Vitro in Biological Technology

NeurogesX Reports Second Quarter 2009 Results

... have been evaluated in in vivo and in vitro preclinical studies and have demonstrated ... to a liver protectant, has been evaluated in vitro and in vivo . Equivalent dose levels of ... evaluated in proof of concept in vivo and in vitro preclinical studies for its potential to deliver ...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

... quarter 2009. Anadys has presented in vitro data supporting the use of ANA598 in combination ... data has shown that ANA598 is synergistic in vitro with interferon-alpha as well as representative ... Furthermore, ANA598 retains full activity in vitro against mutations conferring resistance to ...

IIVS Announces Initiation by EPA of a Pilot Program to Evaluate Non-Animal Eye-Irritation Methods

... Johnson & Son, Inc. - provided data from in vitro as well as previously conducted animal studies ... the credence the EPA's leadership gives to in vitro methods and hope that this will lead to EPA ... 18-month project encompasses the use of three in vitro assays: the Bovine Corneal Opacity and ...

Agendia Supports Genentech's Citizen's Petition Urging FDA to Hold In-Vitro Diagnostic Tests to One Set of Scientific and Regulatory Standards

... No. FDA-2008-P-0638-0001/CP petitions that all in vitro diagnostic tests be held to one set of scientific ... In 2007, MammaPrint became the first in vitro diagnostic multivariate index assay (IVDMIA) ... is an important step in the movement towards in vitro diagnostic regulatory standardization. ...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

... for anti-proliferative effects on cell lines in vitro and on tumors in vivo. Combination index ... BH3 family member BIM Given the superior in vitro apoptosis observed with TRU-016 treatment and ... and powerful mechanism of action, synergizes in vitro with a broad array of small molecule ...

NeurogesX Reports First Quarter 2009 Results

... have been evaluated in in vivo and in vitro preclinical studies and demonstrate ... to a liver protectant, has been evaluated in vitro and in vivo . Equivalent dose levels of ... evaluated in proof of concept in vivo and in vitro preclinical studies for its potential to deliver ...

AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting

... In vitro and In Vivo Data Show AEZS-126 as Promising Oral ... and demonstrated favorable properties in early in vitro ADMET screening including microsomal stability, ... are well above the nanomolar IC50 values in in vitro studies. Significant antitumor activity was ...

Oncolytics Biotech(R) Inc. Collaborators Present Reovirus Research at Replicating Oncolytic Virus Meeting

... In this study, the investigators examined the in vitro and in vivo oncolytic activity of reovirus ... rapamycin. The investigators concluded that in vitro synergy between rapamycin and reovirus is only ... and viral replication. However, unlike the in vitro observations, the combination of rapamycin and ...

EPA Presents Initial Results from Caliper Life Sciences' ToxCast Screening Effort

... under its ToxCast initiative to develop new in vitro (laboratory) approaches to identify chemicals ... program was aimed at creating a database of in vitro assay data on a broad set of compounds for which ... and more than 200 correlations between the in vitro results generated at CDAS and in vivo toxicity ...

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

... XenoTech's scientific consultants with in vitro drug metabolism study data to support its ... of quality into XenoTech's products and in vitro services," states Andrew Parkinson, CEO / CSO of ... expertise for XenoTech. Its unique system of in vitro metabolite profiling can alleviate the need for ...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

... BALTIMORE, Feb. 9 /PRNewswire/ -- Celsis In vitro Technologies (Celsis IVT), a division of Celsis ... analytical laboratory services and ADME-Tox in vitro products and services. The company is listed on ... time and cost of drug development by supplying in vitro testing products to the pharmaceutical ...

2009 Marks 50 Years of Innovative 'Firsts' for Instrumentation Laboratory

... -- In vitro Diagnostics Leader Celebrates 50th Anniversary -- ... developer, manufacturer and distributor of in vitro diagnostic instruments, related reagents and ... continue to meet the changing needs of the in vitro diagnostic market, today and into the future." ...

Positive Study Results for Ceftaroline Phase III Clinical Study for the Treatment of Complicated Skin and Skin Structure Infections Presented at ICAAC / IDSA

... and many gram-negative pathogens in both in vitro and in vivo models of infection. Results of the ... of surveillance data examining ceftaroline in vitro activity against isolates from cSSSI and CAP. ... ceftaroline, and ceftobiprole, have greater in vitro activity against MDRSP than ceftriaxone. ...

