Dendritic cells ensure immune tolerance
... surface for recognizing just one single antigen. antigens
are molecular structures, mostly fragments of ... they rely on other cells which can present antigens
to them. It is the dendritic cells that are ... other things, they are specialized in presenting antigens
to T cells, which is what makes an immune ...
TB breakthrough could lead to stronger vaccine
... been made to improve the vaccine by incorporating antigens
(molecular components of the bacteria) to induce ... at Houston.
Tuberculosis hides in cells so the antigens
are not recognized by the immune system. The BCG ... movement of particles in cells, would cause BCG antigens
to enter pathways leading to improved ...
Frost & Sullivan Lauds Aesku.Diagnostics For Providing an Overall Analysis Platform For a Wide Range of Autoimmune Complications
... tests are developed based on human recombinant antigens
or native antigens
(conformational epitopes) depending on the ... CE marked kits incorporating human recombinant antigens
synthesized in-house to assure maximum ...
NIH scientists discover crucial control in long-lasting immunity
... displayed on the surface of the B cell. These antigens
signal to T cells, which have specialized receptors that can bind to antigens
on the B cells. Thus coupled, the T cells deliver ... SAP do not bind strongly to B cells carrying antigens
the T cells otherwise could recognize.
Also in the June 24 JNCI
... Intestinal Proteins May Be Effective Anti-Tumor antigens
Mice immunized with an intestinal protein ... the development of cancer vaccines by a lack of antigens
that are specific for tumors and not expressed elsewhere in the body. Immunization with antigens
that are expressed elsewhere in the body raises ...
Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show
... is the lack of immune system-alerting protein antigens
that are specific for tumors only. According to ... and metastasize, carrying with them all the antigens
that typically reside in the mucosal system. They ... researchers suggest that this approach of using antigens
from tumors originating in immune-restricted ...
New study shows potential to treat or prevent viral cancers
... that radioimmunotherapy (RIT) targeting viral antigens
offers a novel option to treator even preventmany ... by targeting cancer cells expressing viral antigens
or infected cells before they convert into ... N.Y. and lead researcher of the study, Viral antigens
as Novel Targets for Radioimmunotherapy of Viral ...
Novel vaccine concept developed by scientists at the Wistar Institute
... These sentinel cells monitor the body for foreign antigens
molecules that can stimulate an immune response ... fusing the glycoprotein D with genes from target antigens
increase the immune systems response to those antigens
in cell cultures and laboratory mice. The ...
Improved diagnosis of cutaneous leishmaniasis thanks to new techniques
... in developing countries. Therefore, different antigens
were also compared in a serological test (ELISA) ... caused by Leishmania guyanensis. The use of antigens
for this species of Leishmania significantly improved the serological test compared to antigens
from other species. These results could be ...
New strategies work to put cancer on the firing line
... infections such as tuberculosis.
It is antigens
proteins on or in all cells that get the attention of the immune system. Dendritic cells present antigens
to T cells so that the host immune system will be ... researchers at Sloan-Kettering are taking key antigens
and modifying them just enough to get the ...
Einstein scientists treat cancer as an infectious disease -- with promising results
... (caused by the Epstein-Barr virus). But while antigens
on the surface of cells are susceptible to attack by antibodies, the viral antigens
associated with cancers typically lurk inside ... in dead tumor cells that might spill their viral antigens
amongst the living cancer cells, says Dr. Arturo ...
Bird Flu Virus Can Infect Fetus
They detected H5N1 genetic material and antigens
in the lungs, certain cells in the trachea, the ... in the intestinal mucosa but did not find any antigens
The dead woman's fetus had H5N1 genetic material and antigens
in the lungs, circulating cells of the immune ...
Scientists Spot Key to Kidney Transplant Success
... incompatibility or because of human leukocyte antigens
(HLA) antigen sensitization.
HLAs, which are ... normal body tissue and foreign substances. antigens
vary from person to person, and HLA typing helps determine how many antigens
a donor shares with a recipient. If individuals ...
Goodbye needle, hello smoothie
... to the gut is the most logical route.
