Muscle in Biological Technology

Heart disease: Research off the beating patch

... that allows us to introduce living, healthy heart muscle cells into damaged areas of the heart in a way ... patch with a sufficiently large number of heart muscle cells (2.5 million or more), the cells start ... and blood flow when implanted into damaged heart muscle in a rat model of myocardial infarction. Dr. ...

Muscular protein bond -- strongest yet found in nature

... The real strength of any skeletal muscle doesn't start with exercise; it comes ultimately ... a molecular "ruler" along which the whole muscle structure is aligned, and it acts as an elastic spring when a muscle is stretched. Titin plays a role in a wide ...

2009: Immunotec announces important clinical research initiative: New study to be launched with the goal of improving the quality of the aging process

... in Combination with Physical Exercise on muscle Function, Body Composition and Inflammatory ... typically associated with a decrease in skeletal muscle mass and muscle function, which contributes decisively to ...

Insmed Announces Results of IPLEX(TM) Phase II Trial in Myotonic Muscular Dystrophy

... of endurance, using the six-minute walk test, muscle function and strength, cognitive function, ... measure of endurance by the six-minute walk test, muscle function, muscle strength, or quality of life in any of the tests ...

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... provide for the advancement of this novel cardiac muscle activator into studies that are designed to ... small-molecule therapeutics that activate cardiac muscle contractility for potential applications in the ... is the cytoskeletal motor protein in the cardiac muscle cell that is directly responsible for converting ...

The Journal of Cardiac Failure Publishes Results From Celladon Corporation's First-in-Human Phase 1/2 Clinical Trial in Advanced Heart Failure

... known to play a critical role in normal cardiac muscle cell activity. Our objective is not only to ... delivered in a single dose directly to the heart muscle during a short outpatient procedure, performed in ... calcium cycling and contractility in heart muscle cells. Celladon's first product candidate, ...

Beverly Hills Surgeon Dr. Payman Simoni Applauds Obama Administration's New Direction in Stem Cell Research

... other types of cells, like skin, bone, nerve, or muscle tissues. Embryonic stem cells are the most ... tissues in their face, adding to lost bone and muscle tissue while improving the quality of the ... transforming adult fat stem cells into smooth muscle cells, which help the normal function of a large ...

FDA Issues Complete Response Letter for RISPERDAL(R) CONSTA(R) for the Adjunctive Maintenance Treatment of Bipolar Disorder

... in pulse, heart rate, or blood pressure; or muscle pain and weakness. Treatment should be stopped if ... are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors, and muscle stiffness. If you observe any of these symptoms, ...

Max Muscle Introduces First-Ever Probiotics Protein Bar

... Feb. 10 /PRNewswire/ -- National retailer Max muscle Sports Nutrition today announced the launch of ... in the U.S. The collaboration between Max muscle and Ganeden Biotech, manufacturer of the patented ... to partner with strong brands such as Max muscle to meet this demand." The 50-gram Max Crunch ...

Phase 3 Data Demonstrate Efficacy and Tolerability of Paliperidone Palmitate, an Investigational Long-Acting Therapy for the Treatment of Schizophrenia

... in pulse, heart rate, or blood pressure; or muscle pain and weakness. Treatment should be stopped if ... are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors, and muscle stiffness. If you observe any of these symptoms, ...

New Partnership Integrates Vibration Therapy Into Stem Cell Procedures

... up a patient's recovery time by recruiting more muscle fibers -- thus increasing strength ... reflex, recruiting more than 90 percent of muscle fibers to push the body upwards against gravity. ... effects on the body include an increase in muscle activity, bone density, and circulation. WAVE ...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

... superficial edema (60%-74%), nausea (50%-73%), muscle cramps (28%-62%), vomiting (23%-58%), diarrhea ... assessed were nausea (57%); diarrhea and muscle cramps (43% each); anemia, fatigue, arthralgia ... adverse reactions were diarrhea, nausea, ascites, muscle cramps, dyspnea, fatigue, peripheral edema, ...

Video: New, Advanced Therapy Program Helps People Who Stutter Acquire Fluent Speech

... people who stutter learn how to replace faulty muscle contractions that cause stuttering with new ... HCRI therapy incorporates new knowledge of muscle movements that actively generate fluent speech ... to understand, learn and maintain details of muscle movements that produce fluent speech; -- An ...

PTC124 Featured at Third Annual Congress of Myology

... Duchenne muscular dystrophy (DMD), a progressive muscle disorder in which patients lack dystrophin, a ... is critical to the structural stability of muscle fibers. PTC recently launched a global, ... muscle disorders that cause the loss of both muscle function and independence. DMD/BMD is perhaps the ...

