Thymocyte

... and negative selection shape thymocytes into a peripheral pool of T cells that are able to respond to ... , deletion, and regulatory T cells . If these peripheral tolerance mechanisms also fail, autoimmunity ... stage. In order to remove thymocytes reactive to peripheral organs, the gene AIRE drives the expression of ...

Autoimmune regulator

... set of self-antigens, such as insulin , in the thymus . [3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease. [4] References ^ OMIM. [1] ^ Ramsey, C. et al. (2002) Aire deficient ...

Central tolerance

... antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due to circulation from peripheral sites. In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription ...

Hematopathology

... Hematopathology is the branch of pathology which studies diseases of hematopoietic cells ( see below ). A hematopathologist looks at peripheral blood smears , bone marrow aspirates and biopsies , lymph nodes , and other tissues, and uses his/her expertise to diagnose diseases such as ...

Medicine

... is or could be pregnant) Musculoskeletal (spine and extremities) Neurological (consciousness, awareness, brain, cranial nerves, spinal cord and peripheral nerves) Psychiatric (orientation, mental state, evidence of abnormal perception or thought) Laboratory and imaging studies results may be ...

Unsolved problems in medicine

... be cured or can the symptoms merely be controlled? Spinal cord injury . Is it possible to completely repair lesions in the spinal cord, and other peripheral nerves, with 100% functional recovery? Malaria How can both new and old tools be used to effectively control or eliminate this disease that ...