"Nature isn't used to seeing antigens
injected into a muscle," said Barrett, who also is a physician at ... your immune system is designed to encounter and mount a defense against antigens
is your gut."
Novel prostate cancer vaccine taking aim at cancer cell 'sweet spot'
... specifically small carbohydrates called tumor-associated carbohydrate antigens
(TACA) expressed on carcinoma cell surfaces. Ideally, this recognition ... she said, noting that tumor cells can use sugar or carbohydrate antigens
to spread. "If ultimately proven successful, this could be used in a first ...
Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies
... histocompatibility complex class II proteins involved in presentation of antigens
to T helper cells work in mouse glial cells, and to identify substrates in central nervous system inflammation as candidate target antigens
in this process. Results may eventually be applied in studies involving ...
Mom's Cells Prime Fetal Immune System
... two coexist by making the fetus' immune system able to tolerate foreign antigens
and could lead to new techniques in stem cell treatments and ways to deal ... a specific role in mediating immune tolerance to both self and foreign antigens
encountered during fetal development, Mold said.
"Little is currently ...
The miseries of allergies just may help prevent some cancers, study finds
... natural venoms and toxins and other potentially carcinogen-carrying antigens
before they can trigger neoplasia [the abnormal proliferation of cells]." ... because they promote the expulsion of toxins and carcinogen-carrying antigens
is also consistent with studies that find that people who express allergy ...
Gender Plays Role in Kidney Transplant Outcomes
The study was published in this week's issue of The Lancet .
can no longer be ignored in the setting of solid-organ transplantation. A lot of work still needs to be done on the actual antigens
and the immunological responses that might be associated with rejection. ...
Penn animal study identifies new DNA weapon against avian flu
... against avian flu. By delivering vaccine via DNA constructed to build antigens
against flu, along with a minute electric pulse, researchers have ... becomes part of the cell, giving it the blueprint it needs to build antigens
that can induce responses that target diverse strains of pandemic flu.
Study finds unique HIV vaccine formula elicits strong immune responses
... received three injections of a DNA vaccine which expresses protective antigens
from the HIV virus, followed by two injections of a protein vaccine whose ... volunteers sera were able to recognize each of a very diverse group of Env antigens
that were included in this study. More significantly, the majority of ...
New TB test means quicker and easier diagnosis for patients
... This is secreted by T cells in the immune system when they encounter antigens
found in the bacterium mycobacterium tuberculosis, which causes most cases ... to distinguish TB infection from BCG vaccination because it uses special antigens
that only pick out the T cells that are induced by TB infection, and not ...
A new more effective tuberculosis screening test for HIV victims
... of T-cells secretion of interferon- when challenged with antigens
specific to Mycobacterium tuberculosis, the bacterium causing ... based on measurement of the immune response to M. tuberculosis-specific antigens
can serve as a reliable diagnostic method for TB infection in geographical ...
New target for cancer therapy may improve treatment for solid tumors
... stroma, the layers of cells that surround a tumor, can accumulate tumor antigens
and present them on their surface. These genetically stable surrounding ... other, healthy cells in tissues like the spleen could also pick up the antigens
and become a target for T cells, said Zhang. We did not see this," he ...
A functional immune system can be derived from embryonic stem cells, preliminary study finds
... bone marrow, umbilical cord blood, and peripheral blood from donors. The antigens
on the surface of donated cells must be compatible (determined by a method ... rejection. The use of embryonic stem cells, which have low levels of these antigens
and may therefore be less likely to provoke a defensive reaction by the ...
ImmunoVaccine Technologies Inc. to Acquire Immunotope Inc.
platform with Immunotope's portfolio of immunotherapeutic antigens
antigen discovery platform, allowing the new private company to create ... prophylactic vaccines. Therapeutic cancer
vaccines that combine the right antigens
with a powerful delivery system
have the potential to treat cancer early ...
Antibody responses in patients with Lyme arthritis
... level of antibody titers to Borrelia burgdorferi and most outer-surface antigens
increased slightly during the first 1 to 3 months of treatment. These ... ridding the body of the Borrelia burgdorferi bacteria and its surface antigens
does not always bring relief from arthritis. Increasing antibody titers ...
