Peptides in Biological Technology

New drugs faster from natural compounds: A UC San Diego breakthrough

... to rapidly characterize ring-shaped nonribosomal peptides (NRPs)a class of natural compounds of intense ... ) Nonribosomal peptides (NRPs) often serve as chemical defenses for the ... called mass spectrometers that blast nonribosomal peptides apart and determine their sizes. Two ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

... proteins that occur at these surfaces. Cyclic peptides have the ability to bind where traditional drugs ... Kritzer created a vast "library" of cyclic peptides containing various amino acid combinations. He then inserted the cyclic peptides into cells of a well-established yeast model of ...

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... called cyclic peptides. Two of the cyclic peptides had a protective effect on the yeast cells and on ... her team tested whether yeast could make cyclic peptides that would save them from alpha-synuclein's toxicity. Cyclic peptides are fragments of protein that connect end-to-end ...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

... that promote the intestinal absorption of peptides and other sensitive drugs that cannot otherwise ... a large number of water-soluble drugs including peptides that are poorly permeable, resulting in increased ... structurally prevent the rapid inactivation of peptides by enzymes in the upper gastrointestinal tract. ...

Organic, Preservative-Free Skin Care Products from Dermaheal Now Available in the United States

... the finest, freshest ingredients, the effective peptides and nanotechnology delivery system of Dermaheal 2 ... The product's active ingredients are proprietary peptides proven to stimulate skin cells to build ... delivery system of nanotechnology, the active peptides are embedded within tiny capsules called ...

Publication on 'Tregitopes' in Blood Journal of October 2008

... Epi-13(TM) Epi-13(TM) is a group of "Tregitope" peptides that induce the body's own natural regulatory T ... T cell epitope mapping, the selection of target peptides from any protein sequence, is a powerful resource ... protein therapeutics. EpiVax research shows that peptides chosen by EpiMatrix(TM) software are highly ...

Chromatide and Novasep Have Extended Their Partnership to Develop Large Scale Solid Phase Peptide and Oligonucleotide Synthesis Technology.

... them with efficient solutions to obtain pure peptides and oligonucleotides. Commenting on the ... to provide a unique, global process solution for peptides but also for oligonucleotides manufacturers". ... and small molecules Synthesis of complex peptides Large scale DNA , peptide and polymer synthesis ...

Stonegate Report About Unigene Laboratories Inc.

... as the only biopharma company that manufactures peptides by recombinant techniques, while also having oral ... focus is on salmon calcitonin (sCT) and other peptides for the treatment of chronic bone and joint ... process for the efficient production of peptides and patented technologies for the oral and ...

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

... Acids and Organic Cations -- Cationic peptides for siRNA Intracellular Delivery -- ... and Methods for Complexes of Nucleic Acids and peptides -- Phage Displayed Cell Binding peptides -- Dry Powder Compositions for RNA Influenza ...

Lethality of H1N1 Influenza Virus Increasing According to Latest Analysis of Virus Peptide Genomic Data

... are based upon the company's discovery of Replikins, a new group of peptides related to the rapid replication function in viral and other diseases. The ... predictive tools are based on the company's discovery of a new group of peptides related to rapid replication called Replikins, whose increase in ...

Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions

... technology that maintains stability of therapeutic proteins and peptides at human body temperature for extended periods of time. The DUROS ... edge are demonstrated by its abilities to stabilize proteins and peptides at above body temperature and to deliver them in a constant and consistent ...

Intarcia Therapeutics, Inc. Announces Acceptance of ITCA 650 Phase 1b Study for Late-Breaker Presentation at the American Diabetes Association 69th Scientific Sessions

... technology that maintains stability of therapeutic proteins and peptides at human body temperature for extended periods of time. The DUROS ... edge are demonstrated by its abilities to stabilize proteins and peptides at above body temperature and to deliver them in a constant and consistent ...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

... are based upon the company's discovery of Replikins, a new group of peptides related to the rapid replication function in viral and other diseases. The ... predictive tools are based on the company's discovery of a new group of peptides related to rapid replication called Replikins, whose increase in ...

