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Chromosome in Medical News

Male Sex Chromosome on Its Way Out: Study

... News) -- Rapid evolution of the male sex chromosome could result in its disappearance within a few ... males and females. The rapid evolution of the Y chromosome has led to a dramatic loss of genes on the chromosome. "Today, the human Y chromosome contains less than 200 genes, while the human ...

Human sperm created from embryonic stem cells

... meiosis - cell division with halving of the chromosome set. These were shown to produce fully mature, ... demonstrates to researchers that the genes on a Y chromosome are essential for meiosis and for sperm ... IVD sperm - characterised by containing half a chromosome set (23 chromosomes). ...

International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant

... publication is entitled “Common variants on chromosome 6p22.1 are associated with schizophrenia. ... of the three datasets highlighted a region in chromosome 6p22.1 that is associated with ... associations for the genes, ERBB4 on chromosome 2q34 and its ligand, neuregulin (NRG1 ...

Chromosome Abnormality Tied to Autistic Behavior in Mice

... June 26 (HealthDay News) -- Mice with an extra chromosome region inherited from their fathers display many ... autism, a finding that suggests that the same chromosome abnormality in humans is one cause of autism, ... region in mice is the equivalent of human chromosome 15q11-13, which is duplicated in about 5 percent ...

Gene findings revealing reasons for neuroblastoma risk

... of DNAalong a structurally weak location on chromosome 1 plays an important role in the development of ... found that an inherited CNV located at chromosome 1q21.1 is associated with neuroblastoma. The chromosome region contains a large family of genes that are ...

Study IDs benefit of donor SCT for adults with acute myeloid leukemia

... offered to patients has largely been based on a chromosome analysis of their AML cells. For AML with "good-risk" chromosome changes, additional chemotherapy or an autologous ... relapse. While the findings support the use of chromosome analysis -- the classification of AML cases as ...

UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage

... first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the ... circulating throughout the body. This means that chromosome damage was not limited to the intestine, but ... and double-strand DNA breaks in the blood, and chromosome damage in peripheral blood indicating systemic ...

Why do people with Down syndrome have less cancer?

... population. Since they have an extra copy of chromosome 21, it's been proposed that people with Down ... extra copy of Dscr1 (one of the 231 genes on chromosome 21 affected by trisomy, with three copies rather ... an extra copy of Dscr1. An extra copy of another chromosome 21 gene, Dyrk1A, also appeared to decrease cells' ...

Five UCSF Scientists Elected to National Academy of Sciences

... Sedat's research is aimed at understanding chromosome structure at the highest levels of organization, ... toward characterizing the relationship between chromosome structure and function. A chromosome is a thread-like package of genes and other DNA ...

New risk variant for atopic dermatitis identified

... Kiel, have identified a gene variant on chromosome 11 that is associated with an increased risk of ... the researchers identified a variant on chromosome 11 that is particularly common in the patients ... for Crohn's disease The same variant on chromosome 11 is also common in patients with Crohn's ...

Gene May Explain Women's Heightened Lupus Risk

... April 2 (HealthDay News) -- A gene on the X chromosome appears to be linked to lupus and might explain ... to lupus. "This first demonstration of an X chromosome gene as a disease susceptibility factor in human ... in rates may in part be attributed to sex chromosome genes," Mohan said. The international, ...

PGD Technology Offers More Than Designer Babies

... from the embryo. The cells are analyzed for chromosome count, specific DNA sequences, or markers linked ... fluorescent light, each color spot represents a chromosome under study. This analysis can show abnormal chromosome pairings such as three copies ...

Scientists Identify More Breast Cancer Genes

... located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide ... the rs11249433 SNP is unknown, but the region on chromosome 1 where it's located is predominately associated ... the researchers said. The region identified on chromosome 14 includes the rs999737 SNP, which is located ...

Study IDs Variations in Black, White Genomes

... in the frequency of two duplications, one on chromosome 15 and another on chromosome 17, said Joseph P. McElroy and his colleagues in ... of California, San Francisco. A duplication in chromosome 17 (region 17q21) was found in 45 percent of the ...

