Transient in Biological Technology

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

... of circadian rhythm sleep disorders, including transient insomnia caused by jet lag. The following ... on Sleep Architecture in Phase Advanced transient Insomnia. NR7-100 Effect of Melatonin ... and Architecture in a Phase Advance Model of transient Insomnia. About Vanda Vanda ...

Fraunhofer USA Center for Molecular Biotechnology Receives Gates Foundation Grant for Avian Influenza Vaccine Development

... to support continued development of an avian influenza vaccine that uses transient plant-based technology. CMB will develop vaccines against highly ... it as a platform for accelerated manufacturing pharmaceuticals. The transient plant- based expression technology is licensed by CMB from its partner, ...

Dry Eye Survey: Ophthalmologists Cite Treatment Limitations/Gaps in Treatment of Moderate to Severe Dry Eye

... . Most adverse reactions with Lacrisert were mild and transient and included transient blurring of vision, ocular discomfort or irritation, matting or stickiness ...

Savient's Pegloticase Data in Treatment-Failure Gout Patients Presented at 72nd Annual Meeting of the American College of Rheumatology Conference

... similar to placebo indicating that the early increase in flares was transient in this treatment arm before returning to the placebo level. The ... 1, GOUT 2, and GOUT 3) identified two adverse safety signals: the transient increase in gout flares in Months 1-3 and the occurrence of infusion ...

A snapshot of the transformation

... DTEM comes in. It provides scientists with the ability to image transient behavior with an unprecedented combination of spatial and temporal ... to binary alloy solidification," Kim said. "This conclusion is based upon transient features that could not have been found using any other technique." ...

Aton Pharma Introduces Expanded Distribution of Lacrisert(R) (hydroxypropyl cellulose ophthalmic insert) at Hawaiian Eye

... with dry eye states. Most adverse reactions with Lacrisert were mild and transient and included transient blurring of vision, ocular discomfort or irritation, matting or stickiness ...

Medicago's H1N1 pandemic vaccine candidate shows positive response in 100% of vaccinated animals after a single dose

... Virus-Like Particle (VLP) and manufacturing technologies. Medicago is developing VLP vaccines to protect against H5N1 pandemic influenza, using a transient expression system which produces recombinant vaccine antigens in non-transgenic plants. This technology has potential to offer advantages of speed ...

Amylin Pharmaceuticals Announces Positive Results from Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment for Obesity

... effects seen with pramlintide/metreleptin combination treatment were injection site adverse events and nausea, which were mostly mild or moderate and transient in nature. "These findings provide us with valuable data that will inform our clinical and product development strategy moving forward," said ...

Biovista Inc. Announces Positive Efficacy Results in a Pre-Clinical Trial of its BVA-601 Repositioned Drug for Epilepsy

... model of epilepsy Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. These seizures may be transient signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain. Epilepsy is one of the world's oldest recognized ...

Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions

... HbA1c and body weight were observed across all dose arms. The most commonly reported adverse events were nausea and vomiting which were mostly mild, transient and dose dependent. "The results from the ITCA 650 phase 1b study have provided important guidance toward dose selection and study design for ...

Medicago succesfully expresses VLP antigen for A H1N1 strain

... Virus-Like Particle (VLP) and manufacturing technologies. Medicago is developing VLP vaccines to protect against H5N1 pandemic influenza, using a transient expression system which produces recombinant vaccine antigens in non-transgenic plants. This technology has potential to offer advantages of speed ...

Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes

... associated with an average weight loss of 8 pounds from baseline. The most commonly reported adverse event was nausea, which was typically mild and transient and occurred less frequently in the exenatide once weekly patients. In addition, a meta-analysis across controlled clinical studies of three months ...

NeurogesX Presents Two Posters at 61st Annual American Academy of Neurology Annual Meeting

... show no detrimental neurologic effects of repeated treatment with Qutenza. The most common adverse reactions observed in these clinical trials were transient application site reactions (pain and/or erythema) that were mostly mild to moderate in intensity. NeurogesX submitted a new drug application ...

Medicago initiates work on Swine Flu strain

... Virus-Like Particle (VLP) and manufacturing technologies. Medicago is developing VLP vaccines to protect against H5N1 pandemic influenza, using a transient expression system which produces recombinant vaccine antigens in non-transgenic plants. This technology has potential to offer advantages of speed ...

Researchers develop new way to see single RNA molecules inside living cells

... dynamic RNA-protein co-localization, which is the joining of RNA molecules and RNA binding proteins in a single cell. "We observed substantial transient interactions between proteins and viral RNA molecules that I don't think had ever been seen before with non-engineered RNA," noted Santangelo. "We ...

Bionovo Announces Publication of Positive Phase 2 Trial Results for Menerba(TM)

... with 98% of participants completing the trial and 91% taking at least 75% of assigned doses. The only statistically significant side effect was transient loose stools (12% on Menerba versus 3% on placebo; p=0.03). Safety analyses showed no cases of endometrial hyperplasia or uterine cancer ...

European Commission Approves EFIENT(R) (prasugrel) for Patients with Acute Coronary Syndrome Undergoing PCI

... readily identifiable: patients who weighed less than 60 kg (132 lbs), patients who were 75 years of age or older and patients who have had a prior transient ischemic attack (TIA) or stroke. Patients who weighed less than 60 kg, or were 75 years of age or older had increased exposure with prasugrel. ...

Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting

... for the development of cervical cancer. While most women will be infected with HPV at some point in their lives, the majority of these infections are transient and resolve without any clinical symptoms or consequences. However, a small number of HPV infections progress and result in disease ranging from ...

deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke

... under diagnosed. Detecting AF frequently requires more extensive cardiac monitoring than is feasible on all patients who have suffered stroke or transient ischemic attack (TIA). deCODE's newly presented data demonstrate that the SNPs measured by deCODE AF(TM) are the most significant known genetic ...

Dry adhesive based on carbon nanotubes gets stronger, with directional gripping ability

... University of Dayton. "This directional difference in the adhesion force is a significant improvement that could help make this material useful as a transient adhesive." The key to the new material is the use of rationally-designed multi-walled carbon nanotubes formed into arrays with "curly entangled ...

Nomad Bioscience Announces Broad License Agreement

... agreement with Bayer Innovation GmbH and Icon Genetics group. It provides Nomad access to Icon's proprietary technology platforms, including its transient expression technology magnICON(R), for manufacturing biomaterials and selected biosimilar pharmaceutical proteins in green plants. The agreement ...

InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting

... safe and well tolerated when given as a single dose to healthy adults in a range of doses from 2mg to 1600mg. Adverse events were generally mild and transient and were similar between treatment groups, with the exception of a higher frequency of mild and transient diarrhea and abdominal pain in the ITMN-191 ...

Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device

... minimally invasive alternative to current treatments to permanently close the hole in the heart. This may potentially reduce the risk of stroke, transient ischemic attack and debilitating migraines." In June 2007, Cardica and Cook entered into an agreement to develop a PFO closure device, whereby ...

Braemar Introduces the ER920W Wireless Cardiac Arrhythmia Monitor

... monitoring products currently under development." Cardiac arrhythmia monitors are worn by patients for up to 30 days to document and record transient cardiac events. Recording of symptomatic events such as syncope, palpitations, dizziness, chest discomfort and shortness of breath is activated by ...

Cardium Launches New AWARE Clinical Study Website

... ischemic stress (insufficient blood flow and myocardial oxygen supply due to coronary heart disease). The natural biologic response to repeated transient ischemia is angiogenesis, the growth of new collateral blood vessels, which is orchestrated by a complex and incompletely understood cascade ...

Gen-Probe Launches in Europe CE-Marked APTIMA(R) HPV Assay for Detection of Human Papillomavirus

... for the development of cervical cancer. While most women will be infected with HPV at some point in their lives, the majority of these infections are transient and resolve without any clinical symptoms or consequences. However, a small number of HPV infections progress and result in disease ranging from ...

Nebulized Formoterol Fumarate Has Comparable Pharmacokinetic and Pharmacodynamic Profile to Dry Powder Formulation

... and DPI," showed comparability in linear kinetics and excreted drug levels between formoterol fumarate administered by nebulization and DPI. transient and dose-related effects on serum potassium, serum glucose and vital signs were observed and found to be comparable between the two formulations. ...

