, until the dendritic
cells have learned instead to ignore it, Dr. ...
Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
... a potential ally, but the brain has few dendritic
cells -- key sentries of the immune system that ... immune attack. Without the surveillance of dendritic
cells, brain tumors go undetected and proliferate ... (the immune stimulatory cytokine Flt3L) attracts dendritic
cells from bone marrow into the tumor while ...
Computer simulation captures immune response to flu
... before or vaccinated.
T cells partner with dendritic
cells to make careful decisions about which key ... will trigger a full-scale immune counterattack. dendritic
cells roam the body, checking each particle they ... invader "label." Upon encountering an invader, a dendritic
cell will "swallow it," cut it up, and carry the ...
Study reveals current multi-component vaccines may need reworking
... T cell, a white blood cell that partners with dendritic
cells to make careful decisions about which ... attention. Upon encountering an invader, a dendritic
cell will "swallow it," cut it up, and carry the ... complex (MHC} class II proteins inside the dendritic
cells present peptides on the cell's surface for ...
Not just a long-distance relationship: Immune cells in skin fight off infection better than the rest
... immune response to viral infection - known as dendritic
"Dendritic cells are like police ... for the first time that a particular type of dendritic
cells was responsible for triggering the immune ... diseases of the skin such as psoriasis, where dendritic
cells trigger the immune system to attack the ...
Dendritic cells ensure immune tolerance
... Vhringer has now investigated exactly what role dendritic
cells play in this process. There has long been ... trigger an autoimmune response. It follows that dendritic
cells play a major part in protecting against ... which can present antigens to them. It is the dendritic
cells that are primarily responsible for this ....
Vitamin A signals offer clues to treating autoimmunity
... Distributed around the body, dendritic
cells act as the security alarms of the immune system. After sensing the presence of intruders, dendritic
cells can transmit the alarm to white blood cells ... Primate Research Center have discovered that dendritic
cells can respond to the same compound, through ...
Helicobacter pylori can multiply in autophagic vesicles
... is not only found in macrophages, but also in dendritic
cells and gastric epithelial cells". This new ... antibodies. In view of the critical role of dendritic
cells in presenting H. pylori antigen to ... it is possible that H. pylori -infected dendritic
cells induce an inadequate immune response to H. ...
Gene therapy eliminates brain tumors through selective recruitment of immune cells
... major hurdles: recruiting key immune cells called dendritic
cells into areas of the brain where they are not ... HMGB1 released from dying tumor cells activates dendritic
cells and stimulates a strong and effective ... receptor 2, or TLR2, found on the surface of dendritic
"Toll receptors play a major role in ...
Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies
... administer a monoclonal antibody, which targets dendritic
cells, followed by a DNA plasmid that works as a ... Investigative Dermatology, to define pathogenic dendritic
cell subsets and maturation states present in human atherosclerosis, to compare the function of dendritic
cells from atherosclerotic plaques compared ...
Mathematical models of adaptive immunity
... in defence against disease, T cells, B cells, and dendritic
cells. T cells are a type of white blood cell ... also playing a key role in adaptive memory. dendritic
cells aid the other immune cells by processing ... cells and APCs (Antigen presenting cells) such as dendritic
cells in the lymph node is one of the great ...
NIH scientists discover crucial control in long-lasting immunity
... B cells and another type of white blood cell, the dendritic
cell, interact dynamically within mouse lymph ... was that that SAP-negative T cells can bind to dendritic
cells without any problems, although dendritic
cells have antigenic arms similar to those of B ...
New nano device detects immune system cell signaling
... signals the researchers detected originated in dendritic
cells the sentinels of the immune system that do ... immune cells."
The reason for this is that the dendritic
cells, T-cells and B-cells in the immune system, ... function as individual, unattached cells. If dendritic
cells detect invaders in the body, they rapidly ...
Arteries from distinct regions of the body have unique immune functions
... cells embedded in the arterial walls called dendritic
cells act like smoke-sensing fire alarms for the ... body, do not.
