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Sequences in Biological Technology

MIT reels in RNA surprise with microbial ocean catch

... our data sets," said Shi. "When I looked into the sequences that cannot be confidently assigned as protein-coding, I found that a big percentage of those sequences are non-coding sequences derived from yet-to-be-cultivated microorganisms ...

Virco Lab, Inc. Enters Into Collaboration with SmartGene, Inc. Enhancing HIV Resistance Test Services for Laboratories and Physicians

... integrated system, laboratories can interpret HIV sequences using multiple algorithms, reinterpret sequences to build cumulative resistance reports for ... this collaboration are: Genetic sequences obtained from patient viruses can be stored ...

Intradigm Receives Notice of Allowance for Key RNA Interference (RNAi) Patent Covering Potent siRNA Sequence

... applications covering proprietary Intradigm siRNA sequences against more than 50 clinically relevant targets. ... an impressive proprietary portfolio of siRNA sequences against more than 50 highly valued oncology and ... range of therapeutic targets using our siRNA sequences and delivery technology. For more ...

Easy assembly of electronic biological chips

... immersed the chip in a solution containing DNA sequences complementary to the three virus-specific sequences on the nanowires. Because they tagged the ... to more nanowire types, such as different DNA sequences or even proteins, and move from fluorescence to ...

New and Updated Online Tutorials for PROSITE, InterPro, IntAct and UniProt

... sequence scan *to find patterns in protein sequences using PRATT *to use MyDomains to create custom ... *to use InterProScan to query novel protein sequences for information on domains and families ... for relevant protein information *to search with sequences as a starting point *to understand the different ...

Use it or lose it? Researchers investigate the dispensability of our DNA

... fraction the genome, and there are many other DNA sequences that are conserved across species. What are these sequences doing, and do we really need them at all? In a ... Other evidence has suggested that ultraconserved sequences can harbor critical functions, such as regulation ...

Scientists fix bugs in our understanding of evolution

... errors in existing methods that compare genetic sequences of different species to learn about their ... course of evolution. A comparison of multiple sequences starts with their alignment. Characters in different sequences that share common ancestry are matched and gains ...

Nanosoftball made of DNA

... 15-base-pair-long, double-stranded DNA sequences with similar physical properties. The double-stranded sequences were assigned to the individual edges of the ... was then determined which three single-stranded sequences needed to be attached to each three-legged ...

On the trail of rogue genetically modified pathogens

... that can distinguish between artificial vector sequences and natural DNA sequences. Natural plasmids and artificial vector sequences have much in common, but these new tools show the ... viruses. The tool clusters the artificial vector sequences into different subgroups based on shared ...

Putting stem cell research on the fast track

... In order to screen how all these different DNA sequences affect stem cell function you need an extremely ... If researchers can isolate the specific genetic sequences that cause a stem cell to transform into a neural ... used to quickly understand how different genetic sequences affect stem cell development. The stamp is ...

DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies

... variety of modified nucleotides that are added to or replace DNA and RNA sequences to increase the sensitivity and specificity of nucleic acid-based ... ThermoBLAST™ quickly and accurately scans DNA, RNA, or hybrid sequences against genome databases, identifies all off-target hybridizations, and ...

Researchers enlist DNA to bring carbon nanotubes' promise closer to reality

... results improve on the 2003 results by identifying more than 20 DNA short sequences that can recognize individual types, or species, of carbon nanotubes and purify them from a mixture. The new method utilizes tailored DNA sequences and "allows the purification of all 12 major single-chirality ...

Chromosome breakpoints contribute to genetic variation

... a type of mutation that increases the copy number of genes and the sequences that flank them. "To me, this was completely counterintuitive. I ... many more copy number variants, insertions and deletions in their sequences than the other parts of the chromosomes. Such variations appear to make ...

