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Apoptosis in Medical News

Critical link in cell death pathway revealed

... found that XIAP (X-chromosome-linked inhibitor of apoptosis protein) is the critical factor that determines ... is FAS, but curiously it does not always activate apoptosis the same way, Professor Strasser said. "One of ... to kill the cells; amplification of the apoptosis signalling pathway is required." Professor ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... just that, by lighting up cells as they die. apoptosis is a carefully orchestrated sequence of ... is possible to noninvasively image the degree of apoptosis occurring in living animals' tumors, and thereby ... diagnostic method is safe for use in humans. apoptosis occurs all the time in healthy bodies. Cells have ...

Amgen Highlights Data to Be Presented at ASCO

... (Monday, June 1, 2009, 5:15pm-5:30pm) apoptosis As part of Amgen's mechanistic approach to targeted cancer therapies, the Company's apoptosis program is focused on the development of highly ... cell death. In cancer, the dysregulation of apoptosis is critical in the development and survival of ...

Cathepsin B increases apoptosis in fulminant hepatic failure

... implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulminant ... cathepsin B expression initiates hepatocyte apoptosis in fulminant hepatic failure. Cathepsin B, a ...

An adjuvant chemotherapeutic agent in gastric cancer therapy

... injection. Morphological changes were observed. apoptosis was determined by transmission electron microscope. apoptosis was also quantified by two methods: the detection ... cancer cell MKN45 were effective in inducing apoptosis in mesothelial cells in a time-dependent manner. ...

Prostaglandin receptor key to atherosclerosis development

... Linton said. The link between macrophage apoptosis and lesion development remains unclear, he said. ... have been some reports that increased macrophage apoptosis in early lesions reduces the lesion area, Linton said. Other studies have suggested that macrophage apoptosis creates a pro-inflammatory environment that ...

Surprise discovery made in cancer research

... In order to do this, they express so-called apoptosis inhibitors (IAPs) among other proteins. Many ... until now, IAPs were well known for their role in apoptosis suppression, but we now realise that they can ... of 'Nature Cell Biology' binds strongly to an apoptosis inhibitor (XIAP). "If we reduce the expression of ...

Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage

... Recognize Conserved Epitopes Associated with apoptosis and Oxidation”, “Angiogenesis and ... in the world they live. The finding suggests that apoptosis generates substances that could stimulate CLL ... Recognize Conserved Epitopes Associated with apoptosis and Oxidation. Rosa Catera and colleagues can be ...

New findings may improve treatment of inherited breast cancer

... progression has been identified. Survivin is an apoptosis inhibitor that is dramatically elevated in many ... allowing BRCA1-deficient cells to overcome apoptosis and undergo malignant transformation. They ... shown to inhibit some types of cancer by inducing apoptosis with very little associated toxicity. In the ...

By amplifying cell death signals, scientists make precancerous cells self-destruct

... Strang Professor and head of the Laboratory of apoptosis and Cancer Biology, is the first to reveal the ... the disease." IAP stands for "inhibitor of apoptosis protein," and these proteins do exactly what ... Steller studied the X-linked inhibitor of apoptosis protein, or XIAP, and the role of its largely ...

Turned-off cannabinoid receptor turns on colorectal tumor growth

... kill cancer cells in lab experiments by inducing apoptosis - programmed cell death. The team confirmed the ... cells with high CB1 expression were sensitive to apoptosis when treated by a cannabinoid agonist. Cell lines ... is associated with poor outcome and reduced apoptosis in colorectal cancer patients. The researchers ...

Clinical study shows biological and clinical activity in relapsed leukemia patients

... trial indicate that single-agent GCS-100 induces apoptosis (programmed cell death) in patients' CLL cells, ... the effects of GCS-100 on various markers of apoptosis and to assess clinical activity and safety. ... evaluate the effect of GCS-100 on biomarkers of apoptosis in patients' CLL cells. Caspases -8 and -9 were ...

JCI table of contents: May 22, 2008

... by mouth markedly decreased photoreceptor apoptosis in the mouse model of retinal detachment. ... their ability to prevent the photoreceptor apoptosis that has a central role in vision loss after ... through inhibition of mitochondrial apoptosis in mice AUTHOR CONTACT: Joan W. Miller ...

