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tolerance in Biological Technology

Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants

... the joint pipeline with other genes for drought tolerance as well as other abiotic stress tolerance traits. Among them is the second-generation ... and advance genes with promising yield and stress tolerance characteristics. Monsanto's discovery ...

Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize

... to enhance nutritional benefits and herbicide tolerance which will produce real benefits to farmers and ... The addition of a herbicide tolerance gene was targeted to disrupt ZmIPK1 in corn, an ... Research results confirmed the herbicide tolerance gene was inserted into the specified domain ...

BASF Sues DuPont for Patent Infringement

... and Company) for infringement of BASF's patented technology that confers tolerance to a key class of herbicides. Specifically, DuPont's Optimum GAT corn ... promoter which is an important genetic component that enables successful tolerance toward an herbicide class known as AHAS or ALS inhibitors. BASF Plant ...

Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species

... and Sangamo used ZFP Nucleases (ZFNs(TM)) to introduce a herbicide tolerance gene into a pre-determined address in the maize genome, simultaneously ... was disabled and permanently linked with the acquisition of herbicide tolerance - i.e. stacking the two desired characteristics in the plant and ...

Synvista Therapeutics Announces Progress in Phase 2 Clinical Trial Program for Alagebrium

... The study is designed to measure the effect of alagebrium on exercise tolerance in patients with chronic systolic heart failure. In addition, the Company ... alagebrium. "Based on our dialogue with the FDA, we believe that exercise tolerance is an approvable regulatory endpoint, in patients with systolic or ...

Phase 1b/2a Program Commences for RVX-208

... of Resverlogix. "This trial will continue to examine safety and tolerance as well it is a proof of principle study for ApoA-I production and HDL ... the required regulatory provisions that must be addressed such as safety, tolerance and pharmacokinetics, the study also will measure key reverse cholesterol ...

Hepatitis B Foundation and AAPCHO Sponsor Congressional Briefing on 'Zero Tolerance for Hepatitis B'

... Health Organizations (AAPCHO) is hosting a Congressional briefing, "Zero tolerance for Hepatitis B: the Health Needs of Women and Children," on May 20 at the ... treatment options, the U.S. has the tools to effectively implement a zero tolerance policy against hepatitis B to protect the health of Americans. Hepatitis ...

The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory

... diseases - SAN FRANCISCO, March 31 /PRNewswire/ -- The Immune tolerance Institute, Inc. (ITI) today announced a collaboration with Beckman ... better informed patient selection for targeted therapies. The Immune tolerance Institute (ITI) is a 501(c)(3) non-profit corporation founded in ...

Mercury Therapeutics Patents Filed

... elevated fasting blood glucose levels and a sluggish response in a glucose tolerance test (GTT). The statistically significant test results (p<0.05) showed a ... its first preclinical proof-of-principle of active compounds in a glucose tolerance test in mice. For further information: Mercury Therapeutics Inc. ...

Transgene in 2007: Partnership and Refinancing Position the Company for its Future Development

... and (iii) TG4040, for chronic hepatitis C, in phase I where initial tolerance and efficacy data are expected shortly," Philippe Archinard added. ... higher dose receive a complementary injection ('boost') at six months. The tolerance and efficacy data after the first injections are expected shortly. The ...

Fourth Genmab Antibody Developed Under Roche Collaboration to Enter Clinic

... of the OX40L-specific antibody may also involve restoration of peripheral tolerance mechanisms. Breaking of tolerance promotes development of autoimmune and allergic diseases. Under the ...

Ricardo Launches Consortium to Evaluate Lubricant Challenges of Future Low Carbon Engine Technologies

... Particular areas of interest for the consortium include: the implications of extreme engine downsizing and increased specific power; tolerance to increasing volumes of exhaust gas recirculation in combustion systems (with consequent issues for soot in oil, wear and sludge formation); the ...

Sanofi-aventis Announces Second Quarter 2009 Results

... with atrial fibrillation will be presented on September 1. Results from the SEPIA-ACS1 TIMI 42 phase II trial, evaluating the efficacy and tolerance of otamixaban (an intravenous selective anti Xa factor) in patients with acute coronary syndrome (without ST segment elevation) will also be ...

Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres

... Trait technology and other agronomic enhancements. The technology is a new family of traits being developed by Dow AgroSciences that will provide tolerance to 2,4-D and other classes of herbicides to provide growers with improved and enhanced weed control versus current herbicide programs. Introduction ...

New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives

... current medication produces inconsistent results. Furthermore, patients cite the pain and discomfort they receive at the injection site as well as tolerance issues as drawbacks from their current medication. "This large patient survey provides key insights into how patients with rheumatoid arthritis ...

