toxicity in Biological Technology

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

... the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner) ... research products, especially in metabolism, toxicity and drug-drug interaction testing. Several large ... study of metabolism, drug-drug interactions and toxicity in drug discovery and development. Since 1990, ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... of total cumulative dose Cardiac toxicity may also occur at lower cumulative doses (400 ... or AIDS-related Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil ... In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil ...

Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution

... York and California, currently offers an in vitro toxicity screening service that determines compound and metabolite toxicity using a novel platform that supports arrays of ... assay platform that generates metabolic toxicity data to assess the safety of compounds at a speed ...

EPA Presents Initial Results from Caliper Life Sciences' ToxCast Screening Effort

... that the database was predictive of in vivo toxicity profiles. Initial analyses of the data generated ... in vitro results generated at CDAS and in vivo toxicity parameters have already been identified. In ... profiling as a tool for predicting potential toxicity liabilities of compounds and highlights the high ...

Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

... colorectal cancer who cannot tolerate the toxicity profile of currently marketed platinums." ... in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with ...

Poniard Announces Positive Incremental Efficacy and Safety Data from Phase 2 Picoplatin Trial in Patients With Metastatic Colorectal Cancer

... the two treatment groups. Acute gastrointestinal toxicity was similar in the two groups, while ... in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with ...

Lilly to Acquire ImClone Systems in $6.5 Billion Transaction

... Myelosuppression is usually the dose-limiting toxicity with ALIMTA therapy. ALIMTA may not be ... Myelosuppression is usually the dose-limiting toxicity with GEMZAR therapy. GEMZAR may not be ... have been rare reports of serious kidney or liver toxicity with GEMZAR treatment, sometimes fatal. Serious ...

Caliper Life Sciences Receives $1.1 Million Task Order from the EPA's ToxCast(TM) Screening Program

... - Caliper Screens Compounds to Detect toxicity - HOPKINTON, Mass., Aug. 19 ... screening compounds and prioritizing further toxicity testing. The ultimate goal is to identify a set ... may have potential relevance to environmental toxicity or adverse effects. With this new funding, we ...

PURE Bioscience Announces DuraBan International as Distributor of SDC-Based Disinfectant

... on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... because of its superior efficacy, reduced toxicity and the inability of bacteria to form ...

Cellumen to Collaborate With the NCTR of the FDA to Apply Cellular Systems Biology (CSB(TM)) to Predictive Toxicology

... Cellumen will use its proprietary CellCiphr(R) toxicity risk assessment technology to profile blinded ... informatics tools. "Failure to predict human toxicity among drug candidates early in ... drugs," added Dr. Taylor. By applying CellCiphr toxicity profiling early in the discovery and lead ...

Increased Drug Related Cardiac Toxicity Leads Gwathmey Preclinical Testing Services to Create Novel Cardionomics(TM) Services for Preclinical Cardiac Safety Screening of Drug Candidates

... -- In response to ever increasing cardiac toxicity found in market drugs, Gwathmey Preclinical ... cardiac safety of drug candidates. Cardiac toxicity has played a major role in shutting down the ... about innovative approaches to preventing cardiac toxicity in new drugs at the World Pharmaceutical Congress ...

FASgen, Inc. Presents Ovarian Cancer Efficacy and Toxicology Data to the American Association for Cancer Research

... toxicity studies, FAS31 showed no observable toxicity in normal tissues in the rat or mouse. FAS31 ... human cancer cells. No gross or microscopic organ toxicity was identified. In maximally tolerated dose ... rats treated with 1000 mg/Kg (ip), no overt toxicity was noted in any other animals; normal motor ...

CHOP-Zevalin(R) Investigational Regimen Produces 95% Complete Remission and 75% Estimated Two Year Progression-Free Survival in Elderly Patients with Diffuse Large B-cell Lymphoma

... with a 2-year overall survival of 95 percent. The toxicity associated with Zevalin included severe (grade 3 or 4) hematologic toxicity in 12 of 20 patients; the most common severe side ... of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow ...