A possible explanation is that dendritic
cells from iliac arteries are better able to ... Weyand says.
Weyand hypothesizes that the dendritic
cells in arteries are mainly performing a ...
Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes
... Researchers conducting a clinical trial of a dendritic
cell vaccine designed to fight malignant brain ... a finding previously reported by the researchers: dendritic
cell vaccination and chemotherapy work ... in 1997, Black led the development of the dendritic
cell vaccine because gliomas and other cancer ...
Cancer drug shows promise against graft vs. host disease
... inhibitors, on key immune system cells called dendritic
cells. In mice, both drugs were able to ... studied the responses of immune system dendritic
cells in mice given SAHA and ITF 2357, another new HDAC inhibitor. dendritic
cells are important immune system cells whose ...
Immune Design Announces $18 Million Series A Financing
novel technologies targeting and controlling dendritic
cells, which have
recently been shown to ... technologies to Immune Design.
"By targeting dendritic
cells, we hope to both improve the response ... at Rockefeller University and the discoverer of dendritic
Dr. Inder Verma, professor in the ...
Neuroscientists show insulin receptor signaling regulates structure of brain circuits
... Dr. Cline said.
Time-Lapse Images of dendritic
The team went on to perform other ...
The team also secured time-lapse images of dendritic
formations, the ethereal, branch-like structures ... engaged and sending signals inside the neuron, dendritic
growth is enhanced, specifically in response to ...
New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh
... were then captured by white blood cells known as dendritic
cells which released the nucleic acid molecules within the dendritic
cells. The released molecules reprogrammed these ... PhD found that the microspheres reprogram dendritic
cells to block the signaling mechanism that sends ...
New Hope for Liver Diseases
... to treatment may be done by monitoring the dendritic
cells, the cells that are the most potent ... Researchers have found that therapy affects the dendritic
cells differently. Mengshol's team studied blood ... at the population of two different types of dendritic
cells, among other factors.
Levels of one type ...
JCI table of contents: May 22, 2008
... A new target for tumor immunotherapy on dendritic
Many researchers are interested in ... proteins to a subset of immune cells known as dendritic
cells (DCs) that express the protein CD8-alpha. ... indicated that the molecule, which was named dendritic
cell NK lectin group receptor-1 (DNGR-1), was an ...
NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO
... is an effective antigen loading platform for dendritic
cell-mediated induction of anti-tumor immunity
... vaccine that employs powerful immune cells called dendritic
cells. The bacterial approach to activate the dendritic
cells may provide a new avenue for developing a ...
Suspected cause of type 1 diabetes caught 'red-handed' for the first time
... They caught the immune cells, known as dendritic
cells, "red-handed": carrying insulin and ... this condition.
"Now that we've isolated dendritic
cells from the pancreas, we can look at why they ... "That may allow us to find ways to inhibit dendritic
cell function in order to block the disorder." ...
Immune system pathway identified to fight allergens, asthma
... of Medicine have identified genetic components of dendritic
cells that are key to asthma and allergy-related ... May edition of the journal Nature Medicine.
cells are vital to immune response in that they ... a pathway that allergens use to act directly on dendritic
cells to propel differentiation into the T ...
Stopping a receptor called 'nogo' boosts the synapses
... molecule also affected tiny structures known as dendritic
spines, crucial connections that are extensions ... lots of the nogo receptor had a different mix of dendritic
spines than normal mice. In the hippocampus, the mutant mice had fewer mushroom-shaped dendritic
spines and more stubby and thin spines than the ...
USC researchers discover novel way to develop tumor vaccines
... restricts inflammatory signal transduction in dendritic
cells. When it is inhibited, the dendritic
cells overproduce an array of cytokines and ... immune responses triggered by A20-deficient dendritic
cells are capable of destroying various types of ...
Scripps research scientists devise approach that stops HIV at earliest stage of infection
... sexual contact, it hitches a ride with the dendritic
cells of the immune system that stand guard for ... receptor protein, known as DC-SIGN, on the dendritic
cells. By sticking to these immune system ... HIV manages to evades immune detection while the dendritic
cells travel to the ultimate goal of the virus: ...