Treatment with Paliperidone ER May Be Associated with Significantly Reduced Use of Mental Health Resources

... in pulse, heart rate, or blood pressure; or muscle pain and weakness. Treatment should be stopped if ... are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors, and ... (for example, involuntary movements, tremors and muscle stiffness). (a) Because only 28 percent of ...

Victhom announces promising results on the proof of concept for its unique closed-loop neuromodulation system

... from a nerve and of stimulating the appropriate muscle groups, which represents, to the knowledge of ... from the nerve, to stimulate the appropriate muscle group to lift the foot in the desired direction ... sensors, the Neurostep(TM) detects intrinsic muscle activities and surface sensation events from ...

TorreyPines Therapeutics Reports Fourth Quarter and Full Year 2007 Financial Results and Highlights

... may be effective in reversing or preventing muscle spasticity and rigidity of spinal ischemia. ... trial of tezampanel for the treatment of muscle spasticity and rigidity secondary to spinal ... and disorders such as migraine, chronic pain, muscle spasticity and rigidity, xerostomia and cognitive ...

Genomas Awarded $1.2 Million NIH SBIR Grant to Develop DNA-Guided System for Management of Statin Therapy

... side effects. Clinical symptoms of SINM include muscle aches (myalgia), cramps, weakness, and muscle injury (myositis, monitored in serum by elevation ... award has been published in the renowned journal muscle & Nerve in September 2007. Researchers at the ...

Bioheart Founder, Howard J. Leonhardt, Becomes Chairman of the Board of Directors

... scar tissue within a patient's heart with living muscle tissue for the purpose of improving ... uses adult stem cells that are precursors to muscle cells, or myoblasts, which are derived from the ... damaged tissue and differentiating into mature muscle cells. The core technology used in MyoCell has ...

Cardium's Corgentin Preclinical Program Shows High Levels of Targeting to Acutely Ischemic Heart Muscle Following Intracoronary Infusion

... vectors within acutely ischemic myocardium (heart muscle lacking sufficient blood flow as a result of ... which the coronary arteries supplying the heart muscle are initially blocked and later reopened, as ... the potential to prevent further damage to heart muscle and improve cardiac healing following a heart ...

Gladstone scientists identify role of tiny RNAs in controlling stem cell fate

... and miR-133, which have been associated with muscle development, not only encourage heart muscle formation, but also actively suppress genes that ... fate, or cell lineage in this case as cardiac muscle cells. Specifically, they found that miR-1 and ...

Abbott Receives FDA Approval for SIMCOR(R) (Niaspan(R) / simvastatin), a Novel Combination Medicine for Comprehensive Cholesterol Management

... health care provider if symptoms of unexplained muscle pain, tenderness, or weakness occur, as this may be a sign of a serious but rare muscle disorder, from which rare cases of death have ... and anyone with liver problems. Unexplained muscle pain or weakness could be a sign of ...

Data from Two Pivotal Trials of AMRIX, a New Once-Daily Extended-Release Muscle Relaxant, Presented at the American Academy of Pain Medicine Meeting

... a new once-daily extended-release skeletal muscle relaxant, was superior to placebo. AMRIX had ... taken three times a day in alleviating acute muscle spasm associated with lower back and neck ... of Pain Medicine in Orlando, FL. "Typically, muscle relaxants are taken multiple times a day, which ...

Schering-Plough Announces Sugammadex New Drug Application Filed in Japan

... reverse to rapidly reverse the effects of certain muscle relaxants, rocuronium bromide (marketed in the ... bromide (marketed in Japan as MUSCULAX(R)). muscle relaxants are used as part of general anesthesia ... of rocuronium bromide or vecuronium bromide, muscle relaxants commonly used during surgeries that ...

Schering-Plough Announces New Drug Application for Sugammadex Assigned Priority Review Status by U.S. FDA

... (rocuronium bromide) and vecuronium bromide. muscle relaxants are used as part of general anesthesia ... reverse both shallow and profound levels of muscle relaxation, which is not possible with current ... or vecuronium bromide, muscle relaxants commonly used during surgeries that ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... characterised by progressive muscle weakness. EN101 has demonstrated safety and ... studies and measures the strength of 13 different muscle groups. The interim data suggest EN101 may have ... bronchorrhea, headache and involuntary muscle twitching. According to the Myasthenia Gravis ...

