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Tethered molecules act as light-driven reversible nanoswitches

... to metal surfaces allows the molecules to be switched between two different configurations in response ... attached to surfaces, they no longer could be switched back and forth, as they could be when they were ... built scanning tunneling microscope, they switched from the trans to the more-compact cis state. ...

Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS

... in severe exacerbations when switched to the equivalent dose of FP combined with ... alone. The study found patients who were switched to Advair were 36 percent less likely to suffer a ... (5.2%) versus FP (7.6%). Additionally, patients switched to Advair needed 34 percent fewer prescriptions ...

Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients

... combination of these agents were eligible for enrollment and immediately switched to a starting dose of 4.5 grams per day of Zerenex (ferric citrate). In ... combination of these agents were eligible for enrollment and immediately switched to a starting dose of 6.0 grams per day of Zerenex (ferric citrate). ...

Gene against bacterial attack unravelled

... He did this by rearing mice DNA in which the gene for Toll2 production was switched on and off. 'The group where the gene for Toll2 was switched off, survived the bacterial infection', says Wiersinga. 'The other ...

Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements

... from its first Phase 2 clinical trial for Gaucher disease in patients who switched from enzyme replacement therapy (ERT) with Cerezyme(R) (imiglucerase) to ... many patients with Fabry, Gaucher and Pompe disease may be successfully switched from ERT to a pharmacological chaperone," noted John Crowley. Other ...

Scientists synthesize memory in yeast cells

... and reactivated the gene. In other words, the second gene continually switched itself on via the very transcription factor it created when it was switched on. The researchers then eliminated the galactose, causing the first ...

Scientists synthesize memory in yeast cells

... and reactivated the gene. In other words, the second gene continually switched itself on via the very transcription factor it created when it was switched on. The researchers then eliminated the galactose, causing the first ...

New angle on gecko research

... now an assistant professor of biological sciences at Clemson. "We show that perception of body orientation determines when the adhesive system is switched on." The scientists discovered that the tipping point which turns on the gecko's adhesive system is 10 degrees. Three of the six geckos studied ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

... brains, including death due to toxic overproduction of alpha-synuclein. Once the cyclic peptides were inserted into the model yeast cells, Kritzer switched the yeast into Parkinson's mode and waited to see which yeast cells survived. Of the approximately 5 million yeast cells that were inserted with a ...

Israeli scientists show bacteria can plan ahead

... and found that, in addition to the genes that enable it to digest lactose, the gene network for utilizing maltose was partially activated. When they switched the order of the sugars, giving the bacteria maltose first, there was no corresponding activation of lactose genes, implying that bacteria have ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently discontinued and patients should not be switched to other erythropoietic proteins. The safety and efficacy of PROCRIT therapy have not been established in patients with a known history of ...

Raptiva Withdrawal Offers Upside for Enbrel and Humira According to Latest BioTrends Survey of U.S. Dermatologists

... expected to be discontinued from biologic therapy, it appears that Enbrel (Amgen/Wyeth) and Humira (Abbott) stand to gain the most for patients being switched to other agents. Roughly 20% of the respondents feel that the withdrawal of Raptiva will result in an overall decline in biologic use in their ...

Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD

... as the dosage of ASMANEX should be reduced slowly. If you or your child took steroids by mouth and are having them decreased or are being switched to ASMANEX, you should be followed closely by your health care provider and the oral steroids should be reduced slowly. Deaths due to adrenal ...

Baseline Research Indicates High Interest in Centocor-Ortho Biotech's SIMPONI(R)

... reported that close to 40% of their severe RA patients could be considered candidates for SIMPONI and that the majority of SIMPONI patients would be switched from other biologic agents. Market share projections suggest that SIMPONI will primarily draw from other TNF-inhibitors and 38% of the respondents ...

ChartTrends(R): Bone and Mineral Metabolism in Dialysis Reveals Latest Trends in the Treatment of Calcium, Phosphorus and PTH

... and FMC's PhosLo. Within the sevelamer franchise, patient conversion to Renvela stands at about 27% and about half of the Renvela patients had been switched from Renagel. The vast majority of dialysis patients are on Active Vitamin D formulations such as Abbott's Zemplar and Genzyme's Hectorol. The ...