Sanofi Pasteur and Institut Pasteur Team up Against Malaria
... the most deadly malaria infections. Sanofi Pasteur
intends to use these antigens
with the goal of developing a safe and
efficacious candidate vaccine ... sub-Saharan Africa. "Institut Pasteur has discovered several promising antigens
last decade that we believe could lead to malaria vaccines to ...
Rapid Swine Flu Test Misses Many Infections
... and Mortality Weekly Report , CDC researchers tested three commercially available rapid influenza diagnostic tests that can identify influenza A or B antigens
in about 15 minutes. Respiratory samples were used from 65 people known to have swine flu or seasonal flu.
The tests were able to detect the H1N1 ...
GenVec Receives Grant for Malaria Vaccine Program
... head of GenVec's malaria program.
This grant, valued at approximately $600,000 over two years, will be used to identify new immunogenic antigens
for malaria vaccine development. Using the funding from this grant, GenVec will be collaborating with the U.S. Naval Medical Research Center (NMRC) ...
Eleven Veterinary Students Win Top Awards at Morris Animal Foundation's Annual Research Competition
... Place for Wildlife, $1,500
Santiago Diaz, University of Florida
D07ZO-607 : "Use of Elephant-Specific Monoclonal Antibodies and Recombinant antigens
of Mycobacterium tuberculosis to Improve an ELISA Test for Elephants"
IMPACT Award, $500
Ana Iris Mota Torres, University of Veracruz ...
Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009
Additionally, our proprietary DVD-Ig technology represents an innovative approach that can target multiple disease-causing antigens
with a single biologic agent. This technology could lead to combination biologics for complex conditions such as cancer or rheumatoid arthritis, ...
Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models
... that leads to other fatal complications in people with the condition.
In the study, one group of experimental mice was vaccinated with Sm (Smith antigens
that are small nuclear ribonucleoproteins: snRNPs) lupus autoantigen in combination with IL-10 and another group vaccinated with the same antigen and ...
CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses
... This data demonstrates that vaccines utilizing its L.E.A.P.S. vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens
can elicit immune responses that would be protective against tuberculosis and have the potential to treat swine and other H1N1 influenzas. The ...
Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Inc's. GCS-100 Molecule
... the Brussels Branch of the Ludwig Institute has found that human tumors contain a large number of T lymphocytes which are directed against specific antigens
of the tumor cells, but that these lymphocytes are in a state of paralysis. An important component of this paralysis appears to be the trapping of T ...
Ortho Biotech Oncology Research & Development Announces Collaboration with National Cancer Institute to Develop Novel Cell Therapies to Treat Cancer
... Biotech Oncology Research & Development independently developed a different and proprietary adoptive immunotherapeutic approach that uses tumor antigens
and other materials to stimulate T cells from a patient's blood to become Cytotoxic T Lymphocytes (CTLs), which recognize and attack tumor cells. ...
Vaccine shows therapeutic promise against advanced melanoma
... works by stimulating patients' T cells, known for controlling immune responses.
"This vaccine activates the body's cytotoxic T cells to recognize antigens
on the surface of the tumor. The T cells then secrete enzymes that poke holes in the tumor cell's membrane, causing it to disintegrate," explained ...
Experts Optimistic About Melanoma Vaccine
... (200M), works by stimulating T-cells, which control immune response.
"This vaccine activates the body's cytotoxic T-cells to recognize antigens
on the surface of the tumor," Hwu said. "The T-cells then secrete enzymes that poke holes in the tumor cell's membrane, causing it to disintegrate." ...
Strategic Diagnostics Appoints Kevin J. Bratton as Chief Financial Officer
... its successful customer-focused research and development efforts. Recent innovations in high throughput production of antibodies from genetic antigens
will complement the Company's established leadership in commercial and custom antibody production for the Research, Human/Animal Diagnostics, and ...
Computer simulation captures immune response to flu
... adjuvants drugs that strengthen vaccines but have no effect alone are available that enhance the ability of dendritic cells to present viral antigens
to T cells.
Experiments on the effects of anti-viral drugs on a "flu-infected" virtual immune system also accurately predicted that lowering the ...