Transcription in Biological Technology

Sigma-Aldrich and Sangamo BioSciences Announce the Achievement of Key Throughput Milestone in Research Reagents Agreement

... are the dominant class of naturally-occurring transcription factors in organisms from yeast to humans. transcription factors, which are found in the nucleus of every ... gene expression. Though there are many kinds of transcription factors, only ZFPs are amenable to engineering ...

Sangamo BioSciences Reports Second Quarter 2008 Financial Results

... formulation of plasmid DNA that encodes a ZFP transcription factor (ZFP TF(TM)), designed to upregulate ... trial demonstrated that administration of the ZFP transcription factor resulted in a statistically significant ... a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene ...

Sangamo BioSciences and Sigma-Aldrich Announce Research and License Agreement With Roche for the Use of ZFN Technology for Generation of Transgenic Animals

... are the dominant class of naturally occurring transcription factors in organisms from yeast to humans. transcription factors, which are found in the nucleus of ... gene expression. Though there are many kinds of transcription factors, only ZFPs are amenable to engineering ...

Dow AgroSciences Announces Early Exercise of Option for Commercial License With Sangamo BioSciences for Plants

... in organisms from yeast to humans. transcription factors, which are found in the nucleus of every ... AgroSciences have demonstrated the utility of ZFP transcription factors for the control of gene expression in ... a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene ...

Dow AgroSciences, Sangamo BioSciences Announce the Achievement of Key Milestones in Plant Agriculture Collaboration

... transgene insertion into crops. Sangamo's ZFP transcription factor (ZFP TF(TM)) technology was used ... in organisms from yeast to humans. transcription factors, which are found in the nucleus of every ... a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene ...

Anesiva and Transcription Factor Therapeutics, Inc. Announce Licensing Agreement for Development and Commercialization of NF-kappa B Clinical Program

... the clinical drug candidate Avrina(TM), to transcription Factor Therapeutics, Inc. (TFT). NF-kB transcription Factor Decoy inhibits NF-kappa B, a ... "With a strong focus on anti-inflammatory transcription factor decoys, we believe that TFT is well ...

Sangamo BioSciences Announces Expansion of Research and License Agreement With Genentech for ZFP Technology for Protein Pharmaceutical Production

... in organisms from yeast to humans. transcription factors, which are found in the nucleus of every ... gene expression. Though there are many kinds of transcription factors, only ZFPs are amenable to engineering ... a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene ...

Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods

... These pathways communicate with DNA by using transcription factors, proteins that bind particular sequences ... of the entire human genome; by assessing transcription factors activities one can capture the status of ... that mirror the activities of the evaluated transcription factors. These reporter messages are ...

Scientists synthesize memory in yeast cells

... simple: two genes that coded for proteins called transcription factors. transcription factors regulate gene activity. Like a hand on a faucet, the transcription factor will grab onto a specific gene and control ...

Scientists synthesize memory in yeast cells

... simple: two genes that coded for proteins called transcription factors. transcription factors regulate gene activity. Like a hand on a faucet, the transcription factor will grab onto a specific gene and control ...

MIT, BU engineer cellular circuits that count events

... first protein in the sequence, an RNA polymerase (an enzyme that controls transcription of another gene). During the second influx, the first RNA polymerase ... and assembled. It then binds the DNA and flips it over, ending its own transcription and setting up the gene for the second invertase to be transcribed next. ...

Sangamo BioSciences Reports Fourth Quarter and Full Year 2008 Financial Results

... initiated a Phase 2 clinical trial (SB-509-801) to evaluate SB-509, a ZFP transcription factor (ZFP TF(TM)) VEGF-A activator, in subjects with ALS. ALS is a ... ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, ...

Updated Online Tutorials for DBTSS, Pfam and PDB

... regions, and those in selected other species as well to locate transcription start sites, promoters, transcription factor binding sites and SNPs to use multiple query strategies to ...

Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award

... for understanding gene regulation and genetic pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA ... technology to understand gene regulation and genetic pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA ...

New yeast trick for eating favorite food: Details in Nature paper

... that the primary mechanism for regulating genes is through proteins called transcription factors, which can either increase or decrease the activity of a gene by ... the control of genes frequently occurs at the intermediated stages between transcription and the formation of functional proteins. This "post-transcriptional" ...

Sangamo BioSciences Announces License Agreement For the Use of ZFP Technology For Generation of Transgenic Animals

... occurring transcription factors in organisms from yeast to humans. transcription factors, which are found in the nucleus of every cell, bind to DNA to regulate gene expression. Though there are many kinds of transcription factors, only ZFPs are amenable to engineering and precise targeting to a ...

New Benefactors Show Support for CDA4CDT:

... dictation routine. M*Modal's focus is on providing hospitals and medical transcription service providers with the industry's most comprehensive yet most ... For more information, visit http://www.ahdionline.org . The Medical transcription Industry Association is the world's largest trade association serving ...

Provista Awards Agreement to Spheris

... -- Spheris has been selected as the first awarded supplier of medical transcription technology and services by Provista, one of the nation's leading group ... with Spheris and to be able to offer our customers quality medical transcription technology and services from one of the clear leaders in the industry," ...