Creating the Bionic Woman: Making Nerves Spring Back to Life

... where nerve fibers from a neighboring muscle are redirected to the damaged muscle to provide function. The nerve branches from the original muscle and the redirected nerve branches to the damaged ...

Topline Findings from Comparative Analysis of INVEGA(TM) and Quetiapine in Schizophrenia to be Postered at the 20th Annual U.S. Psychiatric and Mental Health Congress

... (for example: involuntary movements, tremors and muscle stiffness). One risk of INVEGA is that it ... in pulse, heart rate, or blood pressure; or muscle pain and weakness. Treatment should be stopped if ... are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors, and ...

Cephalon, Inc. Announces Agreement to Acquire AMRIX, A Once-Daily Extended-Release Muscle Relaxant

... to rest and physical therapy for relief of muscle spasm associated with acute, painful ... HCl is the most widely prescribed muscle relaxant in the United States, representing 37 percent of the 45 million prescriptions for muscle relaxants written in 2006, according to IMS. ...

FDA Approves RISPERDAL(R) to Treat Adolescents with Schizophrenia and Children and Adolescents with Bipolar Mania

... saliva increased, constipation, fever, tremors, muscle stiffness, abdominal pain, anxiety, nausea, ... malignant syndrome (NMS). NMS is characterized by muscle rigidity, fever and can be serious. You may have ... are usually persistent movement disorders or muscle disturbances, such as restlessness, tremors ...

European EMEA Acceptance of Marketing Authorization Application Filing for SNT-MC17 in Friedreich's Ataxia by Santhera

... and muscle tissue. This disorder causes loss of muscle control, uncoordinated movements, muscle wasting and thickening of heart walls which ... increasing the energy production within nerve and muscle cells of FRDA patients, protecting these cells ...

United States FDA Clears the REGEN Trial to Test Bioheart's Combination Gene and Stem Cell Therapy in Heart Failure Patients

... is a composition of myogenic stem cells derived from a patient's own thigh muscle that has been modified to over express the SDF-1 protein. The product ... the patient's heart. The goal of MyoCell SDF-1 is to grow new contractile muscle within the scar tissue that will have the ability to release additional ...

Sinobiopharma Updates on Progress; Projects Increases in Sales and Revenues In 2009

... of Cisatracurium Besylate is now China's top-selling pre-surgical skeletal muscle relaxant. Sales of Clindamycin, an antibiotic, increased by 150 ... application for approval of Rocuronium bromide, a next generation skeletal muscle relaxant that is also the first that can be stored at room temperature, to ...

Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs

... severe pain. VA111913 acts by blocking vasopressin 1a receptors in smooth muscle in the uterus wall, which in response to elevated vasopressin levels leads ... VA111913 has demonstrated in preclinical trials it can normalise smooth muscle contraction thereby offering the potential for it to be the first licensed ...

Sinobiopharma Signs Export Agreement With U.S. Pharmaceutical Supplier

... as Agent to Find Partner to Co-Develop Company's Chinese Patented Skeletal muscle Relaxant for North American Markets LAS VEGAS, April 3 ... version of Cisatracurim besylate, a non-depolarizing pre-surgical skeletal muscle relaxant, for use in North America. Kingchem will also source buyers in ...

Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session

... of AMR-001, the company's lead product for the treatment of damaged heart muscle following acute myocardial infarction (AMI), that showed a significant ... ventricular remodeling. Caused by the progressive decline in heart muscle function following an AMI, ventricular remodeling can lead to permanent ...

Cephalon and Eurand File Patent Infringement Lawsuit Against Mylan Pharmaceuticals and Barr Pharmaceuticals

... This patent claims extended-release formulations containing the muscle relaxant cyclobenzaprine, including AMRIX(R) (Cyclobenzaprine ... short-term use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. ...

Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results

... as muscarinic receptor antagonists. These compounds relax detrusor smooth muscle tissue found in the bladder, thus decreasing bladder contractions. Overactive or unstable detrusor muscle function is believed to be the cause of overactive bladder. ...

The human brain minimizes energy expenditure and integrates gravity in to the action plan

... organisms. The simple observation of vertical arm movements reveals that muscle activity when moving upwards differs from when moving downwards. This led ... mathematical method which predicted short periods of muscle inactivation and direction-dependent hand kinematics. These predictions ...

ARCA biopharma Appoints William R. Hiatt as Director of Clinical and Regulatory Strategy

... disease and understanding its pathophysiology in terms of the effects of muscle ischemia on muscle metabolism and function. Dr. Hiatt also is President of the Colorado ...