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CSHL scientists are part of consortium that sequences platypus genome

... noted. CSHL study shows small-RNA roles are conserved in platypus In a related paper, published ... interference (RNAi). That the RNAi mechanism is conserved by evolution in the monotremes is hardly ... of the platypus has highlighted both unique and conserved roles for miRNAs and piRNAs in monotremes; at the ...

Insmed Provides Update on Supply of IPLEX(TM)

... The Company has determined that its limited inventory on hand must be conserved for the treatment of existing patients. Following the previously ... receiving IPLEX(TM) to ensure that our current limited inventory is conserved in order to maintain their drug supply as long as possible, while allowing ...

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

... of the most remarkable findings of our work is that we identified a highly conserved region in the neck of the influenza hemagglutinin protein to which humans ... head of the HA protein and do not readily generate antibodies against the conserved region in the neck. "An important goal is to redirect the immune ...

Evolution and epilepsy

... along the axon. They also found that these anchoring sequences were conserved in the potassium and sodium channels of vertebrates over 350 million years ... combination of channels clustered together on nerves has been completely conserved for about 400 million years in all types of vertebrates underlines its ...

Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage

... issue: “Chronic Lymphocytic Leukemia Cells Recognize conserved Epitopes Associated with Apoptosis and Oxidation”, ... type of normal B lymphocyte. Chronic Lymphocytic Leukemia Cells Recognize conserved Epitopes Associated with Apoptosis and Oxidation. Rosa Catera and ...

Penn researchers discover new target for preventing and treating flu

... a pocket in the channel next to the location where amantadine fits that is conserved in all influenza A viruses. This newly discovered space could be the target for new drugs. "Inhibitors that target this cavity adjacent to two highly conserved amino acids in M2 might reclaim the M2-blocking class of drugs so that ...

Evolution of human genome's 'guardian' gives people unique protections from DNA damage

... investigators determine how the function of p53 response elements was conserved or changed as different species developed. Dr. Jegga said researchers ... cell death capability in the p53 network, is thought to be evolutionarily conserved throughout the development of vertebrate species and was probably ...

FOXO factor promotes survival of oxygen-deprived cancer cells

... Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the ... in a protein called FOXO3a. FOXO transcription factors are evolutionarily conserved proteins that are critical regulators of cell survival under stressful ...

Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas

... and colleagues investigated the role of additional classes of highly conserved noncoding RNAs in human cancer that have not been studied to the extent of ... is altered in human leukemias and carcinomas. These UCRs are highly conserved among different species, and although they do not encode proteins, they ...

Researchers Discover the Tale Behind Short Dogs

... to find that just one retrogene inserted at one point during the evolution of a species could yield such a dramatic physical trait that has been conserved over time." Retrogenes occur when a transcription error in the creation of DNA code causes a functional, but imperfect duplicate of a gene to be ...

Premiere Fibers Unveils New Logo, Names for Innovative Brands

... Earth-Color(TM) Fiber is also Earth-friendly. Since there is no separate dyeing process, thousands of gallons of water, resources and chemicals are conserved each year. Earth-Color(TM) Fiber has numerous potential applications including hosiery, apparel, military, upholstery and industrial market ....

Wistar Institute team finds key target of aging regulator

... Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature , provides fundamental knowledge about key mechanisms of aging ...

Fate Therapeutics Adds Pratik Multani, M.D., M.S., as Vice President Clinical Development to Advance Upcoming Clinical Programs of Stem Cell Modulators

... to become some or all of the major specialized cell types of the particular tissue or organ in which it is found. The discovery of a number of conserved mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell ...

Study Links Sugar Production in Yeast Cells to Longevity

... group and which other studies have strongly link to the aging process and several diseases in mammals. "Because the NuA4 complex is highly conserved among species, what we've found in yeast translates to humans as well," researcher Heng Zhu, a Johns Hopkins assistant professor of pharmacology and ...

MicroRNA undermines tumor suppression

... has p53 target sites in humans, in zebrafish, and in many other vertebrates, indicating that it was important enough in cellular processes to be conserved through evolution. Le tested miRNA125b's effects on several types of cells known to express p53, including human neural and lung cells. When Le ...

Molecule tracking reveals mechanism of chromosome separation in dividing cells

... to drive the movement of chromosomes." The same coupling behavior is found in living things from yeast cells to humans, indicating that it was conserved during evolution as a good way of getting the job done. The question is how this mechanism works. Previous studies implicated a large, ...

Delcath Systems to Host Quarterly Update Conference Call

... Cancer Institute to 10 regionally diversified leading cancer hospitals and passed the important milestone of 50% of patient enrollment. We have also conserved cash resources and assembled a first class executive team and Board of Directors to execute on our clinical and financial milestones as we prepare ...

Molecular events involved in liver regeneration

... an impaired ability of the liver to regenerate on a molecular and cellular level. This seems to involve signalling of NF-kappa B and maybe highly conserved TLR systems. Upcoming projects of the research group already adress this possibility. Further knowledge about the interrelation of liver ...

Study first to show that RNA interference can facilitate vaccine development

... diseases. "Making siRNAs today is relatively simple because most disease-causing viruses have been sequenced or have closely-related cousins with conserved regions in their genes that can be targeted," Tripp said. "So you could prophylactically treat an animal, challenge it with the virus and see if you ...

Researchers gain new insight on wonder of cell division

... is used in many genetics research laboratories to discover basic requirements for the 20,000 genes that compose its genome; most of the genes are conserved in humans and carry out similar processes. Using these nematodes, Bowerman said, is allowing researchers to "find players inside that previously ...

Crystallography reveals the 3-D structure of mammalian sperm receptor

... surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain. "ZP3 was identified almost 30 years ago, but obtaining structural information on this key ...

