Suppressor in Biological Technology

Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells

... cells and deliver its payload: a fully functioning copy of the P53 tumor suppressor gene. Normal cells have two copies of the functioning P53 gene. The ... effects in another way as well. When the job of reinstating a normal P53 suppressor gene is done, the nanoparticle essentially a little fat droplet wrapped ...

New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor

... target receptor could have unexpected results, especially if a major tumor suppressor gene -- p53 -- is already compromised, according to new research by ... cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers. Hence the ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... in a number of cancer cell lines, and restores function of the p53 tumor suppressor protein through a novel mechanism of action; the compound is in phase I ... Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumour suppressor Pathway and Accelerates Tumour Formation in Humans. Cell; 2004; 119: ...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

... 24 to 30 months. "Sirtuins represent a new component of epigenetic tumor suppressor gene silencing that may potentially link some epigenetic changes ... agents, targeted epigenetic therapy reactivates the silenced tumor suppressor genes thereby re-establishing the cancer cell's natural mechanisms to ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

... of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI ...

First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418

... cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

... of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI ...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

... of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI ...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

... and sensitive quantification of miRNAs individually or in an array format. GeneCopoeia also plans to release soon a set of vector based miRNA suppressor construct products currently in development. Together with other miRNA products aforementioned, this product line will provide a complete set of ...

FDA Accepts Investigational New Drug (IND) Application for Tigris Pharmaceutical's GGTI-2418

... cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation ...

Tigris Pharmaceuticals Files IND Application for GGTI-2418

... cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation ...

Large-scale genetic study sheds new light on lung cancer

... Our work uncovered many new targets for therapy of this deadly disease -- oncogenes that drive particular forms of lung adenocarcinoma and tumor suppressor genes that would ordinarily prevent cancer cell growth," said Matthew Meyerson, M.D., Ph.D., a senior author of the paper. Dr. Meyerson is a senior ...

Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL

... is a small molecule class I and II histone deacetylase inhibitor (HDACi). HDACi's modulate gene expression within tumor cells, including tumor suppressor genes, leading to G1 and G2/M cell cycle arrest, induction of apoptosis (programmed cell death), inhibition of angiogenesis, immune modulation, and ...

SuperGen Reports 2008 Second Quarter Financial Results

... bioavailable and well-tolerated in a first in human study (Abstract No. 4083). The presentation entitled, "MP-470, a potent oral Rad51 suppressor is safe and tolerable in first-in-human study," summarized the data suggesting that MP-470 is well-tolerated when administered in doses ...

DermTech Names Herbert A. Fritsche, Ph.D., Chief of Clinical Chemistry at M.D. Anderson Cancer Center to Company's Scientific Advisory Board

... tumor markers (CEA, AFP, HCG, LDH, B2M, estrogen and progesterone receptors), more recently, tests for circulating DNA (promoter regions of tumor suppressor genes for prostate cancer detection), urine mRNA survivin for bladder cancer detection and circulating tumor cell assays for establishing prognosis ...

SuperGen Reports 2008 First Quarter Financial Results

... was shown to be bioavailable and safe in humans (Abstract No. 4083). The presentation entitled, "MP-470, a potent oral Rad51 suppressor is safe and tolerable in first-in-human study," summarized the data indicating that MP-470 can be safely administered in doses of up to ...

EMEA Accepts for Review Vidaza(R) Marketing Authorization Application for Higher-Risk Myelodysplastic Syndromes

... expression and, unlike DNA mutations, may be reversed by targeting the mechanisms involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic regulation has been demonstrated in vitro and in vivo in hematological malignancies and in solid ...

JCI table of contents: Dec. 3, 2007

... findings lead to new sunscreens for the prevention and treatment of UV lightinduced skin cancer. TITLE: CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice AUTHOR CONTACT: Mohammad Athar The University of Alabama at Birmingham, ...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

... library vector map). Pilot screens using a tumor suppressor gene family set were performed to address ... shRNAs found in a panel targeting tumor suppressor genes (Sigma-Aldrich, MISSION ↓ TRC shRNA ... by lentiviral particles. The entire tumor suppressor panel, consisting of approximately 75 gene ...

Real-Time PCR/Melt-Curve Analysis: SNP Detection With FRET, Rev A

... The DNA source was the p53 dominant-negative vector set (Clontech), which provides vectors containing the wild-type p53 suppressor gene and the dominant-negative p53 mutant, differing only by a G/A transition at nucleotide 1,017. The experiments were done ...

Detection of Mutant K-ras in a Kindred With Hereditary Pancreatic Cancer by DGGE

... or equivocal in early disease. Tumorigenesis is believed to involve the K-ras oncogene, DCC, p16, APC, bcl-2 and p53 tumor suppressor genes; screening for mutations or loss of heterozygosity in these genes may provide better diagnostic tests that are more sensitive ...

RNA Interference and Gene Silencing: History and Overview

... is defective in germline cells where ego-1 is primarily expressed. In Arabidopsis SDE-1 / SGS-2 mutants ("SGS" stands for suppressor of gene silencing), siRNAs are produced when dsRNA is introduced via an endogenously replicating RNA virus, but not when introduced ...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... from Cell 120 : 635647. This study suggests that let-7 miRNA might function as a tumor suppressor in lung. Misregulation of let-7 might contribute to oncogenesis by triggering up-regulation of RAS ...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

... lymphocytic leukemia (CLL) patients commonly exhibit a chromosomal abnormality at 13q14. No known tumor suppressor genes exist at this locus and no consistent involvement of any of the genes in the deleted region has been ...

Big Blue Rodent Cell Cultures for Mutagenesis Studies

... in vitro mutagenesis studies, these cell lines are useful for various toxicological applications, studies of the effects of oncogenes and tumor suppressor genes on mutation frequencies and studies of DNA repair. REFERENCES Kohler, S.W., et al. (1991) Proc. Natl. Acad. Sci. USA ...