Gene therapy 'trains' immune system to destroy brain cancer cells and reverses behavioral deficits
... sustain a systemic anti-tumor immune response dendritic
cells, or antigen-presenting cells do not ... FMS like tyrosine kinase 3 ligand (Flt3L), drew dendritic
cells into the brain. Another protein, herpes ... gancyclovir (GCV), killed tumor cells.
cells clean up debris from dying cells and in the ...
A new view of drugs used to treat rheumatoid arthritis
... and organization of cells known as follicular dendritic
cells, which help form the germinal centers. Follicular dendritic
cells have long tentacles that lock onto B cells ... were smaller and less organized.
cells are like the fabric that keeps together the ...
Vaccines for Ovarian and Breast Cancer in Early Trials
... cells, which are then put into the patients' own dendritic
cells are responsible for initiating the body's ... drugs is most effective.
The "re-educated" dendritic
cells are then injected back into the patient at ...
UCR researcher awarded $2.1M stem cell grant to study Alzheimer's disease
... to become a certain kind of immune cell, called a dendritic
cell. By engineering the stem cells to express certain proteins, his lab will attempt to coax the dendritic
cells into activating Alzheimers specific immune ... kinds of stem cells from a patient to make dendritic
cells that can then be given back to the same ...
Clinical trial evaluating brain cancer vaccine is underway at NYU
... component of the vaccine. Separately, patients dendritic
cells, a powerful type of immune cell, will be obtained and sent to a laboratory for purification. dendritic
cells may be able to teach the immune system to ... patients tumor cell material is combined with the dendritic
cells to form the vaccine.
New understanding of basic units of memory
... nubs, or protrusions in the synapses known as dendritic
spines. The recycling plants are located within the body of these dendritic
We believe that the existence of this recycling ability explains in part how individual dendritic
spines retain their unique identity amidst this ...
M.D. Anderson-led team reports possible key to autoimmune disease
... immune defense cells in psoriasis. Plasmacytoid dendritic
cells (pDCs) are highly specialized to recognize ... drives the development of human psoriasis
cells normally do not respond to self-DNA, ... ingredient in psoriatic tissue that activates the dendritic
cells. The peptide is a member of a family of ...
Scientists learn why even treated genital herpes sores boost the risk of HIV infection
... found a significantly higher concentration of immune cells called dendritic
cells with the surface protein called DC-SIGN at the sites of healed ... in control tissue, whether or not the patient was treated with acyclovir. dendritic
cells with DC-SIGN ferry HIV particles to CD4+ T cells, which the virus ...
Scientists show how a neuron gets its shape
... They specifically looked at a group of 12 sensory neurons whose dendritic
tips converge at the worm's nose in a sensory organ called the amphid. These dendritic
tips collect information from the outside environment and give the worm ...
New discovery gives tuberculosis vaccine a shot in the arm
... a new role for type I interferon, in which it improves the ability of dendritic
cells to stimulate an immune response against the bacterium known to cause ... work.
Coccia and her colleagues made this discovery by obtaining human dendritic
cells from the blood of healthy volunteers. The cells were divided in two ...
Brain Cancer Vaccine's Immune Response Key to Outcomes
... study finds
TUESDAY, July 15 (HealthDay News) -- An in-trial dendritic
cell vaccine that fights malignant brain tumors called glioblastoma ... medical center.
The study also supports past findings that the dendritic
cell vaccination can work well with chemotherapy to improve treatment. The ...
OHSU Cancer Institute finds that drug stimulated immune system in prostate cancer
... CTLA-4. The T cells are initially activated by other immune cells, called dendritic
cells, that display the foreign, or cancerous, antigens to the T cells and ... appears on the surface of the T cells, and when CTLA-4 interacts with the dendritic
cells, the next set of signals are to turn the response down, or even off. ...