Neurotransmitter in Biological Technology

Ceregene Receives Additional Grant From Michael J. Fox Foundation to Expand Long-Term Testing of CERE-120 Patients

... and gait, are caused by a loss of dopamine-containing nerve cells in the substantia nigra, which project their axons to the putamen. Dopamine is a neurotransmitter involved in controlling movement and coordination, so Parkinson's patients exhibit a progressive inability to initiate and control physical ....

Inaugural Kavli Prize ceremony and symposia: Sept. 8-11 (Oslo, Norway)

... function of neurogenesis in the adult mammalian brain" Eric Gouaux (Oregon Health & Science University, USA). Topic: "Structure and mechanism of neurotransmitter receptors and transporters" Sten Grillner (Karolinska Institute, Sweden). Topic: "Kavli Laureate Lecture" Thomas Jessell (Columbia University, ...

FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder

... potentially life-threatening serotonin syndrome may occur when EFFEXOR XR is coadministered with other drugs that may affect the serotonergic neurotransmitter systems. Concomitant use of EFFEXOR XR with MAOIs is contraindicated. If concomitant use of EFFEXOR XR with an SSRI, SNRI, or a triptan is ...

Addrenex Pharmaceuticals Reaches Milestone with Filing of NDA for First Product, CloniBID, to Treat Hypertension

... Triangle Park. The company was formed in 2006 by a practicing physician and a drug development expert with the mission to explore the impact that neurotransmitter regulation has on a variety of diseases and disorders. Addrenex identified adrenergic regulation as its initial research focus. Adrenergic ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... field of acetylcholinesterase ("AChE"), developed by Professor Hermona Soreq of the Hebrew University of Jerusalem. AChE is a degrading enzyme of the neurotransmitter acetylcholine, the imbalance of which plays a central role in a range of currently incurable and highly debilitating neurodegenerative conditions. ...

Anavex advances drug candidate for treatment of Alzheimer's disease

... and shown to be distinct from any known receptor class. In the CNS, they are involved in the modulation of neurotransmitter receptor function, neurotransmitter release and response, as well as memory and learning processes, demonstrating potential neuroprotective and anti-amnesic properties. The modulatory ...

Lexicon Pharmaceuticals Reports 2007 Third Quarter Financial Results

... tract. In preclinical studies with these molecules, serotonin levels could be reduced in the intestine without affecting levels of the neurotransmitter in the brain, where it mediates mood and other behaviors. -- Lexicon received stockholder approval for and completed a financing transaction ...

Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome

... commented Arthur T. Sands, M.D., Ph.D., president and chief executive officer of Lexicon Pharmaceuticals. "Given serotonin's established role as a neurotransmitter modulating gastrointestinal function, these findings have allowed us to pursue a potential new mechanism for treating conditions, such as IBS, that ...

Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System

... as renal Na + re-absorption, insulin secretion, platelet aggregation, and neurotransmitter release at sympathetic nerve endings (1). They consist of three highly ... and α 2c subtypes are required for normal presynaptic control of neurotransmitter release from sympathetic nerves from the heart and from central ...

Gender hormones may lend to social disorder therapies

... the females, Auger says. To the scientists' surprise, a similar result took place when they treated the females with a mimic of the neurotransmitter dopamine, a chemical messenger in the brain that regulates emotions and feelings of pleasure. The UW-Madison study results imply that many ...

Medical College receives $377K to study brain disease

... of biophysics, will examine the link between oxygen deficit and loss of a key agent in the regulation of the oxidation-reduction process and in neurotransmitter production in the brain. Hypoxia, or oxygen deficit, in the preterm fetal brain is an important gestational complication leading to movement ...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

... carried out to discover the mode of action of various transmitters, in order to understand and combat these diseases. In many cells, binding of the neurotransmitter to its receptor alters the production of the second messenger adenosine 3', 5' cyclic monophosphate (cAMP), through the enzyme adenylyl cyclase. ...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

... in this region that are likely to involve GABAergic interneurons (neurons that synthesize and release the major inhibitory neurotransmitter in the brain, γ-aminobutyric acid or GABA). The synthesis of GABA is catalyzed by the enzyme glutamic acid decarboxylase ...

Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*

... central nervious system cells (hNT Neurons) to imitate the aging human brain, neurodegeneration, and to investigate the role of sex steroids in neurotransmitter transcription and synthesis. Preliminary data show the potential of this model system. The normal, physiological aging of the human brain has ...

Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling

... synapsin I, the synapse-specific protein, that is useful for studying synaptogenesis and synapse elimination. Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive ...