Toxic in Biological Technology

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... showed that they can rescue yeast cells from toxic levels of a protein implicated in Parkinson's ... genetic switch that causes the cells to produce toxic levels of alpha-synuclein. If the yeast make ... lead, manganese, iron and mercury are known to be toxic to brain cells. The researchers are conducting ...

Independent Study Corroborates Prana's Strategy to Treat Alzheimer's Disease Patients.

... strategy for Alzheimer's Disease in blocking the toxic interaction between Abeta and brain metals, such ... Alzheimer's disease compound, PBT2, targets a toxic form of the Abeta protein in the synapses of the ... of Abeta and zinc leading to the build up of toxic Abeta oligomers at the synapse. Previous studies ...

Safer nanoparticles spotlight tumors, deliver drugs

... that was purposely designed to minimize toxic side effects," said Michael Sailor, a chemistry ... that is most commonly achieved by including toxic organic chemicals or tiny structures called ... to the whole body, doxorubicin often has toxic side effects. At about 100 nanometers, these ...

Katrina Proven Certified Organic Toxic Mold Remedy Now Available for Mold Remediation Professionals and Homeowners

... Inc. announced the availability of a 100% organic toxic mold remedy for mold remediation professionals ... today the availability of a certified organic toxic mold remedy for mold removal and mold abatement ... same technology that was used effectively on the toxic mold that spread like the plague in the wake of ...

Nanoscale silver: No silver lining?

... an environmental hazard by EPA because it is more toxic to aquatic plants and animals than any metal ... increase the effectiveness of delivering toxic silver ions to locations where they can cause ... even if concentrations rise to levels that are toxic to aquatic ecosystems." The U.S. federal ...

NIH collaborates with EPA to improve the safety testing of chemicals

... automated screening robots to test suspected toxic compounds using cells and isolated molecular ... cellular components to identify chemicals with toxic effects. Importantly, the strategy calls for ... of chemicals a day to determine their possible toxic effect. NCGC is part of a larger Molecular ...

Biochip mimics the body to reveal toxicity of industrial compounds

... body, and whether those compounds will become toxic when metabolized in the body, all in one ... chemical like acetaminophen can become highly toxic when metabolized by the liver. Because of ... What is harmless to one person may be toxic to another. By arranging the ratio of enzymes on ...

Dragon Announces R&D Achievement in Biotech Manufacturing Process

... process involves the use of expensive solvents, toxic and pollutant reactants such as methylene ... and trimethylchlorosilicane, which lead to toxic wastes that are difficult to recycle and costly ... eliminating the use of expensive solvents and toxic reagents, leading to a considerable reduction in ...

Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases

... measures and analyzes the effects of chemical and toxic exposures on human health and the environment. ... and industrial consulting services focused on toxic tort issues, as well as ... environmental, health, safety, and toxic tort issues. Prior to Willis, Mr. Rodrigues ...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

... modulator, EVP-0962 selectively inhibits the production of the toxic AB42 peptide without affecting the total amount of AB. As EVP-0962 does ... the progression of Alzheimer's disease by reducing the disease-associated toxic AB42 species and to display an intrinsically superior safety profile ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

... of cells in Parkinson's disease patients' brains, including death due to toxic overproduction of alpha-synuclein. Once the cyclic peptides were ... which can be mutated in Parkinson's disease patients, protects cells from toxic levels of manganese. With these possible modes of action in mind, ...

Bionovo Announces Publication of Data on Active Compound and Mechanism of Action for Its Preclinical Cancer Treatment, BN108

... cell death in breast cancer cells and other tumor cells without having a toxic effect on normal cells. Timosaponin AIII (TAIII) has been ... are associated with severe toxicity. Significantly more effective, less toxic therapies are urgently needed. Our studies suggest that therapeutic ...

Scientists patent corrosion-resistant nano-coating for metals

... - which renders the metal resistant to corrosion and eliminates the use of toxic chromium for this purpose. The scientists have been awarded U.S. Patent ... to aviation to power plants. Traditionally, compounds containing a toxic form of chromium have provided the best corrosion resistance. Scientists ...

