Autoimmune regulator
... the thymus . It causes transcription of a wide
selection of organ-specific genes. This reduces the threat ... autoreactive T cells by the process of negative
selection if they are too reactive to self.
It is mutated ... Liston, A. et al. (2003) Aire regulates negative
selection of organ-specific T cells. Nat Immunol 4 (4), ...
Thymocyte
... . The processes of beta-selection, positive
selection and negative
selection shape thymocytes into a peripheral pool of T ...
2.1 Thymus Settling
2.2 Beta
selection
2.3 ...
Central tolerance
... AIRE .
After exposure to self antigens, T cells and B cells become immunologically tolerant (non-reactive) in a number of ways :
Negative
selection ( apoptosis )
Anergy (non-responsiveness)
Receptor editing (changing the specificity of the autoreactive cell) [4]
Division to a ...
Pathology
... Main article: Clinical pathology
Pathogenic organisms are grown from patient specimens in clinical microbiology labs, allowing
selection of the correct antibiotics
Clinical pathology , also known as laboratory medicine , is the medical specialty concerned with diagnosing ...
Medicine
... at university is 5 years (4 if the student already holds a degree). Amongst some institutions and for some students, it may be 6 years (including the
selection of an intercalated BSc - taking one year - at some point after the pre-clinical studies). This is followed by 2 Foundation years afterwards, namely ...