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Androgens in Medical News

Androgen Production Continues in Prostate Cancer Tumors

... a critically important reason behind why those androgens are there -- the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the ... start honing in on the specific source of those androgens and how we can eliminate them," Mostaghel said. ...

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

... So far weve targeted systemic, or circulating, androgens in men with advanced prostate cancer, Mostaghel ... a critically important reason behind why those androgens are there the discovery that the gene pathways for synthesizing androgens from cholesterol appear to be present in the ...

New research may show why some prostate cancer recurs after treatment

... to stop the production of testosterone and other androgens that fuel cancer cell growth. New research has ... treatments that could block the development of androgens in the cancer cells. The study, funded by the ... have the ability to adapt and produce their own androgens that permit these cancer cells to survive, ...

Standard treatment for prostate cancer may encourage spread of disease

... he says. Speculating that depriving cells of androgens might also, however, affect nestin expression, ... on a prostate cancer cell line that depends on androgens to grow. When they removed androgens from the chemical mixture that the cells live in, ...

Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne

... thereby contributing to the formation of acne lesions. For example, when androgens (the male hormones present in both men and women) over-stimulate the oil ... The estrogen component decreases the production of testosterone and other androgens by the ovaries and decreases the amount of active testosterone in the ....

Why prostate cancer patients fail hormone deprivation therapy

... continually receiving androgensturning on at least 20 genes that rely on androgens for activationeven though no androgens were present. The results suggest that hormone therapy might encourage ...

Radiation Plus Hormone Therapy Cuts Prostate Cancer Deaths

... randomly assigned to receive either the drug flutamide (Eulexin), to block androgens (male hormones), or hormone therapy along with radiation. androgens are thought to encourage the spread of prostate cancer, so blocking their ...

Scientists discover key event in prostate cancer progression

... journal Cell , focuses on androgen receptors, molecules located in the nucleus of cells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes that control cell growth. The researchers show that in androgen-independent prostate cancer, androgen ...

Changing Paradigms in Hereditary Angioedema: A Focus on Timely Diagnosis and New Therapies

... HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is ...

Prostate screening studies reviewed in European Urology July issue

... Prostate Cancer: Revisiting Old Paradigms" by H. Isbarn et al. The notion that pathologic prostate growth, benign or malignant, can be stimulated by androgens is a commonly held beliefbut one without scientific basis. In the article, Dr. Isbarn writes that, "We therefore conducted a Medline search to ...

Changing Paradigms in Hereditary Angioedema: Pathophysiology, Diagnosis and Treatment

... HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is ...

New Prostate Cancer Drug May Hold Promise

... tumor growth. Existing anti-androgens try to "shut down the factory" that produces the hormones, but the new drug blocks the receptors for those androgens on the tumor cells, said Dr. Howard I. Scher, chief of the genitourinary oncology service at Memorial Sloan-Kettering Cancer Center in New York City ...

Castrate resistant prostate cancer: New therapeutic approaches

... therapies may become available". Recent studies indicate that tumour cells can develop an ability to synthesise enzymes to produce their own androgens for androgen receptor (AR) activation after castration. CRPC tumours are not uniformly hormone resistant and may remain sensitive to therapies ...

New Initiative Urges Women to Address Men's Health this New Year

... or if you have breast cancer. - You are a woman who is breastfeeding, pregnant, or may become pregnant. -- Patients treated with androgens may be at an increased risk for prostate cancer. Your doctor will likely monitor for prostate cancer before and during treatment with androgens. ...

Hormone therapy for prostate cancer does not appear to increase cardiac deaths

... safety and impact on cardiac health of hormonal therapies particularly GnRN agonists our study is quite timely." Since the male hormones called androgens can accelerate the development of prostate cancer, reducing their activity is a standard part of treating the disease. Most commonly this is done ...

New recommendations by scientific societies about late-onset hypogonadism

... by typical symptoms and a deficiency in serum testosterone levels. Late-onset hypogonadism (LOH) is caused by a decline in gonadal production of androgens in males that occurs with aging. Data indicate that a significant percentage of men over age 60 have serum testosterone levels that are below the ...

New research on sexual function

... sexual function faster post-prostatectomy than androgen deprivation with (PDE ) 5 inhibitors. New studies are underway to test this theory. androgens and Sexual Function. Mohit Khera, MD, MBA While most studies group diabetic subjects into one cohort, Chitaley's study separated mice into ...

JCI online early table of contents: July 10, 2008

... tumor of male sex hormones (androgens) are usually effective, but only briefly as the tumors typically develop the ability to grow in the absence of androgens and the diseases progresses. New data, generated using two prostate cancer cell lines that lack expression of androgen receptors and that were ...

Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer

... of the drug drop significantly after five years. Aromatase inhibitors block the other, less potent sources of estrogen in the body by keeping androgens from the adrenal glands and other tissues from transforming into estrogen. The current study was based on data collected from the original MA.17 ...

How DDT metabolite disrupts breast cancer cells

... of sex-steroid dependent genes including ESR1 and CCND1, the latter coding for a key protein involved in cell proliferation. When estrogens and androgens were present in the cell culture medium, increasing concentrations of p,p'-DDE accelerated the growth of CAMA-1 breast cancer cells. p,p'-DDE had a ...

What's good for the heart may be good for the prostate

... In contrast, a low fat, high vegetable and moderate alcohol consumption pattern is associated with less obesity, lower circulating estrogens and androgens and less stimulation of the sympathetic nervous system. It is possible that these physiological effects moderate both the hormonally regulated ...