Sangamo BioSciences Reports Second Quarter 2009 Financial Results

... (ZFP) technology for therapeutic gene regulation and modification. By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Sangamo BioSciences Announces Second Quarter 2009 Conference Call and Webcast

... (ZFP) technology for therapeutic gene regulation and modification. By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR

... multi-step signaling covering the full spectrum of cellular signaling from ligand-receptor interaction through enzymes and scaffold proteins to transcription factors. The donated maps describe the role of interferons and cytokines in the immune response, development (via a variety of growth hormones), cell ...

Sangamo BioSciences Announces Presentation at the Needham Life Sciences Conference

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... the redox protein thioredoxin. Thioredoxin is involved in the first unique step in DNA synthesis. Thioredoxin also provides control over a number of transcription factors affecting cell proliferation and death through the mechanism of redox regulation. An initial Phase 1 trial involving 38 patients with ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... squirt"). The compound is now produced synthetically. Trabectedin binds to the minor groove of DNA, interfering with cell division and genetic transcription processes and DNA repair machinery. Trabectedin is currently in Phase 3 development in ovarian cancer and to expand its uses in sarcoma. ...

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

... and have not been found in normal individuals or those with benign prostate hyperplasia (BPH). However, multiple partner genes, including ETS transcription genes, and breakpoints have been reported. Scientists at Quest Diagnostics Nichols Institute developed a laboratory test based on TMPRSS2 5' and 3' ...

Transgenomic, Inc. Announces Appointment of New Board Members

... STI is a seed-stage biotechnology company built on a proprietary antibody library construction technology, the STI technology, which applies RNA transcription rather than PCR for the amplification of variable lgG domains to yield high fidelity mAb libraries. Prior to STI, Dr. Schuh was the Founding Chief ...

Sangamo BioSciences Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

ImQuest BioSciences and Arisyn Therapeutics Announce Strategic Partnership to Develop Infectious Disease and Cancer Drugs

... human clinical trials with lead products ATI-0312 for HIV and ATI-0810 for HCV and will initiate mechanistic studies to define the unique virus transcription inhibitory mechanism of action of the class of inhibitors. ImQuest will also lead Arisyn's efforts to develop next generation inhibitors from ...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... looking forward to screening the MISSION esiRNA library at ICCB-Longwood." esiRNA are endoribonuclease-prepared siRNAs synthesized by in vitro transcription of a 300-600-bp gene specific double-stranded RNA, followed by enzymatic digestion. This collection of siRNA-like molecules is then purified, ...

Fate Therapeutics and Stemgent Launch Catalyst: A Unique Industry Program for First Access to the Most Advanced Induced Pluripotent Stem Cell Technology

... optimized for and screened against stem cells, and includes small molecules for pluripotency, self-renewal, and differentiation, viral-delivered transcription factors, matrices, cell lines, cytokines, antibodies, transfection reagents, and more. This unique product mix is designed to serve researchers who ...

deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes

... that AF is a much greater cause of stroke than previously recognized," Circulation (2008);118:S_652. 4. Grant, et. al., "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes," Nature Genetics (2006) 38, 320 - 323; Florez, et. al., "TCF7L2 Polymorphisms and ...

Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation

... United States and Canadian Academy of Pathology ) meeting demonstrated that the expression of FOXA1, now known to be an estrogen receptor associated transcription factor, correlated with Oncotype Dx(R) when performed in patient samples from Indiana University . In this clinical study of 79 ER-positive, ...

Sangamo BioSciences Announces First Quarter 2009 Conference Call and Webcast

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Stemgent, CellDesign Sign Co-Exclusive Marketing Agreement on Stem Cell-Based Adipocyte Research Products

... and differentiation, as well as cytokines, antibodies, transfection reagents, and more. Stemgent's latest innovations include viral vectors encoding transcription factors necessary for the generation of induced pluripotent stem (iPS) cells. This unique product mix is designed to serve researchers who study ...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

... of expression constructs, GeneCopoeia plans to launch All-in-One(TM) miRNA RT-qPCR system in the next few weeks. This system consists of a reverse transcription kit, a SYBR green RT-qPCR master mix kit, and a complete set of validated primers for human, mouse, and rat miRNAs, which allows specific and ...

Genetic discovery could lead to advances in dental treatment

... production of tooth enamel," said Chrissa Kioussi, an assistant professor in the College of Pharmacy at Oregon State University. "This is the first transcription factor ever found to control the formation and maturation of ameloblasts, which are the cells that secrete enamel." The researchers used a ...

Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Sangamo BioSciences Announces Fourth Quarter and Year-End 2008 Conference Call and Webcast

... proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases ...

Cordex Pharma Presents 'New Frontiers in Cardiovascular Medicines' on January 29

... a ubiquitous protein modification. The ramifications of his work extend to all major classes of proteins: ion channels, receptors, G proteins, transcription factors, membrane trafficking proteins and numerous enzymes that are now known to be regulated by S-nitrosylation. Accumulating evidence suggests ...