Progress toward an Alzheimer's drug that saves brain cells

... development that act on the whole γ-secretase complex run up against toxic side effects. Aph1B Under the direction of Bart De Strooper, and ... will succeed in stopping Alzheimer's disease. Furthermore, because the toxic side effects have been cut away, it could also be administered ...

Addiction Treatment Finds Success Treating Brain Deficiencies through the Belly

... the natural absorption process. As a result of its effort to decrease toxic load, the body's GI tract inhibits absorption of many essential vitamins, ... of the body. It is a common, natural response to a high systemic toxic load. The result is a body that is not receiving the appropriate level of ...

Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading

... but it poses a risk just the same. Mercury in any form can be toxic to the developing brain." (Wallinga et al, 2009). The ATSDR (Agency for toxic Substances and Disease Registry) is a sister agency of the Centers ...

A need for improved efficiency in nanomanufacturing

... materials to reduce energy use, emissions, solid waste, and the use of toxic input materials. "Research in this issue reveals the potential of ... Studies. "To date, most attention has focused on the possible toxic effects of exposure to nanoparticles and appropriately so. But the ...

Water purification down the nanotubes

... water molecules can pass along their interiors, whereas viruses, bacteria, toxic metal ions, and large noxious organic molecules cannot. The team points ... on carbon nanotubes that could remove arsenic, fluoride, heavy metals and toxic organic chemicals. Carbon nanotubes have impressive credentials for water ...

Local officials move toward monitoring nanotechnologies

... member of California State Assembly Committee on Environmental Safety and toxic Materials is holding meetings around the state in advance of introducing ... (D), a member of the Assembly's Committee on Environmental Safety and toxic Materials, is holding meetings at major state universities and research ...

Detecting dangerous chemicals with lasers, exploring the brain's circuitry with light and more

... require labeling neural cells with electrically-sensitive dyes that may be toxic to neurons. Now Jiayi Zhang, Tolga Atay, and Arto Nurmikko at Brown ... can detect even trace amounts of a wide range of chemicals, including toxic components of hazardous waste or chemical weapons, because many chemicals ...

Glowing zebrafish help researchers track role of sugars in the cell

... The researchers then modified a chemical reaction that is normally toxic to cells to eliminate the toxic copper catalyst and employed this reaction to attach a small fluorescent ...

Genetic Engineering and Biotechnology News (GEN) Reports on Early ADMET Use

... for example, uses a suite of validated assays and protocols to monitor the toxic characteristics of all small molecule compounds in its drug discovery ... a number of different cell models to assess not only hepatocellular-based toxic potential but also cardiotoxicity. The company introduced the use of ...

Modifying an anti-cancer drug makes it more specific

... functions and it has been reported that in some patients this causes a toxic effect on the heart. To address some of these problems, Ariel Fernndez and ... that neither inhibited the tyrosine kinase behind CML (BCR-Abl) nor had toxic effects on the heart when it was administered to mice. Importantly, WBZ_4 ...

JCI table of contents: Dec. 3, 2007

... functions and it has been reported that in some patients this causes a toxic effect on the heart. To address some of these problems, Ariel Fernndez and ... that neither inhibited the tyrosine kinase behind CML (BCR-Abl) nor had toxic effects on the heart when it was administered to mice. Importantly, WBZ_4 ...

Scientists discover how cancer may take hold

... cell, resulting in an excess of kynurenine in the body fluids, which is toxic to T-cells. Its double trouble for T-cells, remarked Wolf Frommer. ... from lack of tryptophan in their surroundings, but it is replaced by the toxic kynurenines, which wipes T-cells out. The scientists think that this ...

New nanoparticle vaccine is more effective but less expensive

... in a particularly potent immune response without the risk of unpleasant or toxic side effects. People have been exploring nanoparticles for a while, ... immunity with a single injection for around a dollar a dose, without toxic side effects, it could have a real impact on public health, in the ...

The Law Offices of Brian D. Witzer Wins 6+ Million Dollar Verdict

... the Plaintiff now depends on others for her activities of daily living. Stevens-Johnson Syndrome (SJS) and its more severe form called toxic Epidermal Necrolysis (TEN) are serious life-threatening disorders which affect the skin and mucous membranes, which can also result in blindness, ...

