Sodium in Biological Technology

Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union

... ESL interacts with site two of the voltage-gated sodium channel, stabilising its inactive form ... Nerve impulses are triggered via voltage-gated sodium channels in the nerve cell membrane. ... acetate (ESL) is a novel voltage-gated sodium channel blocker. It specifically targets the ...

SENOMYX ANNOUNCES THIRD QUARTER 2008 FINANCIAL RESULTS

... discovery of a number of enhancers of sodium chloride that are active in our salt receptor ... effective in taste tests. The ability to decrease sodium chloride without a negative impact on taste could ... ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty ...

Parion Sciences and Kainos Medicines Sign Clinical Development Agreement for Novel Dry Mouth Treatment

... to co-develop Parion's proprietary epithelial sodium channel blocker, P-552, for the treatment of dry ... the second application of our portfolio of sodium channel blockers as we continue to expand ... strategy of Kainos Medicines." Epithelial sodium channel (ENaC) blockers, such as P-552, are ...

FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

... for whom the expected benefit of raising serum sodium outweighs the increased risk of adverse events. ... Hyponatremia, a condition of low serum sodium concentration, often results from elevated levels ... and occurs when retained water dilutes serum sodium content. Patients with hyponatremia are ...

CV Therapeutics Announces Presentations at American Heart Association Scientific Sessions 2008

... extended-release tablets): Ranolazine, a Late sodium Current Inhibitor, as an Adjunct to Cardioplegia ... Tuesday, November 11, 2008, 9:00 a.m. CST Late sodium Current Discordant T Wave and Mechanical Alternans in Left Ventricular Hypertrophy: Role of Late sodium Current; Poster Presentation, Wednesday, November ...

SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides

... technology. SAFC Hitech also offers high-purity sodium and cesium iodide (NaI and CsI) providing a ... materials more efficiently than thallium doped sodium iodide." Lanthanum and cerium bromides ... and europium halides in addition to thallium, sodium and cesium iodides as part of their ...

US Neuropathic Pain Market Value Doubles to $5 Billion by 2018

... antidepressant milnacipran and Schwarz Pharma's sodium ion channel antagonist/CRMP2 modulator lacosamide ... (Pfizer) and gabapentin GR (Depomed); a sodium channel antagonist mexiletine ... (Ortho-McNeil); a dopamine receptor agonist sodium oxybate (Jazz), and a neuromuscular blocking ...

Iowa Resident Dies After Using Contaminated Blood Thinner

... reports associated with the use of Baxter Heparin sodium Injections. After receiving additional reports ... reactions from other lots of their Heparin sodium Injection Products, Baxter recalled their ... Moreover, the methods employed to test Heparin sodium United States Pharmacopoeia (USP) had not been ...

Illinois Pharmaceutical Manufacturer Sued for Injuries to Kentucky Resident

... reports associated with the use of Baxter Heparin sodium Injections. After receiving additional reports ... reactions from other lots of their Heparin sodium Injection Products, Baxter recalled their ... Moreover, the methods employed to test Heparin sodium United States Pharmacopoeia (USP) had not been ...

Baxter to Proceed With Recall of Remaining Heparin Sodium Vial Products

... of all remaining lots and doses of its heparin sodium injection multi-dose, single-dose vials and ... company initially recalled nine lots of heparin sodium injection multi-dose vials on January 17, 2008 as ... now proceed with recalling its remaining heparin sodium injection and heparin flush products. Although ...

FDA Approves New Mechanism of Action Labeling for Ranexa(R)

... the ability of ranolazine to inhibit the late sodium current at therapeutic levels. Published data ... suggests that during ischemic episodes excess sodium can flow into cardiac cells through sodium channels. This ...

Hyperion Therapeutics, Inc. Announces Senior Management Team and $15M Financing Event

... approval of AMMONUL(R) (sodium phenylacetate and sodium benzoate) Injection 10%/10%. Dr. Gargosky was ... to patients with known hypersensitivity to sodium phenylacetate or sodium benzoate. Acute symptomatic hyperammonemia should ...

The Foundation for National Institutes of Health Announces Unprecedented Product Donation by sanofi-aventis in the U.S.

... (Taxotere(R)), oxaliplatin injection (Eloxatin(R)) and enoxaparin sodium injection (Lovenox(R)) - will be made over the course of one year. ... see the accompanying Eloxatin (oxaliplatin injection), Lovenox (enoxaparin sodium injection), and Taxotere (docetaxel) Injection Concentrate full ...

SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2009 FINANCIAL RESULTS

... is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to consumers. Senomyx has identified more than 250 enhancers of sodium chloride (table salt) that are active in the proprietary screening assays ...

Mylan Receives Tentative FDA Approval for Generic Version of Singulair(R)

... (FDA) for its Abbreviated New Drug Application (ANDA) for Montelukast sodium Tablets, 10 mg (base). Montelukast sodium Tablets are the generic version of Merck and Co.'s Singulair(R), which had ...

SENOMYX ANNOUNCES FIRST QUARTER 2009 FINANCIAL RESULTS

... is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to ... perception, the Company has identified more than 160 enhancers of both sodium chloride (table salt) and potassium chloride that are active in the ....

SENOMYX ANNOUNCES EXTENSION OF ITS COLLABORATION WITH CAMPBELL SOUP COMPANY

... is committed to using innovative approaches to create flavorsome, lower sodium products. This is an exciting time for the Company as we continue to ... taste desirable to consumers while facilitating a meaningful reduction of sodium in foods and beverages. "This is the second agreement that Senomyx ...

Catilin Receives Renewable Energy Award for Pilot Plant

... is commonly produced using a homogeneous (liquid) catalyst, such as sodium hydroxide or sodium methylate. These catalysts require excessive amounts of water, energy, ...

Cerimon Pharmaceuticals Initiates Phase III Clinical Studies to Evaluate Its Topical Diclofenac Sodium Patch for Mild-to-Moderate Pain

... has enrolled its first subjects in its once-daily topical diclofenac sodium patch Phase III program. The program consists of three randomized, ... studies will randomize subjects to receive Cerimon's topical diclofenac sodium patch or placebo at a ratio of 1:1. "Results from our Phase II acute ...

SENOMYX ANNOUNCES FOURTH QUARTER AND YEAR-END 2008 FINANCIAL RESULTS

... is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to ... based on SNMX-29, Senomyx has identified well over 100 enhancers of both sodium chloride (table salt) and potassium chloride that are active in the ....

Diffusion Pharmaceuticals Announces Completion of a $2.9 Million Private Placement and Company Presentations at Upcoming Industry Conferences in Geneva, Switzerland and Naples, Florida

... overall growth and clinical programs for its lead drug compound, trans sodium crocetinate (TSC). In addition, David G. Kalergis, Chief Executive ... in cancerous tumors. A Phase I study for Diffusion's lead molecule, trans sodium crocetinate (TSC), in healthy subjects was successfully completed in ....

Beyond Seizure Control in the Treatment of Epilepsy With New Anti-Epileptic Drug, Zebinix(TM)

... to the affected areas. Nerve impulses are triggered via voltage-gated sodium channels in the nerve cell membrane. About Zebinix(TM) Zebinix(TM) is a novel voltage-gated sodium channel blocker that has been designed to reduce the frequency of ...

Parion Sciences Announces Initiation of Phase I Clinical Trial to Evaluate Safety and Tolerability of GS9411

... of pulmonary disease. Previously known as P-680, GS9411 is an epithelial sodium channel (ENaC) blocker discovered by Parion, a privately held ... fibrosis, COPD and other serious lung conditions." Epithelial sodium channel blockers, such as GS9411, are unique therapeutic agents developed ...

GeneraMedix Inc. Receives Approval for Epoprostenol for Injection 1.5 mg

... Injection is available in 10 mL vials containing lyophilized epoprostenol sodium equivalent to 1.5 mg of epoprostenol. When reconstituted and diluted for administration with Water for Injection or sodium Chloride Injection, the infusion solution is stable for up to 24 hours at ...

U.S. Food and Drug Administration Advisory Committee Recommends Approval of Tolvaptan, an Investigational Treatment for Hyponatremia

... with hyponatremia." Hyponatremia, characterized by low concentrations of sodium in the blood, is a known predictor of mortality in patients with serious underlying illnesses.(i) sodium is an important electrolyte that plays a role in blood pressure ...

MacroChem Acquires Virium Pharmaceuticals

... development program involves an amino acid derivative commonly known as sodium phenylbutyrate ("PB"). Through sponsorships with the National Cancer ... of malignant glioma, certain leukemias, and advanced prostate cancer. sodium PB has received orphan designation by the FDA as an adjunct to surgery, ...

Hydrogen storage in nanoparticles works

... Bald discovered that 30 nanometre particles of the metal hydride sodium alanate make the favourable extraction and storage of hydrogen possible. ... to this problem. Bald demonstrated that 30 nanometre particles of sodium alanate store hydrogen in a highly efficient manner. With the addition of ...

