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Cyclic in Medical News

Second gene linked to familial testicular cancer

... The key pathway in this disease is the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the cyclic AMP pathway are widely available, and, in theory, ... that slowed down the enzyme's destruction of cyclic AMP. "The mutations don't cause cancer ...

BioFit Intensive Plus™ Chairs Meet Federal Standard for Continuous Intensive Use

... Chairs. The protocol included a series of four cyclic durability and load tests of the backrest, seat ... in two back durability and tilt mechanism cyclic tests was granted only if the chair and all ... case of the fourth portion of the protocol, the cyclic Increasing Back Load Test, the acceptance level ...

Drug Might Restore Sense of Smell

... had previously discovered that people with hyposmia had reduced levels of cyclic nucleotides in their saliva and nasal mucous, and that treatment with ... of this growth factor and restored some of the sense of smell. These cyclic nucleotides are growth factors for olfactory (related to smell) and other ...

New biomarker may predict leukemia aggressiveness

... previous work, Insel's group had discovered that among a group of enzymes, cyclic nucleotide phosphodiesterases, one of the phosphodiesterases, PDE7B, was ... in CLL patients than in healthy individuals. PDE7B controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process ...

Force Tester Shoulders The Burden

... tension, in the line of pull of normal muscles. The MultiTest 10-x cyclic testing feature is particularly useful for this application, with a range ... cycling between different loads for 999 times. The results from these cyclic tests show which shoulder replacement prosthesis is the strongest. ...

Rice U. conference to explore music's role in human cognition and behavior

... connections between thought and feeling. He has studied how music with cyclic structure -- a main idea repeating in its entirety either identically or ... has to be active and diligent, according to Brandt. "Because of the cyclic nature of pop music, you are constantly at risk of tuning it out," Brandt ...

UCSD researchers identify potential new drug target for chronic leukemia

... They found that one form of the group of enzymes, collectively known as cyclic nucleotide phosphodiesterases, was 10 times higher in CLL patients than in ... type of enzyme, phosphodiesterase 7B (PDE7B), controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process ...

Another Genetic Link to Testicular Cancer Is Found

... and Human Development, said in the news release. The PDE11A gene is located in a key biochemical pathway in testicular germ-cell cancer, the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the AMP pathway are widely available and, in theory, ...

Materials and Processes for Medical Devices Event Brings Clinicians, Engineers, Designers Together

... regulators of both vascular and orthopedic implants. The effects of various manufacturing procedures, surface conditions and surface damage on the cyclic polarization, ion-leaching, and fatigue performance of implant materials will be examined. Effect of Materials on Surgical Techniques will ...

Meckel's diverticulum masked by intermittent recurrent subocclusive episodes

... but painless hemorrhage, the classical presenting symptom of Meckel's diverticulum, was never experienced. These symptoms were firstly interpreted as cyclic vomiting of childhood. Only the persistence of the condition accompanied by weight loss prompted physicians to investigate further. A supravesical ...

For Patients With Irritable Bowel Syndrome (IBS), iPhone to the Rescue

... of North Carolina at Chapel Hill . Dr. Weinland focuses on working with patients who have medical concerns such as Irritable Bowel Syndrome, cyclic Vomiting Syndrome and other GI conditions. For more information, please visit the BHANC, Inc. website at http://www.everydaypsychologist.com . ...

Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligonucleotide Synthesis

... Inc. ABOUT SOLID SUPPORT Manufacture of oligonucleotide drugs involves use of solid support matrix upon which chemical reactions occur in a cyclic manner. These reactions are performed on a fully automated synthesizer. At the end of synthesis, drugs are purified by various chromatographic ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging ...

Cancer treatment may result in bone loss

... University, the Universit Laval, the University of Toronto and the University of British Columbia. "Bone is a dynamic tissue which undergoes a cyclic process of breaking down and rebuilding," adds Dr. Saad. "Medications called bisphosphonates help with the rebuilding process and have been ...

CCNY researchers demonstrate effectiveness of contrast agent Cytate in detectcing prostate cancer

... conjugate consisting of Indocyanine Green (ICG), an FDA-approved near-infrared dye, and a somatostatin receptor ligand. Somatostatin is a small cyclic neuropeptide that is believed to regulate the production of other hormones and perform an important role in the cancer development. Previous studies ...

UCR chemists use 'green chemistry' to produce amines, chemical compounds used widely in industry

... Chemie . A print version of the research paper will appear soon in the journal as well. The catalyst in question a gold atom linked to a cyclic alkyl amino carbene or CAAC is a ligand (a special molecule that binds to metals) that Bertrand's lab discovered in 2005. The gold compound ...

Type of anesthetic will improve sleeping medication, probe mysteries of the snooze

... benefiting patients. By comparing the brainwaves of rats under the anesthetic to those occurring with natural sleep, researchers discovered cyclic changes of brain states that were almost identical to those seen during the natural sleep cycle. Changes in muscle tone, respiration rates and ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

... crystals in order to collect the diffraction data necessary to determine the proteins atomic configuration. These experiments were performed using cyclic particle accelerators at the Argonne National Laboratory in Illinois and the Paul Scherrer Institute in Switzerland. Called synchrotrons, these ...

Blind humans lacking rods and cones retain normal responses to non-visual effects of light

... the effect of light on melatonin secretion was examined. Melatonin is a hormone produced at night that influences arousal and is secreted in a cyclic fashion. Just like sighted individuals, the blind patient exhibited acute suppression of melatonin in response to light and was most sensitive to ...

Penn's Abramson Cancer Center part of major phase III study for myeloma

... dexamethasone a potent synthetic steroid or dexamethasone with placebo. These trials were designed to investigate the effectiveness and safety of cyclic dosing of REVLIMID at 25mg combined with high-does dexamethasone (HDD) compared with placebo and HDD in previously treated patients with multiple ...

