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Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report

... Pyrazinamide in the lab, they found that the concentration of the drug declined at a rate that matches the ... "Using this model, we can actually copy this concentration profile of the drugs to human-like exposures." ... dose that depends not just on the kinetics or the concentration time profile of patients, but also how the bug ...

ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species

... these samples without first having to conduct a concentration step, thereby significantly simplifying and ... GEM(R) Bacteria kits, without the need for the concentration step that is often required before extracting DNA ... possibility of sample contamination during the concentration process. The prep GEM(R) Bacteria kit is ...

Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors

... inhibit a signaling pathway and deliver a higher concentration of medication to the specific area. Details of ... inhibit a signaling pathway and deliver a higher concentration of medication to the specific area. Details of ... drugs must be administered in high concentration throughout the body in order to destroy tumor ...

Male Hormone Treatment Provider Announces Family Doctor Alert

... depression, erectile dysfunction, fatigue, poor concentration or hot flashes, then you need to read this alert. ... Inability to maintain or build muscle Poor concentration and memory Muscle and joint aches Mood ... depression, erectile dysfunction, fatigue, poor concentration or mood swings, it is highly advised they have ...

Patent pending for pain-free method of monitoring drug levels in transplant patients

... researching the use of saliva for monitoring the concentration of two other immunosuppressive drugs, tacrolimus and sirolimus. "Routine concentration measurement for these agents is essential for ... patients is required for two reasons; if the concentration of an immunosuppressive agent is low, the patient ...

Healing heart attack victims, one cell at a time

... muscle cells) in humans. Carbon 14 atmospheric concentration levels remained relatively stable until the Cold ... cell has gone through its last cell division, the concentration of carbon 14 in DNA serves as a date mark for ... the time at which the sample's carbon 14 concentration corresponded to the atmospheric concentration. ...

Naturally fluorescent molecules may serve as cancer biomarker

... fluorescence into an accurate measure of NADH concentration in live cells. Heikal and Yu, graduate student, bioengineering, have found that the average concentration of NADH in breast cancer cells is about twice ... the first time, we have been able to quantify the concentration of NADH in both live breast cells and breast ...

Large users of zopiclone assessed as impaired

... have now studied if there is a link between the concentration of zopiclone or zolpidem in the blood and being ... alcohol in the blood. Link between substance concentration and impairment The proportion of drivers who ... the proportion of impaired drivers and alcohol concentration in the blood. - We know that the clinical ...

New OTC Allergy Treatment Available to Food Allergy Sufferers

... a dairy allergy can be treated with a homeopathic concentration of dairy. Traditional immunotherapy, or allergy ... natural treatment that uses a significantly lower concentration than used in traditional immunotherapy, making it ... as well as in traditional immunotherapy, the concentration was increased over time. Many of the adverse ...

Vitamin D may not be the answer to feeling SAD

... Vitamin D deficiency exists when the concentration of 25-hydroxy-vitamin D (25-OH-D) in the blood ... (nanograms/millilitre) or less. The normal concentration of 25-hydroxy-vitamin D in the blood serum is ... association between depressive symptoms and the concentration of vitamin D in the blood. Dr Oscar Franco, ...

Climate change reduces nutritional value of algae

... wanted to know whether an increased CO2 concentration exerted an influence on underwater life. They ... ordinary air or with air containing an elevated concentration of CO2. The researchers then examined the ratio ... of the algae. The algae cultured at a higher CO2 concentration contained relatively more carbon and relatively ...

New study shows how spikes in nitrite can have

... composition of a large number of proteins, the concentration of several small molecule metabolites, and ... to believe that even small spikes in nitrite concentration can alter protein function in the heart in ways ... by a single, short-lasting elevation in nitrite concentration and believe that our findings will have broad ...

Coria Laboratories Announces Acanya(TM) Gel Data Presentations at 67th American Academy of Dermatology Annual Meeting

... and skin irritation minimized using a lower concentration of benzoyl peroxide in a fixed ... of clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel in the ... combination clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel for the ...