Researchers develop new way to see single RNA molecules inside living cells

... called fluorophores to a modified nucleic acid sequence and combining the sequences with a protein exhibited single-molecule sensitivity and allowed the ... cells. "The great thing about these probes is that they recognize RNA sequences and bind to them using the same base pairing most people are familiar with ...

Babies Learn Music While Sleeping

... The babies were then played music - to be more exact, simplified tone sequences - to test what sort of patterns they were sensitive to and whether they ... based on what had gone before. "The babies were presented with sequences of sounds of different tone colour - different musical instruments, if you ...

Using living cells as nanotechnology factories

... and there has also been significant work in using long-stranded DNA sequences replicated from cells or phage viruses to scaffold short helper DNA sequences to form 2-D or 3-D objects," said Yan, who is also a professor in the ...

Tips on how to build a better home for biological parts

... of the Registry database but also the collection of publicly available DNA sequences or clones (BioBricks) that are used to make the biological devices and ... down into smaller parts; (b) to set curation standards to document the sequences of basic parts by associating them with entries in bioinformatic or ...

Tips on how to build a better home for biological parts

... of the Registry database but also the collection of publicly available DNA sequences or clones (BioBricks) that are used to make the biological devices and ... down into smaller parts; (b) to set curation standards to document the sequences of basic parts by associating them with entries in bioinformatic or ...

Lentigen Licenses Fundamental Lentiviral Vector Technology Patent From the University of Cambridge

... the most efficient vehicles for stable delivery of genes or gene silencing sequences (e.g. RNAi) into cells. Gene delivery is accomplished by the binding and ... the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, ...

Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods

... with DNA by using transcription factors, proteins that bind particular sequences within target genes. An estimated few hundreds of transcription factor ... is that all reporter constructs have virtually identical reporter sequences and thus produce nearly identical messages," says Dr. Makarov. "These ...

Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9

... 954 represents a novel class of oligonucleotides, named immunoregulatory sequences (IRS), that specifically inhibit the TLR-induced inflammatory response ... are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control ...

Free shopping in a virtual bazaar of gene regulation data

... it fulfils a longstanding need for a large data collection of regulatory sequences unrestricted by commercial concerns. Its novel shopping-mall-like ... used the Pleiades Promoter Project collection of brain-linked regulatory sequences as a show case. They have been working internationally with boutique ...

Dynavax Issued Landmark Patent Covering Second-Generation TLR9 Agonists

... The claims cover a broad class of novel TLR9 agonists containing short DNA sequences separated by spacer molecules. These linear chimeric immunomodulatory ... are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control ...

SmartGene's Services for Faster, More Precise Identification of Bacteria and Fungi to be Used by The Johns Hopkins Hospital

... an organism's DNA, by integrating a number of tasks, including sequence editing, alignment, interpretation, creation of dendrograms and reports. DNA sequences are interrogated using SmartGene's broad, constantly updated reference databases, which take account of newly characterized and emerging pathogens. ...

Medicago's H1N1 pandemic vaccine candidate shows positive response in 100% of vaccinated animals after a single dose

... and cost over competitive technologies. It could deliver a vaccine for testing in about a month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic ...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

... development activities in the fields of wound healing and cardiovascular disease, the Company has access to a portfolio of protein-producing DNA sequences that include Platelet Derived Growth Factor-B (PDGF-B), Insulin like Growth Factor-I (IGF-I) and Fibroblast Growth Factor-4 (FGF-4). In ...

New England Journal of Medicine Study Highlights Need for Rapid, PCR-based Group B Streptococcus (GBS) Testing at Time of Admission for Labor and Delivery

... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. Modular in design, the GeneXpert System has a variety of configurations to meet the ...

DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches

... the validity of the algorithms. The claims in application 12/184,240 broadly cover the use of this successful and powerful approach to optimize sequences for expression in any organism. "Our overarching gene design technology is far more effective than traditional codon optimization ...