Caliper Life Sciences Receives $1.1 Million Task Order from the EPA's ToxCast(TM) Screening Program

... toxic to the environment. Caliper uses in vitro biochemical assays, which have been validated in ... 320 well-known chemicals through more than 230 in vitro assays. The new task order will support further ... goal is to identify a set of predictive in vitro assays that can supplement or replace in ...

Advanced Life Sciences Announces Second Quarter 2008 Financial Results

... Chemotherapy showing potent cethromycin in vitro CA-MRSA activity; * Opened enrollment and ... Cethromycin Cethromycin has shown higher in vitro potency and a broader range of activity than ... tract infections, and, again in in vitro tests, it appears to be effective against ...

Ondine Biopharma Announces Second Quarter 2008 Financial Results

... In July of 2008, a poster presentation titled "In vitro Bactericidal Efficacy of Periowave Photodynamic ... photosensitizer from UCL Business plc. In vitro studies have shown this compound to be ... 50%. In the recently published article titled "In vitro Photodynamic Eradication of Pseudomonas ...

Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop 'Designer' Transplants

... for patients. The paper, "Overlap Between in vitro Donor Anti-Host and in vivo Post Transplantation ... that there was a robust overlap between the in vitro culture responses and those in the patient, indicating that what was seen in vitro was representative of what would happen in ...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

... and radiation in human and murine tumour cells in vitro and in vivo. The paper, entitled "Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and ... viral replication and cytotoxicity was tested in vitro and the combination was assessed in three tumour ...

Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Radiation Therapy

... and radiation in human and murine tumour cells in vitro and in vivo. The paper, entitled "Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and ... viral replication and cytotoxicity was tested in vitro and the combination was assessed in three tumour ...

The Dark Report and Siemens Introduce the World's First Integrated Molecular Summit

... Summit on the integration of in vivo and in vitro diagnostics on February 5-6, 2008, at the ... Summit on the integration of in vivo and in vitro diagnostics. Conference attendees will have a ... created through the marriage of in vivo and in vitro diagnostics, arming clinicians with the tools ...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

... New In vitro Data presented at AACR-NCI-EORTC International ... II inhibition than AEZS-112; - In vitro plasma and liver microsomal stability of the ... efficacy models. Based on their interesting in vitro profiles, all three follow-up candidates will be ...

Empire Genomics and Reprogenetics Join Forces to Improve Preimplantation Genetic Diagnosis (PGD)

... Spontaneous Pregnancies as well as PGD with In vitro Fertilization - BUFFALO, N.Y., and LIVINGSTON, ... from Empire Genomics, tested and developed for in vitro fertilization in partnership with Reprogenetics, ... and efficiently for preimplantation use with in vitro fertilization. The data will be presented ...

Caliper Life Sciences Awarded National Institute of Environmental Health Services Contract Valued to $7.0 Million

... business in recent months, following the in vitro Environmental Protection Agency contract ... of NovaScreen Biosciences, a provider of in vitro discovery services, and Xenogen Biosciences, ... in August 2006. CDAS provides a wide range of in vitro and in vivo products and services that enable ...

BioReliance Launches Next-Generation Genotoxicity Screening Service

... with Gentronix to offer their GreenScreen HC in vitro assay as a major part of BioReliance's portfolio ... false positives seen with other in vitro assays, accelerating the development process." ... specificity, in contrast to other in vitro genetic toxicology assays that often provide ...

Targanta Therapeutics to Have Significant Presence at 47th Annual ICAAC Meeting

... A-50 Poster McKay In vitro Post Antibiotic ... D-241 Poster Tomfohrde Newly Defined In vitro ... B-1357 Slide Tanaka Preparation and In vitro 10:30AM ...

Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia

... that is in development for the treatment of CAP. It has shown higher in vitro potency and a broader range of activity than macrolides against ... bacteria associated with respiratory tract infections, and, again in in vitro tests, it appears to be effective against penicillin-, macrolide- and ...

