Nucleotide in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

... include data on IDX184, a once-daily, oral nucleotide polymerase inhibitor prodrug currently being ... an optimal combination therapy." IDX184 nucleotide Prodrug Polymerase Inhibitor IDX184 is a liver-targeted, oral nucleotide prodrug designed to enhance the formation of its ...

Pharmasset Reports Fiscal First Quarter 2009 Financial Results

... 30, 2009, Pharmasset filed an IND for PSI-7851, a nucleotide inhibitor of HCV, with the FDA and expects to ... filing an IND for PSI-7851, our second generation nucleotide for HCV and, strengthening our balance sheet by ... phase 1 studies with its second generation nucleotide inhibitor for HCV, PSI-7851 in the first quarter ...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... not limited to assessment of known common single nucleotide polymorphisms (SNPs). It thus bridges the current ... recognition of both the sequence of the variant nucleotide and the sequence context of the mutation. The ... of mismatches arising from the presence of single nucleotide polymorphisms (SNPs) or from small insertions or ...

Pharmasset Reports Fiscal Second Quarter 2009 Financial Results

... healthy volunteer in the phase 1 trial with PSI-7851, a second generation nucleotide inhibitor of HCV. "Our HCV pipeline continues to make ... collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the ...

SeqWright to Invest in LaserGen's Novel Lightning Terminators(TM)

... while lowering cost. These benefits are achieved through LaserGen's nucleotide chemistry by attaching a special terminating group directly to the base, ... cleavage, however, Lightning Terminators(TM) restore the incorporated nucleotide back to its natural state. This distinguishes the LaserGen chemistry from ...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

... as follows: ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE ... 16:00 - 18:00 IDX184, A LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR: RESULTS OF A FIRST-IN-MAN SAFETY AND ...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... drug for a kidney target, ISIS-SGLT2Rx is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs, an attribute that reduces the ...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... non-variant DNA, but is not limited to assessment of known common single nucleotide polymorphisms (SNPs). It thus bridges the current technology gap between ... reference sample, allowing recognition of both the sequence of the variant nucleotide and the sequence context of the mutation. The library can be sequenced ...

Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis

... allows researchers to quickly and easily find DNA mutations and Single nucleotide Polymorphisms (SNPs) in their sequences. SNPs are single nucleotide changes in the DNA associated with diversity and certain diseases. ...

Pharmasset to Present at Canaccord Adams Conference

... being conducted through a strategic collaboration with Roche. Our other clinical stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide analog which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV, which has completed a Phase 2 clinical trial. ...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

... changes to assays and biomarkers throughout the validation process. MassARRAY technology supports key genomic applications, including single nucleotide polymorphism (SNP) genotyping, quantitative gene expression, and copy number variation (CNV) analysis, providing a multi-faceted view of a ...

Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results

... that it had successfully completed a proof-of-concept study of its lead HCV antiviral development program, IDX184, a novel once-daily liver-targeted nucleotide prodrug. This double-blind, placebo-controlled, monotherapy, dose-escalation study in HCV genotype-1-infected patients evaluated the safety and ...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

... of specificity is uncommon in natural proteins and is an inherent property of the I-CreI enzyme, which can recognize and modify a distinctive 22 nucleotide DNA 'address' in the genome of certain algae. "Precision successfully adapted this natural DNA editing system for use in biotechnology by ...

Beyond associations: Colorectal cancer culprit found

... in this search by the genome-wide association study (GWAS), a technique that scans the genome for known common genetic variants, also known as single nucleotide polymorphisms, or "SNPs," that are more prevalent in patients with a specific disease. However, a SNP associated with a disease is not necessarily ...

Frost & Sullivan Lauds BioTrove for Providing Research-Enabling Life Sciences and Drug Discovery Technologies

... to assist research efforts with the company's innovative technologies. These research endeavors ranged from lead compound discovery to single nucleotide polymorphism (SNP) genotyping on the OpenArray(R) system to investigating novel therapeutic targets with the RF-MS system. Researchers often ...

California Grants SeqWright License to Operate as a Clinical Laboratory

... today that it has been granted a California clinical laboratory license. This license enables SeqWright to utilize its DNA sequencing and Single nucleotide Polymorphism (SNP) Genotyping expertise in order to provide genetic tests to California residents and represents a significant step forward in the ...

Discovery of a new retinal gene involved in childhood blindness

... detailed screen are then subjected to a second DNA chip, this one to identify significant stretches of homozygosity in SNP markers. SNPs are single nucleotide repeats, which are natural variations in the human genome. These homozygous regions may contain new genes and are carefully probed based on ...

Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results

... million in development, regulatory and sales milestones. During 2008, Idenix completed a phase I, healthy volunteer study of IDX184, its lead nucleotide polymerase inhibitor for the treatment of hepatitis C, and advanced the drug candidate into proof-of-concept testing in treatment-naive HCV-infected ...

Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance

... is possible in DCIS that is adjacent to invasive ductal carcinoma of the breast. - Results indicating that multiple single nucleotide polymorphisms in the genes that encode ER were not associated with the level of ER expression in breast cancer. This suggests that ...

23andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases

... for genome-wide association studies and has the unique capability to include custom markers. This feature enabled 23andMe to select SNPs (single nucleotide polymorphisms), or variants that provide coverage of genes associated with drug response, information that is proving to be critical for the ...

Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum

... underlying serum-microRNA platform is extremely sensitive, and has demonstrated detection sensitivity on the order of a single molecule, single nucleotide specificity, and up to 700 fold test-to-control increase of certain serum microRNA biomarkers." said Dr. Ayelet Chajut, EVP R&D Molecular Biology ...

World's First Low Radiocarbon Food May Reduce Risks of Cancer and Birth Defects, and Possibly Even Slow the Aging Process

... to 99% of the radiocarbon in the most critical food components. They will also be growing algae to produce affordable low radiocarbon amino acid and nucleotide nutritional supplements that can be used in infant formula, baby foods, and child and maternal dietary supplements. All ordinary food, ...

Idenix Pharmaceuticals Reports Second Quarter and Six Month Financial Results

... amended to also evaluate a 100 mg/day dose. -- Idenix has submitted an investigational new drug (IND) application for IDX184, a once-daily, oral nucleotide prodrug candidate for the treatment of chronic hepatitis C, to the United States Food and Drug Administration (FDA) and has initiated a phase I ...

DNA Study Unlocks Mystery to Diverse Traits in Dogs

... Kennels in Gilroy, California and Mars' Waltham Center for Pet Nutrition in the United Kingdom, studied simple genetic markers known as Single nucleotide Polymorphisms, or SNPs, to find places in the dog genome that correlate with breed traits. Because many traits are "stereotyped" -- or fixed within ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ. A Single nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumour Formation in Humans. Cell; 2004; 119: 591-602. ...

Honey bee invaders exploit the genetic resources of their predecessors

... The researchers were looking for tiny variations in the sequences of nucleotides that make up all genes. Certain versions of these single nucleotide polymorphisms (SNPs, or snips) are more common to African honey bees, while others occur more frequently in honey bees in western Europe, eastern ...

Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study

... is the complete DNA sequence present in every cell of an organism. "The location of naturally occurring variations in human DNA, known as Single nucleotide Polymorphisms (SNPs), serve as signposts or markers in the genome. Associating these SNP markers with diseases in different individuals provides ...

Anadys Pharmaceuticals Reports Third Quarter 2007 Financial Results and Operational Highlights

... for the treatment of certain cancers. Included within this restructuring were the decisions to discontinue further development of ANA380, a nucleotide analog for the treatment of hepatitis B virus (HBV) infection, halt all work on early discovery projects, and effect an immediate reduction ...

Consortium publishes Phase II map of human genetic variation

... treat and prevent disease. The second-generation haplotype map, or Phase II HapMap, contains more than 3.1 million genetic variants, called single nucleotide polymorphisms (SNPs) three times more than the approximately 1 million SNPs contained in the initial version. The more SNPs that are on the map, the ...

454 sequencing uncovers significant genetic variation

... appears online (ahead of print) today in the journal Science. Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural ...

454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation

... appears online (ahead of print) today in the journal Science. Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural ...

SNPs Powerful Tools for Association Studies

... studies. This analysis will clarify why single nucleotide polymorphisms (SNPs) are powerful tools for ... from each other. In this case, the nucleotide change that results in a RFLP is also the ... change (i.e., an A-to-T change in the number two nucleotide of the sixth exon in the - globin chain of the ...

Isolation and Characterization of Anti-Viral Nucleoside Compounds from the Chinese Herb Taraxacum Mongolicum

... Characterization of nucleotide and nucleoside analogs from Taraxacum mongolicum, ... ingredients in the herb were characterized using nucleotide and nucleoside standards with product and ... of drugs with anti-HSV-1 properties, including nucleotide and nucleoside analogs. LC/MS/MS conditions were ...

Real-Time PCR/Melt-Curve Analysis: SNP Detection With FRET, Rev A

... powerful tool for the identification of single nucleotide polymorphisms (SNPs). The frequency of ... 6-FAM-labeled probe, with the polymorphic nucleotide placed in the middle, hybridizes next ... Reverse: 5'-CACAGGGCAGGTCT-3' The third nucleotide position from the 3' end of the reverse primer ...

Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System

... the wild-type G nucleotide and the variant A nucleotide at position 1934 (*4 allele) of the CYP2D6 gene. ... CYP2D6 gene contains numerous Single nucleotide Polymorphisms (SNPs) that alter enzyme ... Accession #M33388), where a variant A nucleotide replaces the wild-type G nucleotide. Our assay ...

Comparison of PCR Kleen Spin Columns to Traditional Methods for Purification of PCR Products Prior to Sequencing, Rev A

... is the most critical factor in nucleotide sequencing. The presence of ... and compared the resulting nucleotide sequences obtained from these samples with the ... Following sequencing PCR, the resulting nucleotide sequences were analyzed on an ABI ...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

... a rapid and sensitive method for the detection of nucleotide sequence variation which can be used ... the 28 identified A1 sequences, with a nucleotide sequence variation between them of 116 nt plus ... all fish analyzed. This rapid rate of analysis of nucleotide sequence variation makes it possible ...

RNA Interference and Gene Silencing: History and Overview

... PTGS indicate that these 21-23 nucleotide dsRNAs mediate PTGS. Introduction of siRNAs can ... embryo lysates was processed to 21-23 nucleotide species. They also found that the homologous ... and that cleavage occurred at 21-23 nucleotide intervals (26 ). ...

Your Data: Silencing of a Pro-apoptotic Transcription Factor Using Synthetic siRNA

... been shown to be mediated by 2123 nucleotide RNA fragments, termed short ... ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101(1) : 2533. ... is mediated by 21- and 22- nucleotide RNAs. Genes Dev. 15(2) : 188200. ...