Somatic in Biological Technology

Animal Eggs Not Suitable Substitutes to Produce Stem Cells

... the cloning of Dolly the Sheep over a decade ago, somatic cell nuclear transfer (SCNT) has been considered ... in a paper entitled, "Reprogramming of Human somatic Cells Using Human and Animal Oocytes." The ... then be differentiated to become any type of somatic cell and used for cell or tissue repair or ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... in samples where DNA sequencing cannot detect very low concentrations of somatic DNA mutation. "We are very excited to be able to work with ... Nuclease promises a significant solution to high sensitivity detection of somatic mutations that are key to cancer biology." Cold-PCR will have ...

Advanced Instruments Acquires D & F Control Systems Inc.

... F Control Systems manufactures and markets milk preservative products and somatic cell dyes for laboratories around the world. Their patented preservatives ... for cryoscopy, pasteurization confirmation, component analysis and somatic cell counting. The company provides products that are internationally ...

Roche Signs Exclusive Distribution Deal with DxS for K-RAS and EGFR Cancer Mutation Tests

... EGFR 29 Test is designed to enable detection of 29 of the most common somatic mutations in the EGFR gene and detects mutations with greater sensitivity ... studies in non-small cell lung cancer have shown that some patients carry somatic mutations in the epidermal growth factor receptor (EGFR) gene. These ...

Stemagen First to Create Cloned Human Embryos From Adult Cells

... world to create, and meticulously document, a cloned human embryo using somatic cell nuclear transfer (SCNT). Stemagen CEO Samuel H. Wood, M.D., Ph.D., ... author on the paper, "Development of Human Cloned Blastocysts Following somatic Cell Nuclear Transfer (SCNT) with Adult Fibroblasts." "No other ...

New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain

... has been demonstrated across a broad spectrum of pain states such as somatic and neuropathic pain(5,6). Recent experimental data in healthy volunteers ... moderate to severe cancer and severe non-cancer related pain types such as somatic (e.g. osteoarthritis), neuropathic (e.g. diabetic neuropathy) and visceral ...

SEQUENOM Reports Second Quarter 2009 Financial Results and Highlights

... continues to benefit from market acceptance of the OncoCarta panel. OncoCarta is a comprehensive multi-gene panel available for profiling rare somatic mutations. It enables researchers to rapidly profile genetic changes associated with tumor initiation and progression. The company expects to add ...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

... senior vice president of sales & marketing at SEQUENOM. "MassARRAY technology enables detection of the most common molecular biomarker classes - somatic mutations via the OncoCarta mutation panel, SNPs, CNVs, methylation patterns, expression signatures - with an unmatched combination of quantitative ...

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

... investigator at the Harvard Stem Cell Institute, and assistant investigator at the Stowers Medical Institute. Dr. Eggan is a world authority on somatic cell reprogramming by nuclear transfer, and the applications of iPS cells to model neurodegenerative disease. Dr. Matthias Hebrok, ...

iZumi Bio Appoints Dr. Corey Goodman to Board of Directors and Scientific Advisory Board

... in the area of cardiovascular disease to identify potential targets that address unmet medical need. iZumi's technology involves reprogramming somatic cells to a pluripotent state. Because iPS cells have stem-cell-like properties and have the potential to differentiate into any cell type, iPS cells ...

Thomson Reuters Names 'Hottest' Researchers and Papers of 2007-2008

... superconductors, which was cited 249 times, more than double that of the second most-cited paper. A paper discussing the reprogramming of human somatic cells took second place with 116 citations, while a paper exploring insulin therapy and pentastarch resuscitation in severe sepsis received 112 ...

Sigma-Aldrich Streamlines Access to Advanced Stem Cell Research Portfolio and Opens Stem Cell Biology Community Through New Web Portal

... affected by a wide range of debilitating and life threatening conditions. New approaches are expected to make it possible to reprogram differentiated somatic cells, such as fibroblasts, into stem cells which can then be used for a variety of research applications. Sigma-Aldrich provides access to a growing ...

Global Psychiatrists Unite to Improve Services in Mental Health

... to help improve the quality of life of persons affected by mental illness. --------------------------------- (i) Fleischhacker WW et al. Comorbid somatic Illness in Patients with Severe Mental Disorders: Clinical, Policy and Research Challenges. J Clin Psychiatry. 2008;69 (4):514-519. ...

New insights into cellular reprogramming revealed by genomic analysis

... Regenerative Biology and associate member of the Broad Institute, who led the multi-institutional effort. Currently, reprogramming requires infecting somatic cells with engineered viruses. This approach may be unsuitable for generating stem cells that can be used in regenerative medicine. Our work provides ...

Fate Therapeutics Taps Successful Biotech CEOs Paul Grayson and John Mendlein for Leadership Team

... disorders including Down syndrome; and metastatic cancers. Fate's approach is designed to therapeutically use or redirect normal adult or somatic cells inside the human body and does not require embryonic stem cells from humans or any other animal. "Fate continues to build momentum as a ...

JCI online early table of contents: March 6, 2008

... human genetic diseases. TITLE: Production of CFTR-null and CFTR-delta-F508 heterozygous pigs by adeno-associated virusmediated gene targeting and somatic cell nuclear transfer AUTHOR CONTACT: Michael J. Welsh University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. Phone: (319) ...

Sir Walter Bodmer Joins Oxford Genome Sciences Scientific Advisory Board

... in the Department of Genetics. Dr Bodmer, who has developed models for population genetics, worked extensively on the HLA system and the use of somatic cell hybrids for human linkage studies, received his Ph.D. in Genetics in 1959 from the University of Cambridge. He became a fellow of the Royal ...

Anaptys Biosciences Appoints R. Scott Greer to Board of Directors

... with Coopers & Lybrand. About Anaptys Biosciences Anaptys is a privately-held biopharmaceutical product company and the leader in the use of somatic hypermutation (SHM) for antibody discovery and protein optimization. The company's proprietary Omnitope-SHM(TM) System provides a robust platform for ...

Nventa announces publication of HspE7 data

... against tumor challenges in mice lacking CD4+ functions. CD8+ T cells are a type of white blood cell capable of inducing the death of infected somatic or tumor cells by killing cells infected with viruses (or other pathogens) or otherwise damaged or dysfunctional. These data further demonstrated ...

NIH Announces Advanced Cell Technology's 'Single Cell Embryo Biopsy Technique' as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding

... sources of pluripotent stem cell lines, including altered nuclear transfer; single cell embryo biopsy, and reprogramming, or dedifferentiation of somatic cells, such as skin cells." In August 2006, ACT published a paper in Nature documenting the technique for removing a single cell (known as a ...

Biologist who cloned Dolly the sheep believes therapeutic cloning will gain acceptance

... science of that cloning technique, also known as somatic cell nuclear transfer, and its potential for ... embryonic stem cell research might bode well for somatic cell nuclear transfer, which has more public ... the nuclear-transfer process, the nucleus of a somatic cell, a body cell other than a sperm or egg cell, ...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... FDA, CBER. Guidance for industry: Guidance for human somatic cell therapy and gene therapy. 1998 Mar 30. Available at URL: ... Ministry of Health of China.Points to consider on human somatic cell therapy and gene therapy. Beijing: 1993 May 1. ...

Wisconsin Senate votes to outlaw cloning; measure still faces veto

... Pro-Life Wisconsin's state director, speaking through a press release. "Both involve the reproduction of a fully human life. The immediate product of somatic cell nuclear transfer - the cloning process - is a human person, whether the intent is to bring that person to birth or to destroy that person for ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... SIP Steam in place or sterilize in place (see CIP). somatic cell In higher organisms, a cell that (unlike germ cells) carries the ... pollen and ovule in plants) and somatic cells (all of the other cells). It is the germ-line DNA that is altered ...

RNA Interference and Gene Silencing: History and Overview

... href="#18">18 ). In C. elegans ego-1 mutants ("ego" stands for "enhancer of glp-1 "), RNAi functions normally in somatic cells, but is defective in germline cells where ego-1 is primarily expressed. In Arabidopsis SDE-1 / SGS-2 mutants ("SGS" ...

An Optimal DNA Microarray Substrate for the Identification of Fetal and Somatic Liver Stem Cells of the Rat

... growth and cell development. In our project we are developing DNA microarrays for the identification of fetal and somatic liver stem cells. The microarrays will be used for the examination of the differentiation status of these cells, which is ...

Principles and applications of electrical cell fusion

... The first step in mammalian cloning is the removal of the nucleus from an oocyte. This enucleated oocyte is then fused with a somatic cell (e.g. from connective tissue). This is carried out by using electrical cell fusion because it is the only method efficient enough ...

Principles and applications of electrical cell fusion

... The first step in mammalian cloning is the removal of the nucleus from an oocyte. This enucleated oocyte is then fused with a somatic cell (e.g. from connective tissue). This is carried out by using electrical cell fusion because it is the only method efficient enough ...