Cancer Mortality Increases With Cancer Cell Replikin Count

... Bogoch of Oncolab, Inc. have found that the concentration of replikins, a new class of peptides in genomic ... Bogoch of Oncolab, Inc. have found that the concentration of replikins, a new class of peptides in genomic ... produced in each case by increasing replikin concentration in the up-regulated Replikin Peak Gene.  An ...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

... and they are strictly defined by the concentration of lysine and histidine residues and the spacing ... them. To demonstrate the correlation between the concentration of replikins and the lethality of influenza virus ... is that there's a strong correlation between the concentration of replikins and the lethality of an influenza ...

Protein made by fat cells may increase risk of heart attack in older adults

... Metabolism (JCEM). As people lose weight, the concentration level of adiponectin in the bloodstream increases. In previous studies, high adiponectin concentration has been associated with lower occurrence of ... Kizer and others theorize that higher adiponectin concentration may reflect underlying disease processes in the ...

Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients

... I or class II (R2 <0.1). However, the median ATP concentration of samples that exhibited ELISA-PRA class II < ... 203) was significantly higher than the median ATP concentration of samples (n = 87) with ELISA-PRA >20% (216 vs. ... for organ transplantation, by measuring the concentration of adenosine triphosphate (ATP) released from CD4 ...

No association found between vitamin D concentration in blood and risk of prostate cancer

... High vitamin D concentration in the blood is not associated with a reduced ... included in the regular screening arm. Vitamin D concentration was measured in a blood sample taken when the men ... risk of aggressive disease associated with higher concentration of vitamin D, but the trend was not statistically ...

Omega-3 intake during last months of pregnancy boosts an infant’s cognitive and motor development

... the umbilical cord blood of 109 infants. DHA concentration in the umbilical cord is a good indicator of ... and motor development were closely linked to DHA concentration in the umbilical cord blood at the time of their ... very little relation between test results and DHA concentration in a mothers milk among infants who were ...

Uric acid may provide early clues to diabetic kidney disease

... The researchers measured serum uric acid concentration in 675 patients with type 1 diabetes. On ... acid, the lower the kidney function. "The serum concentration of uric acid in these patients varied in a manner ... diabetic kidney disease. "The serum uric acid concentration is modifiable by drugs or by decreasing the ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... to be lost from LDL, but also reduces the concentration of circulating LDL particles. In ... lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce ... 33 times higher than the mean human serum drug concentration (as total inhibitory activity) after a 40 mg ...

Study suggests adjusting PSA scores for obese men or cancers may be missed

... than normal weight men, and as a result, the concentration of prostate-specific antigen, or PSA, in the ... index -- which is a measure of obesity -- and PSA concentration levels, while also examining the blood volume in ... blood volume is responsible for lowering the concentration of PSA, which is what doctors typically measure ...

Obesity associated with lower PSA levels in men with prostate cancer

... be compromised by any factor that decreases PSA concentration in the circulation, according to background ... the association between hemodilution and PSA concentration in obese men with prostate cancer. The study ... may be responsible for the observed decreased PSA concentration in men with higher BMI. This association needs to ...

Obesity-linked high blood volumes render PSA prostate cancer test less effective, study suggests

... enlarged - due to cancer or other disorders - the concentration of PSA in the bloodstream can increase, signaling ... size, which has the effect of thinning out the concentration of PSA. Partin and Stephen Freedland, M.D., ... and their colleagues compiled information on PSA concentration and body mass index (BMI), a ratio of body weight ...

Increased glucose level is a strong risk factor for colorectal cancer

... unusually elevated. Researchers used a glucose concentration of 99 mg/dl as the cut point for the patients in ... in absolute risk. Patients who had a high concentration of glucose experienced more than 2.4 times ... recurrence. The subjects with the highest glucose concentration also tended to be slightly older and have higher ...

Scientists explain how insulin secreting cells maintain their glucose sensitivity

... how the human body can keep the blood glucose concentration within the normal range and thereby avoid the ... the cell surface subsequent to elevation of sugar concentration in a Ca2+- and protein kinase A-dependent ... being able to adequately keep the blood glucose concentration within the normal range thus avoiding the ...

Pitt study finds inequality in tobacco advertising

... pro-tobacco mass media messages in terms of both concentration and density, said Brian A. Primack, M.D., Ed.M., ... each market area, they were able to calculate the concentration and density of tobacco advertising in each market. concentration of tobacco advertising can be defined as the ...

Scientists learn why even treated genital herpes sores boost the risk of HIV infection

... skin. Treatment with acyclovir did not reduce this long-lasting, high concentration of HSV-2-specific CD4+ T cells at the sites of healed herpes lesions. ... those who had not. Third, the scientists found a significantly higher concentration of immune cells called dendritic cells with the surface protein called ...

Nitrous gases and zinc in the crosshairs

... substances. The results of the re-examination showed that the maximum concentration of zinc oxide fumes in the breathing air supply to which workers can be ... health. In addition to the MAK values, the list also shows the concentration of a substance in the body to which a person can be exposed during his or ...

Vancouver Fertility Acupuncture Clinic Announces New Fellows of the American Board of Oriental Reproductive Medicine

... Canada to exclusively focus on reproductive health, now has the highest concentration of American Board of Oriental Reproductive Medicine-accredited ... exclusively focus on reproductive health and is proud to have the highest concentration of Fellows of the ABORM practitioners of any clinic in the world. The ...

Atlantic Pharmaceuticals, Inc. Announces Completion of Successful Pre-IND Meeting with FDA for Abuse Deterrent Narcotic

... it orally, nasally or intravenously results in a rapid rise in the blood concentration of the opioid. A rapid rise in blood concentration is more likely to result in drug liking and reinforcement and increases ...

Platelet Rich Plasma Therapy (PRP) Accelerates Healing of Joint Injuries, Osteoarthritis Pain

... linked to cartilage regeneration. Therefore after increasing the baseline concentration of these platelets, we are able to deliver a powerful cocktail of growth ... the PRP. The entire process takes less than 15 minutes and increases the concentration of platelets and growth factors over 500%. When PRP is injected into ...

Novel light-sensitive compounds show promise for cancer therapy

... "For cancer treatment, you want localized delivery of a very high concentration of nitric oxide. We've designed these molecules to do just that," said ... can place in the treatment site, then shine light on it to produce a high concentration of nitric oxide." In designing the ruthenium nitrosyls, Rose and ...

Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Inc's. GCS-100 Molecule

... which inhibits the activity of Galectin-3, a protein found in high concentration in a broad range of human cancers. Prospect reported that GCS-100 could ... designed to inhibit the activity of galectin-3, a protein found in high concentration in a broad range of human cancers and whose over-expression is associated ...

Research says older people need more sun

... D we had when we were younger." Vitamin D deficiency exists when the concentration of 25-hydroxy-vitamin D (25-OH-D) in the blood serum occurs at 12ng/ml (nanograms/millilitre) or less. The normal concentration of 25-hydroxy-vitamin D in the blood serum is 25-50ng/ml. This study ...

City-dwellers have higher risk of late-stage cancer than rural residents

... the ages and races of individuals in the various geographic areas. A high concentration of vulnerable populations and economically disadvantaged areas in Chicago ... view that late-stage cancer risks are highest for rural residents. "The concentration of health disadvantage in highly urbanized places emphasizes the need for ...

PARI Pharma Receives 2nd ODD From EMEA; Moves Inhaled Tobramycin - eFlow Technology Program Forward

... device were granted in Europe and several other countries. Low volume/high concentration drug products such as PARI Tobramycin 100 delivered using eFlow Technology ... an improvement for patients. The volume reduction to 1.5 mL and high drug concentration of 100 mg/mL developed for delivery via a customized Investigational eFlow ...

Vitamin D Linked to HDL Cholesterol - Shaklee Corporation Research Links Vitamin D with Key Biomarkers for Metabolic Syndrome and Heart Disease

... level. High density lipoprotein cholesterol (HDL-C or "good cholesterol") concentration increased as vitamin D intakes increased. Each 10 ng/mL increase in serum ... says, "Results from population studies suggest that a low serum vitamin D concentration is an independent risk factor for cardiovascular mortality, but this is ...

