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Cost-effectiveness of cetuximab in metastatic colorectal cancer

... more efficient to use the drug cetuximab only in colorectal cancer patients whose tumors have a wild-type ... treatment for all patients with advanced colorectal cancer," the authors write. "Use of cetuximab may ... shows that even when restricted to metastatic colorectal cancer patients with wild-type KRAS tumors, the ...

Micromet, Inc. Reports Second Quarter 2009 Financial Results

... antibodies against KRAS- and BRAF-mutated human colorectal cancer cells at the AACR meeting. The ... T cells to eliminate EpCAM-expressing human colorectal cancer stem cells in cell culture and in animal ... Adecatumomab is in a phase 2 clinical trial in colorectal carcinoma patients after complete resection of ...

Genetic testing may be valuable in treating colorectal cancer

... patients in the United States with metastatic colorectal cancer, chemotherapy with irinotecan is a ... pharmacogenetic testing for metastatic colorectal cancer, but remains to be verified by clinical ... irinotecan) chemotherapy regimen for metastatic colorectal cancer. The model assumed that under usual care, ...

Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)

... predictive biomarker in patients with metastatic colorectal cancer (mCRC) treated with anti-EGFr antibody was ... that retrospective subset analyses of metastatic colorectal cancer trials have not shown a treatment benefit ... Vectibix is not recommended for the treatment of colorectal cancer with these mutations. The ...

News from Cancer

... August 15, 2009 RACIAL DISPARITIES IN colorectal CANCER SURVIVAL DISSIPATE AFTER ADJUSTING FOR OTHER DEMOGRAPHIC AND CLINICAL FACTORS colorectal cancer (CRC) is the third leading cause of cancer ... to care. Article: "Racial Differences in colorectal Cancer Survival in the Detroit Metropolitan ...

Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award

... components may play in preventing prostate and colorectal cancer. Selenium, for example, found in ... consortium for genomewide association studies of colorectal cancer that combines data from several ... aims to determine whether genetic variants affect colorectal cancer and whether environmental factors, ...

40 Northwest Hospital Physicians Named Among Seattle's Top Doctors by Seattle Magazine

... MD -- Cardiology Richard Billingham, MD - colorectal Surgery Daniel Froese, MD -- colorectal Surgery and Oncology, colorectal Cancer (Surgical) Gregory Schroedl, MD - ...

Cell Pathway May Be Key to Lung Cancer's Spread

... focusing on the same cellular pathway that causes colorectal cancer to develop and spread. Their work appears ... goes wrong with the pathway, as in the case of colorectal and adenocarcinoma lung cancers. Scientists ... WNT/TCF pathway can trigger the development of colorectal cancer. Though WNT/TCF does not appear to play a ...

GIE: Gastrointestinal Endoscopy June issue study highlights

... is recommended as a primary screening method for colorectal cancer and is the final common pathway for all ... tests. It is considered the "gold standard" for colorectal cancer screening for its ability to diagnose and ... performance. The U.S. Multi-Society Task Force on colorectal Cancer has established targets for continuous ...

Risk of cancer

... change in the human genome increases the risk of colorectal cancer. The focus in this study was on a ... be considerably reduced by lifestyle changes. colorectal cancer is the third most common cancer worldwide ... cancer The variant that increases the risk of colorectal cancer was found to be located in a regulatory ...

New piece found in colorectal cancer puzzle

... cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access ... levels of prostasin and its inhibitors in colorectal tissue samples from 222 patients and 23 controls. ... at the transition between severe dysplasia and colorectal cancer. According to Vogel, "It has previously ...

Study Finds Possible Genetic Indicator of Colorectal Cancer

... be moving closer to developing a genetic test for colorectal cancer that could indicate who needs a more ... the procedure, said Wishner, director of the colorectal cancer program at Northern Westchester Hospital ... the idea of genetic screening, which could make colorectal cancer easier to detect by finding signs of the ...

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

... a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential ... promoter methylation and expression in human colorectal cancer cell lines, noncancerous colon mucosa, and colorectal cancer tissue. Quantitative methylation-specific ...

For Some, Virtual Colonoscopy May Be Just As Good

... be present. "People should be aware that colorectal cancer is a preventable disease," said one of the ... test also in subjects at increased risk of colorectal cancer." Laudi said the findings are ... an option for people who have an average risk of colorectal cancer, according to Dr. Durado Brooks, director ...