Cancer gene drives pivotal decision in early brain development

... Nf1, in neural stem cells. Studies of these mice revealed that the Nf1 protein, neurofibromin, controls the activity of two signaling pathways, the cyclic adenosine monophosphate (cAMP) pathway and the Ras pathway. This allows neurofibromin to regulate the development of both neurons and astrocytes. ...

International Isotopes Inc. Announces Third Quarter and Nine Months 2007 Financial Results

... Cobalt Products segment declined by about 8% and 28% respectively for the three and nine-month periods of 2007 compared to 2006 primarily due to the cyclic nature of bulk cobalt sales. The Radiochemical Products segment revenue increased by about 16% and 23% respectively for the three and nine-month ...

Study suggests existing drugs may be useful in treating brain tumors

... In contrast, glia from the mouse model divided and grew in response to CXCL12. Rubin then linked that effect to levels of a compound known as cyclic adenosine monophosphate (cAMP). Lower cAMP levels meant cells thrived after exposure to CXCL12. Higher levels meant they died in response to it. He ...

Mathematics might save you a trip to the ER

... the days of Hippocrates, people have known that certain illnesses come and go with the seasons. More recently, researchers have learned that these cyclic recurrences of disease, known as seasonality, are often related to the weather. In order to accurately predict when outbreaks of disease will occur, ...

UCSD study reveals the regulatory mechanism of key enzyme

... the dynamic regulatory subunit of PKA. PKA belongs to a large superfamily of proteins whose activity is regulated by an important small molecule, cyclic AMP (cAMP), in the cell. Protein kinases transmit chemical signals within the cell to regulate a host of functions, such as cell growth or ....

UCSD study reveals the regulatory mechanism of key enzyme

... the dynamic regulatory subunit of PKA. PKA belongs to a large superfamily of proteins whose activity is regulated by an important small molecule, cyclic AMP (cAMP), in the cell. Protein kinases transmit chemical signals within the cell to regulate a host of functions, such as cell growth or ....

Mathematics might save you a trip to the ER

... the days of Hippocrates, people have known that certain illnesses come and go with the seasons. More recently, researchers have learned that these cyclic recurrences of disease, known as seasonality, are often related to the weather. In order to accurately predict when outbreaks of disease will occur, ...

Common misdiagnosis: most women believe they have a yeast infection when they don't

... treat yourself and it never goes away, you shouldnt continue to treat yourself, Hoffstetter said. Youre making a situation worse and you can get into cyclic episodes where you think you have a yeast infection all of the time. Vaginal yeast infections are common; three out of four women have had one at ...

Genetic Link to Adrenal Tumor Revealed

... triggers the cell to produce substances known as cyclic nucleotides. These function as 'second ... begin an activity. In the case of adrenal cells, cyclic nucleotides, such as cyclic AMP ...

New Treatment For Patients With Paralysis

... nerve cells, a cell messenger molecule called cyclic AMP, and the antidepressant Rolipram. ... prior to transplanting Schwann cells to preserve cyclic AMP. cyclic AMP helps enable the growth of nerve fibers that ...

Sticky Proteins Provide New Insight Into Drug Action

... epinephrine, that should mean the alpha subunit enables production of cyclic AMP, which increases the heart rate, while the beta-gamma pair should ... it has been known for some time that while epinephrine does increase cyclic AMP in heart cells, it does not activate ion channels. While this ...

Nitric Oxide Levels In Brain Indicate Sleep

... promotes sleep is by stimulating production of a signaling molecule called cyclic GMP, and it may be possible to achieve the same effect by using drugs that block cyclic GMP's breakdown, Rosenberg says. One surprise in the research was ...

Novel Technique For Targeting Small-Cell Lung Cancer

... In a recent work, researchers from Israel used novel backbone cyclic peptides, which function as Somatostatin receptor (SSTR) binding, ... vectors. They synthesized novel somatostatin analogs, based on backbone cyclic peptides, and conjugated them with fluorescent agents. Nineteen conjugates ...

New Diagnostic Test for Mad Cow Disease Developed

... levels of abnormal proteins called prions, which kill off brain cells and are thought to cause the disease. Dubbed as 'Protein Misfolding cyclic Amplification', the new technique works by boosting the replication of prions, so that they can be easily detected in test samples of the brain ...

Significant Advances in VCJD Prion Detection

... proteins that progressively kill off brain tissue and are thought to cause the disease. The method, known as known as Protein Misfolding cyclic Amplification (PMCA), enables the level of prions to be increased so that they can be recognised by existing detection methods. Researchers ...

Researchers Identifies Molecules That is Effective in Fighting Against Breast Cancer

... breast cancer drugs that have different molecular targets. Previous work by the Albany Medical College researchers had shown that 8-mer and cyclic 9-mer peptides inhibit breast cancer in mouse and rat models, interacting with an unsolved receptor, while peptides smaller than eight amino acids ...

Viagra may Be Useful for Treating Jet Lag

... for the treatment of high blood pressure and angina, works by interfering with an enzyme that reduces levels of a naturally-occurring compound, cyclic guanine monophosphate (cGMP). In the brain, cGMP has a vital function in a signalling pathway that regulates the circadian cycle, the body's ...

New Light on Working of Brain Networks

... as schizophrenia and bipolar disorder. The current study found that brain cells in PFC contain ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN) that reside on dendritic spines, the tiny protrusions on neurons that are specialized for receiving information. ...

Brain Networks Strengthened by Closing Ion Channels

... as schizophrenia and bipolar disorder. The current study found that brain cells in PFC contain ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN) that reside on dendritic spines, the tiny protrusions on neurons that are specialized for receiving information. ...
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