ReachBio Partners with Axiogenesis to Distribute Novel Cell-Based Products in North America

... products for drug discovery, toxicity testing, and R&D applications SEATTLE, Feb. 27 ... cellular model systems for drug discovery and toxicity testing should utilize highly relevant cells that ... stem cells and progenitors for drug discovery and toxicity testing applications. Furthermore, their ...

NIH collaborates with EPA to improve the safety testing of chemicals

... Agency (EPA), who today announced a new toxicity testing agreement. The concept behind this ... implementation of the hoped-for paradigm shift in toxicity testing will require validation of the new ... testing goals, including: identification of toxicity pathways; selection of chemicals for testing; ...

Study Shows Coronado Biosciences' Bcl-2 Inhibitor, Apogossypol, is More Efficacious, Less Toxic than Gossypol in Animal Models

... of cancer cells in vitro while demonstrating less toxicity than Gossypol in vivo in mice. Published online ... less hepatotoxicity and gastrointestinal toxicity than those treated with Gossypol. The ... in the first half of the year. If the toxicity profile in animals approximates what was shown in ...

Biochip mimics the body to reveal toxicity of industrial compounds

... MetaChip, that combine to reveal the potential toxicity of chemicals and drug candidates on various ... without the use of live animals. Traditional toxicity testing involves the use of animals to predict ... legislation stipulating that chemicals undergo toxicity analysis, there is a rapidly emerging need for ...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

... to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent ... to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent ... as drug metabolism and bioavailability, excessive toxicity and treatment resistance. More information can be ...

Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients

... immunoassay analyzer may help clinicians to monitor cyclosporine-induced toxicity and adjust doses of cyclosporine drugs to prevent possible irreversible ... may be able to assist in the detection of chronic cyclosporine-induced toxicity in the kidneys following heart transplant procedures. Abbott is ...

NIMOTUZUMAB DEMONSTRATES EFFICACY IN RANDOMIZED HEAD & NECK CANCER STUDY WITHOUT THE TOXICITIES ASSOCIATED WITH OTHER EGFR DRUGS

... the adopted tenet that the efficacy of EGFR inhibitors is linked to the toxicity of the class. "These data are further evidence of the unsupported ... BK et al study. The major difference between the studies is the benign toxicity profile reported with nimotuzumab. No deaths in the nimotuzumab trial were ...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

... Patients in both treatment arms receive therapy until disease progression, toxicity or after receiving ten 3-week cycles of therapy. The primary endpoint of ... with measurable disease at baseline, determining the tolerability and toxicity of weekly OGX-011 and docetaxel when administered in combination, ...

Lilly Set to Unveil More Than 50 Studies at ASCO 2009

... marrow function. There have been rare reports of serious kidney or liver toxicity with GEMZAR treatment, sometimes fatal. Serious lung toxicity has also been reported, sometimes fatal. If you think you are pregnant, ...

Novagali Pharma Announces FDA Clearance of IND for Phase III of Catioprost(R), its Cationic Emulsion of Latanoprost in Patients With Glaucoma

... of whom in the US. For these patients treated on a long term basis, toxicity of preservatives is a major concern. In fact the prevalence of ocular ... glaucoma. This is a major advantage since it is admitted that BAK exerts toxicity after long term use and that glaucoma is a chronic disease needing ...

Independent Data Monitoring Committee Supports Continuation of Picoplatin Phase 3 SPEAR Registration Trial in Small Cell Lung Cancer

... date suggest manageable hematologic adverse events with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Picoplatin in Patients with Metastatic Colorectal Cancer

... date suggest manageable hematologic adverse events with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

GeneGo Announces Systems Tox Relationship With Entelos

... to expand our collection of biological pathway-based classifiers with toxicity models for a wide variety of adverse drug effects in key target tissues." ... product, MetaDrug 5.2(TM) is designed for prediction of human metabolism, toxicity and biological effects for novel small molecules compounds. MetaBase(TM) ...