MIT: New method could lead to narrower chip patterns

... CAMBRIDGE, Mass.--Researchers at MIT have found a novel method for etching extremely narrow lines on a microchip, using a material that can be switched from transparent to opaque, and vice versa, just by exposing it to certain wavelengths of light. Such materials are not new, but the researchers ...

A molecular ripcord for chemical reactions

... Systems (ICMS) and the Department of Chemical Engineering and Chemistry, both at TU/e, is the first to have demonstrated that a catalyst can be switched from a dormant to an active state (see illustration) by pulling on a polymer chain, a "molecular ripcord." The researchers were able to use this ...

Frost & Sullivan Applauds SHL Telemedicine for Excellence in Product Innovation

... This full 12 lead ECG personal digital cellular transmitter is a monitoring system that uses either cellular network (GPRS) or public switched telephone network (PSTN) to transmit real-time medical cardiological data remotely. It effectively fulfils the need for an end-user friendly system. ...

Anti-cancer gene discovered: Perspective for therapy

... cancer in all three. Reciprocally, switching off the gene leads to cancer. The scientists think there is a good chance that the gene can be switched on again with a drug. They report their findings in the reputed scientific journal PLoS Biology . Specialized cells All of us begin our ...

KanekaQH(TM) Ubiquinol Dramatically Boosts Ejection Fraction in Patients With Late-Stage Congestive Heart Failure

... study, led by cardiologist Peter Langsjoen, assessed the effect of changing their ubiquinone supplementation to ubiquinol (Kaneka QH(TM)). When switched to supplemental ubiquinol, there was a dramatic increase in both the patients' EF and plasma CoQ10 levels with corresponding improvements in clinical ...

Researchers measure elusive repulsive force from quantum fluctuations

... quantum theory, when the scientists replaced one of the two metallic surfaces immersed in a fluid with one made of silica, the force between them switched from attractive to repulsive. As a result, for the first time, Capasso and his colleagues measured what they have deemed a repulsive Casimir. To ...

Miniaturizing memory: Taking data storage to the molecular level

... the inner tube to an electrode, creating the 'zero' or 'one' states required to store information using binary code. When the power source is switched off, van der Waals force which governs attraction between molecules keeps the Inner tube in contact with the electrode. This makes the memory ...

BioTrends Releases TreatmentTrends(TM): Nephrology and Renal Dietitians, Two Syndicated Reports Providing Continuing Insight into the Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism

... Renvela has given overall sevelamer share a boost compared to the same quarter last year, although most of the patients on Renvela have been switched from Renagel. Close to two-thirds of MDs and over three quarters of RDs have used Renvela in their hemodialysis patients, however, Renagel and ...

One-Year Data Show Golimumab Improved Signs and Symptoms In Patients with Psoriatic Arthritis In Phase 3 Study

... (50 or 100 mg) at week 0 and every 4 weeks thereafter through the end of the study. At week 16, patients with inadequate arthritis response were switched to golimumab 50 mg (patients originally receiving placebo) or golimumab 100 mg (patients originally receiving golimumab 50 mg). At week 24 all ...

Video: ASMANEX(R) TWISTHALER(R) 110 MCG (Mometasone Furoate Inhalation Powder) is Now Available Nationwide for the Maintenance Treatment of Asthma in Children Ages 4 to 11

... provider as the dosage of ASMANEX should be reduced slowly. If you or your child took steroids by mouth and are having them decreased or are being switched to ASMANEX, you should be followed closely by your health care provider and the oral steroids should be reduced slowly. Deaths due to adrenal ...

Cardiac Science Launches 'Anywhere' Data Management for HIS and EMR Systems

... modality recordings (ECG, stress, and Holter) in one application. Stephen French, program manager-PACS for WellSpan Health of Pennsylvania, switched from GE MUSE to Pyramis. He explained, "We needed a stable system for new and current hardware. Pyramis is better for ECG and stress tests on a ...

Agent in red wine found to keep hearts young

... by looking for changes in gene expression in those tissues. As animals age, gene expression in the different tissues of the body changes as genes are switched on and off. In the new study - which compared the genetic crosstalk of animals on a restricted diet with those fed small doses of resveratrol - ...