MCG receives $100,000 Grand Challenges Explorations grant for innovative global health research

... of the sugar coating with the idea that they are sites of potential vulnerability for the durable virus. "My idea is that these areas are always conserved and are consistent for a reason," said Dr. Koni. While his goal is to develop a protective vaccine, Dr. Koni said if he's successful in his pursuit, ...

Elaborate Network Drives When and Where Proteins Are Made

... all of an organism's cells contain the same genes? "If you gaze into the genome, you see lots of regions that don't code for proteins but are conserved in nature -- they remain unchanged from organism to organism over eons of evolutionary time," investigator Dan Hogan, a graduate student at the ...

Penn researchers find key to Sonic hedgehog control of brain development

... for mutations in the enhancer sequence in holoprosencephalic patients. They identified one mutation in a region of the enhancer that has been conserved for over 300 million years of evolution, attesting to the importance of these sequences. The mutation caused a significant reduction in Shh enhancer ...

Penn researchers identify natural tumor suppressor

... mutations. Their findings were published in a recent issue of Cancer Cell . The actual mutations researchers found are located within a highly conserved region of Fbx4 that functions like an on switch. Mutations within that switch region inhibit activation of Fbx4, which means it can't trigger ...

The first autism disease genes

... in the process of synapse formation (synaptogenesis) have been described. Autism and synapse formation (synaptogenesis) In 2003 two new highly conserved members of the human neuroligin family HNL4, located at Xp22.3 were characterized (Jamain et al, 2003). A crucial factor in synapse formation, ...

Therapeutic DNA Vaccine Company Inovio Biomedical Reports Second Quarter 2008 Financial Results

... pathogenic H5N1 influenza virus (A/Vietnam/1203/04) survived and showed only minor weight loss. These experimental universal vaccines are based on conserved genes common to multiple strains of seasonal influenza and even potential pandemic influenza, suggesting they may have the possibility to provide ...

LabBits: A media tip sheet from the MBL in Woods Hole

... photoreceptors that regenerate by manipulating the siphon's diameter, this summer Jeffery will test the role of the Notch signaling pathway, a highly conserved molecular cascade that determines how an embryo forms. If Jeffery is on the right track, not only will he develop a model of regeneration in sea ...

Next generation data analysis for next generation sequencing data

... state, expression levels or any data derived by other NGS experiments can be added with a few mouse clicks. Identification of phylogenetically conserved functional elements add another dimension of analytic power. Transcriptome studies result in normalized and quantified expression values and allow ...

To branch or not to branch

... RA1 appears to be absent in rice and is found only in the large tribe, Andropogoneae, which includes maize and sorghum. RA2 and RA3 appear to be conserved over many grass taxa suggesting that they are important in controlling inflorescence architecture in all grasses. Vollbrecht and his colleagues ...

Weizmann Institute scientists discover how an injured embryo can regenerate itself

... team. The importance of the role of these morphogenic substances, as well as their mechanism of action, is evident by the fact that they have been conserved throughout evolution, where different variants can be found to exist in species ranging from worms to fruit flies and up to higher species including ...

Could new discovery about a shape-shifting protein lead to a mighty 'morpheein' bacteria fighter?

... bacterial version of the PBGS enzyme, " Jaffe says. "Because PBGS is so crucial for life, the part of the enzyme where chemistry happens is highly conserved through evolution," Jaffe says, meaning that an all-around PBGS-inhibiting drug would harm bacteria, peas and people alike. The area where the ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

... Corvallis, Oregon, is using a model of small RNA biogenesis in plants to study the basic mechanisms governing the process of RNA silencing, which is conserved in different organisms. As this process is differentially regulated in several types of cancer, this work will be lead to insights in the ...

Eating Habits Not Sole Cause of Thinness or Obesity

... eat," he said. "Now, the focus is primarily on feeding behavior. As important as that is, it's only part of the story. If the logic of the system is conserved across species, a strategy that focuses solely on behavior can only go so far. It may be one reason diets fail." The findings were published in ...

UK's organic cows are cream of the crop

... our future research is focusing on how to improve the nutritional composition of milk during the winter, when cows are kept indoors and fed mainly on conserved forage. The study, which involved Newcastle scientists working with the Danish Institute for Agricultural Science, is part of the ongoing ...

Researchers Publish Genome Sequence for Duck-Billed Platypus

... University School of Medicine's Genome Sequencing Center, said in a prepared statement. "Now, we'll be able to pinpoint genes that have been conserved throughout evolution, as well as those that have been lost or gained." The research was published in the May 8 issue of the journal Nature . ...

Huge virulence gene superfamily responsible for devastating plant diseases

... are also found in the effector proteins produced by the malarial parasite Plasmodium as it invades red blood cells. The team also detected some conserved amino acid motifs (W, Y and L) at the other end (C terminus) of some of the proteins that have been selected over years of evolution. These ...

Researchers Gain Insights Into 'On-Off' Switch for Cells

... an external chemical signal to grow. "The wiring diagram is fundamentally the same. It's very likely that different organisms have evolved a very conserved design principle to regulate their growth," study lead author Guang Yao, a postdoctoral fellow in Duke's department of molecular genetics and ...

U of Minn researchers discover genetic cancer link between humans and dogs

... millions of years of divergence, the evolving genomes of dogs and humans seem to have retained the mechanism associated with cancer, and that the conserved changes in the genomes have similar consequences in dogs and humans. Like ourselves, our pet dogs suffer from a wide range of spontaneous cancers. ...

Cancer stem cell marker also drives transcription in normal cells

... studies, published by Cell Press in the January 18th issue of Molecular Cell, provide insight into novel subunits associated with an evolutionarily conserved transcriptional regulatory complex and reveal a previously undescribed chromatin function that is required for full activity of nuclear receptors in ...
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