PURE Bioscience Schedules Second Quarter 2009 Financial Results Conference Call for March 12, 2009 at 1:30 P.M. PDT

... challenges, including Staph (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver dihydrogen citrate-based ... competitors in the marketplace because of its superior efficacy, reduced toxicity and the inability of bacteria to form a resistance to it. PURE is ...

PURE Bioscience Board Appoints John J. Carbone, MD to Board of Directors

... challenges, including Staph (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver dihydrogen citrate-based ... competitors in the marketplace because of its superior efficacy, reduced toxicity and the inability of bacteria to form a resistance to it. PURE is ...

Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer

... anti-tumor activity in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet(R) (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients

... "Moreover, the incidence of hand foot syndrome, a rate limiting toxicity of other liposomal anthracyclines, is rare with nonpegylated liposomal ... studies of Myocet in women with breast cancer have shown that the cardiac toxicity of doxorubicin can be significantly reduced, while the efficacy of the ...

Rules-Based Medicine, Inc. Launches Human Kidney Damage Biomarker Panel

... early signs and locations of drug-induced kidney damage, known as renal toxicity or nephrotoxicity, thereby guiding important decisions on lead compounds ... in the kidney compared to plasma, magnifying the potential for renal toxicity of any drug. Kidney damage also occurs in connection with diseases ...

YM BIOSCIENCES RECEIVES CLEARANCE TO INITIATE RANDOMIZED DOUBLE-BLIND CLINICAL TRIALS OF NIMOTUZUMAB IN LUNG CANCER AND BRAIN METASTASES FROM LUNG CANCER

... and following radiotherapy until disease progression, unacceptable toxicity or at the discretion of the physician. Radiotherapy will consist of 30 Gy, ... Unrelated to the rash, Grade III/IV radiation dermatitis is a severe toxicity reported in almost half the patients treated with another EGFR-targeting ...

EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma

... include determining the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of ENMD-2076 when administered orally once a day in patients with ... lines in vitro. Significant dose-dependent antitumor activity with minimal toxicity was also induced in vivo when ENMD-2076 was administered as a single agent ...

PURE Bioscience and Ciba Strike New Contract for Natural Antimicrobial

... challenges, including Staph (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver dihydrogen citrate-based ... competitors in the marketplace because of its superior efficacy, reduced toxicity and the inability of bacteria to form a resistance to it. PURE is ...

FDA Accepts Cell Therapeutics' Zevalin sBLA and Grants Priority Review

... median progression-free survival (PFS) by approximately two years, with a toxicity profile comparable to that seen with Zevalin's use in approved ... associated with pre-administration of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin ...

GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology

... the industry gold standard replicon assay without significantly increased toxicity as demonstrated in Rhesus Monkeys compared to standards of care IFN alpha ... binding site provide for superior anti-HCV efficacy without increased toxicity of GEA007.1 as compared to IFN alpha 2 which is the core agent of ...

Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer

... anti-tumor activity in multiple indications with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

High-Dose Zevalin(R) With Tandem Stem Cell Infusion Produces 87 Percent Overall Survival in Relapsed/Refractory or High Risk Non-Hodgkin's Lymphoma

... vital organ toxicities of any grade. Mucositis, a major cause of toxicity and even infectious mortality after myeloablative treatments, was absent, ... associated with pre-administration of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin ...

Elsevier's PharmaPendium(TM) Adds European Medicines Agency (EMEA) Documents

... - some not approved in the US. It also presents preclinical and clinical toxicity and adverse effects data manually extracted from these documents. General ... Approval Documents as well as other data sources. Adverse events and toxicity data are carefully extracted from preclinical and clinical studies from ...

Cell Therapeutics Submits Supplemental Biologics License Application for Zevalin Use in First-Line Consolidation Therapy

... median progression-free survival (PFS) by approximately two years, with a toxicity profile comparable to that seen with Zevalin's use in approved ... associated with pre-administration of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin ...