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Cocaine in Medical News

Brain Scans Show Differences in Cocaine Addicts

... were issues in these regions of the brain when cocaine users were given a test in which fast, correct ... . In the experiment, a group of active cocaine users and demographically similarly but healthy ... monitor their own behavior was far quieter in the cocaine users, especially during the parts of the test in ...

Cocaine Spurs Long-Term Change in Brain Chemistry

... offers insight into how addictive drugs such as cocaine "cook" the brain. "The study's findings enable us to glimpse for the first time exactly how cocaine modifies the activity of genes in regions of the ... for the development of medications to treat cocaine addiction," she said. Scientists led by Dr. ...

Catalyst Pharmaceutical Partners Reports First Quarter 2009 Financial Results

... to complete the Company's currently ongoing cocaine clinical trial and methamphetamine ... the use of CPP-109 for the treatment of cocaine addiction by the end of the second quarter of ... FDA and begin designing the Phase III 'pivotal' cocaine trial during the second half of 2009 that we ...

Cocaine Use Among U.S. Workers Declines Sharply in 2008, According to Quest Diagnostics Drug Testing Index(TM)

... Show MADISON, N.J., May 6 /PRNewswire/ -- cocaine use among U.S. employees and job applicants in ... as a factor in recent drug use declines. cocaine and methamphetamine use decline sharply; ... increases Positivity rates of recent use of cocaine in the general U.S. workforce dropped 29 percent ...

Treating addiction by eliminating drug-associated memories

... this study, we found that after repeatedly giving cocaine injections to rats within a particular ... the old associations, in this case between the cocaine and the environment. Dr. Olive also notes that ... whether this approach extends to the treatment of cocaine abuse or other addictions. Further, it will be ...

UCI researchers find new way to fight cocaine addiction

... a hormone related to hunger regulation can limit cocaine cravings. Their findings could herald a new ... center" to create an addictive response to cocaine use. The researchers further found that blocking MCH in these brain cells limited cocaine cravings. Dopamine is a neurotransmitter ...

Gene Variant Tied to Cocaine-Induced Paranoia

... News) -- Genetic variants that increase cocaine addicts' risk of paranoia have been identified by ... the genome previously shown to be associated with cocaine dependence and cocaine-induced paranoia. The ... this area of the genome were also associated with cocaine dependence. The study was published in the ...

70 percent of drug-addicted men admit they consume drugs to increase their sexual pleasure

... sexual relations and most of them (58%) choose cocaine to this purpose, the narcotic which increases the ... to this purpose, and when they do, they resort to cocaine (37%), speed ball (25%) and alcohol (25%). ... test which assesses consumption seriousness. cocaine and alcohol to lose inhibition Another ...

Catalyst to Focus Resources on its Lead Indication for CPP-109; Cocaine Addiction

... As previously announced, Catalyst's Phase II cocaine trial is now fully enrolled, with 186 patients at ... the United States, and top-line results from the cocaine trial are expected to be available during the ... our lead candidate CPP-109 for the treatment of cocaine addiction. Furthermore, this modification does ...

American Chemical Society's Weekly PessPac -- Feb. 18, 2009

... licorice ingredient show promise as treatment for cocaine addiction Journal of Proteome Research An ... promise as an antidote for the toxic effects of cocaine abuse, including deadly overdoses of the highly ... is currently no effective medicine for treating cocaine abuse or addiction. Recent animal studies ...

Mouse Study Suggests ADHD Drug Might Be Addictive

... brain in a way comparable to cocaine. Ritalin and cocaine are both psycho-stimulants, the researchers noted. "Methylphenidate [Ritalin] and cocaine have similar chemical structures and their ... the effects of chronic exposure to Ritalin and cocaine in specific reward-related brain regions of mice. ...

Honey Bees on Cocaine 'Dance' When Food Is Found

... insect's brain and altruism in the bee world. cocaine affects the transit of octopamine, a ... because of poor quality or lack of need. The cocaine causes the bees to dance more -- an altruistic ... reward system in the insect brain. The bees on cocaine do not dance every time they go foraging, and ...

Drug-related preference in cocaine addiction extends to images

... When given a choice between viewing pictures of cocaine and a variety of other images, cocaine addicted individuals, as compared to healthy, ... for the first time that drug-related choice in cocaine addiction extends to abstract, ...

College Freshmen See Rx Drug Misuse More Risky Than Alcohol, Pot

... But surveys found cocaine viewed as most dangerous to health ... every weekend, a new study indicates. But cocaine is perceived as far more dangerous than any of ... and stimulants), alcohol, marijuana and cocaine to be harmful. Six months later, the ...

Cocaine addiction linked to voluntary drug use and cellular memory, UCSF study shows

... Rats that voluntarily use cocaine show a persistent cellular memory in the brain's ... conclude that the pharmacologic effects of cocaine alone are not enough to cause long-lasting ... onto the significance of active choice in using cocaine and extends our understanding that addiction is ...

Rutgers scientist receives prestigious 'Young Investigator Award'

... preclinical studies relevant for the problem of cocaine addiction in women during the postpartum period ... conducted in Morrell's lab "aim to understand how cocaine can hijack the normal motivational patterns of ... benefit the survival of offspring. In humans, cocaine use is not compatible with good parental care, ...

Research reveals molecular fingerprint of cocaine addiction

... of proteins in the brains of monkeys addicted to cocaine reveals new information on how long-term cocaine use changes the amount and activity of various ... may provide a biological explanation for why cocaine addiction is so difficult to overcome, according ...

Rat study suggests why teens get hooked on cocaine more easily than adults

... researchers who found that adolescent rats given cocaine a powerfully addicting stimulant were more ... preference, a small reinstating dose of cocaine appeared to rekindle that preference but only in ... injected them with a preference-forming dose of cocaine (either 10 or 20 mg per kg of weight, to assess ...

Gene Therapy in Rats Reduces Cocaine Use

... in rats' brains reduced their desire for cocaine by 75 percent, U.S. researchers say. Previous ... an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential ... the brain could help treat addiction to alcohol, cocaine and other drugs. More information The ....

Gene therapy reduces cocaine use in rats

... a pleasure-related chemical, can reduce use of cocaine by 75 percent in rats trained to self-administer ... an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential ... individuals may have their need for cocaine decreased if their D2 levels are boosted. Thanos' ...

Animal research suggests new strategy for treating cocaine addiction

... in monkeys suggests the feasibility of treating cocaine addiction with a replacement drug that mimics the effects of cocaine but has less potential for abuse similar to the ... reduced their self-administration of cocaine for up to a month. This suggests the ...

Subordinate monkeys more likely to choose cocaine over food

... faced with a stressful situation will choose cocaine over food, according to a study at Wake Forest ... between pressing a lever that they knew delivered cocaine or one that they knew delivered a food reward. The subordinate monkey was more likely to choose cocaine while the dominant monkey was less likely to ...

Animal Study Links Social Standing With Drug Use Risk

... monkeys placed under stress more likely to choose cocaine over food SUNDAY, April 6 (HealthDay ... are more likely than dominant monkeys to choose cocaine over food when faced with a stressful situation, ... select between a lever that they knew delivered cocaine or one that delivered food. The subordinate ...

Use of Methamphetamine Among U.S. Workers and Job Applicants Drops 22 Percent in 2007 and Cocaine Use Slows Dramatically, Reports Quest Diagnostics

... The report also shows that positive tests for cocaine in the general U.S. workforce were down ... "The fact that America's workers are using cocaine and methamphetamine at some of the lowest levels ... argumentativeness or nervousness. cocaine Use Continues to Decline The Quest Diagnostics ...

Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance

... of CPP-109 for the treatment of both cocaine addiction and methamphetamine addiction." Mr. ... enrollment of subjects for our U.S. Phase II cocaine trial and the expected initiation in the second ... in Mexico, treating patients addicted to cocaine with vigabatrin, was included in Newsweek ...

New research indicates that a common heart drug

... in the treatment of high blood pressure, reduces cocaine cravings in a rat model. These findings will ... independently contribute to the development of cocaine addiction. This new research indicates that ... that drives the intense craving associated with cocaine addiction. Diltiazem, one of a class of drugs ...

Cocaine's effects on brain metabolism may contribute to abuse

... UPTON, NY - Many studies on cocaine addiction - and attempts to block its ... "reward" chemical once its signal is sent. Since cocaine blocks dopamine transporters from doing their ... go beyond the dopamine system. In the study, cocaine had significant effects on brain metabolism, even ...