Video of EpiDerm Skin Irritation Test (SIT) Method Now Available

... published in the Journal of Visualized Experiments (JoVE). Titled, "An In vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal ... MatTek - MatTek Corp. is the world's largest independent producer of in vitro human epithelial tissue equivalents. With over 15 years of publicly ...

Champions Biotechnology Partners with Do-Coop Technologies to Advance Its Novel Oncology Compound Into Biomerk Tumorgraft(TM) Testing

... MAPT (Microtubule-Associated Protein Tau) deficient tumors. In both in vitro and in vivo models, SG410 has demonstrated promising activity against ... to market by allowing researchers to use the same delivery system from in vitro to in vivo research, avoiding a key factor in late-stage failure. Biotech ...

Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer

... "Veridex is committed to providing oncologists with high-value in vitro diagnostic solutions, such as the CellSearch(R) CTC test, to help them ... is an organization dedicated to providing physicians with high-value in vitro diagnostic oncology products. Veridex's products may significantly ...

Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement

... of compounds. While it is already standard practice to perform in vitro testing of drug candidates on cardiomyocytes, the cell models currently ... said, "CDI well understands the limitations associated with current in vitro testing models that do not appropriately reflect the target cell ...

New IVF Software MedITEX to be Presented at the ESHRE Exhibition

... in medical solutions, is set to present its new software for in vitro fertilisation, MedITEX IVF, at the 25th Annual Meeting of the European ... ranges from the only officially approved software in Germany for in vitro fertilisation (MedITEX IVF) to an appointment calendar for medical ...

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

... Celsis IVT Celsis IVT is the premier world provider of specialized in vitro products for the study of metabolism, drug-drug interactions and toxicity ... and biotechnology companies have relied on Celsis IVT for quality in vitro products for lead optimization. Celsis delivers faster time to results ...

Serial Monitoring With ImmuKnow(R) is Useful in the Risk Assessment of Kidney Transplant Recipients

... company that is the leader in the development and manufacture of in vitro diagnostic products that are intended to illuminate immunity. ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an ...

Rib-X Pharmaceuticals Announces Presentations at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

... and Skin Structure Infections. The second poster session details the in vitro activity of delafloxacin against a large, worldwide panel of ... by human THP-1 macrophages. May 17, 1:30pm - Poster In vitro activity of Topic 31: New 2009 2:30pm Session 3 ...

AMDL, Inc. Signs First Customer Agreement With Precision Diagnostic Laboratory for DR-70 (FDP) Cancer Test

... (PDL) Inc. as its first customer to offer the AMDL DR-70 (FDP) in vitro cancer test to patients and doctors in the US. PDL Inc. is a ... first diagnostic laboratory in the US to offer the AMDL DR-70 (FDP) in vitro cancer test to doctors and their patients. To drive product awareness and ...

Caliper Life Sciences Reports First Quarter 2009 Results

... the first quarter of 2008. The net decrease resulted from a decrease in in vitro services revenues partially offset by in vivo services revenue ... is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures ...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... metabolite were similar to that of its active triphosphate measured in vitro in human hepatocytes. In this healthy volunteer study, IDX184 doses of 50 ... multiple genotypes (1a, 1b, 2a and 4a) and in HCV replicons. Long-term in vitro treatment (14 days) with IDX316 produced high levels of suppression that ...

Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting

... molecule: a single-chain, bispecific immunotherapeutic with potent in vitro activity against B-cell lymphoma B-cell depletion with agents such ... demonstrated highly potent activities against B-cell lymphoma cells in vitro . The CD79BxDR SCORPION can bind to two different targets: CD79B, a ...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... The studies demonstrated that AT-406 was active as a single agent in vitro in a number of cell lines, including breast cancer, lung cancer, ... when used together with tyrosine kinase inhibitors or chemotherapy in vitro in those cell lines. "AT-406 is the second agent in our development ...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... as a single agent, inhibits neuroblastoma tumor cell growth in in vitro and in vivo preclinical models. Author(s): Zhijie Li, Fei Tan, Jenna ... AM - 12:00 PM, Hall B-F, Poster Section 10, # 13 Abstract Summary: In vitro studies in neuroblastoma cell lines indicate that perifosine treatment ...