Schering-Plough Announces Filing of U.S. Application for OTC ZEGERID(R)

... bicarbonate) contains omeprazole, a proton pump inhibitor (PPI), and sodium bicarbonate, which raises the gastric pH and thus protects omeprazole from ... from patients treated long term with omeprazole. ZEGERID contains sodium bicarbonate. This should be taken into consideration for patients on a ...

Barr Launches Generic Fosamax(R) Tablets, 70 mg

... to share 180 days of marketing exclusivity for its 70 mg Alendronate sodium product. This exclusivity bars the entry of competition for this product ... their quality of life in their advanced years." Barr's Alendronate sodium product is indicated for the treatment and prevention of osteoporosis in ...

RG Global Corporate Update: First Coal Bed Methane Water Treatment Plant Near Completion; Expanding Water Treatment Applications

... the end of March 2008. The plant, located in Wyoming, will remove excess sodium and other environmentally harmful minerals from the CBM-produced water as ... ion exchange technology, which can be used to remove nitrates, arsenic, sodium and a wide variety of inorganic contaminants from water to make it ...

Clexane(R)/Lovenox(R) Approved in Japan

... announced today that the anticoagulant Clexane(R) (enoxaparin sodium injection) has been approved for marketing in Japan by the Ministry of ... established with the results of Japanese clinical trials. Enoxaparin sodium is known by the brand name Lovenox(R) or Clexane(R) or Klexane(R) and its ...

New Drug Application for Tolvaptan, Otsuka's Investigational Novel Oral Treatment for Worsening Heart Failure and Hyponatremia, Accepted by the U.S. Food and Drug Administration

... About Hyponatremia Hyponatremia, characterized by low concentrations of sodium in the blood, is a known predictor of death in patients with serious ... and in its mildest forms slowed thoughts and reflexes.(7) Normal serum sodium is between 135 to 145 mEq/L, whereas patients diagnosed with hyponatremia ...

Masimo Launches Patient SafetyNet and Showcases the Rainbow SET Upgradable Noninvasive Monitoring Platform at 2007 ASA Annual Meeting

... Dapsone, EMLA Creams, Flutamide, Nitrates, Nitric Oxide, Nitroglycerin, sodium Nitroprusside, sodium Nitrate and Sulfonamides. In a surgical setting, continuous monitoring of ...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... in blood pressure, increases in plasma cGMP (cyclic guanosine monophosphate), a natural messenger nucleotide, and increases in urine volume and sodium excretion. There were no serious or severe adverse events. PL-3994 incorporates a novel and proprietary amino acid mimetic developed by ...

Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009

... competition on certain products. In the current quarter, new products contributed revenues of $112.2 million, primarily consisting of Divalproex sodium Extended-release (Divalproex), which Mylan launched in the first quarter of 2009. Total revenues from EMEA were $367.8 million in the ...

Bedford Laboratories(TM) to Begin Shipping Fluconazole Injection in PVC Flexible Containers

... presentations, Bedford Laboratories will supply Fluconazole injection as a sterile iso-osmotic solution containing 2mg / mL of fluconazole in 0.9% sodium chloride diluent in the following presentations: 200mg / 100mL in single-dose PVC flexible containers packaged in cartons containing 10 bags and ...

Dr. Paul Korner Promoted to Senior Vice President of Ferring International PharmaScience Center U.S.

... company. Ferring Pharmaceuticals offers a line of urology, orthopaedic and infertility products in the U.S. market. They include: EUFLEXXA(R) (1% sodium hyaluronic acid), BRAVELLE(R) (urofollitropin for injection, purified), MENOPUR(R) and REPRONEX(R) (menotropins for injection, USP), Novarel(R) ...

GeneraMedix, Inc. Announces Sale of Innovative Epoprostenol Formulation to Actelion Ltd.

... 23 /PRNewswire/ -- GeneraMedix, Inc. announced today that it has entered into a definitive agreement to sell its improved formulation of epoprostenol sodium for the intravenous treatment of pulmonary arterial hypertension (PAH) to Actelion LTD., a biopharmaceutical company with its headquarters in ...

Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix

... company. Ferring Pharmaceuticals offers a line of urology, orthopaedic and infertility products in the U.S. market. They include: EUFLEXXA(R), (1% sodium hyaluronic acid), BRAVELLE(R) (urofollitropin for injection, purified), MENOPUR(R) and REPRONEX(R) (menotropins for injection, USP), NOVAREL(R) ...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... Inc. (Nasdaq: ISIS ) announced today it has initiated a Phase 1 study of ISIS-SGLT2Rx, an antisense drug that inhibits the production of sodium dependent glucose co-transporter type 2 (SGLT2). SGLT2 is the major transporter responsible for glucose re-absorption in the kidney. Decreasing ...