Transduction in Biological Technology

Laureate Announces Manufacturing Agreement with ARIUS for Trop-2 Targeting Antibody

... Candidate Trop-2 Signal transduction Antibody - PRINCETON, N.J., Jan. 31 ... cancer and other diseases, for its Trop-2 Signal transduction Antibody Program. Laureate will produce ARIUS' ... and the manufacturing of their Trop-2 Signal transduction Antibody," said Robert J. Broeze, ...

ARIUS announces manufacturing Agreement with Laureate Pharma For Trop-2 targeting antibody

... and the manufacturing of their Trop-2 Signal transduction Antibody," said Robert J. Broeze, ... manufacturing objectives." ARIUS' Trop-2 Signal transduction Antibody Program has produced the only ... Trop-2 was one of 12 selected. The Trop-2 Signal transduction Program was generated using ARIUS' ...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

... cell lung cancer (NSCLC) with its novel, first-in-class, oral signal transduction inhibitor compound, perifosine. In 177 patients receiving radiotherapy for ... first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical ...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

... (270). These lentiviral vector based expression constructs allow efficient transduction of miRNAs into dividing and non-dividing cells transiently or stably, and can be used for in vitro assays and in vivo animal studies. The transduction efficiencies are monitored by the expression level of an ...

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

AEterna Zentaris Partner, Keryx, Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial with Perifosine (KRX-0401) for the Treatment of Multiple Myeloma

... and extend their survival. About Perifosine Perifosine is a novel, first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical for the survival of cancer cells. Perifosine has demonstrated single agent ...

Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Announces Appointment of Ron Bentsur as Chief Executive Officer

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Announces Poster Presentations Highlighting Clinical Activity of KRX-0401 (Perifosine) at the Upcoming Annual Meeting of the American Society of Clinical Oncology

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Sigma-Aldrich Introduces Precisio(TM) Kinases for High-Throughput Screening and Kinase Profiling

... may provide the foundation for new drug and therapeutic targets." Protein kinases are essential in intercellular communication, mediating signal transduction in development, transcription, immune response, metabolism, apoptosis and cell differentiation. Improper kinase function plays a role in many ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on First Quarter 2009 Financial Results on Thursday, May 14, 2009 at 8:30am EDT

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. Announces Michael P. Tarnok as Interim Chairman and Chief Executive Officer

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Otonomy Introduces Scientific Advisory Board

... the world devoted to the study of hearing and deafness. Research in his laboratory includes studies of sound transmission in the middle ear, signal transduction in the inner ear, neural processing in the central nervous system and applications of cell-based therapies to repair inner ear damage. Dr. Liberman ...

Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2008 Financial Results

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Fourth Quarter and Year-End 2008 Financial Results on Friday, March 13, 2009 at 8:30am EDT

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Inc. Announces Receipt of Nasdaq Delisting Notification

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Gene Network Sciences Announces Michael Gilman as Board Member

... Dr. Gilman spent eight years on the scientific staff of Cold Spring Harbor Laboratory in New York, where his research focused on mechanisms of signal transduction and gene regulation. Dr. Gilman holds a Ph.D. in Biochemistry from University of California, Berkeley , and an S.B. in Life Sciences from ...

Tigris Pharmaceuticals Files IND Application for GGTI-2418

... inhibitors. I look forward to the fruitful translation of our preclinical work to target patients whose tumors harbor aberrant signal transduction pathways most likely to respond to GGTI-2418," stated Said M. Sebti, Ph.D., Director of the Drug Discovery Program at the Moffitt Cancer Center and ...

ScienceFirst Staff Expansion

... PhD, has been named science manager. Before joining ScienceFirst, Dr. Sudakin was an investigator at GlaxoSmithKline, where he co-lead the signal transduction kinase 1 matrix team from program inception to successful initiation of start of chemistry on three different series. A published author, Dr. Sudakin ...

Keryx Biopharmaceuticals to Present at the J.P. Morgan 27th Annual Healthcare Conference

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

SuperGen Receives Clearance to Begin Clinical Trials With SGI-1776, a PIM Inhibitor

... pathways implicated in cancer. Pim kinases can induce progression of the cell cycle, inhibition of apoptosis, and modulation of other signal transduction pathways. Transformation of Pim kinase in conjunction with other oncogenes is thought to contribute to malignancies including Burkitt's lymphoma, ...