What's Good for the Heart May Be Good for the Prostate

... In contrast, a low fat, high vegetable and moderate alcohol consumption pattern is associated with less obesity, lower circulating estrogens and androgens and less stimulation of the sympathetic nervous system. "It is possible that these physiological effects moderate both the hormonally regulated ...

Sex Hormones Don't Seem to Affect Prostate Cancer Risk

... Research UK Epidemiology Unit at the University of Oxford. "What we have shown in this collaboration is that these natural fluctuations in levels of androgens [and estrogens] do not appear to be related to subsequent risk [for] the disease." The findings were published online in the Jan. 29 issue of the ...

Hormone Therapy Only Helps Some Older Men With Prostate Cancer

... . The old message, reported in 2004 on the five-year point of the study, was that treatment to suppress the activity of male hormones known as androgens improved survival of older men with aggressive prostate cancer, D'Amico said. But the new report showed the benefit was limited to men without ...

Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer

... growth, and whether or not Stat5 synergizes with androgen receptors activated by adrenal androgens, which are present in the absence of testicular androgens during the hormone therapy of prostate cancer in patients. ...

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer

... stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor. At the first stage of the research, 201 organic extracts from 68 types of fungi ...

Evidence links anemia drugs with leukemic transformation in patients with primary myelofibrosis

... 1x109/L (both are measures of elevated white blood cells), hypercatabolic symptoms (results of excess metabolism), a splenectomy and treatment with androgens (a type of hormones). However, they were not independent predictors. ...

Researchers discover new way to predict survival in older women with lung cancer

... it may have more to do with levels of another family of hormones, androgens, which steadily decrease in women over 65. Aromatases use certain androgens as starting material to make estrogen. The cancer may be devising ever-changing strategies to, in effect, feed itself so it can grow and spread more ...

International Society of Hair Restoration Surgery Hosts 15th Annual Scientific Meeting in Las Vegas, September 26-30, 2007

... accelerate the wound healing process of donor and recipient areas after hair transplant surgery -- A review of hormone receptor physiology and androgens in female hair loss -- Best practices in non-scalp hair transplants, including eyebrow and eyelash transplantation One of this year's ...

High Testosterone Destroys Nerve Cells

... School Of Medicine have shown for the first time that excessive use of androgens or steroids to enhance muscle mass or for replacement therapy//, which ... are brought about. Neurodegenerative effects and neuroprotective role of androgens have now been noted. The studies conducted have revealed that ...

FDAs Gesture for Firm Manufacturing Drug for Cushings Syndrome

... body. Another adrenal cortex hormone, aldosterone, regulates salt and water levels which affects blood volume and blood pressure. Small amounts of androgens (male hormones) are also normally produced in the adrenal cortex. Cortisol production is regulated by adrenocorticotrophic hormone (ACTH), made in ...

Study to Investigate Gene's Effect on Bone Loss in Breast Cancer Patients

... inhibitors, and researchers are calling for interested women to volunteer. Aromatase is an enzyme that transforms testosterone and other androgens into estrogen. This process represents the major, if not only, source of estrogen in postmenopausal women. So giving women aromatase inhibitors can ...

Study Implicates Protein as a Trigger of Advanced Prostate Cancer Recurrence

... hormones, or androgens. The new research may help solve a mystery: why does prostate cancer recur in men treated to get rid of circulating androgens such as testosterone" Moreover, because chemotherapy after recurrence extends life by only a few months, the new research, "raises the ...

Dry Eyes Are More Than a Nuisance

... women may be disproportionately affected by DES include the balance of female and male sex hormones. “There are data to support the hypothesis that androgens (male sex hormones) are protective whereas estrogens (female sex hormones) appear to play a more detrimental role,” Schaumberg said. Despite ...

Prostate Cancer Therapy may Increase Risk of Death in Older Patients

... therapy, or ADT, against the risk of heart problems in older prostate cancer patients. The goal of ADT is to block the level of circulating androgens (male hormones), which can fuel the growth of prostate cancers. "Androgen deprivation therapy is associated with elevated body mass index, increased ...

Benefits of ADT Against Risk of Heart Ailments

... Society for Therapeutic Radiology and Oncology and the Society of Urologic Oncology. The goal of ADT is to block the level of circulating androgens (male hormones), which can fuel the growth of prostate cancers. "Androgen deprivation therapy is associated with elevated body mass index, increased ...

Lost That Lovin' Feeling? Don't Blame the Pill

... no predictable patterns for this in the literature. When looking for a consistent biological effect of hormonal contraception on sexual desire, androgens would probably be the factor most suspected to play a role, said Schaffir. ‘It was shown that the birth control pill decreased the concentration of ...

Excessive Male Hormones can Cause Bulimia in Women

... were notably higher than healthy individuals. The male hormone testosterone plays a significant role in regulation of appetite. Increased levels of androgens or male hormones may therefore trigger off a greater appetite. High levels of testosterone may be regulated by administration of oestrogen ...

Increase Testosterone Levels To Slow Down Alzheimer’

... that testosterone depletion in aging men may be a risk factor for AD by promoting accumulation of Aa in the brain. Recent studies suggest that androgens may lower Aa levels. "This study raises the possibility that androgen replacement therapy might lower the risk for Alzheimer's, but this is far ...
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