Critical link in cell death pathway revealed
... found that XIAP (X-chromosome-linked inhibitor of apoptosis
protein) is the critical factor that determines ... is FAS, but curiously it does not always activate apoptosis
the same way, Professor Strasser said. "One of ... to kill the cells; amplification of the apoptosis
signalling pathway is required."
Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows
... just that, by lighting up cells as they die.
is a carefully orchestrated sequence of ... is possible to noninvasively image the degree of apoptosis
occurring in living animals' tumors, and thereby ... diagnostic method is safe for use in humans.
occurs all the time in healthy bodies. Cells have ...
Amgen Highlights Data to Be Presented at ASCO
... (Monday, June 1, 2009, 5:15pm-5:30pm)
As part of Amgen's mechanistic approach to targeted cancer therapies, the Company's apoptosis
program is focused on the development of highly ... cell death. In cancer, the dysregulation of apoptosis
is critical in the development and survival of ...
Cathepsin B increases apoptosis in fulminant hepatic failure
... implicates a dominant role for hepatocyte apoptosis
in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis
is involved in the pathogenesis of fulminant ... cathepsin B expression initiates hepatocyte apoptosis
in fulminant hepatic failure.
Cathepsin B, a ...
An adjuvant chemotherapeutic agent in gastric cancer therapy
... injection. Morphological changes were observed. apoptosis
was determined by transmission electron microscope. apoptosis
was also quantified by two methods: the detection ... cancer cell MKN45 were effective in inducing apoptosis
in mesothelial cells in a time-dependent manner. ...
Prostaglandin receptor key to atherosclerosis development
... Linton said.
The link between macrophage apoptosis
and lesion development remains unclear, he said. ... have been some reports that increased macrophage apoptosis
in early lesions reduces the lesion area, Linton said. Other studies have suggested that macrophage apoptosis
creates a pro-inflammatory environment that ...
Surprise discovery made in cancer research
... In order to do this, they express so-called apoptosis
inhibitors (IAPs) among other proteins.
Many ... until now, IAPs were well known for their role in apoptosis
suppression, but we now realise that they can ... of 'Nature Cell Biology' binds strongly to an apoptosis
inhibitor (XIAP). "If we reduce the expression of ...
Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
... Recognize Conserved Epitopes Associated with apoptosis
and Oxidation”, “Angiogenesis and ... in the world they live. The finding suggests that apoptosis
generates substances that could stimulate CLL ... Recognize Conserved Epitopes Associated with apoptosis
and Oxidation. Rosa Catera and colleagues can be ...
New findings may improve treatment of inherited breast cancer
... progression has been identified. Survivin is an apoptosis
inhibitor that is dramatically elevated in many ... allowing BRCA1-deficient cells to overcome apoptosis
and undergo malignant transformation.
They ... shown to inhibit some types of cancer by inducing apoptosis
with very little associated toxicity. In the ...
By amplifying cell death signals, scientists make precancerous cells self-destruct
... Strang Professor and head of the Laboratory of apoptosis
and Cancer Biology, is the first to reveal the ... the disease."
IAP stands for "inhibitor of apoptosis
protein," and these proteins do exactly what ... Steller studied the X-linked inhibitor of apoptosis
protein, or XIAP, and the role of its largely ...
Turned-off cannabinoid receptor turns on colorectal tumor growth
... kill cancer cells in lab experiments by inducing apoptosis
- programmed cell death. The team confirmed the ... cells with high CB1 expression were sensitive to apoptosis
when treated by a cannabinoid agonist. Cell lines ... is associated with poor outcome and reduced apoptosis
in colorectal cancer patients. The researchers ...
Clinical study shows biological and clinical activity in relapsed leukemia patients
... trial indicate that single-agent GCS-100 induces apoptosis
(programmed cell death) in patients' CLL cells, ... the effects of GCS-100 on various markers of apoptosis
and to assess clinical activity and safety. ... evaluate the effect of GCS-100 on biomarkers of apoptosis
in patients' CLL cells. Caspases -8 and -9 were ...
JCI table of contents: May 22, 2008
... by mouth markedly decreased photoreceptor apoptosis
in the mouse model of retinal detachment. ... their ability to prevent the photoreceptor apoptosis
that has a central role in vision loss after ... through inhibition of mitochondrial apoptosis
Joan W. Miller
Key step in the 'puncture' mechanism of cell death revealed
... cells self-destruction.