Keryx Biopharmaceuticals Notified that Nasdaq Has Extended Minimum Bid Price Rule Compliance Period

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Revealing the regulating mechanism behind signal transduction in the brain

... found that complexes of FMRP and CYFIP1 are located at the synapses and together suppress the local production of a number of proteins. In the transduction of signals between brain cells, i.e. synaptic activation, CYFIP1 is released from the complex, whereby FMRP can no longer exercise its suppressing ...

Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium

... hepatoma models and cytostatic potential in multiple cell based models of cancer" Abstract: 577 Session Title: Signal transduction Modulators Location: Poster Hall, GenevaPalExpo About Ardea Biosciences, Inc. Ardea Biosciences, Inc., of San Diego, California, is a ...

UC Riverside researcher develops novel method to grow human embryonic stem cells

... could affect the way embryonic stem cells are grown in the future. "His work is certainly an important step forward in both understanding signal transduction pathways in stem cells and in the development of an improved methodology for culturing stem cells," she said. Study results appear online in the ...

LI-COR Updates Product and Application Guide for Summer 2008

... The MPX can be incorporated into a variety of assays including primary and secondary antibody screening, monoclonal antibody screening, signal transduction pathway analysis, and time course studies. However, it is possible to adapt nearly all common Western procedures that generate a PVDF or ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2008 Financial Results on Monday, August 11, at 8:30 A.M. EDT

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

ARIUS announces second quarter fiscal 2008 financial results

... the fourth quarter of 2008 and then a Phase I IND application is expected to be filed and human clinical trials commenced. Trop-2 Signal transduction Program - Completed two toxicology studies with no dose-limiting toxicity. - Presented a Trop-2-focused poster at AACR Annual Meeting. - ...

Keryx Biopharmaceuticals to Present at the Jefferies & Co. Healthcare Conference

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

LI-COR(R) Biosciences Introduces New Tools for High Throughput Western Blotting

... The MPX System can be incorporated into a variety of assays including primary and secondary antibody screening, monoclonal antibody screening, signal transduction pathway analysis, or any other common Western blotting procedure that generates a PVDF or nitrocellulose blot of 7 x 8.5 cm. Processing is as ...

Keryx Biopharmaceuticals, Inc. Announces First Quarter 2008 Financial Results

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on First Quarter 2008 Financial Results on Monday, May 12, at 8:30 A.M. EDT

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals to Present at the Deutsche Bank 33rd Annual Health Care Conference

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Keryx Biopharmaceuticals Receives Nasdaq Notification

... agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell ...

Paloma Pharmaceuticals to Present at the American Association for Cancer Research

... broad activity as an anti-angiogenic agent and anti-tumor agent is shown to reside in its ability to target and inhibit the PI3K/Akt/mTOR signal transduction pathway as a TORC1/TORC2 inhibitor. The first of the three presentations, "Palomid 529, a Dual Acting Anti-angiogenic and Direct Anti-tumor Agent ...

ARIUS presents new findings for anti-cancer antibody programs at AACR

... AML cancer stem cells. CD9 is the first description of a marker that is differentially expressed on cancer versus normal stem cells. Trop-2 Signal transduction Program AR47A6.4.2, a naked monoclonal antibody targeting Trop-2, exhibits anti-tumor efficacy in multiple human cancer models as a ...

ARIUS announces first quarter fiscal 2008 financial results

... - Prepared to file a Phase I IND application and begin human clinical trials for the CD44 Cancer Stem Cell program in 2008. Trop-2 Signal transduction Program - Completed first toxicology studies. - Selected to present a Trop-2-focused poster at AACR Annual Meeting. - ...

Oncothyreon announces data from multiple small molecule programs to be presented at American Association of Cancer Research Annual Meeting

... rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening Abstract # 2761, Session: Signal transduction and Therapeutics Poster Session: Monday, April 14, 2008, 1:00 p.m. to 5:00 p.m. P.T. - Phosphatidylinositol 3-kinase stimulates ...