Key step in the 'puncture' mechanism of cell death revealed

... cells self-destruction. This insight into how apoptosis starts will assist in the development of drugs that can flick on the apoptosis switch to kill cancer cells more effectively. The ... is also important: to switch off unwarranted apoptosis in degenerative disorders. ...

US honor for professor Jerry Adams

... research has focussed on the control of apoptosis (programmed cell death) and its role in cancer ... is normally regulated give us confidence that the apoptosis machinery can be harnessed to better eliminate ... now attempting to develop drugs that can flip the apoptosis switch, as they offer the prospect of more ...

JCI online early table of contents: March 3, 2008

... 13-cis RA induces a form of cell death known as apoptosis in sebaceous glands, the parts of the skin that ... glands by 13-cis RA. As NGAL was found to mediate apoptosis of human sebaceous glands and to be essential for 13-cis RA to mediate apoptosis of human sebaceous glands, the authors suggested ...

St. Jude Researchers Find Key Step in Programmed Cell Death

... death. Understanding the fine points of apoptosis is important to researchers seeking ways to ... of granulocytes in children, caused by excessive apoptosis of granulocytes, results from a deficiency in one ... as we described in mice," Ihle said. apoptosis rids the body of faulty or unneeded cells. ...

St. Jude researchers find key step in programmed cell death

... cell death. Understanding the fine points of apoptosis is important to researchers seeking ways to ... of granulocytes in children, caused by excessive apoptosis of granulocytes, results from a deficiency in one ... humans as we described in mice, Ihle said. apoptosis rids the body of faulty or unneeded cells. ...

New genetic association with schizophrenia found by researchers

... that a gene, i.e. MEGF10, directly involved in apoptosis is found associated with schizophrenia. It has long been speculated that dysfunction of apoptosis may be a cause of schizophrenia, but there [has been] little direct evidence. apoptosis is an important biological process of programmed ...

Sigma-Aldrich Licenses From NeuroSurvival Technologies a Leading Marker for Molecular Imaging of Apoptosis in Vivo

... developed by NST, for molecular imaging of apoptosis in vitro and in vivo in animals. The marker, ... tomography) and is not part of this agreement. apoptosis (programmed cell death) is a fundamental ... is continuously being performed in the field of apoptosis worldwide, involving thousands of ...

Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology

... sequence 1, or MCL-1, and X-linked Inhibitor of apoptosis Protein, or XIAP, both of which are associated ... survival and proliferation. SNS-032 induces apoptosis in CLL cells, and its activity appears to be ... demonstrates potent and selective induction of apoptosis in primary CLL cells at concentrations that we ...

EpiCept Releases New Data Demonstrating Prolonged Five-Year Leukemia-Free Survival for AML Patients Treated with Ceplene(TM) + IL-2

... formation in phagocytes, completely prevented apoptosis in the T-cell subset (n=8, p<0.0001). In the ... these cytotoxic lymphocytes from apoptosis in an environment of oxidative stress. In ... the risk that the development of our other apoptosis product candidates will not be successful, the ...

How 'IAP antagonist' chemicals kill tumors

... show that these chemicals are capable of inducing apoptosis all on their own. It appears that when you ... in deciding the life-or-death balance. apoptosis or programmed cell death is a cell suicide ... animals, Vucic explained. It is now accepted that apoptosis is also an extremely important defense against ...

Combination targets: some drugs may work best when they work together

... chemically inhibited at the same time, caused apoptosis cell suicide. This combination therapy approach ... farther down the pathway, called TOR, caused apoptosis in the breast cancer cells. One molecule known to ... cancer cell lines with EGFR mutations undergo apoptosis when exposed to erlotinib. In particular, they ...

Human C-reactive protein regulates myeloma tumor cell growth and survival

... protected myeloma cells from chemotherapy-induced apoptosis and apoptosis induced by IL-6 withdrawal. The protective ... cell survival. CRP protects myeloma cells from apoptosis induced by chemotherapy drugs and stimulates ...

Human cells secrete cancer-killing protein, UK study finds

... on the surface of a tumor cell, it triggers a biological process called apoptosis or "cell suicide." Consistent with previous research by Rangnekar's ... effects. However, Rangnekar's most recent study discovered that apoptosis inducible by TRAIL is dependent upon extracellular Par-4 signaling via ...

