Therapeutic gene modulation
... modulation refers the practice of altering the expression
of a gene at one of various stages, with a view ... in that gene modulation seeks to alter the expression
of an endogenous gene (perhaps through the ... aids the recipient directly.
Modulation of gene expression
can be mediated at the level of transcription by ...
... are classified into a number of distinct maturational stages based on the expression
of cell surface markers. The earliest thymocyte stage is the double ... thymocytes reactive to peripheral organs, the gene AIRE drives the expression
of multiple peripheral antigens, such as insulin, creating an ...
... that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin , in the thymus .  This expression
then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease. 
... and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression
within the organ and importation of antigen due to circulation from peripheral sites. In the case of T cell central tolerance, additional sources of ...
Patients commonly request rejuvenation surgery on the forehead because the area is large enough to comprise the major focal and expression
point of the upper face , the eyes notwithstanding. Given time and gravity , the muscles that hold the forehead smooth become loose and weak, ...
... A good example of this is Tourette syndrome , which Ferenczi (1921), although never having seen a Tourette patient, suggested was the symbolic expression
of masturbation caused by sexual repression. However, starting with the efficacy of neuroleptic drugs in attenuating symptoms (Shapiro, Shapiro and ...
... Personalized medicine is the use of detailed information about a patient's genotype or level of gene expression
and a patient's clinical data in order to select a medication , therapy or preventative measure that is particularly suited to that patient at the ...