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Antibodies in Medical News

Micromet, Inc. Reports Second Quarter 2009 Financial Results

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... of preclinical data on EGFR-targeting BiTE antibodies as well as Micromet's BiTE antibody MT110, which ... in vivo and in vitro of EGFR-targeting BiTE antibodies against KRAS- and BRAF-mutated human colorectal ...

Anti-growth factor drugs raise hope and concern for treatment of children's eye diseases

... Calif., discusses issues related to the use of antibodies against vascular endothelial growth factor (VEGF) in pediatric ophthalmology. The two anti-VEGF antibodies available so farbevacizumab and ranibizumabhave ... cause of vision loss in older adults. The antibodies work by blocking the development of new blood ...

Bcl6 gene sculpts helper T cell to boost antibody production

... that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune ... the B cells expand and produce a large volume of antibodies to destroy an intruder. Tfh cells are ... said. "These mutations also allow production of antibodies with stronger affinity for their target ...

Tips from the journals of the American Society for Microbiology

... deadly form of skin cancer, in mice by eliciting antibodies that target a gastrin-releasing peptide which is ... cell production and tumor formation. Anti-GRP antibodies have displayed promising antitumoral activity and ... injections induced high levels of specific antibodies against GRP as well as suppressed the growth of ...

QuikByte Software, Inc. and Sorrento Therapeutics, Inc. Announce Merger Agreement

... into the growing pharmaceutical field of human antibodies with an experienced team led by Drs. Schuh and ... for the generation of fully human monoclonal antibodies based on its proprietary technology. Sorrento ... provider and developer of fully human monoclonal antibodies for research, diagnostic and therapeutic use. ...

Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2009

... us to expand the evaluation of our anti-PS antibodies as potential broad spectrum agents for the ... contract to assess bavituximab and other anti-PS antibodies for biodefense applications against viral ... broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids, ...

Caltech chemists say antibody surrogates are just a 'click' away

... that have the potential to take the place of the antibodies used in many standard medical diagnostic tests. ... say, 200 proteins in the barcode chip is that the antibodies that you use to detect the proteins are unstable ... says Heath. "We have been frustrated with antibodies for a long time, so what we wanted to be able to ...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform

... Claims Cover Use of Phosphatidylserine-Targeting antibodies to Image Solid Tumors and Other Malignancies -- ... by Published Data Showing Utility of PS-Targeting antibodies for the Molecular Imaging of Cancer -- ... in patients with cancer. "PS-targeting antibodies such as bavituximab preferentially bind to tumor ...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine

... generate infection-fighting proteins called antibodies that either block infection or help eliminate the ... Attempts to create a vaccine that induces antibodies that prevent HIV infection or disease, however, ... for people infected with HIV to naturally make antibodies that can neutralize a variety of HIV strains. ...

Anxiety and depression lower quality of life in majority of systemic lupus erythematosus patients

... in 39.3% of the patients) Antiphospholipid antibodies (a disorder of coagulation) (identified in 66.1% ... Clinics (SLICC) damage indexes, antiphospholipid antibodies and hyperhomocysteinemia were recorded for all ... occurs as a result of the production of abnormal antibodies that target and cause damage to cells of the ...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

... SLE was induced in the mice and the levels of antibodies against various lupus autoantibodies were analysed. The study found that levels of anti-Sm antibodies in the IL-10 vaccinated group were lower than ... mechanisms that regulate the production of these antibodies are poorly understood, however, the results of ...

Vaccine Shields Monkeys From Simian Form of HIV

... long time have been able to naturally develop antibodies that neutralize a lot of the circulating virus," ... we could take the genes that represent these antibodies 'off the shelf,' so to speak, give them directly ... inserting genes already known to express anti-SIV antibodies directly into the monkeys' muscles. Once the ...

Recent developments at Burnham Institute for Medical Research, May 2009

... Human monoclonal antibodies effective against bird and seasonal flu viruses ... reported the identification of human monoclonal antibodies that neutralize an unprecedented range of ... and some seasonal influenza viruses. These antibodies have the potential for use in combination with ...

Micromet, Inc. Reports First Quarter 2009 Financial Results

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... Its product development pipeline includes novel antibodies generated with its proprietary BiTE(R) antibody ...

Gray matter under attack in multiple sclerosis

... which proteins in human brain tissue the antibodies of MS patients dock onto, instead of docking onto ... triggers an immune response in which T-cells and antibodies turn against this molecule," reports Meinl. "In ... normally not get past. "Without this barrier, the antibodies were able to invade the brain in great numbers, ...

Medarex to Receive Milestone Payment for Approval of SIMPONI(TM) for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... Howard H. Pien, Chairman and CEO of Medarex. "As antibodies continue to grow as a source of breakthrough ... UltiMAb(R) technology for the generation of human antibodies in 1997. The agreement was expanded in 2000 and ... access to Medarex's UltiMAb(R) technology. Other antibodies generated from Medarex's UltiMAb(R) technology in ...

Medarex Highlights Oncology Pipeline at Needham Cancer Therapeutics Conference in New York City

... MDX-1105 and MDX-1106 are two fully human antibodies that target the PD-L1/PD-1 pathway for the ... promising products outside of oncology, including antibodies to IP-10 and CD19 for inflammation and antibodies for infectious diseases. Throughout this year and ...

Study Suggests Blood Test for Alzheimer's Possible

... a direct relationship between two specific antibodies and the severity of Alzheimer's disease symptoms, ... a direct relationship between two specific antibodies and the severity of Alzheimer's disease ... consistent relationship between two particular antibodies and the level of impairment," said study ...

Study suggests blood test for Alzheimer's possible

... a direct relationship between two specific antibodies and the severity of Alzheimer's disease symptoms, ... consistent relationship between two particular antibodies and the level of impairment," said study ... Alzheimer's Research Center. The team focused on antibodies that the body creates in response to two proteins ...

Scripps research scientists engineer new type of vaccination that provides instant immunity

... the adapter molecules self-assembled with the antibodies to create covalent antibody-adapter complexes. "The antibodies in our vaccine are designed to circulate inertly ... is that it opens up the possibility of having antibodies primed and ready to go in the time it takes to ...

AnaptysBio Selects Gable PR of San Diego for National Communications Program During Key Phase in Growth

... developed a platform for generating therapeutic antibodies that is unique in the field. The platform mimics ... and selection processes for creating potent antibodies to fight disease. As a result, AnaptysBio believes the antibodies generated by its platform will result in ...

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

... A viruses. Because large quantities of monoclonal antibodies can be made relatively quickly, after more testing, these influenza-specific monoclonal antibodies potentially could be used in combination with ... event of an influenza pandemic, human monoclonal antibodies could be an important adjunct to antiviral drugs ...

Scientists May Have New Way to Fight the Flu

... range of flu strains. "We identified new human antibodies that inactivate influenza, not just bird flu, but ... and the Dana-Farber Cancer Institute. The antibodies recognize a new part of the influenza virus and ... target, new mechanism, new human antibodies." antibodies can be used as drugs, he noted, adding that drugs ...

JCI online early table of contents: Feb. 16, 2009

... NEUROBIOLOGY: antibodies hidden potential to damage nerves unmasked ... with the presence of specific immune factors: antibodies that recognize molecules known as GM1 gangliosides. Whether these antibodies actually cause disease has been hotly debated. ...

Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference

... is focused on developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... antibody platform, representing a new class of antibodies that specifically activate T cells from the ... disease related cells. Four of the Company's antibodies are currently in clinical trials, with the ...

New test may help to ensure that dengue vaccines do no harm

... people infected with their first dengue serotype, antibodies bind tightly to the viral surface and escort the ... system then stores away a few of the successful antibodies in case that same virus is ever encountered ... encounters a second dengue serotype, however, the antibodies from the first infection do not attach as ...

Landmark Rh Immune Globulin Celebrates 40 Years of Saving Babies' Lives

... Rh-negative women become sensitized and make antibodies that attack the blood of the Rh-positive ... globulin products prevent the body from making antibodies that would destroy Rh-positive cells in future ... during treatment of patients with high-titered antibodies to IgA, the attending physician must weigh the ...

GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer

... from the binding sites targeted by other CD20 antibodies currently available.(10) The CD20 molecule is a ... into plasma cells, which make antibodies. These antibodies directly inactivate pathogens or attach to ... The Biological Activity of Human CD20 Monoclonal antibodies Is Linked to Unique Epitopes on CD20. J Immunol. ...

New Data Published in Immunobiology Describe Mode of Action of BiTE Antibody MT110

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... this study is expected to be identical for BiTE antibodies targeting other surface targets, and shows that ... (ASH) in San Francisco. About BiTE antibodies ...

UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases

... transplant rejection. The research identified antibodies from a woman's immune system that prevent ... Based on studies in which the woman's antibodies were transferred into mice, researchers hope these antibodies can be used to treat patients with autoimmunity ...

InNexus Biotechnology Completes Preclinical Study Confirming in Vivo Effectiveness and Safety of Lead Candidate DXL625, Schedules Meeting With FDA

... commercializing the next generation of monoclonal antibodies based on its Dynamic Cross Linking (DXL(TM)) ... commercializing the next generation of monoclonal antibodies based on its DXL(TM) technology, which improves ... new markets and disease applications. DXL(TM) antibodies utilize unique, novel and patented methods and ...

Intellect Neurosciences, Inc. Grants to Top Tier Global Pharmaceutical Company License to Certain Alzheimer's Patents and Patent Applications

... patents and patent applications related to antibodies and methods of treatment for Alzheimer's disease ... patent estate relating to the use of monoclonal antibodies designed to slow or arrest progression of the ... potential for adverse side-effects by generating antibodies that bind only the toxic beta amyloid and not the ...

BioMarin and La Jolla Pharmaceutical Sign Worldwide (Excluding Asia Pacific) Development and Commercialization Agreement for Riquent

... of kidney disease in lupus patients, antibodies to double stranded DNA. Mr. Bienaime ... reduces circulating levels of anti-dsDNA antibodies and is also designed to specifically suppress the ... that make these antibodies. Decreases in these antibodies are believed to be associated with a decreased ...

Alexion Pharmaceuticals and PDL BioPharma Resolve Patent Dispute

... to commercialize additional Alexion humanized antibodies that may be covered by the Queen patents in the ... revolutionize the development of therapeutic antibodies to treat patients with previously untreatable and ... was a leader in the humanization of monoclonal antibodies and enabled the discovery of a new generation of ...

Hopkins-led team solves failed vaccine mystery

... researchers said, the problem occurred when the antibodies created by the vaccine failed to successfully ... receptor activation to see if it would created antibodies better equipped to bind to and neutralize the ... form of the inactivated vaccine produced antibodies with better binding and virus-neutralizing ...

Medarex to Receive Milestone Payment for Approval of STELARA(TM) (Ustekinumab) for the Treatment of Moderate to Severe Plaque Psoriasis

... role of Medarex in enabling human monoclonal antibodies in expanding treatment options for patients with ... UltiMAb(R) technology for the generation of human antibodies in 1997. The agreement was expanded in 2000 to ... access to Medarex's UltiMAb(R) technology. Other antibodies generated from Medarex's UltiMAb(R) technology in ...

Micromet, Inc. to Host Webcast and Conference Call to Discuss Blinatumomab Data Presented at American Society of Hematology Annual Meeting

... The Company is developing novel, proprietary antibodies for the treatment of cancer, inflammation ... antibody platform to create a new class of antibodies that specifically activate T cells from the ... cells. Four of the Company's antibodies are currently in clinical trials, with the ...

Micromet to Present at the Piper Jaffray 20th Annual Health Care Conference

... company developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... is focused on developing novel, proprietary antibodies for the treatment of cancer, inflammation and ... antibody platform, representing a new class of antibodies that specifically activate T cells from the ...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Anti-Viral Applications of Phospholipid-Targeting Antibodies

... biopharmaceutical company developing monoclonal antibodies for the treatment of serious viral infections and ... broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids. The ... (CMV), using one or more anti-phospholipid antibodies that directly bind to an ...
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