For Some, Virtual Colonography May Be Just As Good

... be present. "People should be aware that colorectal cancer is a preventable disease," said one of the ... test also in subjects at increased risk of colorectal cancer." Laudi said the findings are ... an option for people who have an average risk of colorectal cancer, according to Dr. Durado Brooks, director ...

Racial Clusters Seem to Affect Access to Colon Care

... -- Black Americans appear to have less access to colorectal cancer specialists, which means they may be less ... the number of specialists who diagnose and treat colorectal cancer. In contrast, counties with a greater population of Asian Americans were found to have more colorectal cancer specialists. The study is in the June ...

Colonoscopy Risks Increase With Age and Illness

... for the determination of the appropriateness of colorectal cancer screening," he said. Dr. Durado Brooks, director of prostate and colorectal cancer prevention programs at the American Cancer ... Md.; Durado Brooks, M.D., director, prostate and colorectal cancer prevention programs, American Cancer ...

New American College of Surgeons risk calculator determines colorectal surgery risk

... the risk of death and complications following colorectal surgery. The tool will also allow surgeons to ... weigh the risks and potential benefits of colorectal operations," said Mark E. Cohen, PhD, Division of ... database, data on 28,863 patients who underwent colorectal operations at 182 hospitals in 2006 to 2007 were ...

What are the risk factors of sporadic colorectal cancer?

... colorectal cancer (CRC) is one of the most common cancers in ... between the epidemiological factors and sporadic colorectal cancer has been studied, the relation between ... of cancer, body mass index (BMI) and sporadic colorectal cancer still remains uncertain. So it is ...

A real-time diagnosis for a treatable cancer

... According to the American Cancer Society, colorectal cancer, America's third leading type of cancer, ... one of the most preventable. One-third of all colorectal cancer deaths could be avoided by simple ... a hospital visit." "Bio"-Marks the Spot colorectal cancer is especially difficult to diagnose in its ...

Colorectal Cancer Rates Rising for Under 50 Set

... 8 (HealthDay News) -- Despite a steady decline in colorectal cancer rates in the United States in the past two ... thinking we've been doing pretty well because colorectal cancer incidence has been declining overall," ... 2005. During this time, the researchers found, colorectal cancer rates increased 1.5 percent a year among ...

U.S. Could Save 100,000 Lives a Year with Five Basic Preventive Services

... counseling, adult influenza immunization, colorectal screening, and breast cancer screening - would ... for tobacco cessation counseling, 48 percent for colorectal screening and 67 percent for breast cancer ... immunization, 14,000 additional lives through colorectal screening, and 3,700 lives through breast cancer ...

CMS Decision - No Material Financial Impact to Medicsight

... (and growing) currently mandate coverage for colorectal cancer screening, most adopting the American ... excited about the enormous potential to improve colorectal screening compliance with the use of screening ... colonoscopies, more people are screened for colorectal cancer. Less than half of those who should be ...

Alcohol, Cigarettes and Diabetes Up Colorectal Cancer Risk

... and eating lots of red meat can raise the risk of colorectal cancer, but new research sheds light on other ... major role in determining who is going to develop colorectal cancer, study findings show. And although exercise seemed to help ward off colorectal cancer, eating lots of fruits and vegetables ...

Simple Test Could Detect More Gastrointestinal Cancers

... has been successfully used for early detection of colorectal cancer, researchers at Minnesota's Mayo Clinic ... cancers and 100 percent of stomach and colorectal cancers. The test was equally successful at ... stage, but the only one widely tested for is colorectal cancer, generally through colonoscopy. ...

Improved DNA stool test could detect digestive cancers in multiple organs

... a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the ... with early-stage detection for each type, only colorectal cancer is currently screened at the population level. Most people associate colorectal cancer screening with invasive colonoscopy, but ...

Alcohol and smoking are key causes for bowel cancer

... high intakes of alcoholic beverages with risk of colorectal cancer. Most people probably know that being ... strongly suggest that a large proportion of colorectal cancer cases could potentially be avoided by ... between major and modifiable risk factors for colorectal cancer including alcohol, smoking, diabetes, ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

... anti-EGFR therapy response in metastatic colorectal cancer patients MADISON, N.J., June 1 ... of the roughly half of all metastatic colorectal cancer (mCRC) patients who, because of certain ... leader in cancer diagnostics, including tests for colorectal cancer. In addition to its EGFR Pathway and ...

Deep Sleep May Improve Colonoscopy Results

... the news release. Not counting skin cancers, colorectal cancer is the third most common cancer among men ... Cancer Society. Nearly 50,000 people will die of colorectal cancer in the United States this year. Men and women at average risk of colorectal cancer should have ...

New research identifies more effective tools for detection of colorectal cancer

... latest advances in polyp detection, assessment of colorectal cancer risk, and patient sedation during ... colonoscopy are the key to early detection of colorectal cancer. Perfecting the frequency of colonoscopy ... goal is to create a more efficient way to prevent colorectal cancer with reasonable use of our resources." ...

Worth of Sigmoidoscopy Screening for Colon Cancer Still Uncertain

... aim of reducing mortality and the risk of getting colorectal cancer, but the effect may be less than ... been results from randomized trials only for one colorectal cancer screening modality -- screening for blood ... "we would not yet expect to see a reduction in colorectal cancer." "There are options, which is good," ...

Surgery not necessary for most late-stage colorectal cancers

... majority of patients who present with advanced colorectal cancer that has spread to other organs (stage IV) ... a multidisciplinary team looked at 233 metastatic colorectal cancer cases treated at MSKCC from 2000 to 2006. ... tumor. It was assumed that the majority of colorectal cancers would have little response to ...

Chemo Alone Is Best for Advanced Colon Cancer

... treatment option for most patients with advanced colorectal cancer that has spread to other organs, a new ... following diagnosis of stage IV metastatic colorectal cancer had previously been the standard ... a finding that 93 percent of advanced metastatic colorectal cancer cases treated over a six-year period at ...

AGA Institute presents cutting-edge research during DDW

... three-fold decrease in the incidence of advanced colorectal neoplasia in IBD patients with longstanding ... Aspirin Use and Survival After Diagnosis of colorectal Cancer. A. T. Chan et al. (8:20 a.m.) First Randomised Trial on the Risk of colorectal Cancer after Flexible Sigmoidoscopy Screening. G. ...

More Living Longer With Advanced Colon Cancer

... survival rate for patients battling advanced colorectal cancer has increased dramatically, new research ... issue of the Journal of Clinical Oncology . colorectal cancer is the fourth most common cancer in the ... first reviewed data regarding nearly 2,500 colorectal cancer patients who had treatments at either M.D. ...

DiagnoCure to host Q2 2009 earnings conference call and webcast

... Inc., launched in 2008 the Previstage(TM) GCC colorectal Cancer Staging Test, the first GCC-based molecular test for the management of colorectal cancer. A major study published in the February ... rights, is the strongest independent predictor of colorectal cancer recurrence. The Company has a strategic ...

U.S. Cancer Death Rates Continue to Fall

... rates; detection which includes screening for colorectal cancer, for breast cancer and for cervical ... the age of 50 currently get regular screening for colorectal cancer, he said. Here is a summary of the ... decreases in the incidence of lung, prostate and colorectal cancer (the three most common cancers). In women, ...

A novel marker of colorectal carcinoma

... The colorectal cancer is thought to be resulted from a ... alterations. The pathogenesis and development of colorectal cancer involve multi-genes and multi-steps. ... the association between TSPAN1 and human colorectal adenocarcinoma. Their study will be published on ...

Amgen Highlights Data to Be Presented at ASCO

... monotherapy findings, it appears that metastatic colorectal cancer (mCRC) patients with wild-type KRAS ... from panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment ... ST in patients (pts) with metastatic colorectal cancer (mCRC) Lead Author: ...

Decision by Medicare's CMS to Deny Coverage for 'Virtual' Colon Cancer Tests Underscores Lack of Evidence on Cancer Prevention

... option for the screening and prevention of colorectal cancer. "One of the primary issues ... and the Multi-Society Task Force Guideline on colorectal Cancer in recent guidelines have stated clear preferences for tests which prevent colorectal cancer. The American College of ...
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