PharmatrophiX, Initially Funded by the Alzheimer's Drug Discovery Foundation, Announces Exclusive Global Collaboration with Elan

... M.D., Ph.D., set out to find small molecules that could activate a receptor on brain cells (p75), protecting the cell from damage caused by the toxic amyloid molecules associated with Alzheimer's disease, but not induce the side effects triggered by the much larger natural biologic molecules. Out ...

Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens

... metabolites by enzymes at or near the site of application after the therapeutic purpose is achieved. By avoiding the formation of active or toxic metabolites, Hygeia topical drugs are expected to have negligible systemic effects and have a better safety profile than other drugs in their ...

CEL-SCI Corporation Releases Letter to Shareholders

... for Multikine. We believe that the success of this study will open cancer therapy to a whole new way of fighting cancer, one that is not toxic and one that works with the body, not against the body. We have high confidence that this study will be successful for the following reasons: ...

MEDS World, LLC Provides Multiple Environments with Designed Solutions - Wherever People Congregate, MEDS Odor Elimination Solutions Offer Eco-Friendly, Odor-Free Air

... day challenges. Law enforcement and EMS personnel reduce health risks with the by-product of our active-oxidant, known to eliminate hazardous and toxic bacteria. In a locker room study of a major University, MEDS products reduced upper respiratory infections by twenty-five percent. The active-oxidant ...

Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study

... studies in humans cannot be ethically conducted because the studies would involve administering a potentially lethal or permanently disabling toxic substance or organism to healthy human volunteers. Approval of a drug under the "Animal Efficacy Rule" is subject to certain post-approval ...

Kuvan Receives Priority Review Status From Health Canada

... foods. If the active enzyme is not present in sufficient quantities, Phe accumulates to abnormally high levels in the blood and becomes toxic to the brain, resulting in a variety of complications including severe mental retardation and brain damage, mental illness, seizures, tremors, and ...

American Biotech Labs(R) Garners 2009 Utah Best of State Award

... performed by a variety of respected laboratories and researchers, ABL's silver hydrosol has consistently demonstrated the ability, without any known toxic side effects, to destroy a wide range of bacteria, viruses, yeast, and molds. ABL products have been approved by the Environmental Protection Agency ...

Cumberland Pharmaceuticals Provides Hospital In-Service Webcast for Acetadote(R)

... medications. It is the only approved injectable product in the United States for the treatment of acetaminophen overdose, the leading cause of toxic drug ingestions reported to U.S. poison control centers(1). Acetadote is contraindicated in patients with hypersensitivity or previous ...

First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease

... voclosporin oral capsule) to significantly improve this chronic eye inflammation. Additionally, in patients who are discontinuing potentially toxic medications for uveitis, such as the corticosteroid prednisone, LX211 actively reduces the rate of inflammatory exacerbations by 50% at six months, ...

Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation

... breast cancer patients, researchers found that FOXA1 expression identified the same low risk, ER-positive, node-negative patients who can be spared toxic chemotherapy (P=0.002). Researchers concluded Oncotype Dx and the FOXA1 marker can potentially be used interchangeably if further validation studies ...

Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting

... in both preclinical models and in human trials. Access believes that ProLindac's unique molecular design potentially could eliminate some of the toxic side effects seen in the currently marketed DACH platinum, Eloxatin, which has sales in excess of $2 billion. About Access: Access ...

Tolera Therapeutics Granted Orphan Drug Designation for Organ Transplant Rejection Drug

... the immune modulation market with the goal of addressing unmet medical needs with safer, more targeted solutions to reduce the risk of serious and toxic side effects often associated with immunotherapy. The company is focusing on commercializing therapeutic monoclonal antibody technology for the ...

Fitting pieces for biosensors

... cell cultures is not required during the process. Beside ethical benefits, another advantage of this is the possibility of aptamer selection even for toxic substances. Once suitable binders (aptamers) for a target molecule have been found by the SELEX process and their sequences have been defined, ...