Molecule tracking reveals mechanism of chromosome separation in dividing cells

... is thought to help push and pull apart chromosome pairs. Understanding how this machine ... Named a kinetochore, it is a site on each chromosome that mechanically couples to spindle fibers. ... hubs," the researchers noted. "They control chromosome movements through the lengthening and shortening ...

Standardized test battery to aid those with Down syndrome

... New research also suggests connections between chromosome 21 and other genes point to some of these ... the probability of heart defects not just to chromosome 21, but other genes that interact with the extra chromosome 21, and had shown the feasability of using that ...

Identification of genetic markers for ulcerative colitis could lead to treatment

... phospholipase A2, group IIE (PLA2G2E) genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15 that play an important role in ... between ulcerative colitis and genetic markers on chromosome 7q31 within or near the laminin, beta 1 (LAMB1) ...

Genetic Markers Identified for Alcohol Response in UCSF Gallo Study

... as a single nucleotide polymorphism (SNP), on chromosome 15 is significantly associated with the level of ... and nicotine dependence and also have connected chromosome 15 with alcohol use disorders, which made those ... association in this study was found on the chromosome 15 SNP labeled RS1051730, with the response being ...

Chromosome Linked to Diabetics' Heart Risks

... has found that genetic variations on a genetic chromosome known as chromosome 9p21 are associated with increased risk of CAD ... with CAD) who were tested for a gene variation of chromosome 9p21 and checked for long-term glycemic control. ...

Presentations at AHA expand on clinical utility of deCODE's DNA-based tests

... and stroke In 2007, deCODE discovered two SNPs on chromosome 4q25 that double the risk of atrial fibrillation ... 1171, "Risk variants for atrial fibrillation on chromosome 4q35 associate with non-cardiogenic stroke, ... associated with atrial fibrillation located on chromosome 4q25 in a whole genome association study and ...

Also in the Oct. 28 JNCI

... Inactivation in BRCA1 Mutation Carriers One X chromosome is more frequently silenced than the other X chromosome in women who carry mutations in the BRCA1 gene, ... and usually occurs randomly so that each X chromosome will be inactivated with equal frequency in a ...

New Genetic Links to Baldness Discovered

... they age, Brockschmidt said. "Screening for the X chromosome locus and also for this new one can possibly show ... from his mother. The new gene locus is on chromosome 20. Men and women alike have two copies of chromosome 20, inherited from both father and mother. Any ...

Genetic region linked to a 5 times higher lung cancer risk

... A narrow region on chromosome 15 contains genetic variations strongly ... but the area identified in this study on chromosome 15 is the only genetic region that is consistent ... specific genetic variations in this region of chromosome 15, a much lower risk than found in the current ...

Schizophrenia Yields Some Genetic Secrets

... where people have a substantial portion of a chromosome either missing or extra. These are called copy ... the consortium found three deletions: one on chromosome 1 and two on chromosome 15, which were seen multiple times in people with ...

Male kidneys for men only?

... 10 percent higher than for other groups. Y chromosome likely responsible for rejection "The higher ... is most likely caused by the gender-specific Y chromosome in men," explains Professor Opelz. In the future, ... Immune functions associated with the Y chromosome and which can lead to rejection of the organ need ...

Also in the June 24 JNCI

... lack one copy of a region on the short arm of chromosome 1, called 1p36.31. Garrett Brodeur, M.D., of the ... , (215) 955-5291 Multiple Regions of chromosome 8 Found To Be Associated with Different Cancers ... discovered, but not yet understood, section of chromosome 8, called 8q24, may contain at least five ...

Prenatal biochemical screening only detects half of chromosomal abnormalities

... Trisomy occurs when the fetus has one additional chromosome (47 instead 46). The extra genetic material from the additional chromosome causes a range of problems of varying severity. ... for example, where the fetus has three copies of chromosome 21, babies are usually born with impaired ...

Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer

... researchers has for the first time identified a chromosome region that is the source of genetic events that ... presence of common DNA variations in a region of chromosome 6 raises the risk that a child will develop a ... levels of a cancer-causing gene and deletions of chromosome material. They used those tumor peculiarities to ...

Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer

... researchers has for the first time identified a chromosome region that is the source of genetic events that ... presence of common DNA variations in a region of chromosome 6 raises the risk that a child will develop ... levels of a cancer-causing gene and deletions of chromosome material. They used those tumor peculiarities ...

Gene Variants Linked to Lung Cancer Identified

... News) -- Scientists have pinpointed an area on chromosome 15 that has three nicotine receptor genes that ... had lung cancer. "Variations in the region of chromosome 15 were more common in cases of lung cancer than ... independent risk factor for lung cancer in this chromosome region." One expert thinks these studies alone ...

Penn researchers identify first sex chromosome gene involved in meiosis and male infertility

... causes of infertility that links a particular sex chromosome meiosis-specific gene to sterility. As with ... infertility in men. Because men have only one X chromosome that they inherit from their mother and thus only ... decades, conventional wisdom stated that the X chromosome had little to do with meiosis or infertility ...

Researchers identify new genetic marker for breast cancer

... study, a new gene locus, a specific place on a chromosome where a gene is located, was associated with ... risk. That gene locus is on the long arm of chromosome 6. These research findings are of great ... is studying possible changes in two genes in the chromosome 6q region. ...

Vet medicine researcher examines link between cancer, Down syndrome

... them a total of three instead of the normal chromosome pair. With improved medical care, people with ... presence of one or more tumor suppressor genes on chromosome 21. However, the identity of such genes has not ... helped us to discover a very important gene on chromosome 21, said Dr. Weston Porter, associate professor ...

Study finds genetic link to human herpes susceptibility

... identify a region on the long arm of human chromosome 21 with high oddsat least 1,000-to-1of being ... of a link between cold sores and the long arm of chromosome 21 to be at least 1,000-to-1. The probable ... said. Therefore, the linkage with the long arm of chromosome 21 came as a surprise. We didnt start with the ...

Evidence found for genes that affect risk of developing Alzheimer's disease

... have already identified three candidate genes on chromosome 10 that is associated with LOAD, and at least one ... and we estimate this locus of three genes on chromosome 10 could be as important, she says. The effect of the chromosome 10 locus could be due to multiple genes, with ...

Genetic Mutations Boost Prostate Cancer Risk

... The five genetic locations include three on chromosome 8q24, one on chromosome 17q12, and one on chromosome 17q24.3, according to the report, published ...

Chromosome Abnormalities Raise Risk for Autism

... Jan. 9 (HealthDay News) -- Abnormalities on chromosome 16 appear to raise children's risk for developing ... New England Journal of Medicine , a section of chromosome 16 is deleted or duplicated in about 1 percent of ... autism. In most cases, the abnormality on the chromosome was not inherited from a parent but occurred ...

JCI table of contents: Dec. 20, 2007

... What tips the balance? Understanding why X chromosome inactivation can be skewed To ensure that ... in the cells of a women is inactive. X chromosome inactivation (XCI) occurs early in development, ... cells stemming from a given cell have the same X chromosome inactivated. Which ...

First look at an enzyme target for antibacterial and cancer drugs

... responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from ... topo II to control the topology of DNA for chromosome segregation and disentanglement. Berger holds ... Failure to properly do so can give rise to chromosome breaks, which in turn can lead to genome ...

Herceptin helps women with multiple chromosomes containing HER2 gene, study finds

... of whether patients have extra copies of chromosome 17, home to the HER2 gene which produces the HER2 ... was to see if patients with more than two chromosome 17s (known as polysomy 17) had a different ... had amplification with two copies (normal) of chromosome 17 did equally well using Herceptin. Their ...
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(Date:12/25/2014)... The report “Nintedanib (Colorectal Cancer) ... on the current treatment landscape, unmet needs, current ... market. Stivarga is a drug which is used ... Boehringer Ingelheim is developing nintedanib (BIBF-1120), an orally ... CRC in the US, Europe, and Japan. The ...
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(Date:12/25/2014)... Angeles, CA (PRWEB) December 25, 2014 The ... Dolcemaschio was created in honor of a true 9/11 ... at two film festivals including the 24 hours of Nuremberg ... Festival in Bangladesh. , Actress, screenwriter and director ... helped produce this film together with her husband, Gregory ...
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(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 ... can receive effective, less expensive care from a clinic that ... team of dedicated health care professionals, a new study shows. ... need either hospitalization or a trip to the emergency room ... at the University of Texas in Houston versus usual care, ...
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