This insight into how apoptosis
starts will assist in the development of drugs that can flick on the apoptosis
switch to kill cancer cells more effectively. The ... is also important: to switch off unwarranted apoptosis
in degenerative disorders.
US honor for professor Jerry Adams
... research has focussed on the control of apoptosis
(programmed cell death) and its role in cancer ... is normally regulated give us confidence that the apoptosis
machinery can be harnessed to better eliminate ... now attempting to develop drugs that can flip the apoptosis
switch, as they offer the prospect of more ...
JCI online early table of contents: March 3, 2008
... 13-cis RA induces a form of cell death known as apoptosis
in sebaceous glands, the parts of the skin that ... glands by 13-cis RA. As NGAL was found to mediate apoptosis
of human sebaceous glands and to be essential for 13-cis RA to mediate apoptosis
of human sebaceous glands, the authors suggested ...
St. Jude Researchers Find Key Step in Programmed Cell Death
... death. Understanding the fine points of apoptosis
is important to
researchers seeking ways to ... of granulocytes in children, caused
by excessive apoptosis
of granulocytes, results from a deficiency in one ... as we described in mice," Ihle said.
rids the body of faulty or unneeded cells. ...
St. Jude researchers find key step in programmed cell death
... cell death. Understanding the fine points of apoptosis
is important to researchers seeking ways to ... of granulocytes in children, caused by excessive apoptosis
of granulocytes, results from a deficiency in one ... humans as we described in mice, Ihle said.
rids the body of faulty or unneeded cells. ...
New genetic association with schizophrenia found by researchers
... that a gene, i.e. MEGF10, directly involved in apoptosis
is found associated with schizophrenia. It has long been speculated that dysfunction of apoptosis
may be a cause of schizophrenia, but there [has been] little direct evidence. apoptosis
is an important biological process of programmed ...
Sigma-Aldrich Licenses From NeuroSurvival Technologies a Leading Marker for Molecular Imaging of Apoptosis in Vivo
... developed by NST,
for molecular imaging of apoptosis
in vitro and in vivo in animals. The
marker, ... tomography) and is
not part of this agreement.
(programmed cell death) is a fundamental ... is continuously being performed
in the field of apoptosis
worldwide, involving thousands of ...
Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology
... sequence 1, or MCL-1, and X-linked
Inhibitor of apoptosis
Protein, or XIAP, both of which are associated ... survival and proliferation. SNS-032 induces apoptosis
cells, and its activity appears to be ... demonstrates potent and selective induction of apoptosis
primary CLL cells at concentrations that we ...
EpiCept Releases New Data Demonstrating Prolonged Five-Year Leukemia-Free Survival for AML Patients Treated with Ceplene(TM) + IL-2
... formation in phagocytes, completely prevented apoptosis
T-cell subset (n=8, p<0.0001). In the ... these cytotoxic lymphocytes from apoptosis
in an environment of
oxidative stress. In ... the risk that the development of our other apoptosis
candidates will not be successful, the ...
How 'IAP antagonist' chemicals kill tumors
... show that these chemicals are capable of inducing apoptosis
all on their own.
It appears that when you ... in deciding the life-or-death balance.
or programmed cell death is a cell suicide ... animals, Vucic explained. It is now accepted that apoptosis
is also an extremely important defense against ...
Combination targets: some drugs may work best when they work together
... chemically inhibited at the same time, caused apoptosis
cell suicide. This combination therapy approach ... farther down the pathway, called TOR, caused apoptosis
in the breast cancer cells. One molecule known to ... cancer cell lines with EGFR mutations undergo apoptosis
when exposed to erlotinib. In particular, they ...
Human C-reactive protein regulates myeloma tumor cell growth and survival
... protected myeloma cells from chemotherapy-induced apoptosis
induced by IL-6 withdrawal. The protective ... cell survival. CRP protects myeloma cells from apoptosis
induced by chemotherapy drugs and stimulates ...
Human cells secrete cancer-killing protein, UK study finds
... on the surface of a tumor cell, it triggers a biological process called apoptosis
or "cell suicide." Consistent with previous research by Rangnekar's ... effects. However, Rangnekar's most recent study discovered that apoptosis
inducible by TRAIL is dependent upon extracellular Par-4 signaling via ...