VIA Pharmaceuticals' DGAT1 Inhibitors Featured in American Diabetes Association Poster Presentation

... lipid metabolism. In studies of obese animals, DGAT1 inhibitors have been shown to induce weight loss and improve insulin sensitization, glucose tolerance and lipid levels. These observations suggest DGAT1 inhibitors may have the potential to treat obesity, diabetes and dyslipidemia. VIA intends to ...

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

... in moderate to severe Crohn's disease patients who have previously received and responded but who no longer have a sustained response and/or tolerance to infliximab. Primary efficacy was defined as at least 100 points decrease in the Crohn's Disease Activity Index (CDAI) versus baseline at week 6. ...

Pierre Fabre Dermatologie Starts Clinical Trials on a Beta-Blocker to Treat Severe Infantile Haemangioma

... in several hundred children throughout the world. Rigorous clinical trials are, however, yet to be conducted to ascertain the efficacy and tolerance of this new therapeutic strategy, hence this agreement with Pierre Fabre Dermatologie, which would ensure safety and availability of the treatment." ...

Leading Advisory Firm, PROXY Governance, Recommends Avigen Shareholders Vote on GOLD Card to Remove Incumbent Directors and Elect BVF's Stockholder-Oriented Nominees

... market reaction to dissident involvement, the reactive nature of the company, governance concerns and the likely diverging incentive and risk tolerance of management and other shareholders such as BVF, we believe some change is needed and the board could benefit from greater shareholder ...

Dow AgroSciences Delivering Beyond Expectations

... launch and ramp-up plans. The Dual Effective Dose provided by SmartStax will drive value in improving yield opportunities. The Dow Herbicide tolerance (DHT) family of traits is also advancing quickly in the company's pipeline. This technology will allow growers to use an additional herbicide over ...

DuPont Expects Increased Global Seed Corn Share, Continued Agriculture Earnings Growth

... on the fast track for introduction: 2010 - Optimum(R) GAT(R) corn, for improved weed control options in corn. 2010 - Drought tolerance I, a product offering with enhanced water use efficiency traits selected through molecular breeding validated in on-farm field trials. ...

Syngenta Enters Into Research Collaboration With Anhui Academy, China

... in China. The collaboration program is centered around conducting laboratory and field tests of novel gene functions and will focus on drought tolerance and nitrogen utilization optimization in key crops such as corn and soybean. ARRI will work closely with Syngenta's new biotech research and ...

Historic Seed Delivery Made in Illinois for First New Soybean Varieties With the Greater Yield Potential of Roundup Ready 2 Yield(TM)

... mark of Biotechnology Industry Organization. ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. Roundup Ready(R) crops contain genes that confer tolerance to glyphosate, the active ingredient in Roundup(R) agricultural herbicides. Roundup(R) agricultural herbicides will kill crops that are not tolerant ...

BioMS Medical reports results of exploratory phase II trial of dirucotide in relapsing remitting multiple sclerosis

... represent approximately 70 percent of all MS patients. The drug's proposed mechanism of action is the induction or restoration of immunological tolerance with respect to ongoing immune attack as a result of high doses of peptide periodically delivered intravenously. The potential benefit of the drug ...

Matching Genetics, Technology and Management Practices Critical to Meeting Strong Demand for Agricultural Crops

... seed corn products are averaging 5.5 bushels per acre better than competitive “double stacks.” Pioneer® brand hybrids with herbicide tolerance are averaging 7.1 bushels per acre better than competitive hybrids with herbicide tolerance. On-farm soybean yield trials are showing an overall ...

Nuvelo Announces Positive Results from Phase 1 Clinical Trial of NU206 in Healthy Volunteers

... from its Wnt Therapeutics Program. This single-center, double-blind, placebo-controlled, single-ascending dose (SAD) trial tested the safety, tolerance and pharmacokinetics of a single intravenous (IV) administration of NU206, in 32 healthy male volunteers. Participants were enrolled in four cohorts ...

Publication on 'Tregitopes' in Blood Journal of October 2008

... illnesses as Rheumatoid Arthritis, Juvenile Diabetes, Multiple Sclerosis, and others The approach used by EpiVax is called "Antigen-Specific Adaptive tolerance Induction (ASATI(TM))" to specifically target and reduce undesirable immune responses. EpiVax used its proprietary computer algorithms to identify ...

Laureate Announces Manufacturing Agreement with Tolerx

... to GITR and is in preclinical development for the treatment of cancer and chronic viral diseases. TRX518 is thought to circumvent immune system tolerance by inhibiting the suppressive activity of T regulatory cells and extending the survival of T effector cells, thereby enhancing responses to tumor and ...

Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in Support of China's Ministry of Science and Technology

... is seeking accurate, reproducible detection of melamine of less than or equal to 2 mg/kg (ppm). Moreover, authorities in the US have declared that no tolerance can be set for the presence of melamine in infant formula. This indicates the need for an analytical method capable of accurately quantifying ...

Synvista Therapeutics Posts Letter to Stockholders on Web Site

... least one-half of the subjects enrolled in this study will have diabetes. The primary efficacy measure of the BREAK study is improvement of exercise tolerance as assessed by the six-minute walk test, an accepted regulatory endpoint. In addition, there will be a number of secondary and tertiary ...

Cardinal Health Invites Health Care Providers to Apply for $1 Million in Grants to Fund Patient Safety Initiatives

... being given to programs that reduce hospital-acquired infections (HAIs) and improve medication safety. "We believe that by taking a zero tolerance approach to medical errors, we can dramatically improve health care quality while also removing considerable, avoidable costs from the health care ...

Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin&#8482;

... only group and the Emulin™ plus metformin group. After one week, peak blood sugar level, meaning the level two hours after a glucose tolerance test, increased 4 percent in the placebo only group, was unchanged in the Emulin™ only group; and decreased 10 percent in the metformin only ...

BioMS Medical's lead drug, dirucotide (MBP8298) for the treatment of multiple sclerosis, receives fast track designation from FDA

... these genes represent 65 to 75 percent of all MS patients. The drug's apparent mechanism of action is the induction or restoration of immunological tolerance with respect to ongoing immune attack as a result of high doses of peptide periodically delivered intravenously. The potential benefit of the drug ...

BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis

... these genes represent 65 to 75 percent of all MS patients. The drug's apparent mechanism of action is the induction or restoration of immunological tolerance with respect to ongoing immune attack as a result of high doses of peptide periodically delivered intravenously. The potential benefit of the drug ...

BioMS Medical completes patient recruitment in phase III U.S. multiple sclerosis trial

... 65 to 75 percent of all MS patients. The apparent mechanism of action of MBP8298 (dirucotide) is the induction or restoration of immunological tolerance with respect to ongoing immune attack as a result of high doses of peptide delivered periodically by the intravenous route. The potential benefit of ...

Nuvelo Initiates Phase 1 Clinical Trial of NU206 in Healthy Volunteers

... lead compound from its Wnt Therapeutics Program. This double-blind, placebo-controlled, single-ascending dose (SAD) trial will determine the safety, tolerance and pharmacokinetics of a single intravenous (IV) administration of NU206, in approximately 48 healthy male volunteers. Participants will be enrolled ...

Carbon Nanoprobes, Inc Announces Production Agreement With Leading MEMS Foundry

... demand for AFM tips as well as forecasted demand several years into the future. Ruby adds, "The foundry also provides levels of precision and tolerance we simply didn't have in our previous production environment." Executives at CN Probes state that intellectual property provisions are ...

SEKAB Agreement: More Verified Ethanol to Europe

... Sweden after the summer holiday period. Zero tolerance The verified sustainable ethanol is produced from sugarcane grown on farms applying zero tolerance to child and slave labour and to farming in the Amazon region. Verified sustainable ethanol will reduce carbon dioxide emissions by at least 85 per ...

DRC's Metrigraphics Announces Family of Micro-Induction Coils for Implanted and Traditional Medical Applications

... over 160 coil variations prototyped, Metrigraphics offers customers the flexibility in process technology, substrate material, size, induction and tolerance ranges and functionality to meet the most rigorous technical specifications not fully addressed by other manufacturers. The new micro-induction coils ...

REMINDER: Exelixis Will Webcast Its June 2 Investor and Analyst Briefing at ASCO

... 42H Abstract Number: 8053 Presenter: Naiyer A Rizvi, MD Monday, June 2 -- XL647 (EGFR, HER2, VEGFR2) - Poster & Discussion "Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase 2 trial" Day: Monday, June 2 Session: ...
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(Date:10/17/2014)... Why do male ... reproduce? And why are there two sexes anyway? These and ... the research journal Molecular Human Reproduction published today ... University Bielefeld has compiled this special issue on sperm competition. ... copulate with several males in quick succession – chimpanzees are ...
(Date:10/16/2014)... human body. Battles are won, lost or sometimes ... stalemate—known as tumor dormancy—can last up to 25 ... is poorly understood. , A new computational ... a Professor of Chemistry at Princeton University, may ... the switch to a malignant state. Published today ...
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