Oncogene in Biological Technology

EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference

... into pre-clinical testing of drug discovery efforts targeting the Myc oncogene pathway utilizing EpiCept's Anti-cancer Screening Apoptosis Platform ... and optimization of lead product candidates related to the Myc oncogene pathway which utilized the cell- and caspase-based apoptosis induction ...

Cequent Names F. Stephen Laroux, Ph.D., Director, Immunology and Inflammatory Diseases

... IBD program. "While we are furthest along with our drug candidate CEQ508, an orally administered tk RNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis) -- our IBD program is actually the company's largest, and Stephen has been critical to ...

NFGC Conducts Multi-Institutional Research Project in Ovarian Cancer

... in ovarian cancer. For the first phase of the project, the group will use a biologically-driven approach to characterize gene expression and oncogene activation of copy number and point mutations in preclinical models by profiling ovarian cancer cells and ovarian cancer stem cells. The consortium ...

Festschrift Issue Honoring Judah Folkman, M.D. in Lymphatic Research and Biology

... Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, ...

Oncomine(TM) Again Key to Prostate Cancer Discovery

... in his continued role as a research investigator at the University of Michigan, led the Oncomine analysis that identified SPINK1 as a candidate oncogene in prostate cancer. Further experimental work by many of the same scientists that previously identified ETS-family gene fusions in prostate cancer ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... ORD has the potential to generate new opportunities to improve cancer care." About Our Compound Targets Human Double Minute 2 (Hdm2) The Hdm2 oncogene is activated in cancers through various mechanisms, including gene amplification and deletion of upstream tumor suppressors. Hdm2 over-expression ...

Micromet is Presenting Four Posters on BiTE(R) Antibodies at the International AACR-NCI-EORTC Conference

... proto- oncogenes (abstract C175). This establishes EpCAM as a signal transducer of cancer cells and explains how EpCAM induces cell proliferation and oncogene expression. EpCAM is found widely expressed on human cancers and is also found on so called 'cancer stem cells' from colon, pancreas, prostate and ...

Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings

... C175). These data not only establish EpCAM as a signal transducer of cancer cells, but could explain how the protein induces cell proliferation and oncogene expression, and support a critical role of EpCAM in cancer stem cell regulation. "All of these new findings correlate well together and highlight ...

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

... miRNAs as Regulators of oncogene Expression To address ... miRNAs and Their Putative oncogene Targets. Measuring the Effect of miRNAs on oncogene Expression Confirming ...

Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries

... Screening for Oncogenes The ability of oncogene expression to confer deregulated growth on ... 2.3 vav-1 oncogene Onco-1 ... 2.0 raf-1 oncogene Onco-3 ...

New Insights Into DNA Decontamination

... of mouse skin endothelial cells in vivo by direct application of plasmid DNA encoding the human T24 H-ras oncogene. oncogene 6(11), 1973-1978. ...

Research Tools for Analysis of ZAP-70

... References 1. Palacios, E.H. and Weiss, A. (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. oncogene 23:7990-8000. 2. Abraham, R.T. and Weiss, A. (2004) Jurkat T cells and development of the T-cell receptor signalling paradigm. Nature ...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... was extended to humans. As detailed in the March issue of Cell [1], let-7 miRNAs regulate human RAS oncogene expression and are often down-regulated in human lung tumors. The correlation between let-7 miRNA ...

The use of TaqMaster PCR Enhancer

... mg Proteinase K is dissolved in 1 ml ddH O @ 4 C. Filter sterilize. (5) Ji H.J., Zhang Q.Q., Leung B.S. Survey of oncogene and growth factor/receptor gene expression in cancer cells by intron-differential RNA/PCR. 1990 Jul 31; 170 (2): pp. 569-575 ...

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

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TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

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Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements

... 315-319. Uhler, M.D., et al. (1986) Proc. Natl. Acad. Sci. USA 83: 1300-1304. Galang, C.K., et al. (1994) oncogene 9: 2913-2921. ...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

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