Nanoparticles May Help Attack Cancer More Directly

... pathway, which is involved in most human tumors, and to carry a higher concentration of anti-cancer drugs to a specific area, according to the scientists at ... drug loading. "Current chemotherapy drugs must be administered in high concentration throughout the body in order to destroy tumor cells, translating to high ...

AcelRx Announces Initiation of Phase 2 Cancer Breakthrough Pain Program

... to fentanyl-based products, the highly consistent time to peak plasma concentration and plasma half-life of two to four hours produces a closer match of effective drug concentration with the breakthrough pain event and allows a high degree of safety if ...
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(Date:9/22/2014)... could be much more useful in homes, if they ... see the world with cameras and lasers, which have ... are hidden in clutter. A complementary way robots can ... of small ultra-high frequency radio-frequency identification (UHF RFID) tags. ... an RFID-equipped robot to search a room for the ...
(Date:9/22/2014)... 7,000 geoscientists will gather in Vancouver, British Columbia, Canada, ... America,s 126th Annual Meeting & Exposition on 19-22 October ... transportation of crude oil, earthquake prediction problems, and how ... and Tribulations of Life on an Active Subduction Zone, ... , A broad range of topics will be presented ...
(Date:9/21/2014)... Diego, have developed a program that predicts the placement ... based on sequences of DNA. They describe their analysis ... cells in a paper published in Nature Methods ... have the same blueprint, the same DNA, although they ... the report. "Skin cells protect, nerve cells send signals, ...
Breaking Biology News(10 mins):New RFID technology helps robots find household objects 2New RFID technology helps robots find household objects 3Geoscience topics in the spotlight -- Vancouver, BC 2Geoscience topics in the spotlight -- Vancouver, BC 3Geoscience topics in the spotlight -- Vancouver, BC 4Geoscience topics in the spotlight -- Vancouver, BC 5Program predicts placement of chemical tags that control gene activity 2
(Date:9/22/2014)... September 23, 2014 Career Step, ... training, will be attending and exhibiting at the ... Health Information Management Association (AHIMA) in San Diego, ... through October 1, and Career Step will be ... suite of coding training products, including CLiM™, its ...
(Date:9/22/2014)... Fashion Footwear Association of New York (FFANY) and leading ... research to the University of Pittsburgh Cancer Institute (UPCI), ... the proceeds of the 20th annual QVC Presents "FFANY ... several cancer research centers across the country, including UPCI ... has been selected to receive funds from this year,s ...
(Date:9/22/2014)... New York, NY (PRWEB) September 22, 2014 ... Women’s Radio Network launched their first evening show, “KC After ... and Marcus Edwards, “KC After Dark” will air every Tuesday ... away a free iPad for the 50th caller, and because ... it well past the call in mark with 500 callers. ...
(Date:9/22/2014)... 2014 United States District Judge ... federal mesh lawsuits ( http://www.meshinjurylawfirm.com/lawsuits/ ) filed against ... for pretrial matters, issued an order in the ... System Products Liability Litigation (United States District Court ... no. 2:12-md-02326)—requiring that four member cases be ready ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Locating the ... industry is now easier using the Quotes Pros portal ... trying to local universal life insurance pricing from different ... coverage plans that are easily viewed when using the ... specific lengths of coverage. The plan data can be ...
Breaking Medicine News(10 mins):Health News:Career Step to Exhibit at AHIMA Convention September 27 through October 1 2Health News:Heels for a cause: FFANY, QVC Present $240,000 from shoe sales to Pitt researchers 2Health News:The Women’s Radio Network, WRNW1’s First Evening Show a Huge Success 2Health News:Federal Court Sets Trial Date for Boston Scientific Vaginal Mesh Cases in Florida, the Rottenstein Law Group LLP Reports 2Health News:Universal Life Insurance Prices for Adults Added to National Insurer Portal Online 2
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