New and Expanded Free Tutorials on UCSC Genome Browser Now Available

... VisiGene. UCSC Genome Browser is a research tool that integrates the work of hundreds of scientists worldwide into a graphical display of genome sequences and aligned annotations. The Genome Browser -- originally developed to assist in the initial assembly of the human genome -- now features a rich set ...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

... BioSciences has already produced hundreds of custom endonucleases for partners and internal development that can precisely alter naturally occurring sequences within genomes. Precision has successfully partnered its DNE technology with several of the world's largest agbiotech firms and is internally ...

Medicago succesfully expresses VLP antigen for A H1N1 strain

... and cost over competitive technologies. It could deliver a vaccine for testing in about a month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic ...

Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3

... and one of the authors on the study, stated, "My laboratory's research has shown that many siRNAs suppress neovascularization regardless of their sequences or targets and can have dangerous off target effects. For that reason, I'm gratified to see this research, suggesting that Quark is seeing success in ...

Avian Adenovirus Genotyping Diagnostic Service

... Should samples display characteristics that indicate possible association with each other, the use of boot strapping analysis on extended genetic sequences allows the investigator to arrive at statistically significant conclusions regarding the genotype of a strain and its association with another ....

DNA Software, Inc. Honored as One of the 2009 "Michigan 50 Companies to Watch"

... computing power to large assay design projects or enterprise applications. ThermoBLAST™ quickly and accurately scans DNA, RNA, or hybrid sequences against genome databases and eliminates all assay false positives or probe/primer mishybridizations. The company has recently expanded its ...

Medicago initiates work on Swine Flu strain

... and cost over competitive technologies. It could deliver a vaccine for testing in about a month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic ...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

... enzymatic digestion. This collection of siRNA-like molecules is then purified, resulting in a complex pool of siRNA molecules all targeting different sequences of a single gene. For more information on MISSION(R) esiRNA, please visit www.sigma.com/esirna . About Sigma-Aldrich: Sigma-Aldrich ...

New cow genome sequence released

... including human, has yet reached - we will continue to incorporate new data to fill in gaps, to correct the mis-oriented regions, and to place more sequences onto chromosomes," says Salzberg. The alpaca and sheep genomes are currently being sequenced, and should provide a rich source for making further ...

SmartGene, Inc. Enters Collaboration with Virco Lab, Inc. to Enhance HIV Genotyping and Resistance Interpretation Services in US

... and laboratorians understand the importance of longitudinal data to resistance assessment; they value the insight gained from reinterpreting sequences with updated algorithms and comparing results derived from different algorithms; they are interested in analyzing new genetic targets, such as ...

Jivan Focuses on Solutions for Transcriptome Sequencing

... and therapeutic areas. By using Jivan's database of mRNA sequences, including exons and exon junctions, Jivan can ensure the capture of all mRNA sequences of each gene of interest, including wildtype transcripts and splice variants. For genes or mRNAs with low expression, Jivan will offer mRNA ...

Fitting pieces for biosensors

... of aptamer selection even for toxic substances. Once suitable binders (aptamers) for a target molecule have been found by the SELEX process and their sequences have been defined, aptamers can be produced very accurately and reliably at any time by chemical synthesis. Accordingly no biologically induced ...
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(Date:12/2/2009)...erican adolescents exposed to cigarette smoking sc...t themselves, and this may be part of the accultur...according to new study findings. , "Our study su...s and highlights the global implementation of the ...Tobacco Control, which includes guidelines for cou...
(Date:12/2/2009)...2; A Smoky Mountain forest,s woodland herb populat...forest understories recover from logging, accordin... logging in portions of the forest nearly 80 years...econdary forest floor was similar to that of undis...professor of forestry and natural resources, said ...
(Date:12/2/2009)... of undergraduate students from Stevens Institute ... poster contest hosted by the International Societ...nnual contest highlights the research conducted by...Annual Meeting in San Diego, Calif. , The winnin...te Ligament Tensioning Device," was presented by A...
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