Novel light-sensitive compounds show promise for cancer therapy

... of cell death known as apoptosis. Also known as "programmed cell death," apoptosis does not lead to the inflammation, pain, and swelling normally associated ... exposure to light quenched the fluorescence, and the cells showed signs of apoptosis within four to eight hours. "That was probably the most exciting day of ...

MicroRNA undermines tumor suppression

... of miRNA125b in the cells, p53 levels and the number of cells undergoing apoptosis (a type of programmed cell death that can be triggered by p53) both ... When she reduced miRNA125b levels in the embryos, cellular p53 levels and apoptosis both increased. "Taking all of this data together, the p53 pathway is ...

Also in the Feb. 10 JNCI

... of human non-small cell lung cancer (NSCLC) tumors and interferes with apoptosis in NSCLC cells grown in culture. Netrin-1 may promote colorectal and ... of the human samples tested. Inhibition of netrin-1 expression induced apoptosis in NSCLC cell lines and reduced tumor growth in animal models. "In ...

Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate

... determine if the technology is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain diseases inflammatory and ischemic ...

Also in the Jan. 27 JNCI

... , 301-496-6641 Benzyl Isothiocyanate Induces apoptosis in Pancreatic Cancer Cells Benzyl isothiocyanate (BITC), a compound found in cruciferous vegetables, induces apoptosis in human pancreatic cancer cells via a mechanism dependent on the protein ...

Dana-Farber Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society

... often is disrupted. Dr. Letai's study, Detecting and Targeting Blocks in apoptosis in Hematologic Malignancies, is designed to identify the molecules that allow cancer cells to proliferate by inhibiting apoptosis in patients with chronic lymphocytic leukemia, acute lymphoblastic ...

Maslinic acid provides a natural defense against colon cancer

... cells. Maslinic acid is a novel natural compound and it is able to induce apoptosis or programmed death in human HT29 colon-cancer cells via the intrinsic ... DNA repair, cell cycle arrest, cell differentiation and the induction of apoptosis in cancer cells. Triterpenoids are compounds present in a wide range ...

Senesco Technologies to Present at 10th Annual Rodman & Renshaw Healthcare Conference

... determine if its technology is applicable in human medicine. Accelerating apoptosis may have applications to the development of cancer treatments. Delaying apoptosis may have applications to certain diseases such as glaucoma, ischemia and ...

Senesco Expands on Preclinical Multiple Myeloma Findings

... Factor 5A technology, encapsulated in nanoparticles, was able to induce apoptosis in multiple myeloma tumors when injected intratumorally. Senesco has ... line studies, Senesco determined that its siRNA may sensitize cells for apoptosis through a reduction in activation of NFkB, a key inflammatory ...

Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting

... inhibitor of Bcl-2 family proteins. The Bcl-2 family proteins regulate apoptosis (programmed cell death), the natural process by which damaged or unwanted ... interested in the Bcl-2 family of proteins since their role in preventing apoptosis -- the natural process by which damaged or unwanted cells die and are ...

JCI online early table of contents: April 8, 2008

... HBV expressed the proapoptotic protein Bim and that blocking Bim-mediated apoptosis increased the number of HBV-specific CD8+ T cells both in culture and directly ex vivo. The authors therefore suggest that Bim-mediated apoptosis of HBV-specific CD8+ T cells contributes to the inability of these cells ...

FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis

... in treating cancer. The results for FASgen's C-93 demonstrated significant apoptosis in SKOV3 and A2780 cell lines, i.e., > 70% within 48 hours. Similar ... resistant cell lines indicating that FAS inhibitors produce significant apoptosis to overcome hypoxia-induced chemoresistance. These in vitro data confirm ...

A tricky tumor virus

... scientists made the surprising observation that TRADD can no longer induce apoptosis if it is activated by the viral protein LMP1. How does Epstein-Barr virus manage to switch off the apoptosis function of TRADD? Kieser and his colleagues discovered that the LMP1 ...

FOXO factor promotes survival of oxygen-deprived cancer cells

... observed that under hypoxic conditions, FOXO3a inhibited HIF-1 induced apoptosis in normal cells and breast cancer cells by stimulating the transcription ... inhibition of HIF1 or very low levels that would permit HIF1- induced apoptosis under hypoxic stress. ...
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