Motif in Biological Technology

New method may accelerate drug discovery for difficult diseases like Parkinson's

... only the first four amino acids to work and those amino acids had a common motif (cysteine any amino acid a hydrophobic amino acid cysteine). This particular four-amino-acid motif is very similar to some important biochemical structures, including ...

It's raining pentagons

... may be good too." Ice structures are usually built out of simple hexagonal arrangements of water molecules and this hexagonal building block motif is easily observed in the structures of snowflakes. However, during their studies Dr Angelos Michaelides and co-workers from the Fritz Haber ...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

... One such peptide, termed CKEY2, is comprised of sequences from the RANTES protein. CKEY2 was shown to be stable and formed the secondary structural motif found in RANTES when stabilized by disulfide bridged cysteines at both ends of the peptide. The scientists demonstrated that CKEY2 disrupts ...

Study reveals principles behind stability and electronic properties of gold nanoclusters

... metallic core of 14 gold atoms and a protective layer of 24 gold atoms bound to sulfur. "In 2006, we predicted that gold atoms in this bonding motif were divided in two groups those that made the metal core and those that helped to protected it," explained Hkkinen. "Now there was evidence that ...

FlexiPlate siRNA

... using the RefSNP database. This increases siRNA potency, as an siRNA spanning a SNP will vary in its effectiveness. Interferon motif avoidance siRNAs are screened for multiple sequence motifs known to result in an interferon response (3, 4). siRNAs with such ...

Protein Depletion for Plasma and Serum Proteomic Analysis

... 2003, 4 :74-80.

Han KK, Martinage A: Possible relationship between coding recognition amino acid sequence motif or residue(s) and posttranslational chemical modification of proteins. Int. J. Biochem. 1992, 24 :1349-1363.

Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

... the requirement for ubiquitin modification. 5 To convert ZsGreen into a proteasomal substrate, its C-terminus was fused to a specific degradation motif that targets the fusion for removal by the proteasome. Under normal conditions, the fluorescence of the cells is very low because ...

Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A

... protease ER 60, Exp Parasitol 86, 17 (1997) Gillingham AK and Munro S, The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin, EMBO Rep 1, 524529 (2000) Grevelding CG et al., Female-specific gene ...

Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A

... Discussion Previous studies have documented that Pdx1 binds in vitro specifically to promoter elements containing the TAAT motif (Watada et al. 1996, Ohneda et al. 2000). However, none of these studies have examined directly the specificity of promoter ...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

... and its similarity to plasma retinol-binding protein, Nature, 383385 (1986). 11. Godovac-Zimmerman, J., The structural motif of -lactoglobulin and retinol-binding protein: a basic framework for binding and transport of small hydrophobic molecules? ...

Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn

... The peptides labeled in blue were not initially identified, however each of these unknown peptides contains an Asn-X-Ser/Thr motif (with the Asn labeled in green), strongly suggesting that these peptides might be glycosylated. N-linked oligosaccharides ...

Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library

... a novel protein with a predicted molecular mass of 64,274 Da. 7 The N-terminal region of ACF showed the presence of RNA recognition motif (RRM)-type RNA binding domain, which is consistent with its function as the RNA-binding subunit of the editing enzyme. The ...