Novel light-sensitive compounds show promise for cancer therapy
... of cell death known as apoptosis. Also known as "programmed cell death," apoptosis
does not lead to the inflammation, pain, and swelling normally associated ... exposure to light quenched the fluorescence, and the cells showed signs of apoptosis
within four to eight hours.
"That was probably the most exciting day of ...
MicroRNA undermines tumor suppression
... of miRNA125b in the cells, p53 levels and the number of cells undergoing apoptosis
(a type of programmed cell death that can be triggered by p53) both ... When she reduced miRNA125b levels in the embryos, cellular p53 levels and apoptosis
"Taking all of this data together, the p53 pathway is ...
Also in the Feb. 10 JNCI
... of human non-small cell lung cancer (NSCLC) tumors and interferes with apoptosis
in NSCLC cells grown in culture.
Netrin-1 may promote colorectal and ... of the human samples tested. Inhibition of netrin-1 expression induced apoptosis
in NSCLC cell lines and reduced tumor growth in animal models.
Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate
... determine if the technology is applicable in human medicine. Accelerating apoptosis
may have applications to development of cancer treatments. Delaying apoptosis
may have applications to certain diseases inflammatory and ischemic ...
Also in the Jan. 27 JNCI
... , 301-496-6641
Benzyl Isothiocyanate Induces apoptosis
in Pancreatic Cancer Cells
Benzyl isothiocyanate (BITC), a compound found in cruciferous vegetables, induces apoptosis
in human pancreatic cancer cells via a mechanism dependent on the protein ...
Dana-Farber Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society
... often is disrupted. Dr. Letai's study, Detecting and Targeting Blocks in apoptosis
in Hematologic Malignancies, is designed to identify the molecules that allow cancer cells to proliferate by inhibiting apoptosis
in patients with chronic lymphocytic leukemia, acute lymphoblastic ...
Maslinic acid provides a natural defense against colon cancer
... cells. Maslinic acid is a novel natural compound and it is able to induce apoptosis
or programmed death in human HT29 colon-cancer cells via the intrinsic ... DNA repair, cell cycle arrest, cell differentiation and the induction of apoptosis
in cancer cells.
Triterpenoids are compounds present in a wide range ...
Senesco Technologies to Present at 10th Annual Rodman & Renshaw Healthcare Conference
... determine if its technology is applicable
in human medicine. Accelerating apoptosis
may have applications to the
development of cancer treatments. Delaying apoptosis
may have applications
to certain diseases such as glaucoma, ischemia and ...
Senesco Expands on Preclinical Multiple Myeloma Findings
... Factor 5A technology, encapsulated in nanoparticles, was
able to induce apoptosis
in multiple myeloma tumors when injected
Senesco has ... line studies, Senesco determined that
its siRNA may sensitize cells for apoptosis
through a reduction in
activation of NFkB, a key inflammatory ...
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
... inhibitor of Bcl-2 family
proteins. The Bcl-2 family proteins regulate apoptosis
death), the natural process by which damaged or unwanted ... interested in the Bcl-2 family of proteins since
their role in preventing apoptosis
-- the natural process by which damaged
or unwanted cells die and are ...
JCI online early table of contents: April 8, 2008
... HBV expressed the proapoptotic protein Bim and that blocking Bim-mediated apoptosis
increased the number of HBV-specific CD8+ T cells both in culture and directly ex vivo. The authors therefore suggest that Bim-mediated apoptosis
of HBV-specific CD8+ T cells contributes to the inability of these cells ...
FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis
... in treating
cancer. The results for FASgen's C-93 demonstrated significant apoptosis
SKOV3 and A2780 cell lines, i.e., > 70% within 48 hours. Similar ... resistant cell lines indicating
that FAS inhibitors produce significant apoptosis
hypoxia-induced chemoresistance. These in vitro data confirm ...
A tricky tumor virus
... scientists made the surprising observation that TRADD can no longer induce apoptosis
if it is activated by the viral protein LMP1.
How does Epstein-Barr virus manage to switch off the apoptosis
function of TRADD? Kieser and his colleagues discovered that the LMP1 ...
FOXO factor promotes survival of oxygen-deprived cancer cells
... observed that under hypoxic conditions, FOXO3a inhibited HIF-1 induced apoptosis
in normal cells and breast cancer cells by stimulating the transcription ... inhibition of HIF1 or very low levels that would permit HIF1- induced apoptosis
under hypoxic stress.