Psylin Neurosciences Commences Development of Compound for Depression

... milestone for Psylin. We believe that PSN0041 validates the utility of peptides in this therapeutic arena," said Mark Gergen, Co-CEO of Psylin and Senior ... valuable biologics that have been taken from nature, including human peptides not previously described. All of these have been synthesized to create a ...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

... targets that induce antibodies against the native antigen. Ordinary peptides are poor mimics of complex protein structures due to their lack of ... possible to mimic complex protein domains by presenting one or more amino peptides in a spatially defined conformation. These molecules have proven to be ...

Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data

... confirms the 2001 discoveries by Dr. Samuel and Elenore Bogoch of peptides in the hemagglutinin unit of influenza, which they named Replikins, which ... verified the Bogoch 2001 findings of conservation of these very Replikins peptides over decades, and the sharing of Replikins between strains of influenza, ...

Pepscan Achieves First Milestone in Research Collaboration With Genmab

... About CLIPS(TM) Technology Chemically Linked Immunogenic peptides on Scaffolds (CLIPS(TM)) is a technology to present one or more peptides in a structurally constrained configuration. These molecules behave as ...

Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix

... company focused on the discovery, development and marketing of biologics, peptides and proteins. The company's research is dedicated to three core ... Administration (FDA) and will be launched in Q1 of 2009 in the U.S. Other peptides discovered by Ferring Research Institute include: barusiban (FE 200440), ...

Sigma-Aldrich Signs Agreement With CPC Scientific for the Distribution of PEPscreen(R) Custom Peptide Libraries

... 150 full- time employees. The Company produces approximately 1,000 custom peptides per month ranging in quantity from milligrams to multiple kilograms with ... also produce almost all commercially available peptide modifications. All peptides are delivered with full documentation including HPLC, Mass Spectrometry ...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

... in the development of atherosclerosis. The scientists also showed that peptides designed to disrupt the formation of PF4-RANTES heteromers inhibited the ... interactions using NMR spectroscopy and then designed a series of peptides to disrupt those interactions. One such peptide, termed CKEY2, is ...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

... The key to this predictive technology is a new class of structural virus peptides that have been shown to be involved in the chemistry of rapid replication. ... -- and are thus poised to become the most lethal outbreak. Replikin peptides are not distributed equally throughout the virus genome, but are ...

Synthetech Announces New Director of Manufacturing

... Dr. Farkas has over 13 years' experience with amino acid derivatives, peptides and API manufacturing from previous positions in manufacturing and supply ... products support the development and manufacture of therapeutic peptides and peptidomimetic small molecule drugs at every stage of a customer's ...

New England Peptide Implements Quality Management System, Prepares for ISO 9001: 2008 Registration

... facilitates the design, synthesis, and production of synthetically made peptides by incorporating data harnessed though each peptide production run with ... ) New England Peptide, founded in 1998, designs and produces custom peptides and polyclonal antibodies for drug and vaccine discovery organizations ...

Raptor Pharmaceuticals Closes $10 Million Private Placement

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target delivery to the liver to potentially treat primary liver cancer and hepatitis. NeuroTrans(TM) represents engineered RAP peptides created to target receptors in the brain and are currently undergoing ...

Raptor Pharmaceuticals Corp. Announces Presentation at 5th International Cystinosis Conference 2008

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target delivery to the liver to potentially treat primary liver cancer and hepatitis. NeuroTrans(TM) represents engineered RAP peptides created to target receptors in the brain and are currently undergoing ...

Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target their delivery to the liver to potentially ... liver cancer and hepatitis. In neurodegenerative diseases, engineered RAP peptides called NeuroTrans(TM) are currently undergoing evaluation at Stanford ...

Raptor Pharmaceuticals Corp. Receives FDA Orphan Drug Designation for Cysteamine in Huntington's Disease

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target their delivery to the liver to potentially ... liver cancer and hepatitis. In neurodegenerative diseases, engineered RAP peptides called NeuroTrans(TM) are currently undergoing evaluation at Stanford ...

Raptor Pharmaceuticals Corp. Enters Agreements to Advance Clinical Pipeline

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target their delivery to the liver to potentially ... liver cancer and hepatitis. In neurodegenerative diseases, engineered RAP peptides called NeuroTrans(TM) are currently undergoing evaluation at Stanford ...

Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets

... GPCRs. About CLIPS(TM) Technology Chemically Linked Immunogenic peptides on Scaffolds (CLIPS(TM)) is a technology to present one or more peptides in a structurally constrained configuration. These molecules behave as ...

Raptor Pharmaceuticals Acquires Orphan Clinical Program

... diseases. HepTide(TM) is designed to utilize engineered RAP-based peptides conjugated to drugs to target their delivery to the liver to potentially ... liver cancer and hepatitis. In neurodegenerative diseases, engineered RAP peptides called NeuroTrans(TM) are currently undergoing evaluation at Stanford ...

MacroChem Announces Michael Zasloff, M.D., Ph.D. Joins Company's Scientific Advisory Board

... In addition, he has been the leader in the discovery of antimicrobial peptides and aminosterols of animal and human origin and their development as human ... and the pathways that control the expression of antimicrobial peptides in human health and disease. "It is my pleasure to join the MacroChem ...

Anesiva Grants Specific-Use License of Its Needle-Free Drug Delivery Technology to Particle Therapeutics for Diabetes Drug

... the potential of our technology to transform the delivery of proteins, peptides and small molecules in a clinically meaningful way that is also safer, ... property covering the delivery of solid particles of proteins, peptides and small molecules (other than vaccines) into the skin at high velocity ...

Synthetech Reports First Quarter Fiscal 2010 Results

... cGMP ) in compliance with U.S. Food and Drug Administration ( FDA ) regulations. Our products support the development and manufacture of therapeutic peptides and peptidomimetic (peptide-like) small molecule drugs from early stages of a customer's clinical development through market launch and into ...

Shire plc: Core Portfolio of Products Delivers 20% Sales Growth

... losses on discontinued Jerini businesses which were either divested or closed during the second quarter of 2009, the loss on divestment of Jerini's peptides business and the write-off of the fair value less costs to sell of assets previously classified as held for sale. FINANCIAL INFORMATION ...

Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies

... and possible development as we continue to grow our therapeutic antibody portfolio." "CII has developed several monoclonal antibodies, peptides and small molecules with potential applications in the treatment of cancer and neo-vascular disorders," said Toni Gray, President and CEO of CII. ...

Novel Product for the Prevention of Post-Surgical Adhesion Formation Completes Phase I Clinical Study

... treatment for preventing harmful scarring and promoting wound healing after surgery. PharmaSurgics product concept is based on proprietary synthetic peptides which have strong anti-inflammatory and anti-infectious properties. The company was founded in 2005, based on extensive research by Dr. Inger ...

PROLOR Biotech Awarded Two U.S. Patents for Its Longer-Acting Human Growth Hormone and Longer-Acting Erythropoietin

... Novik, president of PROLOR. "We have also filed several other patent applications for additional CTP-enhanced long-acting therapeutic proteins and peptides that are currently pending. We are confident that our growing CTP patent estate will provide excellent protection for both our compounds under ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defenses. Its ...

METTLER TOLEDO Introduces an Affordable Reaction Block for Solid Phase Peptide Synthesis (SPPS)

... is a cost effective and scalable platform for solid phase peptide synthesis enabling the synthesis of arrays and libraries from 6 to 96 peptides and is a viable alternative to traditional techniques like SPOT synthesis. For a limited time*, you can register to win a MiniBlock® to ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

... helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defenses. Its ...