Carbon nanoribbons could make smaller, speedier computer chips

... in and out of the semiconductor. This allows the electric current to either pass through or be blocked, which in turn controls how the devices can be switched on and off, thereby regulating the flow of data. Researchers predict that silicon chips will reach their maximum shrinking point within the next ...

Awareness of Genzyme's Renvela(R) (Sevelamer Carbonate) is High, Although Uptake of this New Phosphate Binding Agent has Been Slower than Nephrologists and Renal Dietitians Initially Expected

... fewer incidences of acidosis and better GI tolerability, according to Nephrologists and RDs. Renvela trials for the most part have been in patients switched from Renagel or naive to binder therapy, although depending on patient types, there are switches from competitive products. Each binder is associated ...

Amicus Therapeutics Announces First Quarter 2008 Financial Results

... of Gaucher disease. At the ACMG meeting in March, clinical investigators presented full data from a 4 week Phase 2 study in Gaucher patients who switched from enzyme replacement therapy (ERT) with imiglucerase to the pharmacological chaperone Plicera. Results showed that Plicera was generally safe and ...

Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa)

... antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently discontinued and patients should not be switched to other erythropoietic proteins. -- The safety and efficacy of PROCRIT therapy have not been established in patients with a known history of a ...

Nanoswitches toggled by light

... that these crystals stretch out to become longer (but not wider) when they are irradiated with laser pulses in the microscope. If the irradiation is switched off, they contract back to their original size. This effect was most obvious when one of these needles was broken by the shock of a short, strong ...

Ortho Biotech Statement On JAMA Publication Regarding Erythropoiesis-Stimulating Agents

... antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently discontinued and patients should not be switched to other erythropoietic proteins. -- The safety and efficacy of PROCRIT therapy have not been established in patients with a known history of a ...

Arpida Receives Green Light From US FDA for Phase II Efficacy Trial With Oral Iclaprim

... cSSSI will receive IV vancomycin for the first two days of treatment and will then be randomised to either continue to receive IV vancomycin or be switched to oral iclaprim for eight additional days. A total of 60 patients will be randomised for this study. Iclaprim is also being developed as an ...

Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine

... and pentamidine. The adverse events associated with currently available treatment options for PCP leads to between 20-57% of all patients being switched to better tolerated regimens during their course of care. The development of pafuramidine for the treatment of PCP was sponsored in part by a ...

Ortho Biotech Modifies Prescribing Information for PROCRIT(R) (Epoetin alfa) Label Reflects Recommendations from Recent FDA Advisory Committee Meetings

... antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently discontinued and patients should not be switched to other erythropoietic proteins. * The safety and efficacy of PROCRIT therapy have not been established in patients with a known history of a ...

ASU researchers improve memory devices using nanotech

... from this problem and can even store multiple bits on one site. Moreover, once the resistance is set, it does not change, even when the power is switched off. CANis previous high-performance resistance-change memory has been licensed to three companies, including Micron Technology and Qimonda, and ...

Kuvan, Naglazyme and Aldurazyme Data to Be Presented at the 57th Annual Meeting of the American Society of Human Genetics

... -- Patients receiving Naglazyme improved by a mean of 183 m +/- 26 m from baseline to week 96 in the 12MWT (p -- The placebo group, which was switched to active drug at week 24, improved by a mean of 117 m +/- 25 m from week 24 to week 96 (p -- Similar improvements in the rate of stairs climbed ...

Digital pioneer wins national physics prize

... of the other mirrors. The tilting of the mirrors allows a digital image to be processed from a digital signal because each pixel-like mirror can be switched on and off thousands of times a second to reflect light onto a screen. When Hornbeck invented the technology at Texas Instruments in 1987, the ...

Researchers improve ability to write and store information on electronic devices

... magnetic field either in the same direction as the top layer (for a "0") or in the opposite direction (for a "1"). Traditionally, MRAM are switched by magnetic fields. As the bit size has shrunk in each successive generation of computers in order to accommodate more memory in the same physical ...
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