UTMB wins $3.4 million federal grant to study addiction-recovery drugs

... the first effective drugs to help people conquer cocaine addiction. The researchers believe this ... linked to success or failure in recovering from cocaine addiction. The scientists will focus on two types ... sound with pressing a lever to self-administer cocaine and then denied the drug for a time, they ...

Catalyst Pharmaceutical Partners Announces Positive Phase II Trial Results for Vigabatrin in the Treatment of Cocaine Addiction

... that vigabatrin is effective for the treatment of cocaine addiction. Catalyst's lead compound, CPP-109, is ... treated with vigabatrin were able to abstain from cocaine usage during the last three weeks of the dosing ... represents a key development in the field of cocaine addiction research. CPP-109, our product ...

Drugs and Injustice

... he is substance dependent. Yet a weekend cocaine user is neither addicted nor substance dependent ... having a more serious disorder than the weekend cocaine user. According to national surveys, it is ... any good reason why the same amounts of crack cocaine and ...

$2.2M NIH grant to develop drugs to suppress cocaine cravings

... develop therapeutics to suppress the cravings of cocaine addicts. Compounds developed by a research ... drugs. Researchers looking for therapies for cocaine addiction have largely overlooked the 5-HT2 ... instead. "In large part, the field of cocaine medications research has been dominated by the ...

News Tips from the Journal of Neuroscience

... drug and the place where it was received. CPP for cocaine is usually attributed to increases in extracellular dopamine, but cocaine also inhibits serotonin and norepinephrine ... in dopaminergic neurons. DD mice showed CPP for cocaine at higher doses than controls, but fluoxetine, a ...

Cocaine Use Dulls Brain's Sensitivity to Rewards

... addiction SUNDAY, Nov. 11 (HealthDay News) -- cocaine addiction dulls the brain's sensitivity to even ... National Laboratory analyzed brain activity in 18 cocaine addicts and 18 age-matched healthy people. ... performance. The results showed that the cocaine addicts had a blunted brain response to the offer ...

New treatment effective in counteracting cocaine-induced symptoms

... a treatment that counteracts the effects of cocaine on the human cardiovascular system, including ... heart rate and blood pressure often found in cocaine users. We have found that cocaines effects on ... drug was effective in reversing the actions of cocaine on heart rate, blood pressure and vascular ...

UCSF Gallo Study Finds Hormone Disorder Drug Could Help Drinkers Stay Sober

... eventually be prescribed for other addictions. A pilot study conducted on cocaine addicts, cited in Ron's paper, reported a substantial reduction in cocaine use. In the United States, 17.6 million people -- approximately one in ...

Risk takers, drug abusers driven by decreased ability to process dopamine

... of natural sources, including food and sex, as well as from drugs such as cocaine and amphetamine. Previous research has shown that individuals differ in ... explore novel environments more are also more likely to self-administer cocaine when given the chance. Dopamine neurons fire at a higher rate in these ...

A research on 'craving' for tobacco establishes the bases for addiction control

... affects cognitive resources, as it has an obsessive component. 180 cocaine users The researchers of the University of Granada analysed, with the ... This study has helped to establish the behavioural mechanisms in cocaine addiction, and consists of the emotional control of different consumption ...

Young Adults Using Alcohol, Drugs for Better Sex

... past year. Similar consequences were noted in those who'd used cannabis, cocaine or ecstasy. Respondents who used alcohol, cannabis, cocaine or ecstasy before age 16 were much more likely to have had sex before that ...

Drug use increasingly glamorized in rap music, according to new study of 2-decade trends

... shift from cautionary songs, such as those that emphasized the dangers of cocaine and crack, to songs that glorify the use of marijuana and other drugs as ... generally cautionary tales about the dangers of crack, base or powdered cocaine (i.e., White Lines), mentions of marijuana and blunts (marijuana-stuffed ...

New study finds glamorization of drugs in rap music jumped dramatically over 2 decades

... Living Baseheads" by Public Enemy - often depicted the destructiveness of cocaine and, particularly, of crack, its freebase form. This cautionary tone about cocaine gave way to rap lyrics in the early 1990s that increasingly portrayed ...
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