JCI online early table of contents: Jan. 10 2008
HEMATOLOGY: PIP5KI-gamma ensures the cytoskeleton
makes a firm attachment to the cell membrane
... to move, rely on the normal functioning of the cytoskeleton
that is attached to the membrane of the cell. The ... unique role in anchoring the cell membrane to the cytoskeleton
of mouse megakaryocytes. Indeed, in the study, ...
Scripps research scientists find new genetic mutation that halts the development of lupus
... show that blocking CoroLmb3 has specific effects, this work suggests other cytoskeleton
proteins might prove to be good targets. This opens up an area that hasnt ... more impetus to study these genes for autoimmunity.
Because the actin cytoskeleton
is essential for many crucial cellular functions and involves complex ...
New technique boosts protein NMR imaging speeds
... types of molecules using this new approach, including the amyloid fibrils often associated with Alzheimer's disease, larger globular proteins and cytoskeleton
proteins. The new approach worked well with each type.
The doping solution they added to enhance the sensitivity of samples did not change the ...
Study helps clarify role of vitamin D in cancer therapy
... one that encodes E-cadherin, a component of the adherens junctions that anchor cells in epithelial layers. The vitamin also induces effects on the cytoskeleton
that are required for gene regulation and short-circuiting the Wnt/b-catenin pathway, which is overactive in most colon tumors. The net result is to ...
Cell skeleton may hold key to overcoming drug resistance in cancer
... Institute Australia for Medical Research (CCIA), led
by Associate Professor Maria Kavallaris, discovered that the bIII-tubulin component of the
could play an important role in resistance to a wide range of drugs used to
treat lung, ovarian and breast cancers.
Advanced non-small cell lung ...
Team Discovers a Gene That Causes Familial Pancreatic Cancer
... the mutated Palladin causes cancer by causing the cytoskeleton
to malfunction, which allowed the cells to move ... more quickly than normal cells.
“A normal cytoskeleton
holds up the cell wall, and gives it direction to ... behave,” said Brentnall. “In cancerous cells, the cytoskeleton
doesn't work correctly, and instead of sitting, ...
Research in the Origin of Microtubules
... are the largest of the three main types of filaments that make up the cytoskeleton
-- a web of microscopic fibers inside the cell.
Microtubules are the largest of the three main types of filaments that make up the cytoskeleton
-- a web of microscopic fibers inside the cell.
They form when two ...
Study of Bacterial Pathogen may Give Insight to Cancer Development
... on Listeria monocytogenes, a cause of food poisoning.
'When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton
that allow the cell to swallow up the bacterium. We discovered that a human protein called CrkII plays a critical role in stimulating internalisation ...
Emotional Stress Could Be a Factor in Causing Alzheimers: Study
... simulated chronic stress by repeating the procedure every day for two weeks, the modification lasted long enough to let tau molecules tumble off the cytoskeleton
and pile up in insoluble heaps of protein.
During the study, the researchers genetically engineered mice to lack either CRFR1 or CRFR2. ...
Erroneous Laboratory Operation May Lead To a Cancer Drug
... with no side effects.
According to Schaefer, mode of action of PPAR-gamma is different from the current drugs. It attacks a section of cell cytoskeleton
called tubulin. While tubulin is involved in building the cell arrangement, PPAR-gamma breaks it down. This indirectly indicates that the gamma ...
Adult stem cells are sensitive to responses from the environment
... the stem cell needs to move its cellular muscles triggers an internal chemical signal that, in turn, directs the cell to differentiate.
uses motors that, like our muscles, are based on the mechanical tension created by molecules of actin and myosin," Engler said. "When we deprive ...
Atherosclerosis and its Mechanics
... amazed at how quickly these cells can reorient these stress fibers when we change the direction of stretch," said Chien. "At the same time, the actin cytoskeleton
of endothelial cells is somehow playing a key role in activating and deactivating JNK."
The tubular geometry of the straight part of arteries ...
A Detail Analysis of Head and Neck Cancer
... found that HA mediates the interaction between CD44 and LARG in a way that stimulates a molecular pathway called RhoA. It causes the tumor cell's cytoskeleton
to reorganize such that the tumor cells migrate to other sites in the body, resulting in cancer metastasis. Then the HA-mediated CD44/LARG complex ...
Prestigious Gairdner Awards for medical research in 2006 Goes To Two Yale biologists
... FRS, chair of the Cell Biology Program at Memorial Sloan-Kettering Cancer Center in New York for their 'discoveries related to understanding the cytoskeleton
of the cell and the basis of cell motility and its relevance to human disease.'