FDA Approves MIXJECT(TM), a Convenient, Easy-to-Use Drug Delivery System For Watson Pharmaceutical's TRELSTAR(R) DEPOT and TRELSTAR(R) LA

... events occurring in patients were hot flushes, skeletal pain, impotence and headache. As with all LHRH agonists, triptorelin causes an initial transient increase in testosterone levels and may initiate or worsen symptoms during this transient period. Rare post-marketing reports of anaphylactic shock ...

Cephalon Announces European Commission Approval of EFFENTORA for the Treatment of Breakthrough Cancer Pain

... In patients with cancer, chronic pain often has two components: persistent pain and breakthrough cancer pain. Breakthrough pain is an intense transient flare of pain that interrupts or "breaks through" their persistent pain. The onset of breakthrough cancer pain is often sudden, reaches peak ...

ABR-Affinity BioReagents Finalizes Agreement for Distribution of Osenses Antibodies in the U.S., Canada and Europe

... antibodies for experimental use in the areas of chemosensory receptors (olfactory, vomeronasal and trace amine-associated), and visual, auditory and transient receptors. According to Ken Wilczek, President of ABR-Affinity BioReagents, "Partnering with Osenses enhances our ability to offer experimental ...

Stereotaxis Reports Fourth Quarter and Full Year 2007 Financial Results

... that a 94% acute success rate was achieved in these cases, with a high satisfaction rating by clinicians, and that there was only one minor and transient adverse event. We are proud of this exemplary safety record. In addition, the average economics per case from disposable revenue at these sites to ...

BSP's New Line of HyperQ Products: Bedside Ischemia Monitoring Systems Announces Successful Results of First Feasibility Study

... on sophisticated analysis of high-frequency ECG components, can be implemented in two products: (i) bedside monitoring system for early detection of transient ischemic episodes and (ii) a resting ECG system for sensitive diagnosis of acute coronary syndrome, including myocardial infarction. A highly ...

Clontech Laboratories, Inc. Releases the ProteoTuner(TM) Systems

... systems have broad applications in basic and applied research. The fast kinetics of protein stabilization/destabilization make it possible to study transient effects of the protein of interest that might otherwise have been masked. The ability to directly control the level of functional protein also makes ...

Cephalon's EFFENTORA Receives Positive Opinion from European Regulatory Authorities for the Management of Breakthrough Cancer Pain

... pain, a transitory exacerbation of pain that occurs on a background of otherwise controlled persistent chronic pain. Patients experience intense transient flares of pain that interrupt, or "break through," their background persistent pain. Breakthrough pain is characterized by its rapid onset, ...

U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD)

... dose changes. ABILIFY is not approved for use in pediatric patients with depression (See Boxed WARNING). Cerebrovascular adverse events (eg, stroke, transient ischemic attack), including fatalities, have been reported at an increased incidence in clinical trials of elderly patients with dementia-related ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

... blood pressure monitoring. Both dose levels of CYT006-AngQb tested were safe and well tolerated. The majority of side effects observed were transient and mostly mild local injection site reactions. During the entire safety follow-up period from month 4 to 12 after the first injection, no ...

New force-fluorescence device measures motion previously undetectable

... to pulling forces in three different directions, the researchers mapped the location of the transition states and deduced the structure of the transient species present during the conformational changes. Based on our previous studies, we knew the Holliday junction fluctuated between two structures, ...

Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain

... as described below in the FENTORA label, for their underlying persistent cancer pain. FENTORA incorporates a drug delivery system that generates transient changes in pH, which may optimize how well the tablet dissolves and how quickly the medicine passes across the lining of the cheek, or buccal mucosa. ...

HTRF IP-One Assay Performed on the PHERAstar and RUBYstar Plate Readers

... of Gq coupled GPCRs result in a transient increase of intracellular Ca 2+ ... its detection highly inaccurate. IP3 induces a transient calcium release in the cell. Calcium ... cellular backgrounds, stable or transient transfected cells, and chimeric constructs. ...